Substance Substance comment ATC Pharmaceutical group Molar mass Type of test Species Critical effect Exposure time Study period Concentrations/Doses Sex Age Number of organisms Route of exposure LC50 EC50 IC50 NOEC LOEC NOEL LOEL Reference short
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             3.32 umol/L             Calleja et al. 1994 (b)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             2120 umol/L
(381.933688 mg/L)
            Calleja et al. 1994 (a)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             2.89 umol/L             Calleja et al. 1994 (b)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             785 umol/L
(141.423559 mg/L)
            Calleja et al. 1994 (a)
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) age at each reproduction (brood 4) 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.56 mg/L
(0,56 mg/L)
1.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) average size of juveniles from first brood 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           84.5 mg/L
(84,5 mg/L)
186.0 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) number of viable offspring 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.32 mg/L
(0,32 mg/L)
0.56 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) neonates per brood (brood 2) 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004b
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia longispina (Crustacean) immobilization 48 h   180.00-1800.00 mg/L   <24h Four replicates of five individuals for each treatment     >1800.00 mg/L           Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) neonates per brood (brood 3) 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.56 mg/L
(0,56 mg/L)
1.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia longispina (Crustacean) immobilization 48 h   180.00-910.00 mg/L   <24h Four replicates of five individuals for each treatment     342.41 mg/L
(342,41 mg/L)
          Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) neonates per brood (brood 5) 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           1.80 mg/L
(1,8 mg/L)
3.20 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) average size of juveniles from first brood 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.56 mg/L
(0,56 mg/L)
1.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) size of neonates-first brood 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           >10.00 mg/L >10.00 mg/L     Marques et al. 2004a
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) number of viable offspring 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           84.50 mg/L
(84,5 mg/L)
186.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) number of viable offspring 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004a
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia longispina (Crustacean) immobilization 48 h   347.00-900.00 mg/L   <24h Five animals in each vessel, four replicates per treatment     647.31 mg/L
(647,31 mg/L)
          Marques et al. 2004a
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574   Daphnia longispina (Crustacean) population growth rate 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           84.5 mg/L
(84,5 mg/L)
186.0 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574   Daphnia longispina (Crustacean) daily growth rate 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           1.80 mg/L
(1,8 mg/L)
3.20 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia longispina (Crustacean) neonates per brood (brood 2) 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.80 mg/L
(1,8 mg/L)
3.20 mg/L     Marques et al. 2004a
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) neonates per brood (brood 1,2,3,4 and 5) 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           409.0 mg/L
(409 mg/L)
900.0 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574   Daphnia magna (Crustacean) population growth rate 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           1.80 mg/L
(1,8 mg/L)
3.20 mg/L     Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574   Daphnia magna (Crustacean) daily growth rate 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.56 mg/L
(0,56 mg/L)
1.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           8.15 mM           Lilius et al. 1995
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) average size of juveniles from first brood 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           409.0 mg/L
(409 mg/L)
900.0 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia magna (Crustacean) immobilization 48 h   900.0-2350.00 mg/L   <24h Five animals in each vessel, four replicates per treatment     1293.05 mg/L
(1293,05 mg/L)
          Marques et al. 2004a
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD Guidelines No. 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               932 umol/L
(167,9066968 mg/L)
          Calleja et al. 1994 (a)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 European Guideline; EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 24 h and 48 h       Younger than 24h four replicates, 5 daphnids each     88.1 mg/L
(88,1 mg/L)
  75 mg/L
(75 mg/L)
      Cleuvers 2004
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) average size of juveniles from first brood 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           >3.20 mg/L >3.20 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     8.15 mM
(1468,28281 mg/L)
          Lilius et al. 1994
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               2.97 umol/L           Calleja et al. 1994 (b)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) number of viable offspring 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004a
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) size of neonates-first brood 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004a
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) neonates per brood (brood 3) 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004a
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia magna (Crustacean) immobilization 48 h   180.00-910.00 mg/L   <24h Four replicates of five individuals for each treatment     402.55 mg/L
(402,55 mg/L)
          Marques et al. 2004b
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (2000) Daphnia magna (Crustacean) immobilization 48 h   180.00-1800.00 mg/L   <24h Four replicates of five individuals for each treatment     >1800.00 mg/L           Marques et al. 2004b
Acetylsalicylic acid gentisic acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) number of viable offspring 21 days   0.32, 0.56, 1.00, 1.80, 3.20 mg/L   <24h           0.32 mg/L
(0,32 mg/L)
0.56 mg/L     Marques et al. 2004b
Acetylsalicylic acid o-hydroxyhippuric acid, acetylsalicylic acid metabolite N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) number of viable offspring 21 days   38.4, 84.5, 186.0, 409.0, 900.0 mg/L   <24h           186.00 mg/L
(186 mg/L)
409.00 mg/L     Marques et al. 2004b
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD no. 202 (1996) Daphnia magna (Crustacean) daily growth rate 21 days   1.00, 1.80, 3.20, 5.60, 10.00 mg/L   <24h           1.00 mg/L
(1 mg/L)
1.80 mg/L     Marques et al. 2004a
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 OECD 202 (1993) Daphnia pulex (Crustacean) immobilization 24 h   5 concentrations           2 mM           Lilius et al. 1995
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 European Guideline; EEC Directive 92/69/EEC (1993) Desmodesmus subspicatus (Green algae) growth inhibition                 106.7 mg/L
(106,7 mg/L)
  32 mg/L
(32 mg/L)
      Cleuvers 2004
Acetylsalicylic acid   N02BA01 Analgesic 180.1574   Hydra vulgaris (Cnidarian) partially contracted polyp, slow reactions 7 days   10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           1 mg/L     Pascoe et al. 2003
Acetylsalicylic acid   N02BA01 Analgesic 180.1574   Hydra vulgaris (Cnidarian) mean number of Artemia ingested 7 days 10 day feeding/budding study followed 7 d exposure 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Acetylsalicylic acid   N02BA01 Analgesic 180.1574   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     27.6 mM
(4972,34424 mg/L)
          Lilius et al. 1994
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               145 umol/L
(26,122823 mg/L)
          Calleja et al. 1994 (a)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               2.16 umol/L           Calleja et al. 1994 (b)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             177 mg/L
(177 mg/L)
177 mg/L
(177 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             988 umol/L
(177.9955112 mg/L)
            Calleja et al. 1994 (a)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.98 umol/L             Calleja et al. 1994 (b)
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               720 mg/L
(720 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     86.2 mg/L
(86.2 mg/L)
            Nalecz-Jawecki and Persoone 2006
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               146.13 mg/L           Ortiz de Garcia et al. 2014
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               133.59 mg/L           Ortiz de Garcia et al. 2014
Acetylsalicylic acid   N02BA01 Analgesic 180.1574 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 471.68 mg/L           Ortiz de Garcia et al. 2014
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             133 umol/L
(36.8946389 mg/L)
            Calleja et al. 1994 (a)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033   Artemia salina (Crustacea) Immobilization 24 h               36,6 mg/L           Callejaa et al. 1993
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             2.12 umol/L             Calleja et al. 1994 (b)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             0.46 umol/L             Calleja et al. 1994 (b)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             2.9 umol/L
(0.80446957 mg/L)
            Calleja et al. 1994 (a)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033   Brachionus calyciflorus (Rotifera) Immobilization 24 h               0,8 mg/L           Callejaa et al. 1993
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 AFNOR procedure XP T90-382 Crassostrea gigas Embryo–larval toxicity 36h   100, 150, 200, 250, 300, 400, 600, 800, and 1,000 μg l−1           185.7±26.7 mg/L           Di Poi et al. 2014
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 AFNOR procedure XP T90-382 Crassostrea gigas Metamorphosis bioassays 24h   100, 200, 400, 600, 800, and 1, 000 μg l−1           385.3±56.1 mg/L           Di Poi et al. 2014
Amitriptyline   N06AA09 Psychoanaleptics 277.4033   Danio rerio Mortality 120h   0,0.1, 1, 2, 3, 5, 10, 25, 50, 75 and 100 mg/L     20 embryos/well   1,4 mg/L     100 μg/L
(0,100 mg/L)
      Yang et al. 2014
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 guideline NF EN ISO 6341 (1996) Daphnia magna Acute immobilization 48h               4.82 [3.43–5.13] mg/L           Minguez et al. 2014
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               20 umol/L
(5,548066 mg/L)
          Calleja et al. 1994 (a)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.00415 mM
(1151,223695 mg/L)
          Lilius et al. 1994
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           4150 mM           Lilius et al. 1995
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               1.25 umol/L           Calleja et al. 1994 (b)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 OECD 202 (1993) Daphnia pulex (Crustacean) immobilization 24 h   5 concentrations           3730 mM           Lilius et al. 1995
Amitriptyline Amitryptyline HCl N06AA09 Psychoanaleptics 277.4033 ISO/WD 20079 (2001) Lemna minor (Duckweed) growth inhibition 7 days       Initially three or four fronds Six-well plates, one plant in each well, three replicates     1.69 mg/L
(1,69 mg/L)
          Kaza et al. 2007
Amitriptyline   N06AA09 Psychoanaleptics 277.4033   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     0.475 mM
(131,7665675 mg/L)
          Lilius et al. 1994
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               1.89 umol/L           Calleja et al. 1994 (b)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               77.8 umol/L
(21,58197674 mg/L)
          Calleja et al. 1994 (a)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             0,7 mg/L
(0.7 mg/L)
0.44 mg/L
(0,44 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Spirotox Spirostomum ambiguum (Ciliate) pherical deformation and autolysis 24 h             1.13 mg/L
(1.13 mg/L)
0.58 mg/L
(0,58 mg/L)
          Nalecz-Jawecki 2008
Amitriptyline   N06AA09 Psychoanaleptics 277.4033   Streptocephalus proboscideus (Crustacea) Immobilization 24 h               0,76 mg/L           Callejaa et al. 1993
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             0.44 umol/L             Calleja et al. 1994 (b)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             2.8 umol/L
(0.77672924 mg/L)
            Calleja et al. 1994 (a)
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               40 mg/L
(40 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Amitriptyline   N06AA09 Psychoanaleptics 277.4033 Thamnotoxkit F Thamnocephalus platyurus (Crustacean) mortality 24 h             1.12 mg/L
(1.12 mg/L)
            Nalecz-Jawecki 2008
Amitriptyline Amitriptyline HCl N06AA09 Psychoanaleptics 277.4033 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     3.0 mg/L
(3 mg/L)
          Nalecz-Jawecki and Persoone 2006
Amitriptyline Amitriptyline HCl N06AA09 Psychoanaleptics 277.4033 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     0.63 mg/L
(0.63 mg/L)
            Nalecz-Jawecki and Persoone 2006
Amlodipine   C08CA01 Calcium antagonists 408.8759   Hydra vulgaris (Cnidarian) mean number of Artemia ingested 7 days 10 day feeding/budding study followed 7 d exposure 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           1 mg/L     Pascoe et al. 2003
Amlodipine   C08CA01 Calcium antagonists 408.8759   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 72h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Amlodipine   C08CA01 Calcium antagonists 408.8759   Hydra vulgaris (Cnidarian) clubbed tentacles, body slightly contracted 7 days   10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           100 ug/L
(0.1 mg/L)
    Pascoe et al. 2003
Amlodipine   C08CA01 Calcium antagonists 408.8759   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 24h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Amlodipine   C08CA01 Calcium antagonists 408.8759   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 48h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Amorolfine   D01AE16 Antifungals for dermatological use     Microcystis aeruginosa (cyanobacteria) Growth   7 days 0, 6.75, 7, 7.25, 7.5, 8, 8.5, 9           8.03µgL
(0.00803 mg/L)
          Liu et al. 2012
Amorolfine   D01AE16 Antifungals for dermatological use     Photobacterium phosphoreum (Bacteria) Luminescence 15min               121.1 mg/L           Liu et al. 2012
Amoxicillin   J01CA04 Antibacterial agents 365.4042 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Amoxicillin   J01CA04 Antibacterial agents 365.4042 OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Amoxicillin   J01CA04 Antibacterial agents 365.4042 Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     20     Hartmann et al. 1998
Amoxicillin   J01CA04 Antibacterial agents 365.4042   Hydra vulgaris (Cnidarian) partially contracted polyp, slow reactions 7 days   10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           100 ug/L
(0.1 mg/L)
    Pascoe et al. 2003
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     > 1000 ug/L           Brain et al. 2004 (a)
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 8692 (1989), modified version Microcystis aeruginosa (Freshwater cyanobacteria) growth inhibition 7 days   0.0009 to 0.0038 mg/L     Initial density; 2*10^4 cells/ml     0.0037 mg/L
(0,0037 mg/L)
          Holten Lutzhoft et al. 1999
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 8692 (1989), modified version Rhodomonas salina (Marine cryptophycean) growth inhibition     5 to 500 mg/L     Initial density; 1*10^4 cells/mL     3108 mg/L (out of measured range)           Holten Lutzhoft et al. 1999
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 8692 (1989), modified version Selenastrum capricornutum (Freshwater green algae) growth inhibition     2.5 to 250 mg/L     Initial density; 1*10^4 cells/mL         250 mg/L
(250 mg/L)
      Holten Lutzhoft et al. 1999
Amoxicillin   J01CA04 Antibacterial agents 365.4042   Synechococcus leopolensis (Blue-green algae, strain UTEX 625) growth inhibition 96 h   50 ng/L to 50 mg/L     10 000 or 100 000 cells/mL (inocula)     2.22 ug/L
(0,00222 mg/L)
  0.78 ug/L
(0,00078 mg/L)
1.56 ug/L
(0.00156 mg/L)
    Andreozzi et al. 2004
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               n.a. mg/L           Ortiz de Garcia et al. 2014
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               n.a. mg/L           Ortiz de Garcia et al. 2014
Amoxicillin   J01CA04 Antibacterial agents 365.4042 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 2423.29 mg/L           Ortiz de Garcia et al. 2014
Amoxicillin   J01CA04 Antibacterial agents 365.4042 Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 15 min                 3597.0 mg/L         Park and Choi 2008
Amoxicillin   J01CA04 Antibacterial agents 365.4042 Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 5 min                 1320.0 mg/L         Park and Choi 2008
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             3.61umol/L             Calleja et al. 1994 (b)
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             0.98 umol/L             Calleja et al. 1994 (b)
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               2.86 umol/L           Calleja et al. 1994 (b)
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           0.164 mM           Lilius et al. 1995
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.164 mM
(22,1741776 mg/L)
          Lilius et al. 1994
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     53.05 mM
(7172,80562 mg/L)
          Lilius et al. 1994
Amphetamine sulfate   N06BA01 Psychoanaleptics 368.49 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.16 umol/L             Calleja et al. 1994 (b)
Ampicillin   J01CA01 Antibacterial agents 349.4048   Anabaena cylindrica NIES-19 Growth inhibition 144 h               0,14   0,013       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Anabaena flos-aquae ATCC 29413 Growth inhibition 144 h               3,3   0,16       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Anabaena variabilis NIES-23 Growth inhibition 144 h               2,2   0,16       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048 OECD (1993) no 201 Chlorella vulgaris (Green algae) growth inhibition     5 concentrations, triplicates           >1000 mg/L   >1000 mg/L       Eguchi et al. 2004
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of GADD45alpha 8 months   0.5, 1, 2 ng/L female     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of GADD45alpha 8 months   0.5, 1, 2 ng/L male     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of Bax 8 months   0.5, 1, 2 ng/L male     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Transcription levels of XPC; XPA; XPD; XPF genes 8 months   0.5, 1, 2 ng/L       flow through system       0.000002 mg/L       Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of p21 8 months   0.5, 1, 2 ng/L male     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of MDM2 8 months   0.5, 1, 2 ng/L female     flow through system       0.5 ng/L
(0.0000005 mg/L)
1 ng/L
(0.000001 mg/L)
    Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of p53 8 months   0.5, 1, 2 ng/L male     flow through system         0.5 ng/L
(0.0000005 mg/L)
    Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of p53 8 months   0.5, 1, 2 ng/L female     flow through system         1 ng/L
(1 mg/L)
    Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of Bax 8 months   0.5, 1, 2 ng/L female     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of p21 8 months   0.5, 1, 2 ng/L female     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin Ethinylestradiol J01CA01 Antibacterial agents 349.4048   Danio rerio (zebrafish Normalised fold expression of MDM2 8 months   0.5, 1, 2 ng/L male     flow through system       2 ng/L
(0,000002 mg/L)
      Soares et al. 2012
Ampicillin   J01CA01 Antibacterial agents 349.4048   Microcystis aeruginosa NIES-44 Growth inhibition 144 h               0,0002   0,000031       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Microcystis wesenbergii NIES-107 Growth inhibition 144 h               0,013   0,002       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Nostoc sp. PCC 7120 Growth inhibition 144 h               >200   100       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Pseudokirchneriella subcapitata ATCC 22662 Growth inhibition 144 h               >1000   >1000       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048 OECD (1993) no 201 Selenastrum capricornutum (Freshwater green algae) growth inhibition     5 concentrations, triplicates           >1000 mg/L   >1000 mg/L       Eguchi et al. 2004
Ampicillin   J01CA01 Antibacterial agents 349.4048   Synechococcus leopoldensis IAM M-6 Growth inhibition 144 h               0,083   0,025       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048   Synechococcus sp. PCC 7002 Growth inhibition 144 h               0,0069   0,00031       Ando and Nagase, 2007
Ampicillin   J01CA01 Antibacterial agents 349.4048 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               163 mg/L
(163 mg/L)
          Backhaus and Grimme 1999
Ampicillin   J01CA01 Antibacterial agents 349.4048 Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 15 min                 2627.0 mg/L         Park and Choi 2008
Ampicillin   J01CA01 Antibacterial agents 349.4048 Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 5 min                 1056.0 mg/L         Park and Choi 2008
Apraclonidine   S01EA03 Ophthalmologicals   OECD 201 Daphnia magna (Crustacean) Immobillization 48h         20 per sample     16.8 mg/L           Straub et al. 2011
Apraclonidine   S01EA03 Ophthalmologicals   OECD 203 Poecilia reticulata (Fish) Lethality 96h         7 per concentration   >0.08 (highest tested concentration) mg/L             Straub et al. 2011
Apraclonidine   S01EA03 Ophthalmologicals     Synechococcus leopoliensis (Cyanobacteria)   72 h               0.069 mg/L           Straub et al. 2011
Atenolol Atenolol C07AB03 Beta-receptor blockers 266.3361   Brachionus koreanus (rotifer) Acute toxicity 24 h   1-500 mg/L   adult approximately 7000/container   300 mg/L             Rhee et al. 2012
Atenolol   C07AB03 Beta-receptor blockers 266.3361 Acute toxicity to Daphnia: EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h Twenty daphnids for the controls and each treatment, subdivided in 4 replicates     313 mg/L
(313 mg/L)
          Cleuvers 2005
Atenolol   C07AB03 Beta-receptor blockers 266.3361 Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h       200 mg/L
(200 mg/L)
          Hernando et al. 2004
Atenolol   C07AB03 Beta-receptor blockers 266.3361 Algal inhibition test: EEC Directive 92/69/EEC (1993) Desmodesmus subspicatus (Green algae) growth 48 h         Initial density: 10^4 cells/mL     620 mg/L
(620 mg/L)
          Cleuvers 2005
Atenolol   C07AB03 Beta-receptor blockers 266.3361   Desmodesmus subspicatus (Green algae) photosynthesis inhibition 24 h               1335 mg/L
(1335 mg/L)
          Escher et al. 2006
Atenolol   C07AB03 Beta-receptor blockers 266.3361 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 500, 800, 1000, 1500, 2000 mg/kg   >2 month     >2000 mg/kg             Pino et al. 2015
Atenolol   C07AB03 Beta-receptor blockers 266.3361 ISO 10253 standard Phaeodactylum tricornutum Growth inhibition 72h               311.9 (262.4–370.7) mg/L           Claessens et al. 2013
Atenolol   C07AB03 Beta-receptor blockers 266.3361 OECD Test 210 (1992) Pimephales promelas (Fathead minnow) wet weight ended 28 d post-hatch   0.1, 0.32, 1, 3.2, 10 mg/L   embryos 2-24 h 20 embryos in each cup, approximately 80 embryos per conc.         3.2 mg/L
(3,2 mg/L)
10 mg/L     Winter et al. 2008
Atenolol   C07AB03 Beta-receptor blockers 266.3361 OECD Test 210 (1992) Pimephales promelas (Fathead minnow) survival (%) ended 28 d post-hatch   0.1, 0.32, 1, 3.2, 10 mg/L   embryos 2-24 h 20 embryos in each cup, approximately 80 embryos per conc.         10 mg/L
(10 mg/L)
>10 mg/L     Winter et al. 2008
Atenolol   C07AB03 Beta-receptor blockers 266.3361 OECD Test 210 (1992) Pimephales promelas (Fathead minnow) hatchability ended 28 d post-hatch   0.1, 0.32, 1, 3.2, 10 mg/L   embryos 2-24 h 20 embryos in each cup, approximately 80 embryos per conc.         10 mg/L
(10 mg/L)
>10 mg/L     Winter et al. 2008
Atenolol   C07AB03 Beta-receptor blockers 266.3361   Pimephales promelas (Fathead minnow) reproduction (condition index) 21 days   0.1, 0.32, 1, 3.2, 10 mg/L   adult 8 pairs per concentation         1 mg/L
(1 mg/L)
3.2 mg/L     Winter et al. 2008
Atenolol   C07AB03 Beta-receptor blockers 266.3361 OECD Test 210 (1992) Pimephales promelas (Fathead minnow) standard length ended 28 d post-hatch   0.1, 0.32, 1, 3.2, 10 mg/L   embryos 2-24 h 20 embryos in each cup, approximately 80 embryos per conc.         3.2 mg/L
(3,2 mg/L)
10 mg/L     Winter et al. 2008
Atenolol   C07AB03 Beta-receptor blockers 266.3361 ISO Guideline 11348-3 (1998) Vibrio fischeri (Bacteria) bioluminescence inhibition 30 min               1304 mg/L
(1304 mg/L)
          Escher et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (modified) Chironomus dilutus (Midge Larvae)   10d       10–12 d 8 per sample Sediment       >3.7 mg kg-1 dw       Gilroy et al. 2012
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) growth 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker     10.2 mg/L
(10,2 mg/L)
          Dussault et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) survival 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker   14.3 mg/L
(14.3 mg/L)
            Dussault et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           172.9 ug/L
(0,1729 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           208.6 ug/L
(0,2086 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           259.4 ug/L
(0,2594 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 200, 500, 1000, 1500, 2000 mg/kg   >2 month     >2000 mg/kg             Pino et al. 2015
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           41.8 ug/L
(0,0418 mg/L)
          Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           154.3 ug/L
(0,1543 mg/L)
          Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           153.6 ug/L
(0,1536 mg/L)
          Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           65.4 ug/L
(0,0654 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (modified) Hyalella azteca (Crustacean)   10d       7–14 d 15 per sample Sediment       >2.7 mg kg-1 dw       Gilroy et al. 2012
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) survival 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker   1.5 mg/L
(1.5 mg/L)
            Dussault et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) growth 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker     2.4 mg/L
(2,4 mg/L)
          Dussault et al. 2008
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     214 ug/L
(0,214 mg/L)
    300 ug/L
(0.3 mg/L)
    Brain et al. 2004 (b)
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) increase in reduced plastoquinone (PQ) 7 days         Two plants in each of the 18 culture dishes     37.7 ug/L
(0,0377 mg/L)
    217 ug/L
(0.217 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) increase in total ubiquinone (UQ) 7 days         Two plants in each of the 18 culture dishes     967 ug/L
(0,967 mg/L)
    67 ug/L
(0.067 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) decrease in fresh weight (quinones) 7 days         Two plants in each of the 18 culture dishes     135 ug/L
(0,135 mg/L)
    19 ug/L
(0.019 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) increase in oxidized plastoquinone (PQ) 7 days         Two plants in each of the 18 culture dishes     3055 ug/L
(3,055 mg/L)
          Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) increase in total plastoquinone (PQ) 7 days         Two plants in each of the 18 culture dishes     85.1 ug/L
(0,0851 mg/L)
    217 ug/L
(0.217 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) decrease in fresh weight (sterols) 7 days         Two plants in each of the 18 culture dishes     157 ug/L
(0,157 mg/L)
    200 ug/L
(0.2 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) decrease in beta-Sitosterol 7 days         Two plants in each of the 18 culture dishes     64.4 ug/L
(0,0644 mg/L)
    67 ug/L
(0.067 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 Modified ASTM E 1415-91 Guideline (1999) Lemna gibba (Duckweed) decrease in stigmasterol 7 days         Two plants in each of the 18 culture dishes     71.6 ug/L
(0,0716 mg/L)
    67 ug/L
(0.067 mg/L)
    Brain et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.0818 mM
(45,69673564 mg/L)
          Caminada et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.0781 mM
(43,62976838 mg/L)
          Caminada et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.302 mM
(168,7092196 mg/L)
          Caminada et al. 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) malformations 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.     23.1 mg/L
(23,1 mg/L)
  10.0 mg/L
(10 mg/L)
      Richards and Cole 2006
Atorvastatin   C10AA05 Blood lipid lowering agents 558.6398 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) mortality 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.   38.6 mg/L
(38.6 mg/L)
            Richards and Cole 2006
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             22700 umol/L
(6568.68538 mg/L)
            Calleja et al. 1994 (a)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Artemia salina (Crustacea) Immobilization 24 h               15556 mg/L           Callejaa et al. 1993
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             4.35 umol/L             Calleja et al. 1994 (b)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             481 umol/L
(139.1866814 mg/L)
            Calleja et al. 1994 (a)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             2.67 umol/L             Calleja et al. 1994 (b)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Brachionus calyciflorus (Rotifera) Immobilization 24 h               325 mg/L           Callejaa et al. 1993
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               2.71 umol/L           Calleja et al. 1994 (b)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               513 umol/L
(148,4465022 mg/L)
          Calleja et al. 1994 (a)
Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           0.372 mM           Lilius et al. 1995
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.372 mM
(107,6454168 mg/L)
          Lilius et al. 1994
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Daphnia magna (Crustacean) Immobilization 24 h               356 mg/L           Callejaa et al. 1993
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     16.83 mM
(4870,087002 mg/L)
          Lilius et al. 1994
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               8010 umol/L
(2317,848894 mg/L)
          Calleja et al. 1994 (a)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               3.9 umol/L           Calleja et al. 1994 (b)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Streptocephalus proboscideus (Crustacea) Immobilization 24 h               664 mg/L           Callejaa et al. 1993
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.98 umol/L             Calleja et al. 1994 (b)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             951 umol/L
(275.1902994 mg/L)
            Calleja et al. 1994 (a)
Atropine Atropine sulfate A03BA01 Drugs for functional gastrointestinal disorders 289.3694   Vibrio fischeri (Bacteria) Bioluminescence inhibition 15 min               5519 mg/L           Callejaa et al. 1993
Azithromycin   J01FA10 Antibacterial agents   Algal Growth Inhibition test Pseudokirchneriella subcapitata Growth inhibition rate 96 h   maximum 10mg/L           0,019 mg/L   5.2 ug/L
(0,0052 mg/L)
      Harada et al. 2008
Benzylpenicillin sodium J01CE01 Antibacterial agents   Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Benzylpenicillin sodium J01CE01 Antibacterial agents   OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Benzylpenicillin   J01CE01 Antibacterial agents   ISO 8692 (1989), modified version Microcystis aeruginosa (Freshwater cyanobacteria) growth inhibition 7 days   0.002-0.01 mg/L     Initial density; 2*10^4 cells/mL     0.006 mg/L
(0,006 mg/L)
          Halling-Sorensen 2000
Benzylpenicillin   J01CE01 Antibacterial agents   ISO 8692 (1989), modified version Selenastrum capricornutum (Freshwater green algae) growth inhibition 3 days   3-100 mg/L     Initial density; 1*10^4 cells/mL         100 mg/L
(100 mg/L)
      Halling-Sorensen 2000
Betaxolol   S01ED02 Ophthalmologicals 307.4278 Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h       >300 mg/L           Hernando et al. 2004
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h         24-well plates, one rotifer in each well (initially), four replicates per concentration     0.44 mg/L
(0,44 mg/L)
  0.156 mg/L
(0,156 mg/L)
0.3125 mg/L     Isidori et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 ASTM E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       neonates 36-well plates, five animals per well, six replicates for each of the five concentrations   60.91 mg/L
(60.91 mg/L)
            Isidori et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 EPA 600/4-90/027F (1993) Ceriodaphnia dubia (Crustacean cladocera) immobilization 48 h       < 24 h 24-well plates, ten organisms per well, three replicates per concentration, five concentrations     75.79 mg/L           Isidori et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days       < 24 h Single organisms in beakers, seven concentrations, ten replicates     0.13 mg/L
(0,13 mg/L)
  0.023 mg/L
(0,023 mg/L)
0.047 mg/L     Isidori et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h       >200 mg/L           Hernando et al. 2004
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 ISO 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       < 24 h Five daphnids per vessel, four replicates for each of five concentrations     100.08 mg/L           Isidori et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 EPA/600/4-90/027F (1993) Daphnia magna (Crustacean) mortality 48 h       <24h (neonates) Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.   30.3 mg/L
(30.3 mg/L)
            Han et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 150, 850, 2000 mg/kg   >2 month     >2000 mg/kg             Pino et al. 2015
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Elliptio complanata (Freshwater mussel) immunotoxic effect: induction of phagocytosis 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           2 uM
(0.7236388 mg/L)
    Gagné et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Elliptio complanata (Freshwater mussel) immunotoxic effect: increased cell viability 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           2 uM
(0.7236388 mg/L)
    Gagné et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Elliptio complanata (Freshwater mussel) immunotoxic effect: decreased cell adherence 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           2 uM
(0.7236388 mg/L)
    Gagné et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Hydra attenuata (Cnidarian) regeneration 96 h   0, 0.1, 1, 5, 10, 25, 50, 100 mg/L     10 per concentration       22.5 mg/L         Quinn et al. 2008b
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Hydra attenuata (Cnidarian) feeding behaviour and hydranth no. 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate     8.59 mg/L
(8,59 mg/L)
          Quinn et al. 2008a
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Hydra attenuata (Cnidarian) morphological changes 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate   70.71 mg/L
(70.71 mg/L)
25.85 mg/L
(25,85 mg/L)
  0.1mg/L
(0,1 mg/L)
1 mg/L     Quinn et al. 2008a
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Mytilus galloprovincialis (Blue mussel) immune parameters in the hemocytes 24 h           Injection             0.01 nmol (3.61 ng/g dry weight) Canesi et al. 2007
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 ISO 10253 standard Phaeodactylum tricornutum Growth inhibition 72h               >WS mg/L           Claessens et al. 2013
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.74 mM
(629,565756 mg/L)
          Caminada et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     2.60 mM
(940,73044 mg/L)
          Caminada et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.23 mM
(445,037862 mg/L)
          Caminada et al. 2006
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           275.7 uM           Schnell et al. 2009
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           266 uM           Schnell et al. 2009
Bezafibrate   C10AB02 Blood lipid lowering agents 361.8194   Thamnocephalus platyurus (Crustacean) mortality 24 h       second- and third instar larvae 24-well plates, ten animals per well, three replicates for each of the five concentrations   39.69 mg/L
(39.69 mg/L)
            Isidori et al. 2007
Bleomycin   L01DC01 Antineoplastic agents   Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     0,05     Hartmann et al. 1998
Capecitabine   L01BC06 Antineoplastic agents   ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       N.E. Up to 500 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       15.4*10^3 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       1.23 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         2.4*10^3 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       224 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       20.5*10^3 mg/L           Parrella et al. 2014
Capecitabine   L01BC06 Antineoplastic agents   ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               197.7 mg/L           Parrella et al. 2014
Captopril   C09AA01 Agents acting on the renin-angiotensin system   European Guideline; EEC Directive 92/69/EEC Daphnia magna (Crustacean) immobilization 48 h   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L   < 24 h Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.     >100 mg/L           Cleuvers 2003
Captopril   C09AA01 Agents acting on the renin-angiotensin system   European Guideline; EEC Directive 92/69/EEC Desmodesmus subspicatus (Green algae) inhibition of average growth rate 3 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Initial density; 10^4 cells/mL     168 mg/L
(168 mg/L)
          Cleuvers 2003
Captopril   C09AA01 Agents acting on the renin-angiotensin system   ISO/WD 20079 (2001), using the Steinberg-medium Lemna minor (Duckweed) inhibition of average growth rate 7 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Three treatment replicates and six control replicates.     25 mg/L
(25 mg/L)
          Cleuvers 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Allium cepa (Terrestrial plant) mitotic index 48 h         Five bulbs and three roots per bulb were used for each treatment     498 uM
(117,6617628 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Allium cepa (Terrestrial plant) root growth 72 h         Five bulbs and three roots per bulb were used for each treatment     447 uM
(105,6120642 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Rotoxkit according to the standard AFNOR T90-377 (2000) Brachionus calyciflorus (Rotifera) reproduction 48 h                           Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 AFNOR T90-377 (2000) Brachionus calyciflorus (Rotifera) reproduction inhibition 48 h       newly hatched 48 rotifers; five concentrations and one control, eight replicates         0.377 mg/L
(0,377 mg/L)
0.754 mg/L     Ferrari et al. 2003
Carbamazepine Carbamazepine N03AF01 Antiepileptics 236.2686   Brachionus koreanus (rotifer) Acute toxicity 24 h   1-500 mg/L   adult approximately 7000/container   138.6 mg/L     81,5 mg/L       Rhee et al. 2012
Carbamazepine   N03AF01 Antiepileptics 236.2686   Carcinus maenas (Crustacean) Lysosomal membrane stability (LMS) 28d   0.1, 1, 10, and 50 μgL F   6 per treatment Water diluted with pharmaceuticals   0.316µgL
(0.000316 mg/L)
          Aguirre-Martínez et al. 2012
Carbamazepine   N03AF01 Antiepileptics 236.2686 AFNOR T90-376 (2000) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7 days       < 24 h           0.025 mg/L
(0,025 mg/L)
0.1 mg/L     Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Chronic toxicity test according to the standard AFNOR T90-376 (2000) Ceriodaphnia dubia (Crustacean cladocera) reproduction 7 days                   25 ug/L
(0,025 mg/L)
      Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA 600/4_90/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mobility inhibition 48 h       < 24 h 28 cups, five daphnids in each, six concentrations and one control, four replicates     77.7 mg/L
(77,7 mg/L)
          Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA 600/4_90/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h               77.70 mg/L
(77,7 mg/L)
  377 ug/L
(0,377 mg/L)
      Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (modified) Chironomus dilutus (Midge Larvae)   10d       10–12 d 8 per sample Sediment       >56.5 mg kg-1 dw       Gilroy et al. 2012
Carbamazepine   N03AF01 Antiepileptics 236.2686   Chironomus riparius (Insecta, diptera) Mortality 24 h   0.5, 10, 200, 4000 ug/L               >4 mg/L       Nentwig et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 Sediment assay Chironomus riparius (Insecta, diptera) Life-cycle 28 days   0.16-100 mg/kg dw               0.625 mg/kg dw 1.25 mg/kg dw     Nentwig et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) survival 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker   47.3 mg/L
(47.3 mg/L)
            Dussault et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) growth 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker     9.5 mg/L
(9,5 mg/L)
          Dussault et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Chlorella vulgaris var viridis (Green algae) growth inhibition 24 h         1 000 000 cells/mL algae culture     469.5 uM
(110,9281077 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Chlorella vulgaris var viridis (Green algae) growth inhibition 48 h         1 000 000 cells/mL algae culture     155 uM
(36,621633 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 algal growth inhibition test Cyclotella meneghiniana (Diatom) growth 96 h               31.60 mg/L
(31,6 mg/L)
  10.00 mg/L
(10 mg/L)
      Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Cyprinus carpio (Common carp) liver, ultrastructural effects 28 days   1, 5, 20, 50, 100 ug/L F+M 1,5 year-old 24 per conc. 6-8 were used           >100 ug/L     Triebskorn et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686   Cyprinus carpio (Common carp) kidney, ultrastructural effects 28 days   1, 5, 20, 50, 100 ug/L F+M 1,5 year-old 24 per conc. 6-8 were used           1 ug/L
(0.001 mg/L)
    Triebskorn et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 OECD protocol "Fish Embryo Toxicity" Danio rerio (Zebrafish) Developmental effects 72 h       Embryo (2 hours old)     >245 mg/L 86.5 mg/L
(86,5 mg/L)
  30.6 mg/L
(30,6 mg/L)
      van den Brandhof and Montforts, 2010
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO 12890 (1999) Danio rerio (Zebrafish) embryos and larvae mortality 10 days       embryos, larvae 50 embryos         25 mg/L
(25 mg/L)
50 mg/L     Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 10-d early life stage test according to ISO 12890 (1999) Danio rerio (Zebrafish) mortality 10 days       fish embryo           25 mg/L
(25 mg/L)
      Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 OECD Guideline 202 (1993) Daphnia magna (Crustacean) immobilization 48 h       neonates replicate groups of ten neonates     414 uM
(97,8152004 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 OECD Guideline 202 (1993) Daphnia magna (Crustacean) immobilization 24 h       neonates replicate groups of ten neonates     475 uM
(112,227585 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 AFNOR T90-301 (1996) Daphnia magna (Crustacean) mobility inhibition 48 h       < 24 h 28 cups, five daphnids in each, six concentrations and one control, four replicates     >13.8 mg/L           Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 European Guideline; EEC Directive 92/69/EEC Daphnia magna (Crustacean) immobilization 48 h   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L   < 24 h Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.     >100 mg/L           Cleuvers 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO 6341 (1996) Daphnia magna (Crustacean) Immobilisation 48h   6 mgL*     5 juvenile Daphnia per beaker Dilution in growth medium       30 mg/L       Donner et al. 2013
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 96 h               76.3 mg/L
(76,3 mg/L)
          Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 48 h               >100 mg/L           Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 Acute toxicity test according to the standard AFNOR T90-301 (1996) Daphnia magna (Crustacean) mortality 48 h               >13.80 mg/L           Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/4-90/027F (1993) Daphnia magna (Crustacean) mortality 48 h       <24h (neonates) Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.   111 mg/L
(111 mg/L)
            Han et al. 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686   Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686 European Guideline; EEC Directive 92/69/EEC Desmodesmus subspicatus (Green algae) inhibition of average growth rate 3 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Initial density; 10^4 cells/mL     74 mg/L
(74 mg/L)
          Cleuvers 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996) Dunaliella tertiolecta (Phytoplankton) cell density 96 h   25, 50, 100, 200, 400 mg/L     Initial density; approximately 50 000 cells/mL     >80.00 mg/L           DeLorenzo and Fleming 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Elliptio complanata (Freshwater mussel) immunotoxic effect: decreased cell adherence 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           61 uM
(14.4123846 mg/L)
    Gagné et al. 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686   Elliptio complanata (Freshwater mussel) immunotoxic effect: induction of phagocytosis 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           61 uM
(14.4123846 mg/L)
    Gagné et al. 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686   Elliptio complanata (Freshwater mussel) immunotoxic effect: increased cell viability 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           3 uM
(0.7088058 mg/L)
    Gagné et al. 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686   Gammarus pulex (Crustacea, amphipoda) activity 1.5 h nine measurements per concentration 0, 1 ng/L to 1 mg/L     24 chambers, one G. pulex in each           0.010 ug/L
(0.00001 mg/L)
    De Lange et al. 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           388.2 ug/L
(0,3882 mg/L)
          Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           43.6 ug/L
(0,0436 mg/L)
          Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           113.4 ug/L
(0,1134 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (modified) Hyalella azteca (Crustacean)   10d       7–14 d 15 per sample Sediment       >35.0 mg kg-1 dw       Gilroy et al. 2012
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) growth 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker     15.0 mg/L
(15 mg/L)
          Dussault et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) survival 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker   9.9 mg/L
(9.9 mg/L)
            Dussault et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686   Hydra attenuata (Cnidarian) morphological changes 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate   29.4 mg/L
(29.4 mg/L)
15.52 mg/L
(15,52 mg/L)
  1 mg/L
(1 mg/L)
5 mg/L     Quinn et al. 2008a
Carbamazepine   N03AF01 Antiepileptics 236.2686   Hydra attenuata (Cnidarian) feeding behaviour and hydranth no. 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate     3.76 mg/L
(3,76 mg/L)
          Quinn et al. 2008a
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO/WD 20079 (2001), using the Steinberg-medium Lemna minor (Duckweed) inhibition of average growth rate 7 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Three treatment replicates and six control replicates.     25.5 mg/L
(25,5 mg/L)
          Cleuvers 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Sediment assay Lumbriculus variegatus (Oligochaeta) Reproduction 28 days                   10 mg/kg dw       Nentwig et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Lumbriculus variegatus (Oligochaeta) Mortality 96 h   0.5, 10, 200, 4000 ug/L               >4 mg/L       Nentwig et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) total protein content 48 h         Initial density: 14 000 cells/mL into 24-well culture plates     62.9 uM
(14,86129494 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) LDH activity 24 h         Initial density: 14 000 cells/mL into 24-well culture plates     72 uM
(17,0113392 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) total protein content 72 h         Initial density: 14 000 cells/mL into 24-well culture plates     33.6 uM
(7,93862496 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) neutral red uptake 24 h         Initial density: 14 000 cells/mL into 24-well culture plates     >100 uM           Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) cell viability: MTT metabolization 72 h         Initial density: 14 000 cells/mL into 24-well culture plates     24.6 uM
(5,81220756 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) neutral red uptake 72 h         Initial density: 14 000 cells/mL into 24-well culture plates     19 uM
(4,4891034 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) cell viability: MTT metabolization 24 h         Initial density: 14 000 cells/mL into 24-well culture plates     >100 uM
(23,62686 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) LDH activity 48 h         Initial density: 14 000 cells/mL into 24-well culture plates     67 uM
(15,8299962 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) cell viability: MTT metabolization 48 h         Initial density: 14 000 cells/mL into 24-well culture plates     94.2 uM
(22,25650212 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) LDH activity 72 h         Initial density: 14 000 cells/mL into 24-well culture plates     38.5 uM
(9,0963411 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) neutral red uptake 48 h         Initial density: 14 000 cells/mL into 24-well culture plates     81.4 uM
(19,23226404 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Monkey kidney (Vero cell line) total protein content 24 h         Initial density: 14 000 cells/mL into 24-well culture plates     76.2 uM
(18,00366732 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 test on hepatocytes, cytotoxicity test, MTT assay Oncorhynchus mykiss (Rainbow trout) cytotoxicity 24 h   31.3-500 uM   immature       318 uM
(75,1334148 mg/L)
          Laville et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Oncorhynchus mykiss (Rainbow trout) Condition factor (CF) 42 days   0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L M+F 10-12 months old 30           2.0 mg/L     Li et al. 2009
Carbamazepine   N03AF01 Antiepileptics 236.2686 EROD activity test Oncorhynchus mykiss (Rainbow trout) inhibition 24 h       immature       318 uM
(75,1334148 mg/L)
          Laville et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Oncorhynchus mykiss (Rainbow trout) Changes in muscle RNA-DNA ratio 42 days   0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L M+F 10-12 months old 30           2.0 mg/L     Li et al. 2009
Carbamazepine   N03AF01 Antiepileptics 236.2686   Oncorhynchus mykiss (Rainbow trout) Antioxidant responces in muscle 42 days   0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L M+F 10-12 months old 30           1.0 ug/L - 0.2 mg/L     Li et al. 2009
Carbamazepine   N03AF01 Antiepileptics 236.2686 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 96 h             35.4 mg/L
(35.4 mg/L)
            Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 48 h             35.4 mg/L
(35.4 mg/L)
            Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO 10253 standard Phaeodactylum tricornutum Growth inhibition 72h               62.5 (58.8–66.6) mg/L           Claessens et al. 2013
Carbamazepine   N03AF01 Antiepileptics 236.2686 test on hepatocytes, cytotoxicity test, MTT assay Poeciliopsis lucida (Topminnow) cytotoxicity 24 h   3.9-500 uM           651 uM
(153,8108586 mg/L)
          Laville et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Potamopyrgus antipodarum (Freshwater mudsnail) No of embryos 28 days   0.4, 2, 10, 50, 250 ug/L     80         250 ug/L       Nentwig et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 Algal Growth Inhibition test Pseudokirchneriella subcapitata Growth inhibition rate 96 h   maximum 10mg/L           48,9 mg/L   520.6 ug/L
(0,5206 mg/L)
      Harada et al. 2008
Carbamazepine   N03AF01 Antiepileptics 236.2686 algal growth inhibition test Pseudokirchneriella subcapitata (Green algae) growth 96 h               >100,00 mg/L   >100 mg/L       Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686   Pseudokirchneriella subcapitata (Green algae) growth inhibition 96 h                   >100 mg/L >100 mg/L     Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO 8692 (2004) Pseudokirchneriella subcapitata (green algeae) Growth inhibition 48h   6 mgL*     5–10·103 cells/ml Dilution in growth medium       27.4 mg/L 40 mg/L     Donner et al. 2013
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community increased bacterial counts (R2A media) 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community decrease in bacterial biomass 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community carbohydrate utility spectra 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community increase in fungal populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community increase in beta proteobacteria and decrease in gamma proteobacteria 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community increase in LGC354c and HGC69a probe positive cells 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686 Riverine biofilm community structure and activity Riverine biofilm community decrease in cyanobacterial biomass 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) total protein content 72 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     933 uM
(220,4386038 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) neutral red uptake 48 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     472.6 uM
(111,66054036 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) LDH leakage 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     >1200 uM           Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) LDH activity 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     >1200 uM           Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) total protein content 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     832 uM
(196,5754752 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) total protein content 48 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     713 uM
(168,4595118 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) neutral red uptake 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     496 uM
(117,1892256 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) MTS metabolization 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     698 uM
(164,9154828 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) MTS metabolization 48 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     608.6 uM
(143,79306996 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) MTS metabolization 72 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     601.4 uM
(142,09193604 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) G6PDH activity 24 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     853 uM
(201,5371158 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) G6PDH activity 48 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     716.7 uM
(169,33370562 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) G6PDH activity 72 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     687 uM
(162,3165282 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   RTG-2 cell line (Rainbow trout gonad) neutral red uptake 72 h         Initial density: 8000 cells/well in 96-well tissue-culture plates     495 uM
(116,952957 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             70,7 mg/L
(70.7 mg/L)
70,7 mg/L
(70,7 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 algal growth inhibition test Synechococcus leopolensis (Blue-green algae) growth 96 h               33.60 mg/L
(33,6 mg/L)
  17.50 mg/L
(17,5 mg/L)
      Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               40,5 mg/L
(40,5 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     43.0 mg/L
(43 mg/L)
          Nalecz-Jawecki and Persoone 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     140 mg/L
(140 mg/L)
            Nalecz-Jawecki and Persoone 2006
Carbamazepine   N03AF01 Antiepileptics 236.2686 AFNOR T90-320-3 (1999) Vibrio fischeri (Bacteria) luminescence 30 min               >81 mg/L           Ferrari et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 15 min               52.5 mg/L
(52,5 mg/L)
          Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686   Vibrio fischeri (Bacteria) bioluminescence 5 min               370 uM
(87,419382 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Vibrio fischeri (Bacteria) bioluminescence 15 min               332 uM
(78,4411752 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686   Vibrio fischeri (Bacteria) bioluminescence 60 min               272 uM
(64,2650592 mg/L)
          Jos et al. 2003
Carbamazepine   N03AF01 Antiepileptics 236.2686 Microtox test according to the standard AFNOR T90-320-3 (1999) Vibrio fischeri (Bacteria) luminescence 30 min               >81.00 mg/L           Ferrari et al. 2004
Carbamazepine   N03AF01 Antiepileptics 236.2686 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 5 min               52.5 mg/L
(52,5 mg/L)
          Kim et al. 2007
Carbamazepine   N03AF01 Antiepileptics 236.2686 ISO 11348-3 (1998) Biotox testing kit; ISO 11348-3, 1998 Vibrio fischeri (bacterium) Inhibition of bioluminescence 30min   6 mgL*     Variable Dilution in growth medium       5.59 mg/L 8.16 mg/L     Donner et al. 2013
Carbamazepine   N03AF01 Antiepileptics 236.2686 Microtox Vibro fischeri bioluminescence inhibition 15 min   maximum 10mg/L           28,3 mg/L           Harada et al. 2008
Cefazolin Cefazolin Na J01DB04 Antibacterial agents   OECD (1993) no 201 Selenastrum capricornutum (Freshwater green algae) growth inhibition     5 concentrations, triplicates           >1000 mg/L   >1000 mg/L       Eguchi et al. 2004
Ceftriaxon disodium J01DD04 Antibacterial agents 554.5799 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Ceftriaxon disodium J01DD04 Antibacterial agents 554.5799 OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Cefuroxime sodium J01DA06 Antibacterial agents 424.3853 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Cefuroxime sodium J01DA06 Antibacterial agents 424.3853 OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Celecoxib   M01AH01 Anti-inflammatory and anti-reumatic agents   EPA 1000.2 Ceriodaphnia dubia Reproduction 7 days   0.0021 - 1.6 mg/L F             0.17 mg/L
(0,17 mg/L)
0.48 mg/L     Constantine and Huggett, 2010
Celecoxib   M01AH01 Anti-inflammatory and anti-reumatic agents   EPA 1000.2 Ceriodaphnia dubia Survival 7 days   0.0021 - 1.6 mg/L F       >1.6 mg/L     1.6 mg/L
(1,6 mg/L)
      Constantine and Huggett, 2010
Celecoxib   M01AH01 Anti-inflammatory and anti-reumatic agents   OECD 211 Daphnia magna (Crustacean) Survival 21 days   0.026 - 1 mg/L F       >0.89 mg/L     0.062 mg/L
(0,062 mg/L)
      Constantine and Huggett, 2010
Celecoxib   M01AH01 Anti-inflammatory and anti-reumatic agents   OECD 211 Daphnia magna (Crustacean) Reproduction 21 days   0.026 - 1 mg/L F             0.062 mg/L
(0,062 mg/L)
0.14 mg/L     Constantine and Huggett, 2010
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Artemia salina (Crustacea) Immobilization 24 h               2039 mg/L           Callejaa et al. 1993
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             3.8 umol/L             Calleja et al. 1994 (b)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             6320 umol/L
(2042.177808 mg/L)
            Calleja et al. 1994 (a)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Bacterial community Inhibation of bacterial protein biosynthesis                 5.698 umol/L   0.074 umol/L       Brosche and Backhaus, 2010
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Bacterial community Inhibation of bacterial protein biosynthesis                 3.388 umol/L   0.212 umol/L       Brosche and Backhaus, 2010
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Brachionus calyciflorus (Rotifera) Immobilization 24 h               2086 mg/L           Callejaa et al. 1993
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             6420 umol/L
(2074.490748 mg/L)
            Calleja et al. 1994 (a)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             3.81 umol/L             Calleja et al. 1994 (b)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OCED Guideline 202 and ISO6341 Daphnia magna Immobilization 48h               5 mg/L           Czech et al. 2014
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OCED Guideline 202 and ISO6341 Daphnia magna Immobilization 24h               5 mg/L           Czech et al. 2014
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 EPA 821/R-02-012 (2002) Daphnia magna (Crustacean) immobilization 96 h       <24h       81.2 mg/L
(81,2 mg/L)
          Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               3360 umol/L
(1085,714784 mg/L)
          Calleja et al. 1994 (a)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 EPA 821/R-02-012 (2002) Daphnia magna (Crustacean) immobilization 48 h       <24h       372.4 mg/L
(372,4 mg/L)
          Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           1.68 mM           Lilius et al. 1995
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     1.68 mM
(542,857392 mg/L)
          Lilius et al. 1994
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               3.53 umol/L           Calleja et al. 1994 (b)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 EPA 821/R-02-012 (2002) Moina macrocopa (Crustacean) immobilization 48 h       <24h       511.5 mg/L
(511,5 mg/L)
          Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 EPA 821/R-02-012 (2002) Moina macrocopa (Crustacean) immobilization 96 h       <24h       273.3 mg/L
(273,3 mg/L)
          Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     0.011 mM
(3,5544234 mg/L)
          Lilius et al. 1994
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD (1992) no 203 Oryzias latipes (Japanese medaka) mortality 96 h       12 +/- 2d posthatch     >1000 mg/L             Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 OECD (1992) no 203 Oryzias latipes (Japanese medaka) mortality 48 h       12 +/- 2d posthatch     >1000 mg/L             Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               3.72 umol/L           Calleja et al. 1994 (b)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               5310 umol/L
(1715,817114 mg/L)
          Calleja et al. 1994 (a)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             707 mg/L
(707 mg/L)
707 mg/L
(707 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Streptocephalus proboscideus (Crustacea) Immobilization 24 h               302 mg/L           Callejaa et al. 1993
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.97 umol/L             Calleja et al. 1994 (b)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             943 umol/L
(304.7110242 mg/L)
            Calleja et al. 1994 (a)
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Protoxkit FTM Tetrahymena termophila (Ciliate) morphological changes/ spherical deformation and autolysis 24 h               53,3 mg/L
(53,3 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 ISO11348-3 Vibrio fischeri EC50 counted                 27.06 mg/L           Czech et al. 2014
Chloramphenicol   J01BA01 Antibacterial agents 323.1294   Vibrio fischeri Bioluminescence inhibition 24 h               0.16 mg/L           Thomulka et al. 1993
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Standard test, bacterial toxicity Vibrio fischeri (Bacteria) inhibition 5 min                 598.0 mg/L         Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 ISO/CD 11348 (1994) Vibrio fischeri (Bacteria) bioluminescence inhibition 30 min   16 test concentrations           80.1 mg/L
(80,1 mg/L)
          Backhaus et al. 1997
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 ISO/CD 11348 (1994) with minor modifications Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h   16 test concentrations           0.06 mg/L
(0,06 mg/L)
          Backhaus et al. 1997
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               0.0643 mg/L
(0,0643 mg/L)
          Backhaus and Grimme 1999
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 Standard test, bacterial toxicity Vibrio fischeri (Bacteria) inhibition 15 min                 537.5 mg/L         Choi et al. 2008
Chloramphenicol   J01BA01 Antibacterial agents 323.1294 ISO/CD 11348 (1994) Vibrio fischeri (Bacteria) bioluminescence inhibition 30 min   16 test concentrations           19.9 mg/L
(19,9 mg/L)
          Backhaus et al. 1997
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             3.6umol/L             Calleja et al. 1994 (b)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             3960 umol/L
(1266.693516 mg/L)
            Calleja et al. 1994 (a)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             0.8 umol/L             Calleja et al. 1994 (b)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             8.5 umol/L
(2.71891285 mg/L)
            Calleja et al. 1994 (a)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               84.3 umol/L
(26,96521803 mg/L)
          Calleja et al. 1994 (a)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.096 mM
(30,7077216 mg/L)
          Lilius et al. 1994
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               1.92 umol/L           Calleja et al. 1994 (b)
Chloroquine P01BA01 P01BA01 Antiprotozoals 319.8721   Glycine max (Soybean) inhibited growth 13 days   0, 2, 4, 8 and 16 mg/g soil     15 (3 per concentration) Through soil       2 mg/g 4 mg/g     Jjemba 2002
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     40.66 mM
(13005,999586 mg/L)
          Lilius et al. 1994
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               1680 umol/L
(537,385128 mg/L)
          Calleja et al. 1994 (a)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               3.22 umol/L           Calleja et al. 1994 (b)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             22.6 umol/L
(7.22910946 mg/L)
            Calleja et al. 1994 (a)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             1.34 umol/L             Calleja et al. 1994 (b)
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     4.70 mg/L
(4.7 mg/L)
            Nalecz-Jawecki and Persoone 2006
Chloroquine Chloroquine phosphate P01BA01 Antiprotozoals 319.8721 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     6.40 mg/L
(6,4 mg/L)
          Nalecz-Jawecki and Persoone 2006
Chlorpromazine Chlorpromazine HCl N05AA01 Psycholeptics 318.8642 ISO/WD 20079 (2001) Lemna minor (Duckweed) growth inhibition 7 days       Initially three or four fronds Six-well plates, one plant in each well, three replicates     0.92 mg/L
(0,92 mg/L)
          Kaza et al. 2007
Chlorpromazine Chlorpromazine HCl N05AA01 Psycholeptics 318.8642 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     0.38 mg/L
(0.38 mg/L)
            Nalecz-Jawecki and Persoone 2006
Chlorpromazine Chlorpromazine HCl N05AA01 Psycholeptics 318.8642 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     1.60 mg/L
(1,6 mg/L)
          Nalecz-Jawecki and Persoone 2006
Chlortetracycline hydrochloride J01AA03 Antibacterial agents   OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             10-100 mg/L         Kümmerer K. et al. 2004
Chlortetracycline hydrochloride J01AA03 Antibacterial agents   Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Chlortetracycline   J01AA03 Antibacterial agents     Bacterial community Inhibation of bacterial protein biosynthesis                 0.138 umol/L   <0.01 umol/L       Brosche and Backhaus, 2010
Chlortetracycline   J01AA03 Antibacterial agents     Bacterial community Inhibation of bacterial protein biosynthesis                 0.496 umol/L   0.01 umol/L       Brosche and Backhaus, 2010
Chlortetracycline   J01AA03 Antibacterial agents   US EPA-821-R-02-012 (2002) Daphnia magna (Crustacean) immobilization 24 h       <24h four replicates of five organisms     380 mg/L
(380 mg/L)
          Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   US EPA-821-R-02-012 (2002) Daphnia magna (Crustacean) immobilization 48 h       <24h four replicates of five organisms     225 mg/L
(225 mg/L)
          Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           575 ug/L
(0,575 mg/L)
          Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           552.8 ug/L
(0,5528 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           950.6 ug/L
(0,9506 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           734.5 ug/L
(0,7345 mg/L)
          Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           358.6 ug/L
(0,3586 mg/L)
          Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           147 ug/L
(0,147 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           397.5 ug/L
(0,3975 mg/L)
          Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           885.7 ug/L
(0,8857 mg/L)
          Hillis et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents   ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     219 ug/L
(0,219 mg/L)
    100 ug/L
(0.1 mg/L)
    Brain et al. 2004 (a)
Chlortetracycline   J01AA03 Antibacterial agents   ISO 8692 (1989), modified version Microcystis aeruginosa (Freshwater cyanobacteria) growth inhibition 7 days   0.002-10 mg/L     Initial density; 2*10^4 cells/mL     0.05 mg/L
(0,05 mg/L)
          Halling-Sorensen 2000
Chlortetracycline   J01AA03 Antibacterial agents   US EPA-821-R-02-012 (2002) Moina macrocopa (Crustacean) immobilization 48 h       <24h four replicates of five organisms     272 mg/L
(272 mg/L)
          Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   US EPA-821-R-02-012 (2002) Moina macrocopa (Crustacean) immobilization 24 h       <24h four replicates of five organisms     515 mg/L
(515 mg/L)
          Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   OECD guideline 203 (1993) Oryzias latipes (Japanese medaka) mortality 48 h       10-14 days post hatch four replicates of five fish each   88.4 mg/L
(88.4 mg/L)
            Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   OECD guideline 203 (1993) Oryzias latipes (Japanese medaka) mortality 96 h       10-14 days post hatch four replicates of five fish each   78.9 mg/L
(78.9 mg/L)
            Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   OECD 201(2006) with minor modifications Pseudokirchnerella subcapitata Growth inhibition 72 h   250-8000 ug/L             1800 ug/L
(1.8 mg/L)
500 ug/L
(0,5 mg/L)
1000 ug/L
(1 mg/L)
    Yang et al. 2008
Chlortetracycline   J01AA03 Antibacterial agents   ISO 8692 (1989), modified version Selenastrum capricornutum (Freshwater green algae) growth inhibition 3 days   0.005-10 mg/L     Initial density; 1*10^4 cells/mL     3.1 mg/L
(3,1 mg/L)
          Halling-Sorensen 2000
Chlortetracycline   J01AA03 Antibacterial agents   Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 5 min                 >20 mg/L         Park and Choi 2008
Chlortetracycline   J01AA03 Antibacterial agents   Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 15 min                 13 mg/L         Park and Choi 2008
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392   Danio rerio Survival 40d                   100 mg/L       Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 OECD TG 211 (OECD, 1998) Daphnia magna Survival 21d   0, 0.048, 0.24, 1.2, 6.0, and 30 mg/L               30 mg/L       Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 OECD TG 211 (OECD, 1998) Daphnia magna Reproduction 21d   0, 0.048, 0.24, 1.2, 6.0, and 30 mg/L               30 mg/L       Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 U.S.EPA (2002) Daphnia magna Immobilization 48h               394,9 mg/L           Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 48 h               379.7 mg/L
(379,7 mg/L)
          Kim et al. 2007
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 96 h               271.3 mg/L
(271,3 mg/L)
          Kim et al. 2007
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392   Moina Macrocopa Survival 48h   0, 0.33, 1.1, 10, and 30 mg/L               3,3 mg/L       Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 U.S.EPA (2002) Moina Macrocopa Immobilization 48h               175,8 mg/L           Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392   Moina Macrocopa Reproduction 48h   0, 0.33, 1.1, 10, and 30 mg/L               1,1 mg/L       Lee et al. 2015
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 96 h             >100 mg/L             Kim et al. 2007
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 48 h             >100 mg/L             Kim et al. 2007
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 15 min               375.9 mg/L
(375,9 mg/L)
          Kim et al. 2007
Cimetidine   A02BA01 Drugs for acid related disorders 252.3392 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 5 min               458.9 mg/L
(458,9 mg/L)
          Kim et al. 2007
Cinoxacin   J01MB06 Antibacterial agents   Long-term bioluminescence inhibition assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h   At least 16 different concentrations           116.95 ug/L
(0,11695 mg/L)
  26.22 ug/L
(0,02622 mg/L)
      Backhaus et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Activated sludge microorganisms Enzymatic (dehydrogenase activity) 30min/24h               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Activated sludge microorganisms Enzymatic (hydrolytic activity) 30min/24h               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 Artoxkit M™ Artemia salina (Crustacean) Immobillization 24h             >100 mg/L             Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     0,005     Hartmann et al. 1998
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 Genotoxicity assay (umuC test) Bacteria Genetoxicity 30 min                     5.9 ug/L
(0.0059 mg/L)
    Hartmann et al. 1999
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 203 (1992) Brachydanio rerio (zebrafish)       30 and 100 mg/L               100 mg/L
(100 mg/L)
      Halling-Sorensen et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Brevundimonas diminuta Growth 18h               5057.0 μg/L
(5.057 mg/L)
  156.3 μg/L
(0.1563 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Citrobacter freundii Growth 18h               4.6 μg/L
(0.0046 mg/L)
  0.04 μg/L
(0.00004 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Comamonas testosteroni Growth 18h               56.1 μg/L
(0.0561 mg/L)
  2.4 μg/L
(0.0024 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 PN-C-04610-04:1990 Danio rerio (fish) Mortality 96 hours             >100 mg/L             Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 215 Danio rerio (fish) Juvenile growth 672h                   <0.78 mg/L       Zaleska-Radziwill et al. 2011
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 2004 Daphnia magna (Crustacean) Acutely toxic 48 h   6.25, 12.5, 25.0, 50.0, 100.0 mg/L     5/replicate     65,3 mg/L           Martins et al. 2012
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 IQ toxicity test Daphnia magna (Crustacean) fluorescence inhibition 1h               3.77 mg/L           Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 Daphtoxkit F™ Daphnia magna (Crustacean) Immobillization 48h             >100 mg/L             Zaleska-Radziwill et al. 2011
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Intrinsic rate of population increase 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate         8,82 mg/L 15 mg/L     Martins et al. 2012
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Somatic growth rate 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate         8,82 mg/L 15 mg/L     Martins et al. 2012
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Number of broods per female 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate         8,82 mg/L 15 mg/L     Martins et al. 2012
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Age at first reproduction 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate         15 mg/L 25.5 mg/L     Martins et al. 2012
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Fecundity 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate     12.8 mg/L   5,19 mg/L 8.82 mg/L     Martins et al. 2012
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1998 Daphnia magna (Crustacean) Size of neonates 21 d   1.79, 3.05, 5.19, 8.82, 15.0, 25.5 mg/L female   10/replicate         1,8 mg/L 3.05 mg/L     Martins et al. 2012
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 211 Daphnia magna (Crustacean) Reproduction 672h             14.4 mg/L     0.156 mg/L       Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 202 (1984) Daphnia magna (Crustacean)       30 and 60 mg/L               60 mg/L
(60 mg/L)
      Halling-Sorensen et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Delftia acidovorans Growth 18h               6.2 μg/L
(0.0062 mg/L)
  1.2 μg/L
(0.0012 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Enterococcus casseliflavus Growth 18h               5023.6 μg/L
(5.023 mg/L)
  156.3 μg/L
(0.1563 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 1992 Gambusia holbrooki (fish) Mortality 96 h   60 mg/L male and non pregnant females   10/replicate     > 60 mg/L           Martins et al. 2012
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Kurthia gibsonii Growth 18h               370.4 μg/L
(0.3704 mg/L)
  4.9 μg/L
(0.0049 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 215 Lebistes reticulatus (fish) Juvenile growth 672h                   0.78 mg/L       Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 PN-C-04610-04:1990 Lebistes reticulatus (fish) Mortality 96 hours             >100 mg/L             Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     697 ug/L
(0,697 mg/L)
    300 ug/L
(0.3 mg/L)
    Brain et al. 2004 (a)
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Lemna minor Growth inhibition     2 mg/L           0.34 mg/L           Wagil et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Lemna minor (Duckweed) reproduction 7 days   four different concentrations     10-15 fronds, triplicate experiments with four concentrations and a control     203 ug/L
(0,203 mg/L)
          Robinson et al. 2005
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 2006b Lemna minor (duckweed) Growth rate 7 d   0.050, 0.137, 0.412, 1.24, 3.70, 11.1, 33.3, 100.0 mg/L           3.75 mg/L   <0,05 mg/L 0.05 mg/L     Martins et al. 2012
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Microbacterium sp. Growth 18h               144.1 μg/L
(0.1441 mg/L)
  19.5 μg/L
(0.0195 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Microcystis aeruginosa (Freshwater cyanobacteria)                   0.005 mg/L
(0,005 mg/L)
          Halling-Sorensen et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Microcystis aeruginosa (Freshwater cyanobacteria) growth and reproduction 5 days   five different concentrations           17 ug/L
(0,017 mg/L)
          Robinson et al. 2005
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Pichia anomala Growth 18h               >10000 μg/L
(>10 mg/L)
  1,250 μg/L
(0.00125 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD 201(2006) with minor modifications Pseudokirchnerella subcapitata Growth inhibition 72 h   5000-20000 ug/L             6700 ug/L
(6.7 mg/L)
<500 ug/L 5000 ug/L
(5 mg/L)
    Yang et al. 2008
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD guideline 201 Pseudokirchneriella subcapitata (algae) Growth inhibition 72h   0.25 to 10 mg/l           5.57
(5.57 mg/L)
          Doorslaer et al. 2015
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 OECD guidline 2006a Pseudokirchneriella subcapitata (algae) Growth inhibition 96 h   0.55, 1.1, 2.2, 4.4, 8.8 mg/L           4,83 mg/L   1,09 mg/L 2.19 mg/L     Martins et al. 2012
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Pseudokirchneriella subcapitata (Green algae) growth and reproduction 3 days   five different concentrations           18 700 ug/L
(18,7 mg/L)
          Robinson et al. 2005
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Pseudomonas aurantiaca Growth 18h               150.0 μg/L
(0.150 mg/L)
  39.1 μg/L
(0.0391 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 107122-1994 Pseudomonas fluorescens Growth 16h               0.175 μg/L
(0.000175 mg/L)
  0.005 μg/L
(0.000005 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 17 012 (1995), modified Pseudomonas putida (Bacteria) growth inhibition                 80 ug/L
(0,08 mg/L)
          Kümmerer et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 OECD.201 (1984) Selenastrum capricornutum (Freshwater green algae)                   2.97 mg/L
(2,97 mg/L)
          Halling-Sorensen et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Serratia rubidaea Growth 18h               265.6 μg/L
(0.2656 mg/L)
  39.1 μg/L
(0.0391 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 15522 (1998) Sludge bacteria                   0.61 mg/L
(0,61 mg/L)
          Halling-Sorensen et al. 2000
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 MARA test Staphylococcus warneri Growth 18h               1528.6 μg/L
(1.5286 mg/L)
  9.8 μg/L
(0.0098 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415   Stream microbial communities microbial respiration 12 days   1.0, 10, 100.0 ug/L (nominal conc.)     Two leaf disks in each experimental chamber           100 ug/L
(0.1 mg/L)
    Maul et al. 2006
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 Protoxkit F™ Tetrahymena thermophila (Ciliate) Growth inhibition 24h               >100 mg/L   0.195 mg/L       Zaleska-Radziwill et al. 2011
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 9.55 mg/L           Ortiz de Garcia et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 24h               0.0137 μg/L
(0.0000137 mg/L)
  0.0015 μg/L
(0.0000015 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               n.a. mg/L           Ortiz de Garcia et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               n.a. mg/L           Ortiz de Garcia et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 LUMIStox test Vibrio fischeri Growth 24h               1.4 μg/L
(0.0014 mg/L)
  0.0015 μg/L
(0.0000015 mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin   J01MA02 Antibacterial agents 331.3415 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 15min/30min               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ciprofloxacin Ciprofloxacin J01MA02 Antibacterial agents 331.3415 Microtox test Vibrio fischeri (Zebrafish) Acutely toxic     60 mg/L           11,5 mg/L           Martins et al. 2012
Cisplatin   L01XA01 Antineoplastic agents   Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     1,25     Hartmann et al. 1998
Cisplatin   L01XA01 Antineoplastic agents   ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       6.52 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       440 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         16.83 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       2.50 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       0.94 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       1.63 mg/L           Parrella et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     0,64 mg/L   0,2 mg/L 0.5 mg/L     Zounkova et al. 2007
Cisplatin   L01XA01 Antineoplastic agents   SOS-Chromotest Escherichia coli (Bacteria) Genotoxicity 4 h                     0.09 mg/L     Zounkova et al. 2007
Cisplatin   L01XA01 Antineoplastic agents   OECD TG 201 (2011) P. Subcapitata Growth inhibition 72h   0.095-50.0 mg/L     5*10^3-5*10^4 cells/mL     1.52 (1.26-1.83 mg/L   0.50 mg/L 0.98 mg/L     Brezovsek et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   ISO 8692:1989, DIN 38412 Pseudokirchneriella subcapitata (Freshwater green alga) Growth inhibition 72 h               2,3 mg/L   0,1 mg/L 1 mg/L     Zounkova et al. 2007
Cisplatin   L01XA01 Antineoplastic agents   ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 1,2 mg/L   0,03 mg/L 0.1 mg/L     Zounkova et al. 2007
Cisplatin   L01XA01 Antineoplastic agents   OECD TG 201 (2011) S. Leopoliensis Growth inhibition 72h   0.03-32.0 mg/L     5*10^4-5*10^5 cells/mL     0.67 (0.336-1.339) mg/L   0.10 mg/L 0.31 mg/L     Brezovsek et al. 2014
Cisplatin   L01XA01 Antineoplastic agents   GreenScreen assay Saccharomyces cerevisiae (Yeast cells) Genotoxicity 16 h                     0.44 mg/L     Zounkova et al. 2007
Cisplatin   L01XA01 Antineoplastic agents   ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               8.44 mg/L           Parrella et al. 2014
Citalopram   N06AB04 Psychoanaleptics 324.3919 EPA/600/4-90/027F (1993) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h   0.59-7.84 mg/L   < 24 h Five treatment concentrations, 20 neonates (4 cups) were exposed to each treatment concentration and the control.   3.90 mg/L
(3.9 mg/L)
            Henry et al. 2004
Citalopram   N06AB04 Psychoanaleptics 324.3919 EPA/600/4-91/002 (1994) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7-8 days       < 24 h Five treatment concentrations, each treatment and the control had ten replicates, each replicate consisted of one neonate.         0.80 mg/L
(0,8 mg/L)
4.00 mg/L     Henry et al. 2004
Citalopram   N06AB04 Psychoanaleptics 324.3919 guideline NF EN ISO 6341 (1996) Daphnia magna Acute immobilization 48h               30.14 [21.19–32.78] mg/L           Minguez et al. 2014
Citalopram   N06AB04 Psychoanaleptics 324.3919 ISO 6341 (1989), except for the test media; OECD guideline 211, Daphnia magna reproduction test. (2006) Daphnia magna (Crustacean) immobilization 48 h       < 24 h Five animals were used for each of four replicates per concentration and 20-40 animals in the control group     20 mg/L
(20 mg/L)
          Christensen et al. 2007
Citalopram   N06AB04 Psychoanaleptics 324.3919   Oncorhynchus mykiss (Rainbow trout) decrease in aggressive behavior and stress responsiveness 7 days   0, 100 ug/kg   2 years old 16 Through food             100 ug/kg Lepage et a.l 2005
Citalopram   N06AB04 Psychoanaleptics 324.3919 A miniscale algal toxicity test. P. Arensberg et al. (1995). Chem. 30, 2103-2115 Pseudokirchneriella subcapitata (Green algae) algal growth inhibition 48 h         Initial density; 10^4 cells/mL     1.6 mg/L
(1,6 mg/L)
          Christensen et al. 2007
Clarithromycin   J01FA09 Antibacterial agents 747.9534 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Clarithromycin   J01FA09 Antibacterial agents 747.9534 OECD 209, prolonged test aerobic bacteria inhibition of respiration 24 h   (0,001-750 mg/L)             10-100 mg/L         Kümmerer K. et al. 2004
Clarithromycin   J01FA09 Antibacterial agents 747.9534 OECD 201 Anabaena flos-aquae Growth 72h               12.1 μg/L           Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h         24-well microplates, one rotifer placed into each well, four replicates per concentration     12.21 mg/L
(12,21 mg/L)
          Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ASTM E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       juveniles (0-2 h) Five test dilutions with six replicates of five animals   35.46 mg/L
(35.46 mg/L)
            Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 USEPA, EPA-600-4-90-027F (1993) Ceriodaphnia dubia (Crustacean cladocera) immobilization 48 h       <24h 24-well plates, ten animals per well, three replicates per concentration     18.66 mg/L
(18,66 mg/L)
          Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days   seven different concentrations   <24h   Exposed individually   8.16 mg/L
(8,16 mg/L)
          Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 DIN EN ISO 15088-T6 Danio rerio Fish embryo lethality 48h               >2000 μg/L           Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 OECD 211 Daphnia magna Reproduction 21d                   >2100 μg/L       Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 EN ISO 6341-L40 Daphnia magna Immobilization 48h               >2000 μg/L           Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO/6341 (1996) Daphnia magna Straus (Crustacean) immobilization 24 h       <24h Five daphnids per vessel, four replicates for each of five concentrations     25.72 mg/L
(25,72 mg/L)
          Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 DIN EN ISO 8692 Desmodesmus subspicatus Growth 72h               37.1 μg/L   25 μg/L       Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 OECD 221 Lemna minor Growth 7d                   >1900 μg/L       Baumann et al. 2015
Clarithromycin   J01FA09 Antibacterial agents 747.9534 OECD 201(2006) with minor modifications Pseudokirchnerella subcapitata Growth inhibition 72 h   5-160 ug/L             46 ug/L
(0.046 mg/L)
<40 ug/L 40 ug/L
(0.04 mg/L)
    Yang et al. 2008
Clarithromycin   J01FA09 Antibacterial agents 747.9534 Algal Growth Inhibition test Pseudokirchneriella subcapitata Growth inhibition rate 96 h   maximum 10mg/L           0,012 mg/L   5.2 ug/L
(0,0052 mg/L)
      Harada et al. 2008
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO/DIS 8692 (1989) Pseudokirchneriella subcapitata (Green algae) growth inhibition 72 h   five different concentrations     Initial density was in the order of 10^4 cells/mL     0.0020 mg/L
(0,002 mg/L)
          Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534   Thamnocephalus platyurus (Crustacean) mortality 24 h       second- and third-instar fairy shrimp larvae 24-well plates, ten animals per well, three replicates per concentration   33.64 mg/L
(33.64 mg/L)
            Isidori et al. 2005b
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 36.40 mg/L           Ortiz de Garcia et al. 2014
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               12.65 mg/L           Ortiz de Garcia et al. 2014
Clarithromycin   J01FA09 Antibacterial agents 747.9534 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               12.08 mg/L           Ortiz de Garcia et al. 2014
Clindamycin   G01AA10 Gynecological antiinfectives and antiseptics   OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Clindamycin   G01AA10 Gynecological antiinfectives and antiseptics   Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Clofibrate   C10AB01 Blood lipid lowering agents     Oncorhynchus mykiss (Rainbow trout) gills, ultrastructural effects 28 days   1, 5, 20, 50, 100 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           5 ug/L
(0.005 mg/L)
    Triebskorn et al. 2007
Clofibrate   C10AB01 Blood lipid lowering agents     Oncorhynchus mykiss (Rainbow trout) liver, ultrastructural effects 28 days   1, 5, 20, 50, 100 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           >100 ug/L     Triebskorn et al. 2007
Clofibrate   C10AB01 Blood lipid lowering agents     Oncorhynchus mykiss (Rainbow trout) kidney, ultrastructural effects 28 days   1, 5, 20, 50, 100 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           >100 ug/L     Triebskorn et al. 2007
Clofibrate   C10AB01 Blood lipid lowering agents   Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           21.8 uM           Schnell et al. 2009
Clofibrate   C10AB01 Blood lipid lowering agents   CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           24.4 uM           Schnell et al. 2009
Clofibrate   C10AB01 Blood lipid lowering agents   ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               192.27 mg/L           Ortiz de Garcia et al. 2014
Clofibrate   C10AB01 Blood lipid lowering agents   ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               348.87 mg/L           Ortiz de Garcia et al. 2014
Clofibrate   C10AB01 Blood lipid lowering agents   ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 769.28 mg/L           Ortiz de Garcia et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 NF EN ISO 6341 guideline (1996) Artemia salina Immobilization 48h               >100,000
(>100 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 AFNOR XP-T-90-382 procedure (2009) Crassostrea gigas Metamorphosis 24h               515 ± 115
(0.515 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 AFNOR XP-T-90-382 procedure (2009) Crassostrea gigas Embryotoxicity 36h               157 ± 41
(0.157 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 AFNOR procedure XP T90-382 Crassostrea gigas Metamorphosis bioassays 24h   100, 200, 400, 600, 800, and 1, 000 μg l−1           514.7±66.5 mg/L           Di Poi et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 AFNOR procedure XP T90-382 Crassostrea gigas Embryo–larval toxicity 36h   100, 150, 200, 250, 300, 400, 600, 800, and 1,000 μg l−1           157.3±23.6 mg/L           Di Poi et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 guideline NF EN ISO 6341 (1996) Daphnia magna Acute immobilization 48h               2.74 [1.79–2.91] mg/L           Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 NF EN ISO 6341 guideline (1996) Daphnia magna Immobilization 48h               2,740 [1,790–2,910]
(2.740 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523   Haliotis tuberculata MTT 48h               4,765 ± 170
(4.765 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523   Haliotis tuberculata LMS 48h               1,318 ± 182
(1.318 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 procedure adapted from Trottier et al. (1997) Hydra attenuata Adult survival 96h               2,950 [2,860–2,990]
(2.95 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 procedure adapted from Trottier et al. (1997) Hydra attenuata Polyp regeneration 96h               2,950 [2,910–2,970]
(2.95 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 NF EN ISO 8692 guideline (2012) ISO 8692 guideline (2012) Pseudokirchneriella subcapitata Growth inhibition 72h               460 [410–490]
(0.460 mg/L)
          Minguez et al. 2014
Clomipramine   N06AA04 Psychoanaleptics 314.8523 NF EN ISO 10253 guideline (2006) Skeletonema marinoi Growth inhibition 72h               4.70 [2.30–4.80]
(0.0047 mg/L)
          Minguez et al. 2014
Clotrimazole   D01AC01 Antifungals for dermatological use     Microalgal communities (Periphyton) Inhibition of sterol biosynthesis                       50 pmol/L     Porsbring et al. 2009
Clotrimazole   D01AC01 Antifungals for dermatological use     Microalgal communities (Periphyton) Xanthophyll cycle pigment ratio                     5 pmol/L       Porsbring et al. 2009
Clotrimazole   D01AC01 Antifungals for dermatological use     Microalgal communities (Periphyton) Chlorophyll a content                     10 nmol/L 500 pmol/L     Porsbring et al. 2009
Clotrimazole   D01AC01 Antifungals for dermatological use     Microalgal communities (Periphyton) Pigment composition                     10 nmol/L       Porsbring et al. 2009
Clotrimazole   D01AC01 Antifungals for dermatological use     Xenopus tropicalis (Frog) aromatase activity in brain     6, 41, 375 nM   Tadpoles             375 nM     Gyllenhammar et al. 2009
Clotrimazole   D01AC01 Antifungals for dermatological use     Xenopus tropicalis (Frog) aromatase activity in gonad/kidney     6, 41, 375 nM F+M Tadpoles             41 nM     Gyllenhammar et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086   Aterias rubens (sea star) increase in righting time 7 days   18, 32, 56 mg/L     4 per concentration           32 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 Mn assay Aterias rubens (sea star) increase in micronuclei induction (cytogenetic damage) (per 1000 cells) 7 days   18, 32, 56 mg/L                 18 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 Comet assay Aterias rubens (sea star) increase in DNA strand breaks (% tail DNA) 7 days   18, 32, 56 mg/L                 18 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086   Aterias rubens (sea star) mortality 7 days   18, 32, 56 mg/L                 56 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     >1000 mg/L   >1000 mg/L >1000 mg/L     Zounkova et al. 2007
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 Comet assay Mytilus edulis (blue mussel) increase in DNA strand breaks (% tail DNA) 7 days   18, 32, 56, 100, 180 mg/L                 18 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086   Mytilus edulis (blue mussel) mortality 7 days   18, 32, 56, 100, 180 mg/L                 >180 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 Mn assay Mytilus edulis (blue mussel) increase in micronuclei induction (cytogenetic damage) (per 1000 cells) 7 days   18, 32, 56, 100, 180 mg/L                 18 mg/L     Canty et al. 2009
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 ISO 8692:1989, DIN 38412 Pseudokirchneriella subcapitata (Freshwater green alga) Growth inhibition 72 h               930 mg/L   250 mg/L 500 mg/L     Zounkova et al. 2007
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 >1000 mg/L   1000 mg/L >1000 mg/L     Zounkova et al. 2007
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 GreenScreen assay Saccharomyces cerevisiae (Yeast cells) Genotoxicity 16 h                     470 mg/L     Zounkova et al. 2007
Cyclophosphamide   L01AA01 Antineoplastic agents 261086 Microtox Vibrio fischeri (bacteria) Chronic luminescence inhibition 24h                     120
(120 mg/L)
    Lutterbeck et al. 2015
Cycloserine   J04AB01 Antimycobacterials   Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               65.5 mg/L
(65,5 mg/L)
          Backhaus and Grimme 1999
Cytarabine   L01BC01 Antineoplastic agents   OECD 211: 1998 (with modifications) Daphnia magna (Crustacean) Reproduction 21 days               10 mg/L     3.7 mg/L     Zounkova et al. 2010
Cytarabine   L01BC01 Antineoplastic agents   ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     200 mg/L     100 mg/L     Zounkova et al. 2010
Cytarabine   L01BC01 Antineoplastic agents   ISO 8692:1989, DIN 38412 Desmodesmus subspicatus (Green algae) Growth inhibition 72 h         100 000 cells /mL in 24 wells     53 mg/L     40 mg/L     Zounkova et al. 2010
Cytarabine   L01BC01 Antineoplastic agents   ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 17 mg/L     10 mg/L     Zounkova et al. 2010
Cytarabine   L01BC01 Antineoplastic agents   ISO/FDIS 13829, DIN 38415-3 Salmonella choleraesius subsp. chol. Genotoxicity 4 h                     167 mg/L     Zounkova et al. 2010
Dacarbazine   L01AX04 Antineoplastic agents   Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     >1     Hartmann et al. 1998
Dexamethasone   H02AB02 Corticosteroids for systemic use 392.4611 ASTM, E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       0-2 h (juveniles) 36-well plates with five rotifers per well, six replicates for each of the five conc.   48.22 mg/L
(48.22 mg/L)
            DellaGreca et al. 2004
Dexamethasone   H02AB02 Corticosteroids for systemic use 392.4611 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days       <24h (juveniles) Exposed individually to seven concentrations, ten replicates per conc.     0.05 ppm           DellaGreca et al. 2004
Dexamethasone   H02AB02 Corticosteroids for systemic use 392.4611 ISO 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       <24h (juveniles) Five daphnids per vessel, four replicates for each of the five conc.     48.30 mg/L
(48,3 mg/L)
          DellaGreca et al. 2004
Dexamethasone   H02AB02 Corticosteroids for systemic use 392.4611   Thamnocephalus platyurus (Crustacean) mortality 24 h       second- and third-instar fairy larvae 24-well plates, ten organisms per well, three replicates for each of the five conc.   60.11 mg/L
(60.11 mg/L)
            DellaGreca et al. 2004
Dextropropoxyphene HCI N02AC54 Analgesic   OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           0.05576 mM           Lilius et al. 1995
Dextropropoxyphene HCI N02AC54 Analgesic   OECD 202 (1993) Daphnia pulex (Crustacean) immobilization 24 h   5 concentrations           0.05644 mM           Lilius et al. 1995
Diazepam   N05BA01 Psycholeptics 284.7402   Artemia parthenogenetica (Hypersaline crustacean) oxidative stress biomarker: increase in glutathione peroxidase activity 48 h   4.07, 4.89, 5.86, 7.04, 8.44 mg/L   <24h 100 animals per replicate and treatment           6.13 mg/L     Nunes et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402 Modified OECD test 202 Artemia parthenogenetica (Hypersaline crustacean) mortality 48 h   6.25, 12.5, 25, 50, 100 mg/L   <24h 10 specimens per replicate, three replicates per concentration   12.2 mg/L
(12.2 mg/L)
            Nunes et al. 2005
Diazepam   N05BA01 Psycholeptics 284.7402   Artemia parthenogenetica (Hypersaline crustacean) oxidative stress biomarker: decrease in TBARS content 48 h   4.07, 4.89, 5.86, 7.04, 8.44 mg/L   <24h 100 animals per replicate and treatment           7.04 mg/L     Nunes et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402   Artemia parthenogenetica (Hypersaline crustacean) oxidative stress biomarker: inhibition of ChE 48 h   4.07, 4.89, 5.86, 7.04, 8.44 mg/L   <24h 100 animals per replicate and treatment           7.04 mg/L     Nunes et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             230 umol/L
(65.490246 mg/L)
            Calleja et al. 1994 (a)
Diazepam   N05BA01 Psycholeptics 284.7402   Artemia salina (Crustacea) Immobilization 24 h               63,7 mg/L           Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             2.35 umol/L             Calleja et al. 1994 (b)
Diazepam   N05BA01 Psycholeptics 284.7402 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             >35100 umol/L
(9994.38102 mg/L)
            Calleja et al. 1994 (a)
Diazepam   N05BA01 Psycholeptics 284.7402   Danio rerio (Zebrafish) Increased activity 3 days   0, 273 ng/l, 273 ug/L   Embryo 15. Six replicates.           273 ug/L
(0.273 mg/L)
    Oggier et al. 2010
Diazepam   N05BA01 Psycholeptics 284.7402   Danio rerio (Zebrafish) Changes in gene expression of circadian rhythm 14 days   0, 273 ng/l, 273 ug/L M Adult 20. Four replicates.           273 ng/L
(0.000237 mg/L)
    Oggier et al. 2010
Diazepam   N05BA01 Psycholeptics 284.7402 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.015 mM
(4,271103 mg/L)
          Lilius et al. 1994
Diazepam Formulation N05BA01 Psycholeptics 284.7402   Daphnia magna (Crustacean) Mortality               14.1 mg/L             Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402   Daphnia magna (Crustacean) Immobilization 24 h               13,9 mg/L           Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402   Daphnia magna (Crustacean) Immobilization                 4,3 mg/L           Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402   Daphnia magna (Crustacean) Mortality               4.2 mg/L             Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               1.69 umol/L           Calleja et al. 1994 (b)
Diazepam   N05BA01 Psycholeptics 284.7402 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               49.5 umol/L
(14,0946399 mg/L)
          Calleja et al. 1994 (a)
Diazepam   N05BA01 Psycholeptics 284.7402 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           0.015 mM           Lilius et al. 1995
Diazepam   N05BA01 Psycholeptics 284.7402 OECD 202 (1993) Daphnia pulex (Crustacean) immobilization 24 h   5 concentrations           0.042 mM           Lilius et al. 1995
Diazepam   N05BA01 Psycholeptics 284.7402 Modified OECD 203 (1984) Gambusia holbrooki (Euryhaline fish) mortality 96 h   5.21, 7.29, 10.2, 14.28, 20 mg/L F+M 2-2.5 cm long   Exposed individually 12.7 mg/L
(12.7 mg/L)
            Nunes et al. 2005
Diazepam   N05BA01 Psycholeptics 284.7402 Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984) Gambusia holbrooki (Euryhaline fish) major behavioural changes and increase of the swim bladder size 96 h   4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.) M 2-2.5 cm long Ten individually exposed fish per treatment, three replicates           7.36 mg/L     Nunes et al. 2008
Diazepam   N05BA01 Psycholeptics 284.7402 Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984) Gambusia holbrooki (Euryhaline fish) alteration of pigmentation and surface swimming 96 h   4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.) M 2-2.5 cm long Ten individually exposed fish per treatment, three replicates           4.26 mg/L     Nunes et al. 2008
Diazepam   N05BA01 Psycholeptics 284.7402   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 72h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Diazepam   N05BA01 Psycholeptics 284.7402   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 48h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Diazepam   N05BA01 Psycholeptics 284.7402   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 24h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Diazepam   N05BA01 Psycholeptics 284.7402   Hydra vulgaris (Cnidarian) clubbed tentacles, body slightly contracted 7 days   10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Diazepam   N05BA01 Psycholeptics 284.7402   Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     2.314 mM
(658,8888228 mg/L)
          Lilius et al. 1994
Diazepam   N05BA01 Psycholeptics 284.7402 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               >35000 umol/L
(9965,907 mg/L)
          Calleja et al. 1994 (a)
Diazepam   N05BA01 Psycholeptics 284.7402 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.363 mM
(103,3606926 mg/L)
          Caminada et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.440 mM
(125,285688 mg/L)
          Caminada et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.604 mM
(171,9830808 mg/L)
          Caminada et al. 2006
Diazepam   N05BA01 Psycholeptics 284.7402   Streptocephalus proboscideus (Crustacea) Immobilization 24 h               101 mg/L           Callejaa et al. 1993
Diazepam   N05BA01 Psycholeptics 284.7402 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.55 umol/L             Calleja et al. 1994 (b)
Diazepam   N05BA01 Psycholeptics 284.7402 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             362 umol/L
(103.0759524 mg/L)
            Calleja et al. 1994 (a)
Diazepam   N05BA01 Psycholeptics 284.7402 Modified OECD 201 (1984) Tetraselmis chuii (Marine algae) growth inhibition 96 h   7.9, 11.85, 17.78, 26.67, 40 mg/L             16.5 mg/L         Nunes et al. 2005
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 AFNOR T90-377 (2000) Brachionus calyciflorus (Rotifera) reproduction inhibition 48 h       newly hatched 48 rotifers; five concentrations and one control, eight replicates         12.5 mg/L
(12,5 mg/L)
25 mg/L     Ferrari et al. 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Rotoxkit according to the standard AFNOR T90-377 (2000) Brachionus calyciflorus (Rotifera) reproduction 48 h                   12.5 mg/L
(12,5 mg/L)
      Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Chronic toxicity test according to the standard AFNOR T90-376 (2000) Ceriodaphnia dubia (Crustacean cladocera) reproduction 7 days                   1,0 mg/L
(1 mg/L)
      Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 AFNOR T90-376 (2000) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7 days       < 24 h           1 mg/L
(1 mg/L)
2 mg/L     Ferrari et al. 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 EPA 600/4_90/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mobility inhibition 48 h       < 24 h 28 cups, five daphnids in each, six concentrations and one control, four replicates     22.7 mg/L
(22,7 mg/L)
          Ferrari et al. 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 EPA 600/4_90/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h               22.704 mg/L
(22,704 mg/L)
          Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 algal growth inhibition test Cyclotella meneghiniana (Diatom) growth 96 h               19.24 mg/L
(19,24 mg/L)
  10.0 mg/L
(10 mg/L)
      Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD protocol "Fish Embryo Toxicity" Danio rerio (Zebrafish) Developmental effects 72 h       Embryo (2 hours old)     7.8 mg/L
(7.8 mg/L)
5.3 mg/L
(5,3 mg/L)
  1.5 mg/L
(1,5 mg/L)
      van den Brandhof and Montforts, 2010
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ISO 12890 (1999) Danio rerio (Zebrafish) embryos and larvae mortality 10 days       embryos, larvae 50 embryos         4 mg/L
(4 mg/L)
8 mg/L     Ferrari et al. 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 10-d early life stage test according to ISO 12890 (1999) Danio rerio (Zebrafish) mortality 10 days       fish embryo           4,0 mg/L
(4 mg/L)
      Ferrari et al. 2004
Diclofenac 2-[(2,6-dichlorophenyl)amino]phenylacetic acid M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 mRNA differential display and quantitative Real Time experiments Danio rerio (Zebrafish) gene expression 48 h   0.5, 1.25, 1.5, 4, 10, mg/l   embryos 100 embryos per concentration         0.5 mg/L
(0.5 mg/L)
1.25 mg/L
(125 mg/L)
    De Felice et al. 2011
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OCED Guideline 202 and ISO6341 Daphnia magna Immobilization 24h               3.18 mg/L           Czech et al. 2014
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OCED Guideline 202 and ISO6341 Daphnia magna Immobilization 48h               2.69 mg/L           Czech et al. 2014
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Acute toxicity test according to the standard AFNOR T90-301 (1996) Daphnia magna (Crustacean) mortality 48 h               22.430 mg/L
(22,43 mg/L)
          Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 AFNOR T90-301 (1996) Daphnia magna (Crustacean) mobility inhibition 48 h       < 24 h 28 cups, five daphnids in each, six concentrations and one control, four replicates     224.3 mg/L
(224,3 mg/L)
          Ferrari et al. 2003
Diclofenac Diclofenac-Na M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 European Guideline; EEC Directive 92/69/EEC Daphnia magna (Crustacean) immobilization 48 h   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L   < 24 h Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.     68 mg/L
(68 mg/L)
          Cleuvers 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 European Guideline; EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 24 h and 48 h       Younger than 24h four replicates, 5 daphnids each     68.0 mg/L
(68 mg/L)
  45 mg/L
(45 mg/L)
      Cleuvers 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD guideline 202 (2004) Daphnia magna (Crustacean) immobilization 48 h   0, 10, 20, 30, 40, 50, 60, 75, 100, 125, 150 mg/L   <24 h 20 per concentration     39.9 mg/L
(39,9 mg/L)
          Haap et al. 2008
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 EPA/600/4-91/002 (1994) Daphnia magna (Crustacean) reproduction inhibition 21 days   0.1-80 mg/L   <24h (neonates) Five replicates, containing one organism per test chamber, were exposed to nine conc and a control.         10 mg/L
(10 mg/L)
      Han et al. 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Daphnia magna (Crustacean) hsp70-level 48 h   0, 5, 10, 20, 30, 40, 50 mg/L   12-19 days           30 mg/L
(30 mg/L)
40 mg/L     Haap et al. 2008
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 EPA/600/4-90/027F (1993) Daphnia magna (Crustacean) mortality 48 h       <24h (neonates) Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.   80.1 mg/L
(80.1 mg/L)
            Han et al. 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 European Guideline; EEC Directive 92/69/EEC (1993) Desmodesmus subspicatus (Green algae) growth inhibition                 71.9 mg/L
(71,9 mg/L)
  50 mg/L
(50 mg/L)
      Cleuvers 2004
Diclofenac Diclofenac-Na M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 European Guideline; EEC Directive 92/69/EEC Desmodesmus subspicatus (Green algae) inhibition of average growth rate 3 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Initial density; 10^4 cells/mL     72 mg/L
(72 mg/L)
          Cleuvers 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 SCGE assay Dreissena polymorpha (freshwater bivalve zebra mussel) increase in DNA damage represented by LDR (genotoxicity)     60, 156, 250 ug/L                 60 ug/L
(0.06 mg/L)
    Parolini et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 DNA diffusion assay Dreissena polymorpha (freshwater bivalve zebra mussel) increase in frequency of apoptotic cells (genotoxicity)     60, 156, 250 ug/L                 156 ug/L
(0.156 mg/L)
    Parolini et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 NRR assay Dreissena polymorpha (freshwater bivalve zebra mussel) decrease in neutral red retention time (cytotoxicity)     60, 156, 250 ug/L                 250 ug/L
(0.25 mg/L)
    Parolini et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Trypan blue exclusion method Dreissena polymorpha (freshwater bivalve zebra mussel) haemocyte viability           4 or 5 mussels, 2 replicates     178 ug/L
(0,178 mg/L)
          Parolini et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996) Dunaliella tertiolecta (Phytoplankton) cell density 96 h   25, 50, 100, 200, 400 mg/L     Initial density; approximately 50 000 cells/mL     185.69 mg/L
(185,69 mg/L)
          DeLorenzo and Fleming 2008
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 30, 60, 100, 150, 180, 200, 500 mg/kg   >2 month     90.49 mg/kg             Pino et al. 2015
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Gyps bengalensis (Oriental white-backed vulture) renal disease varying   0,007 mg/kg to 0,940 mg/kg   adult, subadult, juvenile 20 (+ 6 controls) Direct orally+through diclofenac-treated livestock             0.007 mg/kg Oaks et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ISO/WD 20079 (2001) Lemna minor (Duckweed) growth inhibition 7 days       Initially three or four fronds Six-well plates, one plant in each well, three replicates     148 mg/L
(148 mg/L)
          Kaza et al. 2007
Diclofenac Diclofenac-Na M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ISO/WD 20079 (2001), using the Steinberg-medium Lemna minor (Duckweed) inhibition of average growth rate 7 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Three treatment replicates and six control replicates.     7.5 mg/L
(7,5 mg/L)
          Cleuvers 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 test on hepatocytes, cytotoxicity test, MTT assay Oncorhynchus mykiss (Rainbow trout) cytotoxicity 24 h   31.3-500 uM   immature       420 uM           Laville et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 EROD activity test Oncorhynchus mykiss (Rainbow trout) inhibition 24 h       immature       63 uM           Laville et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oncorhynchus mykiss (Rainbow trout) kidney, ultrastructural effects 28 days   1, 5, 20, 100, 500 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           1 ug/L
(0.001 mg/L)
    Triebskorn et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oncorhynchus mykiss (Rainbow trout) liver, ultrastructural effects 28 days   1, 5, 20, 100, 500 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           1 ug/L
(0.001 mg/L)
    Triebskorn et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oncorhynchus mykiss (rainbow trout) cytological alterations in liver, kidney and gills 28 days   0, 1, 5, 20, 100, 500 ug/L   about 2 years old 6 per concentration           1 ug/L
(0.001 mg/L)
    Triebskorn et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oncorhynchus mykiss (rainbow trout) renal lesions and alterations of the gill 28 days   0, 1, 5, 20, 100, 500 ug/L   1.8 years 10 per concentration.         1 ug/L
(0,001 mg/L)
5 ug/L
(0.005 mg/L)
    Schwaiger et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oncorhynchus mykiss (Rainbow trout) gills, ultrastructural effects 28 days   1, 5, 20, 100, 500 ug/L F+M 1,5-1,8 year-old 24 per conc. 6-8 were used           1 ug/L
(0.001 mg/L)
    Triebskorn et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oryzias latipes (Japanese medaka) mortality 96 h   1, 12.5, 19, 25, 50, 100, 120 mg/L   35-50 days old (juveniles) Seven fish per each concentration (7) and each test was conducted three times   8 mg/L (LC10)       1 mg/L     Hong et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Oryzias latipes (Japanese medaka) induction of CYP1A, p53 gene and VTG 4 days   1 ug/L and 8 mg/L   5-6 months old Three fish per concentration and solvent at each time point (0h, 12h, 1 day, 2 days, 4 days)           1 ug/L
(0.001 mg/L)
    Hong et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.243 mM
(71,963964 mg/L)
          Caminada et al. 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.269 mM
(79,663812 mg/L)
          Caminada et al. 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 test on hepatocytes, cytotoxicity test, MTT assay Poeciliopsis lucida (Topminnow) cytotoxicity 24 h   31.3-500 uM           19 uM           Laville et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Polystichum setiferum (plant) DNA quantification 48h                     0.3 ug/L
(0.0003 mg/L)
    Feito et al. 2012
Diclofenac Diclofenac M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Polystichum setiferum (plant) Mitochondrial activity 24h                   0.3ug/L
(0.0003 mg/L)
3 ug/L
(0.003 mg/L)
    Feito et al. 2012
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Polystichum setiferum (plant) chlorophyll auto-fluorescence 1 week                     300 ng/L
(0.0003 mg/L)
    Feito et al. 2012
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Polystichum setiferum (plant) Mitochondrial activity 48h                     0.3 ug/L
(0.0003 mg/L)
    Feito et al. 2012
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Polystichum setiferum (plant) DNA quantification 24h                     30 ug/L
(0.03 mg/L)
    Feito et al. 2012
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 algal growth inhibition test Pseudokirchneriella subcapitata (Green algae) growth 96 h               16.3 mg/L
(16,3 mg/L)
  10.0 mg/L
(10 mg/L)
      Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Pseudokirchneriella subcapitata (Green algae) growth inhibition 96 h                   10 mg/L
(10 mg/L)
20 mg/L     Ferrari et al. 2003
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Rainbow trout (fish) Growth 95d   3.2, 10, 32, 100, 320, and 1000 µgL   eggs-juveniles 15 eggs per replicate Dilution in the water       1084 µg/L
(1,084 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Rainbow trout (fish) Histopathological effect 95d   3.2, 10, 32, 100, 320, and 1000 µgL   eggs-juveniles 15 eggs per replicate Dilution in the water       368 µg/L
(0,368 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Rainbow trout (fish) Survival 95d   3.2, 10, 32, 100, 320, and 1000 µgL   eggs-juveniles 15 eggs per replicate Dilution in the water       1084 µg/L
(1,084 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Rainbow trout (fish) Development rate of eggs 95d   3.2, 10, 32, 100, 320, and 1000 µgL   eggs-juveniles 15 eggs per replicate Dilution in the water       1084 µg/L
(1,084 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Rainbow trout (fish) Hatching rate 95d   3.2, 10, 32, 100, 320, and 1000 µgL   eggs-juvenile 15 eggs per replicate Dilution in the water       1084 µg/L
(1,084 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.78 mM
(527,14344 mg/L)
          Caminada et al. 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           266.8 uM           Schnell et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           257.4 uM           Schnell et al. 2009
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Salmo trutta f. fario (Fish) monocyte infiltration/accumulation in liver 21 days   0.5, 5, 50ug/L   18 months 36 fish per exposure concentration         0.5 ug/L
(0,0005 mg/L)
      Hoeger et al. 2005
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 A cell-reproduction test Scenedesmus vacuolatus (Green algae) inhibition of algal reproduction 144 h   50 mg/L     Initial density: 7.5*10^4 cells/mL     0.023 mg/L
(0,023 mg/L)
          Schmitt-Jansen et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 A cell-reproduction test Scenedesmus vacuolatus (Green algae) inhibition of algal reproduction 53 h   50 mg/L     Initial density: 7.5*10^4 cells/mL     0.48 mg/L
(0,48 mg/L)
          Schmitt-Jansen et al. 2007
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Siriella armata Mortality 96h       <24h 20 rep/conc. 1 neonate/rep.   2919 μg/L
(2,919 mg/L)
    250 μg/L
(0,25 mg/L)
500 μg/L
(0.5 mg/L)
    Pérez et al. 2015
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Siriella armata Mortality 48h       <24h 20 rep/conc. 1 neonate/rep.   10,436 μg/L
(0,010436 mg/L)
    8000 μg/L
(8,0 mg/L)
10000 μg/L
(10 mg/L)
    Pérez et al. 2015
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 algal growth inhibition test Synechococcus leopolensis (Blue-green algae) growth 96 h               14.5 mg/L
(14,5 mg/L)
  10.0 mg/L
(10 mg/L)
      Ferrari et al. 2004
Diclofenac diclofenac M01AB05 Anti-inflammatory and anti-reumatic agents 296.148   Tetrahymena pyriformis (Ciliophora) growth inhibition 24 h               26.56 mg/L           Láng and Kőhidai 2012
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     41 mg/L
(41 mg/L)
            Nalecz-Jawecki and Persoone 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     46 mg/L
(46 mg/L)
          Nalecz-Jawecki and Persoone 2006
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ISO11348-3 Vibrio fischeri EC50 counted                 14.04 mg/L           Czech et al. 2014
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Microtox test according to the standard AFNOR T90-320-3 (1999) Vibrio fischeri (Bacteria) luminescence 30 min               11.454 mg/L
(11,454 mg/L)
          Ferrari et al. 2004
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 AFNOR T90-320-3 (1999) Vibrio fischeri (Bacteria) luminescence 30 min               11.45 mg/L
(11,45 mg/L)
          Ferrari et al. 2003
Diclofenac Diclofenac-Na M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 Microtox Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               13.7 mg/L
(13,7 mg/L)
          Farré et al. 2001
Diclofenac Diclofenac-Na M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 ToxAlert 100 Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               13.5 mg/L
(13,5 mg/L)
          Farré et al. 2001
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Zebra fish Hatching rate 38d   10, 32, 100, 320, 1000, and 3200 µg/L   eggs-juveniles 15 eggs per replicate Dilution in the water       1131 µg/L
(1,131 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Zebra fish Development rate of eggs 38d   10, 32, 100, 320, 1000, and 3200 µg/L   eggs-juveniles 15 eggs per replicate Dilution in the water       1131 µg/L
(1,131 mg/L)
      Memmert et al. 2013.
Diclofenac   M01AB05 Anti-inflammatory and anti-reumatic agents 296.148 OECD 305 Zebra fish Survival 38d   10, 32, 100, 320, 1000, and 3200 µg/L   eggs-juveniles 15 eggs per replicate Dilution in the water       336 µg/L
(0,336 mg/L)
      Memmert et al. 2013.
Digoxin   C01AA05 Cardiac therapy 780.9385 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             >12800 umol/L
(9996.0128 mg/L)
            Calleja et al. 1994 (a)
Digoxin   C01AA05 Cardiac therapy 780.9385 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             >12800 umol/L
(9996.0128 mg/L)
            Calleja et al. 1994 (a)
Digoxin   C01AA05 Cardiac therapy 780.9385 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.031 mM
(24,2090935 mg/L)
          Lilius et al. 1994
Digoxin   C01AA05 Cardiac therapy 780.9385 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               >12800 umol/L
(9996,0128 mg/L)
          Calleja et al. 1994 (a)
Digoxin   C01AA05 Cardiac therapy 780.9385   Hydra vulgaris (Cnidarian) mean number of Artemia ingested 7 days 10 day feeding/budding study followed 7 d exposure 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           100 ug/L
(0.1 mg/L)
    Pascoe et al. 2003
Digoxin   C01AA05 Cardiac therapy 780.9385   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 24h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Digoxin   C01AA05 Cardiac therapy 780.9385   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 48h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Digoxin   C01AA05 Cardiac therapy 780.9385   Hydra vulgaris (Cnidarian) regeneration of digestive region 17 days regeneration of digestive region observed for 72h 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Digoxin   C01AA05 Cardiac therapy 780.9385 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               >12800 umol/L
(9996,0128 mg/L)
          Calleja et al. 1994 (a)
Digoxin   C01AA05 Cardiac therapy 780.9385 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             35.4 mg/L
(35.4 mg/L)
8.84 mg/L
(8,84 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Digoxin   C01AA05 Cardiac therapy 780.9385 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             >12800 umol/L
(9996.0128 mg/L)
            Calleja et al. 1994 (a)
Digoxin   C01AA05 Cardiac therapy 780.9385 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               26,3 mg/L
(26,3 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Dihydrostreptomycin Veterinary use QA07AA90 Antidiarrheals, intestinal antiinflammatory /antiinfective agents   OECD (1993) no 201 Selenastrum capricornutum (Freshwater green algae) growth inhibition     5 concentrations, triplicates           0.107 mg/L
(0,107 mg/L)
  <0.039 mg/L       Eguchi et al. 2004
Diltiazem   C08DB01 Calcium antagonists 414.5179 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 48 h               28 mg/L
(28 mg/L)
          Kim et al. 2007
Diltiazem   C08DB01 Calcium antagonists 414.5179 EPA/600/4-90/027F (2002) Daphnia magna (Crustacean) immobilization 96 h               8.2 mg/L
(8,2 mg/L)
          Kim et al. 2007
Diltiazem   C08DB01 Calcium antagonists 414.5179 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 48 h             25.6 mg/L
(25.6 mg/L)
            Kim et al. 2007
Diltiazem   C08DB01 Calcium antagonists 414.5179 OECD, 1992, TG 203 Oryzias latipes (Japanese medaka) mortality 96 h             15.0 mg/L
(15 mg/L)
            Kim et al. 2007
Diltiazem Diltiazem HCl C08DB01 Calcium antagonists 414.5179 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     10.2 mg/L
(10,2 mg/L)
          Nalecz-Jawecki and Persoone 2006
Diltiazem Diltiazem HCl C08DB01 Calcium antagonists 414.5179 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     73 mg/L
(73 mg/L)
            Nalecz-Jawecki and Persoone 2006
Diltiazem   C08DB01 Calcium antagonists 414.5179 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 15 min               263.7 mg/L
(263,7 mg/L)
          Kim et al. 2007
Diltiazem   C08DB01 Calcium antagonists 414.5179 Microtox Toxicity Analyzer Vibrio fischeri (Bacteria) alteration in light output 5 min               407.4 mg/L
(407,4 mg/L)
          Kim et al. 2007
Diltiazem   C08DB01 Calcium antagonists 414.5179 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               152 mg/L
(152 mg/L)
          Backhaus and Grimme 1999
Diphenhydramine   R06AA02 Antihistamines for systemic use   US EPA 600/4-90/027F Ceriodaphnia dubia (Crustacean) Lethality 48h   0.0–4.5 mgL     5 to 8 per sample   3.94 mg/L             Goolsby et al. 2013
Diphenhydramine   R06AA02 Antihistamines for systemic use   US EPA 600/4-91/002 Ceriodaphnia dubia (Crustacean) Reproduction 7d   0.0–4.5 mgL     1 per samle     0.991 mg/L           Goolsby et al. 2013
Diphenylhydantoin   N03AB02 Antiepileptics   Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             >39600 umol/L             Calleja et al. 1994 (a)
Diphenylhydantoin   N03AB02 Antiepileptics   Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             >39600 umol/L             Calleja et al. 1994 (a)
Diphenylhydantoin   N03AB02 Antiepileptics   OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               >39600 umol/L           Calleja et al. 1994 (a)
Diphenylhydantoin   N03AB02 Antiepileptics     Oncorhynchus mykiss (Rainbow trout hepatocytes) extracellular radioactivity 3h         Cell density: 2*10^6 cells/mL     5.63 mM           Lilius et al. 1994
Diphenylhydantoin   N03AB02 Antiepileptics   Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               >39600 umol/L           Calleja et al. 1994 (a)
Diphenylhydantoin   N03AB02 Antiepileptics   Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             >100 mg/L >100 mg/L           Nalecz-Jawecki and Sawicki 2003
Diphenylhydantoin   N03AB02 Antiepileptics   Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             248 umol/L             Calleja et al. 1994 (a)
Diphenylhydantoin   N03AB02 Antiepileptics   Protoxkit FTM Tetrahymena termophila (Ciliate) morphological changes/ spherical deformation and autolysis 24 h               47,6 mg/L
(47,6 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Diphenylhydantoin 5,5-Diphenylhydantion N03AB02 Antiepileptics   Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     44 mg/L
(44 mg/L)
            Nalecz-Jawecki and Persoone 2006
Diphenylhydantoin 5,5-Diphenylhydantion N03AB02 Antiepileptics   Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     33.7 mg/L
(33,7 mg/L)
          Nalecz-Jawecki and Persoone 2006
Doxorubicin Adriamycin hydrochloride = Doxorubicinklorid L01DB01 Antineoplastic agents 543.5193 Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     2,5     Hartmann et al. 1998
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       12.69 mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       7.7*10^3 mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         - mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       5.18 mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       - mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       2.14 mg/L           Parrella et al. 2014
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     2 mg/L   0,01 mg/L 0.1 mg/L     Zounkova et al. 2007
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 SOS-Chromotest Escherichia coli (Bacteria) Genotoxicity 4 h                     0.074 mg/L     Zounkova et al. 2007
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.00260 mM
(1,41315018 mg/L)
          Caminada et al. 2006
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.00217 mM
(1,179436881 mg/L)
          Caminada et al. 2006
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 8692:1989, DIN 38412 Pseudokirchneriella subcapitata (Freshwater green alga) Growth inhibition 72 h               13 mg/L   1 mg/L 10 mg/L     Zounkova et al. 2007
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 >1000 mg/L   1 mg/L 10 mg/L     Zounkova et al. 2007
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.00470 mM
(2,55454071 mg/L)
          Caminada et al. 2006
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 GreenScreen assay Saccharomyces cerevisiae (Yeast cells) Genotoxicity 16 h                     2.8 mg/L     Zounkova et al. 2007
Doxorubicin   L01DB01 Antineoplastic agents 543.5193 ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               0.31 mg/L           Parrella et al. 2014
Doxycycline   J01AA02 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           36.9 ug/L
(0,0369 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           274.9 ug/L
(0,2749 mg/L)
          Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           87.1 ug/L
(0,0871 mg/L)
    1000 ug/L
(1 mg/L)
    Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents     Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           45 ug/L
(0,045 mg/L)
    100 ug/L
(0.1 mg/L)
    Hillis et al. 2008
Doxycycline   J01AA02 Antibacterial agents   ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     316 ug/L
(0,316 mg/L)
          Brain et al. 2004 (a)
Drosperinone   G03FA17 Sex hormones   OECD 21 days fish reproduction (draft) Pimephales promelas (Fathead minnows) Inhibition of reproduction (no of laid eggs) 21 days   0, 0.66, 6.5, 70 ug/L F+M Adult 4 pairs         0.66 ug/L
(0,00066 mg/L)
6.5 ug/L
(0.0065 mg/L)
    Zeilinger et al. 2009
Duloxetine   N06AX21 Psychoanaleptics   AFNOR procedure XP T90-382 Crassostrea gigas Embryo–larval toxicity 36h   100, 150, 200, 250, 300, 400, 600, 800, and 1,000 μg l−1           162.5±53.3 mg/L           Di Poi et al. 2014
Duloxetine   N06AX21 Psychoanaleptics   AFNOR procedure XP T90-382 Crassostrea gigas Metamorphosis bioassays 24h   100, 200, 400, 600, 800, and 1, 000 μg l−1           154.7±17.9 mg/L           Di Poi et al. 2014
Enalapril Enalapril maleate C09AA02 Agents acting on the renin-angiotensin system 376.4467 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     184 mg/L
(184 mg/L)
            Nalecz-Jawecki and Persoone 2006
Enoxacin   J01MA04 Antibacterial agents   Long-term bioluminescence inhibition assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h   At least 16 different concentrations           49.33ug/L
(0,04933 mg/L)
  2.88 ug/L
(0,00288 mg/L)
      Backhaus et al. 2000
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   OECD guideline 202 (1993) Daphnia magna (Crustacean) adult survival 21 days   five different concentrations: 0.03-0.5 mg/L   <24h organisms maintained individually     11.47 mg/L
(11,47 mg/L)
  5 mg/L
(5 mg/L)
15 mg/L     Park and Choi 2008
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   OECD guideline 202 (1993) Daphnia magna (Crustacean) reproduction 21 days   five different concentrations: 0.03-0.5 mg/L   <24h organisms maintained individually         5 mg/L
(5 mg/L)
15 mg/L     Park and Choi 2008
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   US EPA-821-R-02-012 (2002) Daphnia magna (Crustacean) immobilization 24 h       <24h four replicates of five organisms     131,7 mg/L
(131,7 mg/L)
          Park and Choi 2008
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   US EPA-821-R-02-012 (2002) Daphnia magna (Crustacean) immobilization 48 h       <24h four replicates of five organisms     56,7 mg/L
(56,7 mg/L)
          Park and Choi 2008
Enrofloxacin   QJ01MA90 Antibacterial agents     Lemna minor Growth inhibition     2 mg/L           0.22 mg/L           Wagil et al. 2014
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents     Lemna minor (Duckweed) reproduction 7 days   four different concentrations     10-15 fronds, triplicate experiments with four concentrations and a control     114 ug/L
(0,114 mg/L)
          Robinson et al. 2005
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents     Microcystis aeruginosa (Freshwater cyanobacteria) growth and reproduction 5 days   five different concentrations           49 ug/L
(0,049 mg/L)
          Robinson et al. 2005
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   US EPA-821-R-02-012 (2002) Moina macrocopa (Crustacean) immobilization 24 h       <24h four replicates of five organisms     285,7 mg/L
(285,7 mg/L)
          Park and Choi 2008
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents     Pseudokirchneriella subcapitata (Green algae) growth and reproduction 3 days   five different concentrations           3100 ug/L
(3,1 mg/L)
          Robinson et al. 2005
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 15 min                 326.8 mg/L         Park and Choi 2008
Enrofloxacin Veterinary use QJ01MA90 Antibacterial agents   Microtox Model 500 analyser Vibrio fischeri (Bacteria) luminescence 5 min                 425 mg/L         Park and Choi 2008
Erythromycin   J01FA01 Antibacterial agents 733.9268 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268 OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             10-100 mg/L         Kümmerer K. et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268   Anabaena cylindrica NIES-19 Growth inhibition 144 h               0,035   0,0031       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Anabaena flos-aquae ATCC 29413 Growth inhibition 144 h               0,27   0,047       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Anabaena variabilis NIES-23 Growth inhibition 144 h               0,43   0,047       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h         24-well microplates, one rotifer placed into each well, four replicates per concentration     0.94 mg/L
(0,94 mg/L)
          Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 ASTM E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       juveniles (0-2 h) Five test dilutions with six replicates of five animals   27.53 mg/L
(27.53 mg/L)
            Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 USEPA, EPA-600-4-90-027F (1993) Ceriodaphnia dubia (Crustacean cladocera) immobilization 48 h   five different concentrations   <24h 24-well plates, ten animals per well, three replicates per concentration     10.23 mg/L
(10,23 mg/L)
          Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days   seven different concentrations   <24h   Exposed individually   0.22 mg/L
(0,22 mg/L)
          Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 OECD (1993) no 201 Chlorella vulgaris (Green algae) growth inhibition     5 concentrations, triplicates           33.8 mg/L
(33,8 mg/L)
  12.5 mg/L
(12,5 mg/L)
      Eguchi et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268 EEC 84/449 1984 Daphnia magna (Crustacean)   48 h   0, 100-800 mg/L   <24 days old 5 per bottle, 4 per replicates     210,57 mg/L           di Delupis et al. 1992
Erythromycin   J01FA01 Antibacterial agents 733.9268 EEC 84/449 1984 Daphnia magna (Crustacean)   24 h   0, 100-800 mg/L   <24 days old 5 per bottle, 4 per replicates     387,7 mg/L           di Delupis et al. 1992
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO/6341 (1996) Daphnia magna Straus (Crustacean) immobilization 24 h   five different concentrations   <24h Five daphnids per vessel, four replicates for each of five concentrations     22.45 mg/L
(22,45 mg/L)
          Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     > 1000 ug/L           Brain et al. 2004 (a)
Erythromycin   J01FA01 Antibacterial agents 733.9268 USEPA(1996) Lemna minor FBR006 (Duckweed) growth inhibition 7 days   0, 1, 10, 100, 1000 ug/L     A total of 12 fronds per test chamber, three replicates     5.62 mg/L
(5,62 mg/L)
          Pomati et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268   Microcystis aeruginosa NIES-44 Growth inhibition 144 h               0,023   0,01       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Microcystis wesenbergii NIES-107 Growth inhibition 144 h               0,023   0,0047       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Nostoc sp. PCC 7120 Growth inhibition 144 h               0,2   0,1       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO/DIS 8692 (1989) Pseudokirchneriella subcapitata (Green algae) growth inhibition 72 h   five different concentrations     Initial density was in the order of 10^4 cells/mL     0.020 mg/L
(0,02 mg/L)
          Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268   Pseudokirchneriella subcapitata ATCC 22662 Growth inhibition 144 h               0,366   0,0103       Ando and Nagase, 2007
Erythromycin Erythromycin phosphate J01FA01 Antibacterial agents 733.9268 According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975) Salvelinus namaycush (Lake trout) mortality 96 h   200-800 mg/L   7.0-8.2 g 20 fish (two replicates of 10 fish each) Water bath exposure 410.0 mg/L
(410 mg/L)
            Marking et al. 1988
Erythromycin Erythromycin phosphate J01FA01 Antibacterial agents 733.9268 According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975) Salvelinus namaycush (Lake trout) mortality 24 h   200-800 mg/L   7.0-8.2 g 20 fish (two replicates of 10 fish each) Water bath exposure 818.0 mg/L
(818 mg/L)
            Marking et al. 1988
Erythromycin   J01FA01 Antibacterial agents 733.9268 OECD (1993) no 201 Selenastrum capricornutum (Freshwater green algae) growth inhibition     5 concentrations, triplicates           0.0366 mg/L
(0,0366 mg/L)
  0.0103 mg/L
(0,0103 mg/L)
      Eguchi et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268   Synechococcus leopoldensis IAM M-6 Growth inhibition 144 h               0,16   0,0020       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Synechococcus sp. PCC 7002 Growth inhibition 144 h               0,23   0,0078       Ando and Nagase, 2007
Erythromycin   J01FA01 Antibacterial agents 733.9268   Synechocystis sp. PCC6803 (Cyanobacteria) growth inhibition 0-5 days   0, 1, 10, 100, 1000 ug/L   Culture in late-logarithmic growth-phase Initial cell density set to approx. 0.1 OD750           1 ug/L
(0.001 mg/L)
    Pomati et al. 2004
Erythromycin   J01FA01 Antibacterial agents 733.9268   Thamnocephalus platyurus (Crustacean) mortality 24 h   five different concentrations   second- and third-instar fairy shrimp larvae 24-well plates, ten animals per well, three replicates per concentration   17.68 mg/L
(17.68 mg/L)
            Isidori et al. 2005b
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 561.91 mg/L           Ortiz de Garcia et al. 2014
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               n.a. mg/L           Ortiz de Garcia et al. 2014
Erythromycin   J01FA01 Antibacterial agents 733.9268 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               n.a. mg/L           Ortiz de Garcia et al. 2014
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Carassius auratus (crucian carp) induction of vitellogenin (reproductive endocrine disruption) 14 days   5, 15, 30, 100, 150, 500 ng/L M   groups of 3     98.14 ng/L
(0,00009814 mg/L)
  30 ng/L
(0,00003 mg/L)
100 ng/L
(0.0001 mg/L)
    Zhang et al. 2008
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 In vitro competitive radioreceptor assay Cyprinus carpio (Common carp hepatic ER) displacement of specific ER binding                 32 nM
(0,00871744 mg/L)
          Segner et al. 2003a
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 In vitro VTG induction assay Cyprinus carpio (Common carp hepatocytes) VTG induction 3 days 4 days   sexually immature or F   Initial density: 1.5-2.0*10^6 cells/mL     90 nM
(0,0245178 mg/L)
          Segner et al. 2003a
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Danio rerio (Zebrafish) vitellogenin induction 8 days   0, 10, 20, 40, 70, 100, 200, 200 or 500 ng/L M adult 20-25 fish exposed to each concentration     41.2 ng/L
(0,0000412 mg/L)
    21 ng/L
(0.000021 mg/L)
    Rose et al. 2002
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 ISO Guideline 6341 (1996) Daphnia magna (Crustacean) moulting frequency 24 h       <24 h 5 daphnids in each beaker, 3 beakers for each test concentration     1.55 mg/L
(1,55 mg/L)
          Brennan et al. 2006
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 ISO Guideline 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       <24 h 5 daphnids in each beaker, 3 beakers for each test concentration     3.67 mg/L
(3,67 mg/L)
          Brennan et al. 2006
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 ISO Guideline 6341 (1996) Daphnia magna (Crustacean) moulting frequency 48 h       <24 h 5 daphnids in each beaker, 3 beakers for each test concentration     2.04 mg/L
(2,04 mg/L)
          Brennan et al. 2006
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 ISO Guideline 6341 (1996) Daphnia magna (Crustacean) immobilization 48 h       <24 h 5 daphnids in each beaker, 3 beakers for each test concentration     2.87 mg/L
(2,87 mg/L)
          Brennan et al. 2006
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Gasterosteus aculeatus (three-spined stickleback) kidney cell primary culture inhibition of DHT-induced spiggin production 48 h   10^-14 - 10^-6 M F               272 ug/L
(272 mg/L)
    Jolly et al. 2009
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Ictalurus punctatus (Channel catfish) elevated serum E2 concentration 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Estradiol 17B-estradiol-glucuronide G03CA03 Sex hormones 272.42   Ictalurus punctatus (Channel catfish) elevated serum E2 concentration 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Estradiol   G03CA03 Sex hormones 272.42 In vivo study Ictalurus punctatus (Channel catfish) hepatic somatic index   10 days 0.6 mg/kg on days 1, 4 and 7 M 2 years 5-7 fish Intraperitoneally injected (i.p.)             0.6 mg/kg Nimrod and Benson 1997
Estradiol   G03CA03 Sex hormones 272.42 In vivo study Ictalurus punctatus (Channel catfish) increased number of hepatic binding sites   10 days 0.6 mg/kg on days 1, 4 and 7 M 2 years 5-7 fish Intraperitoneally injected (i.p.)             0.6 mg/kg Nimrod and Benson 1997
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Ictalurus punctatus (Channel catfish) induction of vitellogenin 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Estradiol   G03CA03 Sex hormones 272.42 In vivo study Ictalurus punctatus (Channel catfish) increase in Kd   10 days 0.6 mg/kg on days 1, 4 and 7 F 2 years 3-5 fish Intraperitoneally injected (i.p.)             0.6 mg/kg Nimrod and Benson 1997
Estradiol   G03CA03 Sex hormones 272.42 In vitro study Ictalurus punctatus (Channel catfish) binding inhibition       F 2 years         2.20 nM
(0.000599324 mg/L)
        Nimrod and Benson 1997
Estradiol   G03CA03 Sex hormones 272.42 In vivo study Ictalurus punctatus (Channel catfish) increase in Kd   10 days 0.6 mg/kg on days 1, 4 and 7 M 2 years 5-7 fish Intraperitoneally injected (i.p.)             0.6 mg/kg Nimrod and Benson 1997
Estradiol   G03CA03 Sex hormones 272.42 In vivo study Ictalurus punctatus (Channel catfish) increase in serum Vg levels   10 days 0.6 mg/kg on days 1, 4 and 7 M 2 years 5-7 fish Intraperitoneally injected (i.p.)             0.6 mg/kg Nimrod and Benson 1997
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 MCF-7 breast tumor cell proliferation (E-Screen) assay MCF-7 cells growth                 8.7*10^-3 ug/L
(0,0087 mg/L)
          Folmar et al. 2002
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Nitocra spinipes (Harpacticoid copepod) sex ratio 18 days       <24h 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group           0.05 mg/L     Breitholtz and Bengtsson 2001
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Swedish standard SS 02 81 06, SIS (1991) Nitocra spinipes (Harpacticoid copepod) mortality 96 h       <24h 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group   1.6 mg/L
(1.6 mg/L)
            Breitholtz and Bengtsson 2001
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 In vitro VTG induction assay Oncorhynchus mykiss (Rainbow trout hepatocytes) VTG induction 3 days 4 days   sexually immature or F   Initial density: 1.5-2.0*10^6 cells/mL     26 nM
(0,00708292 mg/L)
          Segner et al. 2003a
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Sex ratio     0, 0.01, 0.12, 1.33 ug/L M+F               0.01 ug/L     Nimrod and Benson, 1998
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Survival     0, 0.01, 0.12, 1.33 ug/L M+F 5-8 days old             1.33 ug/L     Nimrod and Benson, 1998
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Fecundity     0, 0.01, 0.12, 1.33 ug/L F               1.33 ug/L     Nimrod and Benson, 1998
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Hepatic Vtg concentrations 25 days   0, 31.3, 62.5, 125, 250, 500 ug/L M Adults 46         29.3 ng/L 55.7 ng/L     Kang et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Developed testis-ova (intersex) 25 days   0, 31.3, 62.5, 125, 250, 500 ug/L M Adults 46           29.3 ng/L     Kang et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Fertility of eggs 21 days för F, 25 days for M   0, 31.3, 62.5, 125, 250, 500 ug/L M+F Adults 48 mating pairs         227 ng/L 463 ng/L     Kang et al. 2002
Estradiol   G03CA03 Sex hormones 272.42 OECD 203 Oryzias latipes (Japanese medaka) Survival               2 mg/L             Kang et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Number of eggs 21 days för F, 25 days for M   0, 31.3, 62.5, 125, 250, 500 ug/L M+F Adults 48 mating pairs         227 ng/L 463 ng/L     Kang et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese medaka) Gonadosomatic index (GSI) 25 days   0, 31.3, 62.5, 125, 250, 500 ug/L M Adults 46         227 ng/L 463 ng/L     Kang et al. 2002
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Oryzias latipes (Japanese ricefish) induced intersex (testis-ova) approximately 90 days       1 day Four test concentrations, one control, 60 fish in each         0.0004 ug/L
(0,0000004 mg/L)
0.004 ug/L
(0.000004 mg/L)
    Metcalfe et al. 2001
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) increase in vitellogenin (VTG) concentration 101 days   0.939, 2.86, 8.66, 27.9 ng/L M 101 days posthatch             8,66 ng/L
(0.00000866 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) change in number of fish with testis-ova 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) change in number of fish with ovary (gonadal histology) 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) change in number of fish with testis (gonadal histology) 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) sex ratio (M:F) skewed towards female 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) increase in body weight 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           2,86 ng/L
(0.00000286 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) increase in total length (growth) 60 days   0.939, 2.86, 8.66, 27.9 92.4 ng/L F+M 60 days posthatch 15 per concentration, four replicates           2,86 ng/L
(0.00000286 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) decrease in fecundity (total number of eggs per pair) 71-100 days   0.939, 2.86, 8.66, 27.9 ng/L F+M 71-100 days posthatch 6 mating pairs treatment group           27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) decrease in vitellogenindecrease in vitellogenin (VTG) concentration 59 days   0.939, 2.86, 8.66 ng/L F 59 days posthatch, F1 generation             2,86 ng/L
(0.00000286 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) reduction in gonadosomal index (GSI) 101 days   0.939, 2.86, 8.66, 27.9 ng/L M 101 days posthatch             27,9 ng/L
(0.0000279 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) mortality 59 days   0.939, 2.86, 8.66 ng/L F+M 59 days posthatch, F1 generation             0,939 ng/L
(0.000000939 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) increase in total length (growth) 59 days   0.939, 2.86, 8.66 ng/L F+M 59 days posthatch, F1 generation             8,66 ng/L
(0.00000866 mg/L)
    Seki et al. 2004
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Twogeneration study Oryzias latipes (medaka) decrease in fertility 71-100 days   0.939, 2.86, 8.66, 27.9 ng/L F+M 71-100 days posthatch 6 mating pairs treatment group           8,66 ng/L
(0.00000866 mg/L)
    Seki et al. 2004
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) increased VTG concentration in plasma 14 days   0, 32, 100, 320 ng/L M 6 months old (mature) 7 males per concentraion           32 ng/L
(0.000032 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) Induction of plasma ALP 19 days   27.24, 272.4, 2724 ng/L M   6     251 ng/L           Kramer et al. 1998
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) Induction of vitellogenin 19 days   27.24, 272.4, 2724 ng/L F+M   12     251 ng/L           Kramer et al. 1998
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) Inhibition of egg production 19 days   27.24, 272.4, 2724 ng/L F+M   12     120 ng/L           Kramer et al. 1998
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) VTG induction 2 weeks               25 ng/L
(0,000025 mg/L)
          Brian et al. 2005
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) P450aromB mRNA expression in the brain 14 days   0, 32, 100, 320 ng/L M 6 months old (mature) 7 males per concentraion           100 ng/L
(0.0001 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) P450aromB mRNA expression in the gonads 14 days   0, 32, 100, 320 ng/L F 6 months old (mature) 7 females per concentraion           100 ng/L
(0.0001 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) P450aromB mRNA expression in the gonads 14 days   0, 32, 100, 320 ng/L M 6 months old (mature) 7 males per concentraion           320 ng/L
(0.00032 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) lower gonadosomatic index 14 days   0, 32, 100, 320 ng/L F 6 months old (mature) 7 females per concentraion           320 ng/L
(0.00032 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) increased VTG concentration in plasma 14 days   0, 32, 100, 320 ng/L F 6 months old (mature) 7 females per concentraion           100 ng/L
(0.0001 mg/L)
    Halm et al. 2002
Estradiol   G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) lower gonadosomatic index 14 days   0, 32, 100, 320 ng/L M 6 months old (mature) 7 males per concentraion           100 ng/L
(0.0001 mg/L)
    Halm et al. 2002
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) reduction in gonadosomatic index (GSI) 21 days   10, 32, 100, 320, 1000 ng/L + control M approaching sexual maturity At the start of the test 7 fish were randomly allocated to each treatment           320 ng/L
(0.00032 mg/L)
    Panter et al. 1998
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Pimephales promelas (Fathead minnow) induction of plasma vitellogenin 21 days   10, 32, 100, 320, 1000 ng/L + control M approaching sexual maturity At the start of the test 7 fish were randomly allocated to each treatment           100 ng/L
(0.0001 mg/L)
    Panter et al. 1998
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     43 nM
(0,01171406 mg/L)
    10-100 nM     Rankouhi et al. 2005
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     19 nM
(0,00517598 mg/L)
    0-10 nM     Rankouhi et al. 2005
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Tisbe battagliai (Crustacean) reproduction 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 In vitro recombinant yeast ER assay Yeast (Saccharomyces cerevisiae strain) induction of B-galactosidase activity                 0.78 nM
(0,0002124876 mg/L)
          Segner et al. 2003a
Estradiol 17B-estradiol G03CA03 Sex hormones 272.42 Yeast estrogen screen (YES) assay Yeast strain hER-ERE growth                 5.7*10^-2 ug/L
(0,0057 mg/L)
          Folmar et al. 2002
Estriol   G03CA04 Sex hormones 288.3813   Oryzias latipes (Japanese ricefish) induced intersex (testis-ova) approximately 90 days       1 day Four test concentrations, one control, 60 fish in each         0.075 ug/L
(0,000075 mg/L)
0.75 ug/L
(0.00075 mg/L)
    Metcalfe et al. 2001
Estrone   G03CA07 Sex hormones 270.3661   Ictalurus punctatus (Channel catfish) elevated serum E2 concentration 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Estrone   G03CA07 Sex hormones 270.3661   Oryzias latipes (Japanese ricefish) induced intersex (testis-ova) approximately 90 days       1 day Four test concentrations, one control, 60 fish in each         <0.0008 ug/L 0.008 ug/L
(0.000008 mg/L)
    Metcalfe et al. 2001
Estrone   G03CA07 Sex hormones 270.3661   Pimephales promelas (Fathead minnow) reduction in gonadosomatic index (GSI) 21 days   9.9, 31.8, 99.3, 318, 993 ng/L + control M approaching sexual maturity At the start of the test 7 fish were randomly allocated to each treatment           317.7 ng/L
(0.0003177 mg/L)
    Panter et al. 1998
Estrone   G03CA07 Sex hormones 270.3661   Pimephales promelas (Fathead minnow) induction of plasma vitellogenin 21 days   9.9, 31.8, 99.3, 318, 993 ng/L + control M approaching sexual maturity At the start of the test 7 fish were randomly allocated to each treatment           31.8 ng/L
(0.0000318 mg/L)
    Panter et al. 1998
Estrone   G03CA07 Sex hormones 270.3661   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     241 nM
(0,06515823 mg/L)
    10-100 nM     Rankouhi et al. 2005
Estrone   G03CA07 Sex hormones 270.3661   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     218 nM
(0,05893981 mg/L)
    10-100 nM     Rankouhi et al. 2005
Estrone main metabolite of estradiol G03CA07 Sex hormones 270.3661   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Estrone main metabolite of estradiol G03CA07 Sex hormones 270.3661   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Estrone main metabolite of estradiol G03CA07 Sex hormones 270.3661   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Estrone main metabolite of estradiol G03CA07 Sex hormones 270.3661   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Estrone main metabolite of estradiol G03CA07 Sex hormones 270.3661   Tisbe battagliai (Crustacean) reproduction 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Etacrynic acid   C03CC01 Diuretic agents   Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               0.561 mg/L
(0,561 mg/L)
          Backhaus and Grimme 1999
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034   Activated sludge microorganisms Enzymatic (hydrolytic activity) 30min/24h               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034   Activated sludge microorganisms Enzymatic (dehydrogenase activity) 30min/24h               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Algae                   0.84 mg/L
(0,84 mg/L)
          Kopf 1995 in Halling-Sorensen et al. (1998)
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 Artoxkit M™ Artemia salina (Crustacean) Immobillization 24h             >100 mg/L             Zaleska-Radziwill et al. 2011
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Brachionus calyciflorus (Rotifera) ovigerous/non-ovigerous females 72 h       newly hatched Eight chambers (7 conc and one control), with eight replicates     4.18 uM/L
(1,238966212 mg/L)
          Radix et al. 2002
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Brachionus calyciflorus (Rotifera) intrinsic rate of population increase 72 h       newly hatched Eight chambers (7 conc and one control), with eight replicates     4.15 uM/L
(1,23007411 mg/L)
          Radix et al. 2002
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Brevundimonas diminuta Growth 18h               >100000 μg/L
(>100 mg/L)
  1562.5 μg/L
(1,5625 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Carassius auratus (crucian carp) induction of vitellogenin (reproductive endocrine disruption) 14 days   0.1, 0.4, 1, 4, 10, 40 ng/L M   groups of 3     7.26 ng/L
(0,00000726 mg/L)
  1 ng/L
(0,000001 mg/L)
4 ng/L
(0.000004 mg/L)
    Zhang et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A three generation test Ceriodaphnia reticulata (Cladoceran) survivorship of newly hatched juveniles 4 weeks   10, 50, 80, 100, 200, 300 ug/L   juveniles One neonate per test vessel, two replicates with eight different concentrations and one control         200 ug/L
(0,2 mg/L)
      Jaser et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Ceriodaphnia reticulata (Cladoceran) swim inhibition 24 h   410, 656, 984, 1640, 2050, 2460, 3280, 4100 ug/L   juveniles 10 cladocerans per concentration, two replicates with eight concentrations     1814 ug/L
(1,814 mg/L)
          Jaser et al. 2003
Ethinylestradiol   G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (modified) Chironomus dilutus (Midge Larvae)   10d       10–12 d 8 per sample Sediment       >7.6 mg kg-1 dw       Gilroy et al. 2012
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Chironomus riparius (Insecta, diptera) Reduced wet weight     10, 100 ng/L, 1, 100 ug/L, 1 mg/L     10 per concentration           1 mg/L     Watts et al. 2003
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Chironomus riparius (Insecta, diptera) Deformities in the mouthparts     10, 100 ng/L, 1, 100 ug/L, 1 mg/L     10 per concentration           10 ng/L
(0.00001 mg/L)
    Watts et al. 2003
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Chironomus riparius (Insecta, diptera) Delayed moulting     10, 100 ng/L, 1, 100 ug/L, 1 mg/L     10 per concentration           1 mg/L     Watts et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Chironomus riparius (Insecta, diptera) mortality 10 days             8.83 mg/L
(8.83 mg/L)
            Segner et al. 2003b
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) survival 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker   4.1 mg/L
(4.1 mg/L)
            Dussault et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (2000) Chironomus tentans, now Chironomus dilutus (Insecta, diptera) growth 10 days       12 days 8-9 conc. 4-5 replicates and 9-10 animals in each beaker     6.6 mg/L
(6,6 mg/L)
          Dussault et al. 2008
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Citrobacter freundii Growth 18h               1088.5 μg/L
(1.0885 mg/L)
  6.1 μg/L
(0.0061 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Comamonas testosteroni Growth 18h               4,364 μg/L
(4.364 mg/L)
  48.8 μg/L
(0.0488 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Coturnix japonica (Japanese quail) Induced oviductal malformations     0, 300 ng/egg (1 nmol/egg F     Injection          300 ng/egg (1 nmol/egg)     Mattsson et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Coturnix japonica (Japanese quail) Retention of oviducts     0, 300 ng/egg (1 nmol/egg M     Injection          300 ng/egg (1 nmol/egg)     Mattsson et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Coturnix japonica (Japanese quail) Reduction of copulatory behavior     0, 300 ng/egg (1 nmol/egg M     Injection          300 ng/egg (1 nmol/egg)     Mattsson et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Coturnix japonica (Japanese quail) anatomical and histological changes in the oviduct     0, 2, 20 ng/g egg F Immature and adult   Injection             2 ng/g egg Berg et al. 2001
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Coturnix japonica (Japanese quail) Weight asymmetry in left and right testes and reduction in the cloacal gland area     0, 300 ng/egg (1 nmol/egg M     Injection          300 ng/egg (1 nmol/egg)     Mattsson et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 In vitro competitive radioreceptor assay Cyprinus carpio (Common carp hepatic ER) displacement of specific ER binding                 30 nM
(0,008892102 mg/L)
          Segner et al. 2003a
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 In vitro VTG induction assay Cyprinus carpio (Common carp hepatocytes) VTG induction 3 days 4 days   sexually immature or F   Initial density: 1.5-2.0*10^6 cells/mL     110 nM
(0,032604374 mg/L)
          Segner et al. 2003a
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) decrease in total number of erythrocytes   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) increase in reticulocytes   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) decrease in the haemooglobin content   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) decrease in the mean corpuscular haemoglobin concentration   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) reduction of total number of leukocytes   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Cyprinus carpio (Common carp) severe morphological alterations in kidney, liver and spleen   70 days 500 ug/kg three times (1st, 5th, 9th week)   Five months (juveniles) 22 fish Intramuscular injection             500 ug/kg bw Schwaiger et al. 2000
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Fecundity From fertilization to 135-155 dpf   0, 0.005, 0.28, 1.7, 10 ng/L               0.31 ng/L
(0,00000031 mg/L)
1.1 ng/L
(0.0000011 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Spawning, egg production, fertilization F2   0, 0.09, 0.36, 2 ng/L               0.36 ng/L
(0,00000036 mg/L)
2 ng/L
(0.000002 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Growth From fertilization to 75 dpf   0, 0.005, 0.28, 1.7, 10 ng/L               0.31 ng/L
(0,00000031 mg/L)
1.1 ng/L
(0.0000011 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Delay in spawning From fertilization to 100 dpf   0, 0.005, 0.28, 1.7, 10 ng/L               0.31 ng/L
(0,00000031 mg/L)
1.1 ng/L
(0.0000011 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Growth F2   0, 0.09, 0.36, 2 ng/L               0.36 ng/L
(0,00000036 mg/L)
2 ng/L
(0.000002 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Developed testis-ova (intersex) From fertilization to 177 dpf   0, 0.005, 0.28, 1.7, 10 ng/L               1.1 ng/L
(0,0000011 mg/L)
9.3 ng/L
(0.0000093 mg/L)
    Schäfers et al. 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio Fertilization success From fertilization to 75 dpf   0, 0.005, 0.28, 1.7, 10 ng/L               0.31 ng/L
(0,00000031 mg/L)
1.1 ng/L
(0.0000011 mg/L)
    Schäfers et al. 2007
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 PN-C-04610-04:1990 Danio rerio (fish) Mortality 96h             4.77 mg/L             Zaleska-Radziwill et al. 2011
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 OECD 215 Danio rerio (fish) Juvenile growth 672h                   0.00038 mg/L       Zaleska-Radziwill et al. 2011
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) Changes in sex ratios 40 days   1, 2, 5, 10, 25 ng/L F 20 dph Three replicates per concentration., 30 fish per replicate.           1 ng/L
(0.001 mg/L)
    Örn et al. 2003
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) Increase in vitellogenin production 18 days   1, 2, 5, 10, 25 ng/L   20 dph Three replicates per concentration.,10 fish per replicate.           2 ng/L
(0.002 mg/L)
    Örn et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 OECD 210 (extended until 42 days postfertilization) Danio rerio (Zebrafish) induction of plasma vitellogenin 42 days   3 ng/L F hatch to juvenile (early life exposure)             3 ng/L
(0.000003 mg/L)
    Fenske et al. 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 OECD 210 (extended until 42 days postfertilization) Danio rerio (Zebrafish) gonadal feminization (inhibited reproduction) 118 days   3 ng/L   hatch to adult (full life-cycle exposure)             3 ng/L
(0.000003 mg/L)
    Fenske et al. 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) egg production 10 days   0.5, 5, 50 ng/L F+M adults 12 fish per replicare, 12 replicates per koncentration         5 ng/L
(0,000005 mg/L)
50 ng/L
(0.00005 mg/L)
    Nash et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) egg production 210 days   0.5, 5 ng/L F+M F1 generation, life-long exposure           0.5 ng/L
(0,0000005 mg/L)
5 ng/L
(0.000005 mg/L)
    Nash et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) fertilization success from fertilization to reproductive age     F+M               1.67 ng/L
(0.00000167 mg/L)
    Segner et al. 2003b
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) VTG induction from fertilization to reproductive age     F+M               1.67 ng/L
(0.00000167 mg/L)
    Segner et al. 2003b
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) expression of estrogen regulated genes (zfvg 3) 21 days   0.25-85 ng/L M adult (2.5-4 cm) 8 individuals exposed per concentration           2.5 ng/L
(0.0000025 mg/L)
    Islinger et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) expression of estrogen regulated genes (zfvg 3) 4 days   0.25-85 ng/L M adult (2.5-4 cm) 8 individuals exposed per concentration           8.5 ng/L
(0.0000085 mg/L)
    Islinger et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) expression of estrogen regulated genes (ERa) 4 days   0.25-85 ng/L M adult (2.5-4 cm) 8 individuals exposed per concentration           2.5 ng/L
(0.0000025 mg/L)
    Islinger et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) increase in average total RNA 17 days   50 ng/L M adult (2.5-4 cm) 8 individuals exposed per concentration           50 ng/L
(0.00005 mg/L)
    Islinger et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Danio rerio (Zebrafish) vitellogenin induction 8 days   0, 1, 2, 4, 8, 12, 16, 20, 30, 100 ng/L M adult 20 fish exposed to each concentration     2.51 ng/L
(0,00000251 mg/L)
    3.0 ng/L
(0.000003 mg/L)
    Rose et al. 2002
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 In vivo full life cycle test Danio rerio (Zebrafish) fertilization success From fertilized eggs until sexual maturation   0.05, 0.28, 1.7, 10 ng/L (nominal conc.)     Initially 100 fertilized eggs per test vessel were exposed     0.0037 nM
(0,00000109669258 mg/L)
          Segner et al. 2003a
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Daphnia (Crustacean)                   5.7 mg/L
(5,7 mg/L)
          Kopf 1995 in Halling-Sorensen et al. (1998)
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Daphnia (Crustacean) reproduction                 0.105 mg/L
(0,105 mg/L)
  0.01 mg/L
(0,01 mg/L)
      Kopf 1995 in Halling-Sorensen et al. (1998)
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 Daphtoxkit F™ Daphnia magna (Crustacean) Immobillization 48h             14.28 mg/L             Zaleska-Radziwill et al. 2011
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 OECD 211 Daphnia magna (Crustacean) Reproduction 672h               1.89 mg/L   0.078 mg/L       Zaleska-Radziwill et al. 2011
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 IQ toxicity test Daphnia magna (Crustacean) fluorescence inhibition 1h               >100 mg/L           Zaleska-Radziwill et al. 2011
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Delftia acidovorans Growth 18h               7307.7 μg/L
(7.3077 mg/L)
  97.7 μg/L
(0.0977 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Domestic hen eggshell thinning and altered shell gland carbonic anhydrase expression     0, 2, 7, 20 ng/g egg   32 weeks 37-40 per dose Injection             20ng/g egg Berg et al. 2004
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Enterococcus casseliflavus Growth 18h               >100000 μg/L
(>100 mg/L)
  390.6 μg/L
(0.3906 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034   Fathead minnows plasma levels of testosterone 48 h     male reproductive mature 8 organisms         5.4 ng/L
(0,0000054 mg/L)
      Martyniuk et al. 2010
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034   Fathead minnows decreased plasma levels of 17beta-estradiol 2-fold 48 h     male reproductive mature 4 organisms           5.4 ng/L
(0.0000054 mg/L)
    Martyniuk et al. 2010
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Gammarus pulex (Crustacea, amphipoda) mortality 10 days             0.84 mg/L
(0.84 mg/L)
            Segner et al. 2003b
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           354.2 ug/L
(0,3542 mg/L)
          Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           168.6 ug/L
(0,1686 mg/L)
          Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           36.9 ug/L
(0,0369 mg/L)
          Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           115.9 ug/L
(0,1159 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           312.6 ug/L
(0,3126 mg/L)
          Hillis et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (modified) Hyalella azteca (Crustacean)   10d       7–14 d 15 per sample Sediment       >1.2 mg kg-1 dw       Gilroy et al. 2012
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Multigeneration toxicity test Hyalella azteca (Freshwater amphipod) sexual development 35 weeks   0.1, 0.32, 1, 3.2, 10 ug/L     At the start of the experiment, 150 precopulatory pairs were added to each treatment.           0.0001 mg/L     Vandenbergh et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) survival 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker   1.1 mg/L
(1.1 mg/L)
            Dussault et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 EPA/600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) growth 10 days       7-14 days 8-9 conc. 4-5 replicates and 8-15 animals in each beaker     1.3 mg/L
(1,3 mg/L)
          Dussault et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Hydra vulgaris (Cnidaria) Impaired sexual reproduction 6 weeks   10 ng/L-5 mg/L                 500 ug/L
(0.0005 mg/L)
    Pascoe et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Hydra vulgaris (Cnidaria) mortality 96 h   1.6, 2.5, 4, 4.6, 5.6, 6.2, 6.8, 7.5, 8.2, 8.6, 9.2, 10 mg/L         3,8             Pascoe et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Hydra vulgaris (Cnidaria) Effects on the structure and physiology of the polyps 72 h   10 ng/L-5 mg/L                 58 ug/L
(0.000058 mg/L)
    Pascoe et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Hydra vulgaris (Cnidaria) Inhibition of generation 72 h   10 ng/L-5 mg/L                 150 ug/L
(0.00015 mg/L)
    Pascoe et al. 2002
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Hydra vulgaris (Coelenterate) mortality 96 h             3.78 mg/L
(3.78 mg/L)
            Segner et al. 2003b
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Ictalurus punctatus (Channel catfish) induction of vitellogenin 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Ethinylestradiol   G03CA01 Sex hormones 296.4034 In vitro study Ictalurus punctatus (Channel catfish) binding inhibition       F 2 years         0.43 nM
(0.000127453462 mg/L)
        Nimrod and Benson 1997
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Ictalurus punctatus (Channel catfish) elevated serum E2 concentration 7 days   1 mg/kg M 12-18 months (200-500 g) Five fish Intraperitoneally injected (i.p.)             1 mg/kg Tilton et al. 2001
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Kurthia gibsonii Growth 18h               32336.2 μg/L
(32.3362 mg/L)
  1562.5 μg/L
(1.5625 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 PN-C-04610-04:1990 Lebistes reticulatus (fish) Mortality 96h             6.55 mg/L             Zaleska-Radziwill et al. 2011
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 OECD 215 Lebistes reticulatus (fish) Juvenile growth 672h                   0.0065 mg/L       Zaleska-Radziwill et al. 2011
Ethinylestradiol   G03CA01 Sex hormones 296.4034 MCF-7 breast tumor cell proliferation (E-Screen) assay MCF-7 cells growth                 5.0*10^-3 ug/L
(0,005 mg/L)
          Folmar et al. 2002
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Microbacterium sp. Growth 18h               51880.0 μg/L
(51.880 mg/L)
  6,250 μg/L
(6.250 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Swedish standard SS 02 81 06, SIS (1991) Nitocra spinipes (Harpacticoid copepod) mortality 96 h       <24h 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group   0.51 mg/L
(0.51 mg/L)
            Breitholtz and Bengtsson 2001
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 In vitro VTG induction assay Oncorhynchus mykiss (Rainbow trout hepatocytes) VTG induction 3 days 4 days   sexually immature or F   Initial density: 1.5-2.0*10^6 cells/mL     65 nM
(0,019266221 mg/L)
          Segner et al. 2003a
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Oryzias latipes (Japanese medaka) sexual differentiation 2 months recovery period of 6 weeks 0, 1, 10 and 100 ng/L   juvenile 50 per konc, 25 for control           100 ng/L
(0.1 mg/L)
    Scholz and Gutzeit 2000
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Oryzias latipes (Japanese medaka) Phenotypic sex-reversal of genetic males     0, 0.005, 0.05, 0.5, 2.5, 5 ng/egg M embryo   Injection             0.5 ng/egg Papoulias et al. 1999
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Oryzias latipes (Japanese medaka) aromatase gene expression 2 months recovery period of 6 weeks 0, 1, 10 and 100 ng/L   juvenile 50 per konc, 25 for control           10 ng/L
(0.01 mg/L)
    Scholz and Gutzeit 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Oryzias latipes (Japanese medaka) decrease in egg production 2 months recovery period of 6 weeks 0, 1, 10 and 100 ng/L   juvenile 50 per konc, 25 for control           10 ng/L
(0.01 mg/L)
    Scholz and Gutzeit 2000
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Oryzias latipes (Japanese ricefish) induced intersex (testis-ova) approximately 90 days       1 day Five test concentrations, one control, 60 fish in each         <0.00003 ug/L 0.00003 ug/L
(0.00000003 mg/L)
    Metcalfe et al. 2001
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Pichia anomala Growth 18h               20458.3 μg/L
(20.4583 mg/L)
  1562.5 μg/L
(1.5625 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) Spawned eggs/pair 21 days   0, 0.1, 1, 3, 10, 100 ng/L M+F               0.1 ng/L
(0.0000001 mg/L)
    Jobling et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) fertilization success sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F+M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           0.32 ng/L (113 dph)
(0.00000032 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) Intersex (testis-ova) 21 days   0, 31.3, 62.5, 125, 250, 500 ng/L M Adults 2-6 per treatment         32.6 ng/L 63.9 ng/L     Seki et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) Regressed ovary 21 days   0, 31.3, 62.5, 125, 250, 500 ng/L F Adults 5-6 per treatment         261 ng/L 488 ng/L     Seki et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) VTG-concentration 21 days   0, 0.1, 1, 3, 10, 100 ng/L M+F               1 ng/L
(0.000001 mg/L)
    Jobling et al. 2004
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) VTG-concentrations 21 days   0, 31.3, 62.5, 125, 250, 500 ng/L M Adults 6 per treatment         32.6 ng/L 63.9 ng/L     Seki et al. 2002
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) Fecundity (no of eggs) 21 days   0, 31.3, 62.5, 125, 250, 500 ng/L F+M Adults 6 pairs per treatment         261 ng/L 488 ng/L     Seki et al. 2002
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) fertilization rate 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months             10 ng/L
(0.00001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Primarily based on EPA 540/9-86-137 (1986) (including evaluation of survival, growth, development and reproduction over two generations) and supplemented with histology and vitellogenin analyses. Pimephales promelas (Fathead minnow) summary of life-cycle effects 305 days   0.2, 1.0, 4.0, 16, 64 ng/L     For each exposure concentration, including the control, replicate systems (two adult tanks, four progeny tanks) were established. Initially 200 embryos per test concentration.         1.0 ng/L
(0,000001 mg/L)
4.0 ng/L
(0.000004 mg/L)
    Länge et al. 2001
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Pimephales promelas (Fathead minnow) VTG induction 2 weeks               0.9 ng/L
(0,0000009 mg/L)
          Brian et al. 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) condition factor 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F+M 6-12 months >/= 25 individuals of each sex           100 ng/L
(0.0001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) gonadosomatic index 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months six individuals           10 ng/L
(0.00001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) gonadosomatic index 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F 6-12 months six individuals           100 ng/L
(0.0001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) plasma vitellogenin 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F+M 6-12 months             1 ng/L
(0.000001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) testes (histology) 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months five fish per concentration and for the control           10 ng/L
(0.00001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) testes (ultrastructure) 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months             1 ng/L
(0.000001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) liver (histology) 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F+M 6-12 months three fish per concentration           3 ng/L
(0.000003 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) liver (ultrastructure) 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months             1 ng/L
(0.000001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) growth sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           23 ng/L (150 dph)
(0.000023 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) number of tubercles 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) M 6-12 months </= 12 individuals           1 ng/L
(0.000001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Primarily based on EPA 540/9-86-137 (1986) (including evaluation of survival, growth, development and reproduction over two generations) and supplemented with histology and vitellogenin analyses. Pimephales promelas (Fathead minnow) juvenile standard lenght 56 dph   0.2, 1.0, 4.0, 16, 64 ng/L (nominal conc.)     200 embryos per test concentration         1.0 ng/L
(0,000001 mg/L)
4.0 ng/L
(0.000004 mg/L)
    Länge et al. 2001
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) liver somatic index sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           9.6 ng/L (150 dph)
(0.0000096 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Primarily based on EPA 540/9-86-137 (1986) (including evaluation of survival, growth, development and reproduction over two generations) and supplemented with histology and vitellogenin analyses. Pimephales promelas (Fathead minnow) VTG induction 172 dph   0.2, 1.0, 4.0, 16, 64 ng/L (nominal conc.)     200 embryos per test concentration         4.0 ng/L
(0,000004 mg/L)
16 ng/L
(0.000016 mg/L)
    Länge et al. 2001
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Primarily based on EPA 540/9-86-137 (1986) (including evaluation of survival, growth, development and reproduction over two generations) and supplemented with histology and vitellogenin analyses. Pimephales promelas (Fathead minnow) gonad histology, ovotestis present 56 dph   0.2, 1.0, 4.0, 16, 64 ng/L (nominal conc.)     200 embryos per test concentration         1.0 ng/L
(0,000001 mg/L)
4.0 ng/L
(0.000004 mg/L)
    Länge et al. 2001
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) male secondary characteristic index sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           0.96 ng/L (150 dph)
(0.00000096 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) liver (ultrastructure) 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F 6-12 months             3 ng/L
(0.000003 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) gonadosomatic index sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           3.5 ng/L (150 dph)
(0.0000035 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Pimephales promelas (Fathead minnow) mean no of spawned eggs/pair 3 weeks   0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) F 6-12 months             0.1 ng/L
(0.0000001 mg/L)
    Pawlowski et al. 2004
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) sex ratio sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           0.32 ng/L (150 dph)
(0.00000032 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) ovipositor development sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F+M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           3.5 ng/L (60 dph)
(0.0000035 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) mean condition factor sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F+M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           9.6 ng/L (60 dph)
(0.0000096 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) growth sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F+M exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           23 ng/L (60 dph)
(0.000023 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 OECD test guideline 204 (1992) Pimephales promelas (Fathead minnow) vitellogenin induction 4, 7, 14 and 21 days   0.002, 0.005, 0.02 ug/L (measured conc.)   45-100 days posthatch 64 fish with two replicates for each concentration and control(s)           0.002 ug/L (4 days of exposure)
(0.000002 mg/L)
    Panter et al. 2002
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 Life-cycle assay Pimephales promelas (Fathead minnow) ovipositor size sampled at 8, 15, 30, 60 and 150 days posthatch 150 days 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) F exposure began 48-60 h after fertilization 30 eggs in each of two cups, placed in each aquarium           3.5 ng/L (150 dph)
(0.0000035 mg/L)
    Parrott and B. R. Blunt 2005
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Potamopyrgus antipodarum (Freshwater mudsnail) Embryo production 21 days   0, 1, 5, 25, 100 ng/L                 1 ng/L
(0.000001 mg/L)
    Jobling et al. 2004
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Pseudomonas aurantiaca Growth 18h               >100000 μg/L
(>100 mg/L)
  6,250 μg/L
(6.250 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 ISO 107122-1994 Pseudomonas fluorescens Growth 16h               1037.1 μg/L
(1.0371 mg/L)
  24.4 μg/L
(0.0244 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) intersex (at stage 36) stages 27-36 (early+mid metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) intersex (at stage 42) stages 27-36 (early+mid metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) delayed climax reaching stages 30-36 (mid-metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) delayed climax reaching entire larval period (chronic) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) body length stages 27-30 (early metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) male/female ratio (at stage 30) stages 27-30 (early metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) male/female ratio (at stage 42) stages 27-30 (early metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) delayed development stages 30-36 (mid-metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) intersex (at stage 42) stages 27-30 (early metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) body weight stages 27-30 (early metamorphosis) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Rana pipiens (Northern leopard frog) intersex (at stage 42) entire larval period (chronic) 154 days (22 weeks) 5 nM F+M stage 27, approx. 2 weeks post-hatch 12 tadpoles per tank, three tanks per treatment           5 nM
(0.001482017 mg/L)
    Hogan et al. 2008
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Rana temporaria Female-biased sex ratios     0, 0.01, 0.1 nM   Tadpoles Two replicates per concentration, 10-19 tadpoles per replicate           0,09 nM     Pettersson and Berg 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     13 nM
(0,003853244 mg/L)
    0-10 nM     Rankouhi et al. 2005
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Rana temporaria (Brown frog hepatocytes) vitellogenesis   5 days   M   Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups.     80 nM
(0,023712272 mg/L)
    10-100 nM     Rankouhi et al. 2005
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Serratia rubidaea Growth 18h               66170.2 μg/L
(66.1702 mg/L)
  781.3 μg/L
(0.7813 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A three generation test Sida crystallina (Cladoceran) shorter juvenile phase 4 weeks   20, 50, 100, 200, 350, 500 ug/L   juveniles One neonate per test vessel, two replicates with eight different concentrations and one control         100 ug/L
(0,1 mg/L)
      Jaser et al. 2003
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 A gonadal recrudescence assay Sida crystallina (Cladoceran) swim inhibition 24 h   410, 656, 984, 1640, 2050, 2460, 3280, 4100 ug/L   juveniles 10 cladocerans per concentration, two replicates with eight concentrations     >4100 ug/L           Jaser et al. 2003
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 MARA test Staphylococcus warneri Growth 18h               17849.3 μg/L
(17.8493 mg/L)
  48.8 μg/L
(0.0488 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17 α - ethinylestradiol G03CA01 Sex hormones 296.4034 Protoxkit F™ Tetrahymena thermophila (Ciliate) Growth inhibition 24h               0.084 mg/L   0.0031 mg/L       Zaleska-Radziwill et al. 2011
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Tisbe battagliai (Crustacean) survival 10 days       <24h 24 well microplate, one organism in each well         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21   >/= 100 ug/L
(0.1 mg/L)
            Hutchinson et al. 1999
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Tisbe battagliai (Crustacean) survival 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034   Tisbe battagliai (Crustacean) reproduction 21 days       <24h 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21         >/= 100 ug/L
(0,1 mg/L)
      Hutchinson et al. 1999
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 LUMIStox test Vibrio fischeri Growth 24h               2.7 μg/L
(0.0027 mg/L)
  0.095 μg/L
(0.000095 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 24h               0.391 μg/L
(0.000391 mg/L)
  0.0015 μg/L
(0.0000015 mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol 17alpha-ethinylestradiol G03CA01 Sex hormones 296.4034 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 15min/30min               23581.8/19009.0 μg/L
(23.5818/19.009 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis Time to complete metamorphosis     0, 0.01, 0.1, 1 nM   Tadpoles Two replicates per concentration, 20 tadpoles per replicate           0,06 nM     Pettersson and Berg 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis Female-biased sex ratios     0, 0.01, 0.1, 1 nM   Tadpoles Two replicates per concentration, 20 tadpoles per replicate           0,06 nM     Pettersson and Berg 2007
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis (Frog) Lacking oviducts 2 mounts   6, 60, 600 pM   Tadpoles (4-5 days)             600 pM
(0.00018 mg/L)
    Gyllenhammar et al. 2009
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis (Frog) Reduced amount of spermatozoa in the testis 2 mounts   6, 60, 600 pM   Tadpoles (4-5 days)             6 pM (1,8 ng/L)
(0.0000018 mg/L)
    Gyllenhammar et al. 2009
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis (Frog) Reduced fertilization rate 2 mounts   6, 60, 600 pM   Tadpoles (4-5 days)             6 pM (1,8 ng/L)
(0.0000018 mg/L)
    Gyllenhammar et al. 2009
Ethinylestradiol   G03CA01 Sex hormones 296.4034   Xenopus tropicalis (Frog) Increase of phenotypic females 2 mounts   6, 60, 600 pM   Tadpoles (4-5 days)             6 pM (1,8 ng/L)
(0.0000018 mg/L)
    Gyllenhammar et al. 2009
Ethinylestradiol 17a-ethinylestradiol G03CA01 Sex hormones 296.4034 In vitro recombinant yeast ER assay Yeast (Saccharomyces cerevisiae strain) induction of B-galactosidase activity                 0.81 nM
(0,000240086754 mg/L)
          Segner et al. 2003a
Ethinylestradiol   G03CA01 Sex hormones 296.4034 Yeast estrogen screen (YES) assay Yeast strain hER-ERE growth                 8.6*10^-2 ug/L
(0,0086 mg/L)
          Folmar et al. 2002
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Daphnia magna   48 h               527 mg/L           Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Daphnia magna                       >12 mg/L       Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Ictalurus punctatus (Channel catfish) Lethality 48 h             965 mg/L             Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Lepomis macrochirus (Fish, fresh water) Lethality 96 h             868 mg/L             Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Oncorhynchus mykiss (rainbow trout) Lethality 96 h             200 mg/L             Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Pseudokirchneriella subcapitata (Green algae)                       1.3-13.2 mg/L       Gledhill and Feijtel, 1992
Etidronic acid   M05BA01 Drugs for treatment of bone diseases     Unspecified algae   96 h               3 mg/L           Gledhill and Feijtel, 1992
Etoposide   L01CB01 Antineoplastic agents   Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     25     Hartmann et al. 1998
Etoposide   L01CB01 Antineoplastic agents   ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       N.E. Up to 120 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       3.7*10^3 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         204 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       16% at 120 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       25% at 120 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       239 mg/L           Parrella et al. 2014
Etoposide   L01CB01 Antineoplastic agents   ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     30 mg/L   10 mg/L 30 mg/L     Zounkova et al. 2007
Etoposide   L01CB01 Antineoplastic agents   SOS-Chromotest Escherichia coli (Bacteria) Genotoxicity 4 h                     2.4 mg/L     Zounkova et al. 2007
Etoposide   L01CB01 Antineoplastic agents   OECD TG 201 (2011) P. Subcapitata Growth inhibition 72h   3.57-351.1 mg/L     5*10^3-5*10^4 cells/mL     30.43 (25.41-36.43 mg/L   10.74 mg/L 34.26 mg/L     Brezovsek et al. 2014
Etoposide   L01CB01 Antineoplastic agents   ISO 8692:1989, DIN 38412 Pseudokirchneriella subcapitata (Freshwater green alga) Growth inhibition 72 h               250 mg/L   <10 10 mg/L     Zounkova et al. 2007
Etoposide   L01CB01 Antineoplastic agents   ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 630 mg/L   200 mg/L 250 mg/L     Zounkova et al. 2007
Etoposide   L01CB01 Antineoplastic agents   OECD TG 201 (2011) S. Leopoliensis Growth inhibition 72h   3.37-351.1 mg/L     5*10^4-5*10^5 cells/mL     n.d. mg/L   351.05 mg/L       Brezovsek et al. 2014
Etoposide   L01CB01 Antineoplastic agents   GreenScreen assay Saccharomyces cerevisiae (Yeast cells) Genotoxicity 16 h                     150 mg/L     Zounkova et al. 2007
Etoposide   L01CB01 Antineoplastic agents   ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               74.85 mg/L           Parrella et al. 2014
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 ASTM E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       neonates 36-well plates, five animals per well, six replicates for each of the five concentrations   64.97 mg/L
(64.97 mg/L)
            Isidori et al. 2007
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h         24-well plates, one rotifer in each well (initially), four replicates per concentration     1.44 mg/L
(1,44 mg/L)
  0.156 mg/L
(0,156 mg/L)
0.3125 mg/L     Isidori et al. 2007
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days       <24 h Single organisms in beakers, seven concentrations, ten replicates     0.76 mg/L
(0,76 mg/L)
  0.039 mg/L
(0,039 mg/L)
0.078 mg/L     Isidori et al. 2007
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 ISO 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       <24 h Five daphnids per vessel, four replicates for each of five concentrations     50.12 mg/L
(50,12 mg/L)
          Isidori et al. 2007
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h       50 mg/L
(50 mg/L)
          Hernando et al. 2004
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 test on hepatocytes, cytotoxicity test, MTT assay Oncorhynchus mykiss (Rainbow trout) cytotoxicity 24 h   1.9-30 uM   immature       53 uM
(19,1240589 mg/L)
          Laville et al. 2004
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 EROD activity test Oncorhynchus mykiss (Rainbow trout) inhibition 24 h       immature       25 uM
(9,0207825 mg/L)
          Laville et al. 2004
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 test on hepatocytes, cytotoxicity test, MTT assay Poeciliopsis lucida (Topminnow) cytotoxicity 24 h   0.1-15.6 uM           9 uM
(3,2474817 mg/L)
          Laville et al. 2004
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 ISO/DIS 8692 (1989) Pseudokirchneriella subcapitata (Green algae) growth inhibition 72 h         Initial density; 10^4 cells/mL, five concentrations and three replicates     19.84 mg/L
(19,84 mg/L)
  3.12  mg/L
(3,12 mg/L)
6.25 mg/L     Isidori et al. 2007
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           28,2 uM           Schnell et al. 2009
Fenofibrate   C10AB05 Blood lipid lowering agents 360.8313 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           21.1 uM           Schnell et al. 2009
Flumequine   J01MB07 Antibacterial agents     Artemia (Crustacea) mortality 24 h   6.25-100 mg/L   48 h     476.8 mg/L
(476.8 mg/L)
            Migliore et al. 1997
Flumequine   J01MB07 Antibacterial agents     Artemia (Crustacea) mortality 48 h   6.25-100 mg/L   48 h     307.7 mg/L
(307.7 mg/L)
            Migliore et al. 1997
Flumequine   J01MB07 Antibacterial agents     Artemia (Crustacea) mortality 72 h   6.25-100 mg/L   48 h     96.35 mg/L
(96.35 mg/L)
            Migliore et al. 1997
Flumequine   J01MB07 Antibacterial agents     Lemna minor (Duckweed) reproduction 7 days   four different concentrations     10-15 fronds, triplicate experiments with four concentrations and a control     2470 ug/L
(2,47 mg/L)
          Robinson et al. 2005
Flumequine   J01MB07 Antibacterial agents     Microcystis aeruginosa (Freshwater cyanobacteria) growth and reproduction 5 days   five different concentrations           1960 ug/L
(1,96 mg/L)
          Robinson et al. 2005
Flumequine   J01MB07 Antibacterial agents   ISO 8692 (1989), modified version Microcystis aeruginosa (Freshwater cyanobacteria) growth inhibition 7 days   0.094 to 0.369 mg/L     Initial density; 2*10^4 cells/mL     0,159 mg/L
(0,159 mg/L)
          Holten Lutzhoft et al. 1999
Flumequine   J01MB07 Antibacterial agents     Pseudokirchneriella subcapitata (Green algae) growth and reproduction 3 days   five different concentrations           5000 ug/L
(5 mg/L)
          Robinson et al. 2005
Flumequine   J01MB07 Antibacterial agents   ISO 8692 (1989), modified version Rhodomonas salina (Marine cryptophycean) growth inhibition     10 to 160 mg/L     Initial density; 1*10^4 cells/mL     18 mg/L
(18 mg/L)
          Holten Lutzhoft et al. 1999
Flumequine   J01MB07 Antibacterial agents   ISO 8692 (1989), modified version Selenastrum capricornutum (Freshwater green algae) growth inhibition     3 to 27 mg/L     Initial density; 1*10^4 cells/mL     5 mg/L
(5 mg/L)
          Holten Lutzhoft et al. 1999
Flumequine   J01MB07 Antibacterial agents   Long-term bioluminescence inhibition assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h   At least 16 different concentrations           19.02 ug/L
(0,01902 mg/L)
  2.64 ug/L
(0,00264 mg/L)
      Backhaus et al. 2000
Flumequine   J01MB07 Antibacterial agents   ISO/CD 11348 (1994) Vibrio fischeri (Bacteria, strain NRRL-B-11177) luminescence 30 min   a minimum of eight different concentrations           12.10 mg/L
(12,1 mg/L)
          Lalumera et al. 2004
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772   Activated sludge microorganisms Enzymatic (hydrolytic activity) 30min/24h               >100000 μg/
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772   Activated sludge microorganisms Enzymatic (dehydrogenase activity) 30min/24h               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 Artoxkit M™ Artemia salina (Crustacean) Immobillization 24h             >100 mg/L             Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 Genotoxicity assay (umuC test) Bacteria Genotoxicity 30 min                     >26     Hartmann et al. 1998
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       N.E. Up to 200 mg/L           Parrella et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       322 mg/L           Parrella et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Brevundimonas diminuta Growth 18h               >10,000 μg/L
(>10 mg/L)
  625 μg/L
(0.625 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         3.35 mg/L           Parrella et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       501 mg/L           Parrella et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Citrobacter freundii Growth 18h               326.9 μg/L
(0.3269 mg/L)
  4.9 μg/L
(0.0049 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Comamonas testosteroni Growth 18h               2648.3 μg/L
(2.6483 mg/L)
  312.5 μg/L
(0.3125 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 PN-C-04610-04:1990 Danio rerio (fish) Mortality 96h             >100 mg/L             Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 215 Danio rerio (fish) Juvenile growth 672h                   <1.56 mg/L       Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       26.40 mg/L           Parrella et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       20.84 mg/L           Parrella et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 211: 1998 (with modifications) Daphnia magna (Crustacean) Reproduction 21 days               0,1 mg/L     0.05 mg/L     Zounkova et al. 2010
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 Daphtoxkit F™ Daphnia magna (Crustacean) Immobillization 48h             >100 mg/L             Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 IQ toxicity test Daphnia magna (Crustacean) fluorescence inhibition 1h             >100 mg/L             Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 211 Daphnia magna (Crustacean) Reproduction 672h               0.0015 mg/L   0.000006 mg/L       Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     15 mg/L     5 mg/L     Zounkova et al. 2010
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     36 mg/L   1 mg/L 10 mg/L     Zounkova et al. 2007
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Delftia acidovorans Growth 18h               45.7 μg/L
(0.0457 mg/L)
  9.8 μg/L
(0.0098 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 8692:1989, DIN 38412 Desmodesmus subspicatus (Green algae) Growth inhibition 72 h         100 000 cells /mL in 24 wells     48 mg/L     40 mg/L     Zounkova et al. 2010
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Enterococcus casseliflavus Growth 18h               11.8 μg/L
(0.0118 mg/L)
  0.08 μg/L
(0.00008 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 SOS-Chromotest Escherichia coli (Bacteria) Genotoxicity 4 h                     1.4 mg/L     Zounkova et al. 2007
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Kurthia gibsonii Growth 18h               3.6 μg/L
(0.0036 mg/L)
  0.08 μg/L
(0.00008 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD 215 Lebistes reticulatus (fish) Juvenile growth 672h                   <1.56 mg/L       Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 PN-C-04610-04:1990 Lebistes reticulatus (fish) Mortality 96h             >100 mg/L             Zaleska-Radziwill et al. 2011
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Microbacterium sp. Growth 18h               37.3 μg/L
(0.0373 mg/L)
  9.8 μg/L
(0.0098 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD TG 201 (2011) P. Subcapitata Growth inhibition 72h   0.004-0.128 mg/L     5*10^3-5*10^4 cells/mL     0.13 (0.07-0.22) mg/L   0.01 mg/L 0.02 mg/L     Brezovsek et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Pichia anomala Growth 18h               242.7 μg/L
(0.2427 mg/L)
  39.1 μg/L
(0.0391 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 8692:1989, DIN 38412 Pseudokirchneriella subcapitata (Freshwater green alga) Growth inhibition 72 h               0,11 mg/L   0,001 mg/L 0.01 mg/L     Zounkova et al. 2007
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Pseudomonas aurantiaca Growth 18h               695.6 μg/L
(0.6956 mg/L)
  19.5 μg/L
(0.0195 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 ISO 107122-1994 Pseudomonas fluorescens Growth 16h               8.3 μg/L
(0.0083 mg/L)
  1.3 μg/L
(0.0013 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 0,044 mg/L     0.03 mg/L     Zounkova et al. 2010
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 0,027 mg/L   0,003 mg/L 0.01 mg/L     Zounkova et al. 2007
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 OECD TG 201 (2011) S. Leopoliensis Growth inhibition 72h   0.038-12.8 mg/L     5*10^4-5*10^5 cells/mL     1.20 (0.72-2.02) mg/L   0.12 mg/L 0.39 mg/L     Brezovsek et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 GreenScreen assay Saccharomyces cerevisiae (Yeast cells) Genotoxicity 16 h                     0.02 mg/L     Zounkova et al. 2007
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Serratia rubidaea Growth 18h               82.2 μg/L
(0.0822 mg/L)
  9.8 μg/L
(0.0098 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 MARA test Staphylococcus warneri Growth 18h               1681.5 μg/L
(1.6815 mg/L)
  9.8 μg/L
(0.0098 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 Protoxkit F™ Tetrahymena thermophila (Ciliate) Growth inhibition 24h               44.02 mg/L   0.195 mg/L       Zaleska-Radziwill et al. 2011
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               0.28 mg/L           Parrella et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 15min/30min               >100000 μg/L
(>100 mg/L)
  -
(- mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 LUMIStox test Vibrio fischeri Enzymatic (bioluminescence) 24h               16.0 μg/L
(0.016 mg/L)
  1.5 μg/L
(0.0015 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil 5-fluorouracil L01BC02 Antineoplastic agents 130.0772 LUMIStox test Vibrio fischeri Growth 24h               10421.8 μg/L
(10.4218 mg/L)
  6,100 μg/L
(6.1 mg/L)
      Załęska-Radziwiłł et al. 2014
Fluorouracil   L01BC02 Antineoplastic agents 130.0772 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               0.122 mg/L
(0,122 mg/L)
          Backhaus and Grimme 1999
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 NF EN ISO 6341 guideline (1996) Artemia salina Immobilization 48h               13,810 [8,510–18,650]
(13.81 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Rotoxkit F™ (modified) Brachionus calyciflorus (rotifer) Mortality 24h         10 animals in each sample, three replicates   0.26 mg/L             Nalęçz Jawecki et al. 2011
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 RotoxRapid Brachionus calyciflorus (rotifer) Intoxication 15min feeding         10 animals in each sample, three replicates food, ingestion 0.97 mg/L             Nalęçz Jawecki et al. 2011
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Carassius auratus (Goldfish) Reproductive physiology 14 days   0, 540 ng/L, 54 ug/L M Adult             0.54 ug/L
(0.00054 mg/L)
    Mennigen et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Carassius auratus (Goldfish) Metabolic changes (glucose) 28 days   0, 540 ng/L, 54 ug/L     72           540 ng/L
(0.00054 mg/L)
    Mennigen et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Carassius auratus (Goldfish) Inhibited weight gain 28 days   0, 540 ng/L, 54 ug/L     72           54 ug/L
(0.054 mg/L)
    Mennigen et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Carassius auratus (Goldfish) Inhibited food intake 28 days   0, 540 ng/L, 54 ug/L     72           54 ug/L
(0.054 mg/L)
    Mennigen et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/4-89-001 (1989) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7 days                   56 ug/L
(0,056 mg/L)
112 ug/L
(0.112 mg/L)
    Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/4-90/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h             234 ug/L
(0.234 mg/L)
            Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/490/027 (1991) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h       < 24 h     234 ug/L (average value for duplicate experiments)
(0.234 mg/L)
            Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/4-90/027F (1993) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h   0.19-2.92 mg/L   < 24 h Five treatment concentrations, 20 neonates (4 cups) were exposed to each treatment concentration and the control.   0.51 mg/L
(0.51 mg/L)
            Henry et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/4-91/002 (1994) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7-8 days       < 24 h Five treatment concentrations, each treatment and the control had ten replicates, each replicate consisted of one neonate.         0.089 mg/L
(0,089 mg/L)
0.447 mg/L     Henry et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/4-89-001 (1989) Ceriodaphnia dubia (Crustacean cladocera) reproduction effects 7 days   0, 45.5, 91, 181, 362, 724 nM (nominal levels)               180 nM
(55,678698 mg/L)
360 nM
(111.357396 mg/L)
    Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 OECD Guideline 218 (2004), modified version Chironomus riparius (Insecta, diptera) emergence reduction 28 days   0.15, 0.38, 0.94, 2.34, 5.86 mg/kg, dw   first-instar larvae (beginning) 20 first-instar larvae in each beaker. All tests were run with four replicates, including a control.           1.12 mg/kg
(1.12 mg/L)
    Nentwig 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Two generation test Chironomus riparius (Insecta, diptera) Reduced F1 44 days   0, 31.25, 62.5, 87.5, 125, 250 ug/L     25           31.25 ug/L
(0.03125 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Two generation test Chironomus riparius (Insecta, diptera) Sex ratio F0 44 days   0, 31.25, 62.5, 87.5, 125, 250 ug/L     25            62.5 ug/L
(0.0625 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Chironomus riparius (Insecta, diptera) mortality 10 days   0, 1.4, 2.8, 5.6, 11.2, 22.4 mg/kg         15.2 mg/kg             Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Chironomus tentans (Insecta, diptera) growth inhibition 10 days   0, 1.4, 2.8, 5.6, 11.2, 22.4 mg/kg                 1.3 mg/kg     Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Chironomus tentans (Insecta, diptera) mortality 10 days   0, 0.14, 2.8, 5.6, 11.2, 22.4 mg/kg         15.2 mg/kg             Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Chironomus tentans (Insecta, diptera) growth inhibition 10 days   0, 0.14, 2.8, 5.6, 11.2, 22.4 mg/kg                 1.3 mg/kg     Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Chlorella vulgaris (Green algae) growth inhibition 96 h   0, 1000, 2000, 4000, 8000, 10,000     initial density; 10^4 cells/mL       4339.25 ug/L
(4.33925 mg/L)
        Johnson et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 AFNOR procedure XP T90-382 Crassostrea gigas Metamorphosis bioassays 24h   100, 200, 400, 600, 800, and 1, 000 μg l−1           187.9±37.8 mg/L           Di Poi et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 AFNOR procedure XP T90-382 Crassostrea gigas Embryo–larval toxicity 36h   100, 150, 200, 250, 300, 400, 600, 800, and 1,000 μg l−1           191.5±23.5 mg/L           Di Poi et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 AFNOR XP-T-90-382 procedure (2009) Crassostrea gigas Metamorphosis 24h               188 ± 65
(0.188 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 AFNOR XP-T-90-382 procedure (2009) Crassostrea gigas Embryotoxicity 36h               192 ± 41
(0.192 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Cyprinodon variegatus (Sheepshead minnows, saltwater fish) Biochemistry and physiology of neurotransmitter pathways related to 5-HT 48 h   0, 0.003, 0.030, 0.300 mg/L   Juvenile (approx 65 days) 2-5 per jar. Three replicates.           0.030 mg/L     Wnder et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 96-hour static renewal test Cyprinodon variegatus (Sheepshead minnows, saltwater fish) mortality 96 h   0,0.050, 0.275, 0.500, 1.250, 2.000 mg/L   Juvenile (48-63 days) Ten per jar. Three replicates.   >2.000 mg/L     1.250 mg/L
(1,25 mg/L)
2.000 mg/L     Wnder et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 guideline NF EN ISO 6341 (1996) Daphnia magna Acute immobilization 48h               5.91 [4.42–6.50] mg/L           Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 NF EN ISO 6341 guideline (1996) Daphnia magna Immobilization 48h               5,910 [4,420–6,500]
(5.91 mg/L)
          Minguez et al. 2014
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Immobilization 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         170 ug/L 429 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Reproduction 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         174 ug/L 430 ug/L     Stanely et al. 2007
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Reproduction 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         195 ug/L 444 ug/L     Stanely et al. 2007
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Grazing rate 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         101 ug/L 195 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Immobilization 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         174 ug/L 430 ug/L     Stanely et al. 2007
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Reproduction 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         170 ug/L 429 ug/L     Stanely et al. 2007
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 Mix of OECD 211 and EPA-712-C-96-120_ Daphnia magna (Crustacean) Immobilization 21 days   10, 50, 100, 250, 500, 1000 ug/L   Less than 24-h-old 10 per treatment         195 ug/L 444 ug/L     Stanely et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM guidelines: E 1192-97 (2000) Daphnia magna (Crustacean) increase in chitobiase activity 24 h   0.1 and 1 ug/L   <24h Five neonates per jar and at least three replicates           0.1 ug/L
(0.0001 mg/L)
    Richards et al. 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Daphnia magna (Crustacean) increase in total number of offspring 30 days   1-100 ug/L F first instar 26 daphnia, one daphnia per jar           36 ug/L
(0.036 mg/L)
    Flaherty and S. I. Dodson 2005
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM guidelines: E 1192-97 (2000) Daphnia magna (Crustacean) decrease in chitobiase activity 72 h   0.1 and 1 ug/L   <24h Five neonates per jar and at least three replicates           0.1 ug/L
(0.0001 mg/L)
    Richards et al. 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/4-90/027 (1991) Daphnia magna (Crustacean) mortality 48 h             820 ug/L
(0.82 mg/L)
            Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/490/027 (1991) Daphnia magna (Crustacean) mortality 48 h       < 24 h     820 ug/L (average value for duplicate experiments)
(0.82 mg/L)
            Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ISO 6341 (1989), except for the test media; OECD guideline 211, Daphnia magna reproduction test. (2006) Daphnia magna (Crustacean) immobilization 48 h       < 24 h Five animals were used for each of four replicates per concentration and 20-40 animals in the control group     6.4 mg/L
(6,4 mg/L)
          Christensen et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Dreissena polymorpha (Zebra mussel) induction of spawning 4 h     M   1 mussel per vial           5*10^-8 M     Fong 1998
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Dreissena polymorpha (Zebra mussel) induction of spawning 4 h     F   1 mussel per vial           5*10^-6 M     Fong 1998
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996) Dunaliella tertiolecta (Phytoplankton) cell density 96 h   25, 50, 100, 200, 400 mg/L     Initial density; approximately 50 000 cells/mL     169.81 ug/L
(0,16981 mg/L)
          DeLorenzo and Fleming 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Elliptio complanata (Freshwater mussel) immunotoxic effect: increased cell adherence 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           100 uM
(30.93261 mg/L)
    Gagné et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Elliptio complanata (Freshwater mussel) immunotoxic effect: increased cell viability 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           100 uM
(30.93261 mg/L)
    Gagné et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Elliptio complanata (Freshwater mussel) immunotoxic effect: induction of phagocytosis 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           100 uM
(30.93261 mg/L)
    Gagné et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Gambusia affinis (Western mosquitofish) decrease in number of fish developing a black spot on the abdomen 45 days   0, 7, 71 ppb   59-159 days Nine plastic tanks, 72 fish in each           71 ppb     Henry and Black 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Gambusia affinis (Western mosquitofish) decrease in number of fish with elongated anal fin 45-59 days   0, 7, 71 ppb   59-159 days Nine plastic tanks, 72 fish in each           71 ppb     Henry and Black 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Gambusia affinis (Western mosquitofish) mortality 7 days   5, 53, 534, 5340 ppb + control   neonates (24-48 h) 3-4 fish/L, three replicate 7-L aquaria   546 ppb             Henry and Black 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Gambusia affinis (Western mosquitofish) female fish larger than male fish 91 days   0.05, 0.5, 5 ppb   neonates (48-72 h) until age 91 days 3-4 fish/L, three replicate 7-L aquaria           0.05 ppb     Henry and Black 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Gammarus pulex (Crustacea, amphipoda) activity 1.5 h six measurements per concentration 0, 1 ng/L to 1 mg/L     24 chambers, one G. pulex in each           0.100 ug/L
(0.0001 mg/L)
    De Lange et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Haliotis tuberculata LMS 48h               2,388 ± 299
(2.388 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Haliotis tuberculata MTT 48h               15,600 ± 3,000
(15.60 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) growth inhibition 42 days   0, 5.4, 10.8, 21.6, 43.2 mg/kg                 5.6 mg/kg     Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) growth inhibition 10 days   0, 5.4, 10.8, 21.6, 43.2 mg/kg                 5.4 mg/kg     Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/R-99/064 (2000) Hyalella azteca (Freshwater amphipod) mortality 10 days   0, 5.4, 10.8, 21.6, 43.2 mg/kg         >43 mg/kg (no effect at the highest conc.)             Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 procedure adapted from Trottier et al. (1997) Hydra attenuata Adult survival 96h               7,940 [7,610–8,410]
(7.94 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 procedure adapted from Trottier et al. (1997) Hydra attenuata Polyp regeneration 96h               8,680 [6,550–10,430]
(8.68 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     > 1000 ug/L           Brain et al. 2004 (a)
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Lithopoma americana Time to air-water interface                       345 μg/L
(0.345 mg/L)
    Fong et al. 2015
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Morone saxatilis x M. chrysops (Hybrid striped bass) Feeding behavoir 6 days 6 days recovery period 0, 35, 75 , 150 ug/L   6-8 months             75 ug/L
(0.075 mg/L)
    Gaworecki and Klaine 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Morone saxatilis x M. chrysops (Hybrid striped bass) Feeding behavoir 6 days   0, 35, 75 , 150 ug/L   6-8 months             35 ug/L
(0.035 mg/L)
    Gaworecki and Klaine 2008
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 test on hepatocytes, cytotoxicity test, MTT assay Oncorhynchus mykiss (Rainbow trout) cytotoxicity 24 h   9-140 uM   immature       66 uM
(20,4155226 mg/L)
          Laville et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EROD activity test Oncorhynchus mykiss (Rainbow trout) inhibition 24 h       immature       77 uM
(23,8181097 mg/L)
          Laville et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) reduction of plasma osmolality     0, 25, 50 ug/g     30 intraperitoneal injection         25 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) survival 24 h   0, 25, 50, 75, 100 ug/g     78 intraperitoneal injection         75 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) increase in plasma serotonin 24 h   0, 25, 50, 75, 100 ug/g     78 intraperitoneal injection         25 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) reduction of hematocrit     0, 25, 50 ug/g     30 intraperitoneal injection         50 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) increase in urea excretion 24 h   0, 25, 50, 75, 100 ug/g     78 intraperitoneal injection         25 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) elevation of Intestinal fluid PEG:Seawater PEG     0, 25, 50 ug/g     30 intraperitoneal injection         25 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) reduction of Intestinal fluid PEG:Seawater PEG     0, 25, 50 ug/g     30 intraperitoneal injection         50 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Opsanus beta (Gulf toadfish) increase in plasma cortisol 24 h   0, 25, 50, 75, 100 ug/g     78 intraperitoneal injection         50 ug/g     Morando et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Oryzias latipes (Japanese medaka) increase in plasma estradiol levels (female fish) 4 weeks   0, 0.1, 0.5, 1, 5 ug/L (nominal conc.) F adults 1 fish/L (first two weeks the fish were exposed in single-sex groups, the last two weeks animals (one male, one female) were paired together           0.1 ug/L
(0.0001 mg/L)
    Foran et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Oryzias latipes (Japanese ricefish) increased female circulating estradiol levels 4 weeks                     0.1 ug/L
(0.0001 mg/L)
    Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Oryzias latipes (Japanese ricefish) reproduction, developmental abnormalities 4 weeks                     0.1 ug/L
(0.0001 mg/L)
    Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Partial life-cycle test Physa acuta (Gastropoda, Pulmonata) Mortality 24 days (up to 44 days)   0, 31.25, 62.5, 87.5, 125, 250 ug/L   Adults (4 months) 20           31.25 ug/L
(0.03125 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Partial life-cycle test Physa acuta (Gastropoda, Pulmonata) Lower egg mass production 30 days (up to 44 days)   0, 31.25, 62.5, 87.5, 125, 250 ug/L   Adults (4 months) 20           250 ug/L
(0.25 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Partial life-cycle test Physa acuta (Gastropoda, Pulmonata) Higher egg mass production 24 days (up to 44 days)   0, 31.25, 62.5, 87.5, 125, 250 ug/L   Adults (4 months) 20           31.25 ug/L
(0.03125 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Partial life-cycle test Physa acuta (Gastropoda, Pulmonata) Offspring output 50 days   0, 31.25, 62.5, 87.5, 125, 250 ug/L   Adults (4 months) 20           250 ug/L
(0.25 mg/L)
    Sánchez-Argüello et al. 2009
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Growth 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           9 ug/L 51 ug/L     Stanely et al. 2007
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 2000.0 EPA-821-R-02-012 Pimephales promelas (Fathead minnow) Survival 48 h   50 to 1600 ug/L   Four to six days old 10 per beaker, 4 replicates   212 ug/L             Stanely et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/490/027 (1991) Pimephales promelas (Fathead minnow) mortality 48 h       11 days (test 1) and 14 days (test 2)     705 ug/L (average value for duplicate experiments)
(0.705 mg/L)
            Brooks et al. 2003b
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Feeding rate 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           9 ug/L 51 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Feeding rate 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           50 ug/L 106ug/L     Stanely et al. 2007
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Feeding rate 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           118 ug/L 170 ug/L     Stanely et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA/600/4-90/027 (1991) Pimephales promelas (Fathead minnow) mortality 48 h             705 ug/L
(0.705 mg/L)
            Brooks et al. 2003a
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Growth 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           118 ug/L 170 ug/L     Stanely et al. 2007
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Survival 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           51 ug/L 101 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Survival 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           106 ug/L 174 ug/L     Stanely et al. 2007
Fluoxetine S-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 2000.0 EPA-821-R-02-012 Pimephales promelas (Fathead minnow) Survival 48 h   50 to 1600 ug/L   Four to six days old 10 per beaker, 4 replicates   216 ug/L             Stanely et al. 2007
Fluoxetine R-enantiomer N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Survival 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           118 ug/L 170 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 US EPA 1000.0 EPA-821-R-02-013 Pimephales promelas (Fathead minnow) Growth 7 days   1, 10, 50, 100, 250 ug/L   Juvenile           9 ug/L 53 ug/L     Stanely et al. 2007
Fluoxetine Rac-enantiomer (racemic) N06AB03 Psychoanaleptics 309.3261 US EPA 2000.0 EPA-821-R-02-012 Pimephales promelas (Fathead minnow) Survival 48 h   50 to 1600 ug/L   Four to six days old 10 per beaker, 4 replicates   198 ug/L             Stanely et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 (ASTM) International acute toxicity methods for Brachionus were used, with modifications Plationus patulus (reference population) Mortality 48h   0, 0.025, 0.05, 0.075, 0.10, 0.20 mg/L     6 rep/treatm, 2-5 ind/rep   0,06 mg/L     0,025 mg/L 0.05 mg/L     Martinez Gomez et al. 2015
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 (ASTM) International acute toxicity methods for Brachionus were used, with modifications Plationus patulus (urbanized population) Mortality 48h   0, 0.05, 0.075, 0.10, 0.20, 0.40 mg/L     6 rep/treatm, 2-5 ind/rep   0,19 mg/L     0,075 mg/L 0.1 mg/L     Martinez Gomez et al. 2015
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.0205 mM
(6,34118505 mg/L)
          Caminada et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.0242 mM
(7,48569162 mg/L)
          Caminada et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 test on hepatocytes, cytotoxicity test, MTT assay Poeciliopsis lucida (Topminnow) cytotoxicity 24 h   1.1-140 uM           5 uM
(1,5466305 mg/L)
          Laville et al. 2004
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Potamopyrgus antipodarum (Freshwater mudsnail) reproduction 56 days   0, 0.64, 3.2, 16, 80, 400 ug/L (nominal conc.)   sexually mature snails At the beginning of the experiment there were 80 snails per replicate. Three replicates were used for each concentration and the control.         0.47 ug/L
(0,00047 mg/L)
      Nentwig 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 NF EN ISO 8692 guideline (2012) ISO 8692 guideline (2012) Pseudokirchneriella subcapitata Growth inhibition 72h               200 [180–210]
(0.20 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/4-89-001 (1989) Pseudokirchneriella subcapitata (Green algae) cell density as a measure of growth inhibition 120 h         Initial density; approximately 1*10^4 cells/mL     39 ug/L
(0,039 mg/L)
          Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/4-89-001 (1989) Pseudokirchneriella subcapitata (Green algae) turbidity as a measure of growth inhibition 120 h         Initial density; approximately 1*10^4 cells/mL     24 ug/L
(0,024 mg/L)
          Brooks et al. 2003b
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 A miniscale algal toxicity test. P. Arensberg et al. (1995). Chem. 30, 2103-2115 Pseudokirchneriella subcapitata (Green algae) algal growth inhibition 48 h         Initial density; 10^4 cells/mL     0.027 mg/L
(0,027 mg/L)
          Christensen et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 EPA 600/4-89-001 (1989) and EPA/600/4-90/027 (1991) Pseudokirchneriella subcapitata (Green algae) growth inhibition                 24 ug/L
(0,024 mg/L)
    13.6 ug/L
(0.0136 mg/L)
    Brooks et al. 2003a
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Pseudokirchneriella subcapitata (Green algae) growth inhibition 96 h   0, 10, 20, 40, 80, 100 ug/L     initial density; 10^4 cells/mL       44.99 ug/L
(0.04499 mg/L)
        Johnson et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Rana pipiens (Northern leopard frog) Delayed development 33 days (up to 50 days)   0, 0.029, 0.29 ug/L   Larvae (stage 21-22) 20 per box. Three replicates.           0.029 ug/L
(0.000029 mg/L)
    Foster et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Rana pipiens (Northern leopard frog) Body weight 73 days   0, 0.029, 0.29 ug/L   Larvae (stage 21-22) 20 per box. Three replicates.           0.29 ug/L
(0.00029 mg/L)
    Foster et al. 2010
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.0107 mM
(3,30978927 mg/L)
          Caminada et al. 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           9.9 uM           Schnell et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           7.1 uM           Schnell et al. 2009
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Scenedesmus acutus (Green algae) growth inhibition 96 h   0, 50, 100, 200, 400, 800 ug/L     initial density; 10^4 cells/mL       91.23 ug/L
(0.09123 mg/L)
        Johnson et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Scenedesmus quadricauda (Green algae) growth inhibition 96 h   0, 50, 100, 200, 400, 800 ug/L     initial density; 10^4 cells/mL       212.98 ug/L
(0.21298 mg/L)
        Johnson et al. 2007
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Sepia officinalis (Cuttlefish) learning and retention 15 days pre-hatching to 1-month post-hatching   0, 1, 100 ngL     20 in control, 23 in 1ngL and 21 in 100ngL           1ngL
(0.000001 mg/L)
    Di Poi et al. 2013
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 NF EN ISO 10253 guideline (2006) Skeletonema marinoi Growth inhibition 72h               43 [21–71]
(0,043 mg/L)
          Minguez et al. 2014
Fluoxetine   N06AB03 Psychoanaleptics 309.3261   Tegula fasciatus (snail) Detachment of foot (to the substrate) 4h   1 µM       Dilution in artificial sea water         345 µg/L
(0.345 mg/L)
    Fong and Molnar. 2013.
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Rapidtoxkit (modified) Thamnocephalus platyurus (Crustacean) Intoxication 15min feeding           food, ingestion 1.16 mg/L             Nalęçz Jawecki et al. 2011
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 Thamnotoxkit F™ microbiotest Thamnocephalus platyurus (Crustacean) Mortality 24h         10 animals in each sample, three replicates   0.85 mg/L             Nalęçz Jawecki et al. 2011
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) mortality 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.   7.5 mg/L
(7.5 mg/L)
            Richards and Cole 2006
Fluoxetine   N06AB03 Psychoanaleptics 309.3261 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) malformations 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.     4.9 mg/L
(4,9 mg/L)
  2.0 mg/L
(2 mg/L)
      Richards and Cole 2006
Flutamide   L02BB01 Endocrine therapy 276.2119   Daphnia magna (Crustacean) decreased neonate numbers 21 days   1 mg/L F <24 h (neonates) 10 per concentration           1 mg/L     Haeba et al. 2008
Flutamide   L02BB01 Endocrine therapy 276.2119   Daphnia magna (Crustacean) mortality 24 h       <24 h (neonates) 20 per concentration and control     7,8 mg/L           Haeba et al. 2008
Flutamide   L02BB01 Endocrine therapy 276.2119   Daphnia magna (Crustacean) suppression of size of maternal organisms 21 days   1 mg/L F <24 h (neonates) 10 per concentration           1 mg/L     Haeba et al. 2008
Flutamide   L02BB01 Endocrine therapy 276.2119   Daphnia magna (Crustacean) delayed maturation 21 days   1 mg/L F <24 h (neonates) 10 per concentration           1 mg/L     Haeba et al. 2008
Flutamide   L02BB01 Endocrine therapy 276.2119   Daphnia magna (Crustacean) mortality 48 h       <24 h (neonates) 20 per concentration and control     2,7 mg/L           Haeba et al. 2008
Flutamide   L02BB01 Endocrine therapy 276.2119   Gasterosteus aculeatus (three-spined stickleback) inhibition of DHT-induced spiggin production 21 days   2, 10, 25, 75, 100, 250 ug/L F   15-20           50 ug/l
(5 mg/L)
    Jolly et al. 2009
Flutamide   L02BB01 Endocrine therapy 276.2119   Gasterosteus aculeatus (three-spined stickleback) kidney cell primary culture inhibition of DHT-induced spiggin production 48 h   10^-14 - 10^-6 M F               0,28 ng/L
(28 mg/L)
    Jolly et al. 2009
Flutamide   L02BB01 Endocrine therapy 276.2119 US EPA/600/R-01/067 (2002) Pimephales promelas (Fathead minnow) fecundity 21 days   50, 500 ug/L F+M adult (six months)           50 ug/L
(0,05 mg/L)
500 ug/L
(0.5 mg/L)
    Jensen et al 2004
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 EPA/600/4-90/027F (1993) Ceriodaphnia dubia (Crustacean cladocera) mortality 48 h   0.10-2.21 mg/L   < 24 h Five treatment concentrations, 20 neonates (4 cups) were exposed to each treatment concentration and the control.   0.84 mg/L
(0.84 mg/L)
            Henry et al. 2004
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 EPA/600/4-91/002 (1994) Ceriodaphnia dubia (Crustacean cladocera) reproduction inhibition 7-8 days       < 24 h Five treatment concentrations, each treatment and the control had ten replicates, each replicate consisted of one neonate.         0.366 mg/L
(0,366 mg/L)
1.466 mg/L     Henry et al. 2004
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Chlorella vulgaris (Green algae) growth inhibition 96 h   0, 5000, 10,000, 20,000, 40,000, 80,000 ug/L     initial density; 10^4 cells/mL       10208.47 ug/L
(10.20847 mg/L)
        Johnson et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347   Chlorostoma funebralis (snail) Detachment of foot (to the substrate) 4h   500 nM       Dilution in artificial sea water         217 µg/L
(0.217 mg/L)
    Fong and Molnar. 2013.
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 ISO 6341 (1989), except for the test media; OECD guideline 211, Daphnia magna reproduction test. (2006) Daphnia magna (Crustacean) immobilization 48 h       < 24 h Five animals were used for each of four replicates per concentration and 20-40 animals in the control group     13 mg/L
(13 mg/L)
          Christensen et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347   Dreissena polymorpha (Zebra mussel) induction of spawning 4 h     M   1 mussel per vial           10^-9 M     Fong 1998
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347   Dreissena polymorpha (Zebra mussel) induction of spawning 4 h     F   1 mussel per vial           10^-7 M     Fong 1998
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347   Lithopoma americanum (snail) Detachment of foot (to the substrate) 4h   100 nM       Dilution in artificial sea water         43.4 µg/L
(0.0434 mg/L)
    Fong and Molnar. 2013.
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 A miniscale algal toxicity test. P. Arensberg et al. (1995). Chem. 30, 2103-2115 Pseudokirchneriella subcapitata (Green algae) algal growth inhibition 48 h         Initial density; 10^4 cells/mL     0.062 mg/L
(0,062 mg/L)
          Christensen et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Pseudokirchneriella subcapitata (Green algae) growth inhibition 96 h   0, 500, 1000, 2000, 4000, 8000 ug/L     initial density; 10^4 cells/mL       4002.88 ug/L
(4.00288 mg/L)
        Johnson et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           45.4 uM           Schnell et al. 2009
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           49.9 uM           Schnell et al. 2009
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Scenedesmus acutus (Green algae) growth inhibition 96 h   0, 500, 1000, 2000, 4000, 8000 ug/L     initial density; 10^4 cells/mL       3620.24 ug/L
(3.62024 mg/L)
        Johnson et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347 US EPA, 96-h static toxicity test using Selenastrum capricornutum (1994), modified version Scenedesmus quadricauda (Green algae) growth inhibition 96 h   0, 500, 1000, 2000, 4000, 8000 ug/L     initial density; 10^4 cells/mL       3563.34 ug/L
(3.56334 mg/L)
        Johnson et al. 2007
Fluvoxamine   N06AB08 Psychoanaleptics 318.3347   Urosalpinx cinerea (snail) Detachment of foot (to the substrate) 4h   2 µM       Dilution in artificial sea water         868 µg/L
(0.868 mg/L)
    Fong and Molnar. 2013.
Fosfomycin   J01XX01 Antibacterial agents 138.059 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               16.8 mg/L
(16,8 mg/L)
          Backhaus and Grimme 1999
Furosemide   C03CA01 Diuretic agents 330.7441 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h               2.493 mg/L 2,493 0.625 mg/L
(0,625 mg/L)
1.250 mg/L     Isidori et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 EPA-600-4-90-027F (1993) Ceriodaphnia dubia (Crustacean cladocera) immobilization 48 h       <24h Ten animals for each dilution, three replicates and five conc.     84.09 mg/L
(84,09 mg/L)
          Isidori et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days       <24h       2.354 mg/L 2,354 0.156 mg/L
(0,156 mg/L)
0.312 mg/L     Isidori et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 ISO 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       <24h Five daphnids per vessel, four replicates for each of the five conc.     60.62 mg/L
(60,62 mg/L)
          Isidori et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     4.05 mM
(1339,513605 mg/L)
          Caminada et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     3.42 mM
(1131,144822 mg/L)
          Caminada et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increased bacterial counts (TSB media) 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in alpha proteobacteria 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in beta proteobacteria and decrease in gamma proteobacteria 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in Pseudomonad populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in fungal populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in actinomycete populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community carbohydrate utility spectra 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increased polymer production 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community decrease in cyanobacterial biomass 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increase in bacterial biomass 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 Riverine biofilm community structure and activity Riverine biofilm community increased bacterial counts (R2A media) 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Furosemide   C03CA01 Diuretic agents 330.7441 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     7.79 mM
(2576,496539 mg/L)
          Caminada et al. 2006
Furosemide   C03CA01 Diuretic agents 330.7441 Thamnotoxkit (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       second- and third-instar fairy larvae Five dilutions with three replicates of ten animals   70.57 mg/L
(70.57 mg/L)
            Isidori et al. 2006
Fusidic acid   J01XC01 Antibacterial agents 516.7092   Bacterial community Inhibation of bacterial protein biosynthesis                 4.55 umol/L   0.01 umol/L       Brosche and Backhaus, 2010
Fusidic acid   J01XC01 Antibacterial agents 516.7092   Bacterial community Inhibation of bacterial protein biosynthesis                 1.041 umol/L   0.001 umol/L       Brosche and Backhaus, 2010
Fusidic acid   J01XC01 Antibacterial agents 516.7092 Chronic bioluminescence assay Vibrio fischeri (Bacteria) bioluminescence inhibition 24 h               1.68 mg/L
(1,68 mg/L)
          Backhaus and Grimme 1999
Gemcitabine   L01BC05 Antineoplastic agents   ISO 6341:1996 (with modifications) Daphnia magna (Crustacean) Immobilization 48 h       less than 24 h old 20 per concentration     110 mg/L     50 mg/L     Zounkova et al. 2010
Gemcitabine   L01BC05 Antineoplastic agents   OECD 211: 1998 (with modifications) Daphnia magna (Crustacean) Reproduction 21 days               >1 mg/L     >1 mg/L     Zounkova et al. 2010
Gemcitabine   L01BC05 Antineoplastic agents   ISO 8692:1989, DIN 38412 Desmodesmus subspicatus (Green algae) Growth inhibition 72 h         100 000 cells /mL in 24 wells     45 mg/L     10 mg/L     Zounkova et al. 2010
Gemcitabine   L01BC05 Antineoplastic agents   ISO 10712:1995 Pseudomonas putida (Bacteria) Growth inhibition                 100 mg/L     50 mg/L     Zounkova et al. 2010
Gemcitabine   L01BC05 Antineoplastic agents   ISO/FDIS 13829, DIN 38415-3 Salmonella choleraesius subsp. chol. Genotoxicity 4 h                     42 mg/L     Zounkova et al. 2010
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ASTM E1440-91 (1991) Brachionus calyciflorus (Rotifera) mortality 24 h       neonates 36-well plates, five animals per well, six replicates for each of the five concentrations   77.30 mg/L
(77.3 mg/L)
            Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ISO/CD 20666 (2001) Brachionus calyciflorus (Rotifera) population growth inhibition 48 h         24-well plates, one rotifer in each well (initially), four replicates per concentration     0.44 mg/L
(0,44 mg/L)
  0.156 mg/L
(0,156 mg/L)
0.312 mg/L     Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Carassius auratus (Goldfish) StAR protein transcript levels 96 h   0, 1500 and 10000 ug/L M   10-12 per tank           1500 ug/L
(15 mg/L)
    Mimeault et al. 2005
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Carassius auratus (Goldfish) decrease in plasma testosterone 96 h   0, 1500 and 10000 ug/L M   10-12 per tank           1500 ug/L
(15 mg/L)
    Mimeault et al. 2005
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Carassius auratus (Goldfish) decrease in plasma testosterone 14 days   0, 1.5 and 1500 ug/L M   10-12 per tank           1.5 ug/L
(0.0015 mg/L)
    Mimeault et al. 2005
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ISO/CD 20665 (2001) Ceriodaphnia dubia (Crustacean cladocera) population growth inhibition 7 days       < 24 h Single organisms in beakers, seven concentrations, ten replicates     0.53 mg/L
(0,53 mg/L)
  0.078 mg/L
(0,078 mg/L)
0.156 mg/L     Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Chlorella vulgaris (Green algae) growth 24 h         Initial density: 1 000 000 cells/mL     778 uM
(194,7593852 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Chlorella vulgaris (Green algae) growth           Initial density: 1 000 000 cells/mL             50 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Chlorella vulgaris (Green algae) growth 48 h         Initial density: 1 000 000 cells/mL     643 uM
(160,9643762 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Chlorella vulgaris (Green algae) growth 72 h         Initial density: 1 000 000 cells/mL     600 uM
(150,20004 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 OECD Guideline 202 (2004) Daphnia magna (Crustacean) immobilization 48 h       neonates replicate groups of 10 neonates     170 uM
(42,556678 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 EPA/600/4-90/027F (1993) Daphnia magna (Crustacean) mortality 48 h       <24h (neonates) Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.   10.4 mg/L
(10.4 mg/L)
            Han et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 OECD Guideline 202 (2004) Daphnia magna (Crustacean) immobilization 72 h       neonates replicate groups of 10 neonates     120 uM
(30,040008 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 OECD Guideline 202 (2004) Daphnia magna (Crustacean) immobilization 24 h       neonates replicate groups of 10 neonates     228 uM
(57,0760152 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ISO 6341 (1996) Daphnia magna (Crustacean) immobilization 24 h       < 24 h Five daphnids per vessel, four replicates for each of five concentrations     74.30 mg/L
(74,3 mg/L)
          Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 48 h       <24h       100 mg/L
(100 mg/L)
          Hernando et al. 2004
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 OECD Guideline 202 (2004) Daphnia magna (Crustacean) immobilization         neonates replicate groups of 10 neonates             30 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 60, 100, 125, 150, 175, 200, 300 mg/kg   >2 month     140.87 mg/kg             Pino et al. 2015
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Elliptio complanata (Freshwater mussel) immunotoxic effect: decreased cell adherence 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           3 uM
(0.7510002 mg/L)
    Gagné et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Elliptio complanata (Freshwater mussel) immunotoxic effect: increased cell viability 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           3 uM
(0.7510002 mg/L)
    Gagné et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Elliptio complanata (Freshwater mussel) immunotoxic effect: induction of phagocytosis 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           3 uM
(0.7510002 mg/L)
    Gagné et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Elliptio complanata (Freshwater mussel) immunotoxic effect: decreased lipid peroxidation 24 h   0, 2.5, 25, 50, 100 uM     Hemolymphs from 10 mussels were collected and analysed           140 uM
(35.046676 mg/L)
    Gagné et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Hydra attenuata (Cnidarian) feeding behaviour and hydranth no. 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate     1.76 mg/L
(1,76 mg/L)
          Quinn et al. 2008a
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Hydra attenuata (Cnidarian) morphological changes 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate   22.36 mg/L
(22.36 mg/L)
1.18 mg/L
(1,18 mg/L)
  0.1mg/L
(0,1 mg/L)
1mg/L     Quinn et al. 2008a
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Hydra attenuata (Cnidarian) regeneration 96 h   0, 0.1, 1, 5, 10, 25, 50, 100 mg/L     10 per concentration       0.9 mg/L         Quinn et al. 2008b
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Mytilus galloprovincialis (Blue mussel) immune parameters in the hemocytes 24 h           Injection             0.01 nmol (2.5 ng/g dry weight) Canesi et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) AChE activity 48 h               467 uM
(116,9056978 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) SDH activity                         200 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) lysosomal function 72 h               436 uM
(109,1453624 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) lysosomal function 48 h               671 uM
(167,9737114 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) lysosomal function 24 h               700 uM
(175,23338 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) SDH activity 48 h               1013 uM
(253,5877342 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) lysosomal function                         225 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH activity 24 h               545 uM
(136,431703 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH activity 48 h               404 uM
(101,1346936 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH activity 72 h               242 uM
(60,5806828 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) AChE activity 24 h               718 uM
(179,7393812 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) MTS metabolization (viability indicator)                         120 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) SDH activity 24 h               971 uM
(243,0737314 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) AChE activity 72 h               403 uM
(100,8843602 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) AChE activity                         50 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) Metallothionein                         400 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH activity                         200 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) protein content 72 h               423 uM
(105,8910282 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) SDH activity 72 h               496 uM
(124,1653664 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) MTS metabolization (viability indicator) 72 h               437 uM
(109,3956958 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) protein content 48 h               582 uM
(145,6940388 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) protein content                         70 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH leakage (indicator of cell death) 24 h               1250 uM
(312,91675 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH leakage (indicator of cell death) 48 h               904 uM
(226,3013936 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH leakage (indicator of cell death) 72 h               868 uM
(217,2893912 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) neutral red uptake (viability indicator) 24 h               527 uM
(131,9257018 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) neutral red uptake (viability indicator) 48 h               433 uM
(108,3943622 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) neutral red uptake (viability indicator) 72 h               328 uM
(82,1093552 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) MTS metabolization (viability indicator) 48 h               599 uM
(149,9497066 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) neutral red uptake (viability indicator)                         70 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) MTS metabolization (viability indicator) 24 h               786 uM
(196,7620524 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) G6PDH leakage (indicator of cell death)                         600 uM   Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   PLCH-1 fish cell line (Topminnow) protein content 24 h               730 uM
(182,743382 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.873 mM
(218,5410582 mg/L)
          Caminada et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.843 mM
(211,0310562 mg/L)
          Caminada et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ISO/DIS 8692 (1989) Pseudokirchneriella subcapitata (Green algae) growth inhibition 72 h         Initial density; 10^4 cells/mL, five concentrations and three replicates     15.19 mg/L
(15,19 mg/L)
  3.125 mg/L
(3,125 mg/L)
6.25 mg/L     Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     3.94 mM
(986,313596 mg/L)
          Caminada et al. 2006
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           102.7 uM           Schnell et al. 2009
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           90.8 uM           Schnell et al. 2009
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Thamnocephalus platyurus (Crustacean) mortality 24 h       second- and third instar larvae 24-well plates, ten animals per well, three replicates for each of the five concentrations   161.05 mg/L
(161.05 mg/L)
            Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 ToxAlert 100 Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               18.8 mg/L
(18,8 mg/L)
          Farré et al. 2001
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 Microtox (Microbics, Carlsbad, CA, USA, 1995) Vibrio fischeri (Bacteria) bioluminescence inhibition 30 min               85.74 mg/L
(85,74 mg/L)
          Isidori et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Vibrio fischeri (Bacteria) bioluminescence 5 min               285 uM
(71,345019 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334 Microtox Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               31.5 mg/L
(31,5 mg/L)
          Farré et al. 2001
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Vibrio fischeri (Bacteria) bioluminescence 15 min               180 uM
(45,060012 mg/L)
          Zurita et al. 2007
Gemfibrozil   C10AB04 Blood lipid lowering agents 250.3334   Vibrio fischeri (Bacteria) bioluminescence                         40 uM   Zurita et al. 2007
Gentamycin sulfate J01GB03 Antibacterial agents   Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Gentamycin sulfate J01GB03 Antibacterial agents   OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             10-100 mg/L         Kümmerer K. et al. 2004
Haloperidol   N05AD01 Psycholeptics 375.8642   Daphnia magna Feeding inhibition                 1.62 (1.37−1.90) mg/L           Furuhagen et al. 2014
Hydrochlorothiazide   C03AA03 Diuretic agents 297.7391 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.98 mM
(589,523418 mg/L)
          Caminada et al. 2006
Hydrochlorothiazide   C03AA03 Diuretic agents 297.7391 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     2.41 mM
(717,551231 mg/L)
          Caminada et al. 2006
Hydrochlorothiazide   C03AA03 Diuretic agents 297.7391 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.54 mM
(458,518214 mg/L)
          Caminada et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Carcinus maenas (Crustacean) Lysosomal membrane stability (LMS) 28d   0.1, 5, 10, and 50 μgL F   6 per treatment Water diluted with pharmaceuticals   0.7µgL
(0.0007 mg/L)
          Aguirre-Martínez et al. 2012
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Environmental Canada standard (1992): EPS 1/RM/21 Ceriodaphnia dubia (Crustacean cladocera) growth inhibition 7 days   32, 10, 3.2, 1.0, 0.1, 0 ug/L and a clean-water control   <24 h             >32 ug/L     Brun et al. 2006
Ibuprofen IB-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 OECD, 2004 no 202 Daphnia magna (Crustacean) Reproduction 24 h 14days 20, 40, 80 mg/L   <24h 310 in the first step, 10 selected for gene expression anylisis and to be observed during the following 13 days to assess the effects of IB on population growth rate, reproduction, survival, stomatic growth and population size structure.     13.4mg/L
(13,4 mg/L)
          Heckmann et al. 2007
Ibuprofen IB-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 OECD, 2004 no 202 Daphnia magna (Crustacean) Survival 24 h 14days 20, 40, 80 mg/L   <24h 310 in the first step, 10 selected for gene expression anylisis and to be observed during the following 13 days to assess the effects of IB on population growth rate, reproduction, survival, stomatic growth and population size structure.         20mg/L
(20 mg/L)
80mg/L     Heckmann et al. 2007
Ibuprofen IB-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 OECD, 2004 no 202 Daphnia magna (Crustacean) Population Growth Rate 24 h 14days 20, 40, 80 mg/L   <24h 310 in the first step, 10 selected for gene expression anylisis and to be observed during the following 13 days to assess the effects of IB on population growth rate, reproduction, survival, stomatic growth and population size structure.         <20mg/L 20mg/L     Heckmann et al. 2007
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 EPA/600/4-90/027F (1993) Daphnia magna (Crustacean) mortality 48 h       <24h (neonates) Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.   132.6 mg/L
(132.6 mg/L)
            Han et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 EPA/600/4-91/002 (1994) Daphnia magna (Crustacean) reproduction inhibition 21 days   0.1-80 mg/L   <24h (neonates) Five replicates, containing one organism per test chamber, were exposed to nine conc and a control.         20 mg/L
(20 mg/L)
      Han et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Modified version of OECD test guideline 211 (1998) Daphnia magna (Crustacean) number of offspring 10 days (followed by 10 days recovery) 20 days 0, 20, 40, 80 mg/L   <24h 40 neonates, kept individually, 10 replicates per treatment           20 mg/L     Hayashi et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Modified version of OECD test guideline 211 (1998) Daphnia magna (Crustacean) brood size 10 days (followed by 10 days recovery) 20 days 0, 20, 40, 80 mg/L   <24h 40 neonates, kept individually, 10 replicates per treatment           80 mg/L     Hayashi et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Modified version of OECD test guideline 211 (1998) Daphnia magna (Crustacean) population growth rate 10 days (followed by 10 days recovery) 20 days 0, 20, 40, 80 mg/L   <24h 40 neonates, kept individually, 10 replicates per treatment           80 mg/L     Hayashi et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 European Guideline; EEC Directive 92/69/EEC (1992) Daphnia magna (Crustacean) immobilization 24 h and 48 h       Younger than 24h four replicates, 5 daphnids each     101.2 mg/L
(101,2 mg/L)
  75 mg/L
(75 mg/L)
      Cleuvers 2004
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Environmental Canada standard (1992): EPS 1/RM/11 Daphnia magna (Crustacean) mortality 48 h   32, 10, 3.2, 1.0, 0.1, 0 ug/L and a clean-water control   <24 h             >32 ug/L     Brun et al. 2006
Ibuprofen Ibuprofen-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 European Guideline; EEC Directive 92/69/EEC Daphnia magna (Crustacean) immobilization 48 h   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L   < 24 h Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.     108 mg/L
(108 mg/L)
          Cleuvers 2003
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 48 hour static toxicity test Daphnia magna (Crustacean)   48 h                   3.37 mg/L
(3,37 mg/L)
      IUCLID 2000
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 48 hour static toxicity test Daphnia magna (Crustacean)   48 h               9.06 mg/L
(9,06 mg/L)
          IUCLID 2000
Ibuprofen Ibuprofen-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 European Guideline; EEC Directive 92/69/EEC Desmodesmus subspicatus (Green algae) inhibition of average growth rate 3 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Initial density; 10^4 cells/mL     315 mg/L
(315 mg/L)
          Cleuvers 2003
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 European Guideline; EEC Directive 92/69/EEC (1993) Desmodesmus subspicatus (Green algae) growth inhibition                 342.2 mg/L
(342,2 mg/L)
  32 mg/L
(32 mg/L)
      Cleuvers 2004
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Trypan blue exclusion method Dreissena polymorpha (freshwater bivalve zebra mussel) haemocyte viability           4 or 5 mussels, 2 replicates     350 ug/L
(0,35 mg/L)
          Parolini et al. 2009
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 NRR assay Dreissena polymorpha (freshwater bivalve zebra mussel) decrease in neutral red retention time (cytotoxicity)     45, 450, 909 ug/L                 450 ug/L
(0.45 mg/L)
    Parolini et al. 2009
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 DNA diffusion assay Dreissena polymorpha (freshwater bivalve zebra mussel) increase in frequency of apoptotic cells (genotoxicity)     45, 450, 909 ug/L                 450 ug/L
(0.45 mg/L)
    Parolini et al. 2009
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 SCGE assay Dreissena polymorpha (freshwater bivalve zebra mussel) increase in DNA damage represented by LDR (genotoxicity)     45, 450, 909 ug/L                 45 ug/L
(0.045 mg/L)
    Parolini et al. 2009
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) Frecuency of micronucleated hemocytes 96 h   1, 9, 35 nM               1 nM
(0.0002 mg/L mg/L)
9 nM
(0.002 mg/L)
    Parolini et al. 2011
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) Neutral red retention time 72 h   1, 9, 35 nM               9 nM
(0.002 mg/L mg/L)
35 nM
(0.008 mg/L)
    Parolini et al. 2011
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) Frecuency of micronucleated hemocytes 72 h   1, 9, 35 nM               9 nM
(0.002 mg/L mg/L)
35 nM
(0.008 mg/L)
    Parolini et al. 2011
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) precentages of apoptotic hemocytes 96 h   1, 9, 35 nM               9 nM
(0.002 mg/L mg/L)
35 mM
(0.008 mg/L)
    Parolini et al. 2011
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) lengt/diameter ratio (LDR) 96 h   1, 9, 35 nM               35 nM
(0.008 mg/L mg/L)
      Parolini et al. 2011
Ibuprofen Ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Dreissena polymorpha (mussels) Neutral red retention time 96 h   1, 9, 35 nM               1 nM
(0.0002mg/L mg/L)
9 nM
(0.002 mg/L)
    Parolini et al. 2011
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 OECD 207 (1984) Eisenia fetida Mortality 14d   0, 15, 30, 50, 60, 80, 100, 150 mg/kg   >2 month     64.80 mg/kg             Pino et al. 2015
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Gammarus pulex (Crustacea, amphipoda) activity 1.5 h nine measurements per concentration 0, 1 ng/L to 1 mg/L     24 chambers, one G. pulex in each           0.010 ug/L
(0.00001 mg/L)
    De Lange et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Hydra attenuata (Cnidarian) feeding behaviour and hydranth no. 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate     3.85 mg/L
(3,85 mg/L)
          Quinn et al. 2008a
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Hydra attenuata (Cnidarian) morphological changes 96 h   0.1-50/100mg/L     3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate   22.36 mg/L
(22.36 mg/L)
1.65 mg/L
(1,65 mg/L)
  0.1mg/L
(0,1 mg/L)
1mg/L     Quinn et al. 2008a
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Hydra attenuata (Cnidarian) regeneration 96 h   0, 0.1, 1, 5, 10, 25, 50, 100 mg/L     10 per concentration       3.84 mg/L         Quinn et al. 2008b
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Hydra vulgaris (Cnidarian) partially contracted polyp, slow reactions 7 days   10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Hydra vulgaris (Cnidarian) mean number of Artemia ingested 7 days 10 day feeding/budding study followed 7 d exposure 10, 100 ug/L, 1.0, 10 mg/L     Five replicate animals used for each concentration and controls           10 ug/L
(0.01 mg/L)
    Pascoe et al. 2003
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     > 1000 ug/L           Brain et al. 2004 (a)
Ibuprofen Ibuprofen-Na M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ISO/WD 20079 (2001), using the Steinberg-medium Lemna minor (Duckweed) inhibition of average growth rate 7 days   (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L     Three treatment replicates and six control replicates.     22 mg/L
(22 mg/L)
          Cleuvers 2003
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ISO/WD 20079 (2001) Lemna minor (Duckweed) growth inhibition 7 days       Initially three or four fronds Six-well plates, one plant in each well, three replicates     18.5 mg/L
(18,5 mg/L)
          Kaza et al. 2007
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 USEPA(1996) Lemna minor FBR006 (Duckweed) growth inhibition 7 days   0, 1, 10, 100, 1000 ug/L     A total of 12 fronds per test chamber, three replicates     4.010 mg/L
(4,01 mg/L)
          Pomati et al. 2004
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 96 hour static toxicity test Lepomis macrochirus (Fish, fresh water)   96 h                   10 mg/L
(10 mg/L)
      IUCLID 2000
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 96 hour static toxicity test Lepomis macrochirus (Fish, fresh water) mortality 96 h             173 mg/L
(173 mg/L)
            IUCLID 2000
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Oryzias latipes (Japanese medaka) reproduction (no of eggs and no of days for reproduction) 6 weeks   0, 1, 10 and 100 ug/L F+M juvenile (approximately 2 months) 160           1 ug/L
(0.001 mg/L)
    Flippin et al 2007
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Planorbis carinatus (Freshwater horn snail) survival 72 h   0.1, 1.0, 10, 100 mg/L   juvenile snails (< 3 mm shell diameter) Five per treatment and 10 in the control   17.1 mg/L (the same LC50 value was seen after 48h)             Pounds et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Planorbis carinatus (Freshwater horn snail) survival 21 days   0.32, 1.0, 3.2, 10 mg/L   adult snails (shell diameter between 7.2-13.1 mm) 360 animals: three exposure tanks per treatment. Each control and treatment had three replicates of 20 adult snails.         5.36 mg/L
(5,36 mg/L)
>5.36 mg/L     Pounds et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Planorbis carinatus (Freshwater horn snail) growth 21 days   0.32, 1.0, 3.2, 10 mg/L   adult snails (shell diameter between 7.2-13.1 mm) 360 animals: three exposure tanks per treatment. Each control and treatment had three replicates of 20 adult snails.         1.02 mg/L
(1,02 mg/L)
2.43 mg/L     Pounds et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Planorbis carinatus (Freshwater horn snail) reproduction 21 days   0.32, 1.0, 3.2, 10 mg/L   adult snails (shell diameter between 7.2-13.1 mm) 360 animals: three exposure tanks per treatment. Each control and treatment had three replicates of 20 adult snails.         2.43 mg/L
(2,43 mg/L)
5.36 mg/L     Pounds et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 NR assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     0.834 mM
(172,04586 mg/L)
          Caminada et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 MTT assay PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) cell viability 24 h         6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates     1.20 mM
(247,548 mg/L)
          Caminada et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Algal Growth Inhibition test Pseudokirchneriella subcapitata Growth inhibition rate 96 h   maximum 10mg/L           2,3 mg/L   520.6 ug/L
(0,5206 mg/L)
      Harada et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increased bacterial counts (R2A media) 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community carbohydrate utility spectra 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in SRB 385 probe positive cells 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in beta proteobacteria and decrease in gamma proteobacteria 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in fungal populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in cytophaga-flavobacteria probe positive cells 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in alpha proteobacteria 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community increase in actinomycete populations 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Riverine biofilm community structure and activity Riverine biofilm community decrease in cyanobacterial biomass 8 weeks   10 ug/L                 10 ug/L
(0.01 mg/L)
    Lawrence et al. 2005
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 MTT assay RTG-2 cell line (Rainbow trout gonad) cell viability 24 h         3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates     5.79 mM
(1194,4191 mg/L)
          Caminada et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           255.8 uM           Schnell et al. 2009
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           207.4 uM           Schnell et al. 2009
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Environmental Canada standard (1992): EPS 1/RM/25 Selenastrum capricornutum (Freshwater green algae) growth inhibition 3 days   32, 10, 3.2, 1.0, 0.1, 0 ug/L and a clean-water control               10 ug/L
(0,01 mg/L)
32 ug/L
(0.032 mg/L)
    Brun et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Static test, five days exposure, 9 days recovery Skeletonema costatum (Algae)   5 days               39.9 mg/L
(39,9 mg/L)
          IUCLID 2000
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Static test, five days exposure, 9 days recovery Skeletonema costatum (Algae)   5 days                   20.5 mg/L
(20,5 mg/L)
      IUCLID 2000
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Synechocystis sp. PCC6803 (Cyanobacteria) growth inhibition 0-5 days   0, 1, 10, 100, 1000 ug/L   Culture in late-logarithmic growth-phase Initial cell density set to approx. 0.1 OD750           1 ug/L
(0.001 mg/L)
    Pomati et al. 2004
Ibuprofen ibuprofen M01AE01 Anti-inflammatory and anti-reumatic agents 206.29   Tetrahymena pyriformis (Ciliophora) growth inhibition 24 h               46.78 mg/L           Láng and Kőhidai 2012
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               16.49 mg/L           Ortiz de Garcia et al. 2014
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               13.87 mg/L           Ortiz de Garcia et al. 2014
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 21.00 mg/L           Ortiz de Garcia et al. 2014
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Environmental Canada standard (1992): EPS 1/RM/24 Vibrio fischeri (Bacteria) decrease in light output 15 min   32, 10, 3.2, 1.0, 0.1, 0 ug/L and a clean-water control                 >500 ug/L     Brun et al. 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ToxAlert 100 Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               12.1 mg/L
(12,1 mg/L)
          Farré et al. 2001
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Microtox Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               19.1 mg/L
(19,1 mg/L)
          Farré et al. 2001
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 Microtox Vibro fischeri bioluminescence inhibition 15 min   maximum 10mg/L           11,3 mg/L           Harada et al. 2008
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) mortality 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.   56.7 mg/L
(56.7 mg/L)
            Richards and Cole 2006
Ibuprofen   M01AE01 Anti-inflammatory and anti-reumatic agents 206.29 ASTM: Standard guide for conducting FETAX E1439-98 (2002) Xenopus laevis (African clawed frog) malformations 96 h       eggs, stage 9 Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.     39.9
(39,9 mg/L)
  20.0 mg/L
(20 mg/L)
      Richards and Cole 2006
Imatinib   L01XX28 Antineoplastic agents   ISO 20666, 2008 Brachionus calyciflorus Population growth inhibition 48h       <2h       740 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   ASTM E1440-91 Brachionus calyciflorus Inhibiton of mobility 24h       <2h       3.82 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   ISO 20665, 2008 Cerodaphnia dubia Inhibition reproduction 7d     F         115 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   EPA-600-4-90 Cerodaphnia dubia Inhibiton of mobility 24h       <24h       31.92 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   OECD 211, 2008 and ISO 10706, 2000 Daphnia magna Inhibition reproduction 21d     F <24h       308 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   OECD 202 (2004) and ISO 6341 (1996) guidelines Daphnia magna Inhibiton of mobility 48h       <24h       11.97 mg/L           Parrella et al. 2014
Imatinib   L01XX28 Antineoplastic agents   OECD TG 201 (2011) P. Subcapitata Growth inhibition 72h   0.120-12.208 mg/L     5*10^3-5*10^4 cells/mL     2.29 (1.88-2.77 mg/L   0.38 mg/L 1.19 mg/L     Brezovsek et al. 2014
Imatinib   L01XX28 Antineoplastic agents   OECD TG 201 (2011) S. Leopoliensis Growth inhibition 72h   1.04-16.0 mg/L     5*10^4-5*10^5 cells/mL     5.36 (4.29-6.70 mg/L   3.84 mg/L 4 mg/L     Brezovsek et al. 2014
Imatinib   L01XX28 Antineoplastic agents   ISO 14380 (2011) Thamnocephalus platyurus Inhibiton of mobility 24h               43.27 mg/L           Parrella et al. 2014
Imipenem   J01DH51 Antibacterial agents   Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             >100 mg/L         Kümmerer K. et al. 2004
Imipenem   J01DH51 Antibacterial agents   OECD 209, prolonged test aerobic bacteria inhibition of respiration 24 h   (0,001-750 mg/L)             1-10 mg/L         Kümmerer K. et al. 2004
Imipramine   N06AA02 Psychoanaleptics   Spirotox Spirostomum ambiguum (Ciliate) pherical deformation and autolysis 24 h             0.74 mg/L
(0.74 mg/L)
0.36 mg/L
(0,35 mg/L)
          Nalecz-Jawecki 2008
Imipramine   N06AA02 Psychoanaleptics   Thamnotoxkit F Thamnocephalus platyurus (Crustacean) mortality 24 h             1.68 mg/L
(1.68 mg/L)
            Nalecz-Jawecki 2008
Isoniazid   J04AC01 Antimycobacterials 137.1393 Artoxkit M (with slight modifications) Artemia salina (Crustacea) mortality 24 h             2350 umol/L
(322.277355 mg/L)
            Calleja et al. 1994 (a)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Artoxkit M (with slight modifications) Artemia salina (Crustacea) Mortality 24 h             3.37 umol/L             Calleja et al. 1994 (b)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) mortality 24 h             22200 umol/L
(3044.49246 mg/L)
            Calleja et al. 1994 (a)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Rotoxkit F (with slight modifications) Brachionus calyciflorus (Rotifera) Mortality 24 h             4.34 umol/L             Calleja et al. 1994 (b)
Isoniazid   J04AC01 Antimycobacterials 137.1393 OECD 202, 1984 Daphnia magna (Crustacean) Immobility 24 h               2.96 umol/L           Calleja et al. 1994 (b)
Isoniazid   J04AC01 Antimycobacterials 137.1393 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.617 mM
(846,149481 mg/L)
          Lilius et al. 1994
Isoniazid   J04AC01 Antimycobacterials 137.1393 OECD 202 (1993) Daphnia magna (Crustacean) immobilization 24 h   5 concentrations           0.617 mM           Lilius et al. 1995
Isoniazid   J04AC01 Antimycobacterials 137.1393 OECD standard protocol (1980), with a few modifications Daphnia magna (Crustacean) immobilization 24 h       <24h (neonates) Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times     0.617 mM
(84,6149481 mg/L)
          Lilius et al. 1994
Isoniazid   J04AC01 Antimycobacterials 137.1393 OECD guideline 202 (1984) Daphnia magna (Crustacean) immobilization 24 h               915 umol/L
(125,4824595 mg/L)
          Calleja et al. 1994 (a)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Microtox test Photobacterium phosphoreum (Bacteria) bioluminescence inhibition 5 or 15 min               79300 umol/L
(10875,14649 mg/L)
          Calleja et al. 1994 (a)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Microtox test Photobacterium phosphoreum (Bacteria) Luminescence inhibition 5 min               4.9 umol/L           Calleja et al. 1994 (b)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             760 mg/L
(760 mg/L)
707 mg/L
(707 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Isoniazid   J04AC01 Antimycobacterials 137.1393 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) mortality 24 h             178 umol/L
(24.4107954 mg/L)
            Calleja et al. 1994 (a)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Streptoxkit F (with slight modifications) Streptocephalus proboscideus (Crustacea) Mortality 24 h             2.24 umol/L             Calleja et al. 1994 (b)
Isoniazid   J04AC01 Antimycobacterials 137.1393 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               600 mg/L
(600 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Isoniazid   J04AC01 Antimycobacterials 137.1393 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     130 mg/L
(130 mg/L)
            Nalecz-Jawecki and Persoone 2006
Ivermectin   P02CF01 Antihelmintics 875.1 Modified ISO Water Quality—Determination of theToxic Effect of Sediment and Soil Samples on Growth, Fertility and Reproduction of Caenorhabditis elegans (Nematoda) Caenorhabditis elegans (nematode) Growth     1.1, 2.1, 3.3, 4.6, 6.9, 9.2 mg/L           5,2 ug/L
(0,0052 mg/L)
  2,1 ug/L
(0,0021 mg/L)
3,3 ug/L
(0.0033 mg/L)
    Brinke et al. 2011
Ivermectin   P02CF01 Antihelmintics 875.1 Modified ISO Water Quality—Determination of theToxic Effect of Sediment and Soil Samples on Growth, Fertility and Reproduction of Caenorhabditis elegans (Nematoda) Caenorhabditis elegans (nematode) Reproduction     1.1, 2.1, 3.3, 4.6, 6.9, 9.2 mg/L           2,9 ug/L
(0,0029 mg/L)
  1,1 ug/L
(0,0011 mg/L)
2,1 ug/L
(0.0021 mg/L)
    Brinke et al. 2011
Ivermectin   P02CF01 Antihelmintics 875.1 Modified ISO Water Quality—Determination of theToxic Effect of Sediment and Soil Samples on Growth, Fertility and Reproduction of Caenorhabditis elegans (Nematoda) P. cf. Thienemanni (nematode) Reproduction     0.3, 0.5, 0.8, 1.1, 2.1 mg/L           0,6 ug/L
(0,006 mg/L)
  0,3 ug/L
(0,0003 mg/L)
0,5 ug/L
(0.0005 mg/L)
    Brinke et al. 2011
Ivermectin   P02CF01 Antihelmintics 875.1 Modified ISO Water Quality—Determination of theToxic Effect of Sediment and Soil Samples on Growth, Fertility and Reproduction of Caenorhabditis elegans (Nematoda) P. cf. Thienemanni (nematode) Growth     0.3, 0.5, 0.8, 1.1, 2.1 mg/L           1,0 ug/L
(0,001 mg/L)
  0,5 ug/L
(0,0005 mg/L)
0,8 ug/L
(0.0008 mg/L)
    Brinke et al. 2011
Ivermectin   P02CF01 Antihelmintics 875.1 DOTTS draft bioassay Scathophaga stercoraria (yellow dung fly) increase in development time                     0,84 ug/kg fresh dung       Römbke et al. 2009
Ivermectin   P02CF01 Antihelmintics 875.1 DOTTS draft bioassay Scathophaga stercoraria (yellow dung fly) survival                 20,9 ug/kg fresh dung   8,1 ug/kg fresh dung       Römbke et al. 2009
Ketoconazole   J02AB02 Antimycotics for systemic use 531.4309   Daphnia magna (Crustacean) mortality 24 h       <24 h (neonates) 20 per concentration and control     8,1 mg/L           Haeba et al. 2008
Ketoconazole   J02AB02 Antimycotics for systemic use 531.4309   Daphnia magna (Crustacean) mortality 48 h       <24 h (neonates) 20 per concentration and control     1,51 mg/L           Haeba et al. 2008
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 Daphtoxkit Daphnia magna (Crustacean) immobilization 48 h   0.065, 1.25, 2.5, 5, 10 mg/L           2,3 mg/L           Harada et al. 2008
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 Algal Growth Inhibition test Pseudokirchneriella subcapitata Growth inhibition rate 96 h   maximum 10mg/L           2 mg/L   1041.3 ug/L
(1,0413 mg/L)
      Harada et al. 2008
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 Alamar Blue assay RTL-W1 (Rainbow trout liver cell line) change in energy metabolism (cytotoxicity) 24 h   five-six different concentrations           201.8 uM           Schnell et al. 2009
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 CFDA-AM assay RTL-W1 (Rainbow trout liver cell line) decrease in membrane integrity (cytotoxicity) 24 h   five-six different concentrations           157.7 uM           Schnell et al. 2009
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 ToxAlert 100 Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               15.6 mg/L
(15,6 mg/L)
          Farré et al. 2001
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 Microtox Vibrio fischeri (Bacteria) bioluminescence inhibition 15 min               19.3 mg/L
(19,3 mg/L)
          Farré et al. 2001
Ketoprofen   M01AE03 Anti-inflammatory and anti-reumatic agents 254.2806 Microtox Vibro fischeri bioluminescence inhibition 15 min   maximum 10mg/L           20,4 mg/L           Harada et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675 Respiration inhibition test OECD 209 aerobic bacteria inhibition of respiration 30 min   (0,001-750 mg/L)             10 mg/L         Kümmerer K. et al. 2004
Levofloxacin   J01MA12 Antibacterial agents 361.3675 OECD 209, prolonged test aerobic bacteria inhibition of respiration 20 h   (0,001-750 mg/L)             1 mg/L         Kümmerer K. et al. 2004
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Daucus carota (Wild carrot) Growth (root length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Daucus carota (Wild carrot) Growth (root length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           451.8 ug/L
(0,4518 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Daucus carota (Wild carrot) Growth (root length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           289.4 ug/L
(0,2894 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Spore production 28 days   0, 10, 30, 100, 300, 1000 ug/L           75.4 ug/L
(0,0754 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 14 days   0, 10, 30, 100, 300, 1000 ug/L           526.5
(0,5265 mg/L)
          Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 21 days   0, 10, 30, 100, 300, 1000 ug/L           460.3 ug/L
(0,4603 mg/L)
          Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Growth (hyphal length) 28 days   0, 10, 30, 100, 300, 1000 ug/L           114.8 ug/L
(0,1148 mg/L)
    300 ug/L
(0.3 mg/L)
    Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Spore production 14 days   0, 10, 30, 100, 300, 1000 ug/L           >1000 ug/L           Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Glomus intraradices (Mycorrhizal fungus) Spore production 21 days   0, 10, 30, 100, 300, 1000 ug/L           100 ug/L
(0,1 mg/L)
          Hillis et al. 2008
Levofloxacin   J01MA12 Antibacterial agents 361.3675 ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) Lemna gibba (Duckweed) growth inhibition 7 days         Two L. gibba plants, each with four fronds, in each dish, eighteen dishes     185 ug/L
(0,185 mg/L)
    30 ug/L
(0.03 mg/L)
    Brain et al. 2004 (a)
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Lemna minor (Duckweed) reproduction 7 days   four different concentrations     10-15 fronds, triplicate experiments with four concentrations and a control     51 ug/L
(0,051 mg/L)
          Robinson et al. 2005
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Microcystis aeruginosa (Freshwater cyanobacteria) growth and reproduction 5 days   five different concentrations           7.9 ug/L
(0,0079 mg/L)
          Robinson et al. 2005
Levofloxacin   J01MA12 Antibacterial agents 361.3675   Pseudokirchneriella subcapitata (Green algae) growth and reproduction 3 days   five different concentrations           7 400 ug/L
(7,4 mg/L)
          Robinson et al. 2005
Levofloxacin   J01MA12 Antibacterial agents 361.3675 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Respirometry                 2021.41 mg/L           Ortiz de Garcia et al. 2014
Levofloxacin   J01MA12 Antibacterial agents 361.3675 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 5min               825.52 mg/L           Ortiz de Garcia et al. 2014
Levofloxacin   J01MA12 Antibacterial agents 361.3675 ISO 11348-3:2007 protocol (ISO 2007) Vibrio fischeri Bioluminescence 15min               788.30 mg/L           Ortiz de Garcia et al. 2014
Levonorgestrel   G03AC03 Sex hormones   OECD 202 Daphnia magna Immobility, acute toxicity 48h   0.11–1.7 mg/L         >1.7 (0.11–1.70) mg/L             Furuhagen et al. 2014
Levonorgestrel   G03AC03 Sex hormones   OECD 211 Daphnia magna Reproduction 21d   0.013–1.02 mg/L                 >1.02     Furuhagen et al. 2014
Levonorgestrel   G03AC03 Sex hormones   OECD 21 days fish reproduction (draft) Pimephales promelas (Fathead minnows) Inhibition of reproduction (no of laid eggs) 21 days   0, 0.8, 3.3, 29.6 ng/L F+M Adult 4 pairs           0.8 ng/L
(0.0000008 mg/L)
    Zeilinger et al. 2009
Levonorgestrel   G03AC03 Sex hormones     Xenopus tropicalis (Frog) Underdeveloped or lacking oviducts From Hatching to metamorphosis   0, 18.7, 156 ng/L F Juveniles 25 per replicate, 2 replicates per concentration.           18.7 ng/L
(0.0000187 mg/L)
    Kvarnryd et al. 2011
Levonorgestrel   G03AC03 Sex hormones     Xenopus tropicalis (Frog) Reduced gonado-somatic index (GSI) From Hatching to metamorphosis   0, 18.7, 156 ng/L F Juveniles 25 per replicate, 2 replicates per concentration.           156 ng/L
(0.000156 mg/L)
    Kvarnryd et al. 2011
Levonorgestrel   G03AC03 Sex hormones     Xenopus tropicalis (Frog) Eggs laid From Hatching to metamorphosis   0, 18.7, 156 ng/L F Juveniles 25 per replicate, 2 replicates per concentration.           18.7 ng/L
(0.0000187 mg/L)
    Kvarnryd et al. 2011
Levonorgestrel   G03AC03 Sex hormones     Xenopus tropicalis (Frog) Immature Oocytes From Hatching to metamorphosis   0, 18.7, 156 ng/L F Juveniles 25 per replicate, 2 replicates per concentration.           18.7 ng/L
(0.0000187 mg/L)
    Kvarnryd et al. 2011
Lidocaine   N01BB02 Anesthetics 234.3373 Spirotox Spirostomum ambiguum (Ciliate) morphological changes/ spherical deformation and autolysis 24 h             179 mg/L
(179 mg/L)
38.9 mg/L
(38,9 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Lidocaine   N01BB02 Anesthetics 234.3373 Protoxkit FTM Tetrahymena termophila (Ciliate) growth inhibition 24 h               1000 mg/L
(1000 mg/L)
          Nalecz-Jawecki and Sawicki 2003
Lidocaine Lidocaine HCl N01BB02 Anesthetics 234.3373 Thamnotoxkit F (1995) Thamnocephalus platyurus (Crustacean) mortality 24 h       larvae hatched from dormant eggs     81.7 mg/L
(81.7 mg/L)
            Nalecz-Jawecki and Persoone 2006
Lidocaine Lidocaine HCl N01BB02 Anesthetics 234.3373 Rapidtoxkit (2004) Thamnocephalus platyurus (Crustacean) food ingestion 1h       larvae hatched from dormant eggs 12 cup multiwells, 15-25 organisms in each     36.0 mg/L
(36 mg/L)
          Nalecz-Jawecki and Persoone 2006
Linezolid   J01XX08 Antibacterial agents   EPA 1000.2 Ceriodaphnia dubia Survival 7 days   0.94 - 30 mg/L F       >31 mg/L     30 mg/L
(31 mg/L)
      Constantine and Huggett, 2010
Linezolid   J01XX08 Antibacterial agents   EPA 1000.2 Ceriodaphnia dubia Reproduction 7 days   0.94 - 30 mg/L F             31 mg/L
(31 mg/L)
>31 mg/L     Constantine and Huggett, 2010
Linezolid   J01XX08 Antibacterial agents   OECD 211 Daphnia magna (Crustacean) Reproduction 21 days   6.3 - 100 mg/L F             24 mg/L
(24 mg/L)
47 mg/L     Constantine and Huggett, 2010
Linezolid   J01XX08 Antibacterial agents   OECD 211 Daphnia magna (Crustacean) Survival 21 days   6.3 - 100 mg/L F       >94 mg/L     94 mg/L
(94 mg/L)
      Constantine and Huggett, 2010
Lithium Lithium sulfate N05AN01 Psycholeptics     Artemia salina (Crustacea) Immobilization 24 h               4275 mg/L           Callejaa et al. 1993
Lithium Lithium sulfate N05AN01 Psycholeptics     Brachionus calyciflorus (Rotifera) Immobilization 24 h               709 mg/L           Callejaa et al. 1993
Lithium Lithium sulfate N05AN01 Psycholeptics     Daphnia magna (Crustacean) Immobilization 24 h               33,2 mg/L