MistraPharma Database

HOME | Effect data

Pharmaceutical group: Substance:

Substance	Substance comment	ATC	Pharmaceutical group	Molar mass	Type of test	Species	Critical effect	Exposure time	Study period	Concentrations/Doses	Sex	Age	Number of organisms	Route of exposure	LC50	EC50	IC50	NOEC	LOEC	LOEL	Reference short
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							3.32 umol/L						Calleja et al. 1994 (b)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							2120 umol/L (381.933688 mg/L)						Calleja et al. 1994 (a)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							2.89 umol/L						Calleja et al. 1994 (b)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							785 umol/L (141.423559 mg/L)						Calleja et al. 1994 (a)
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	neonates per brood (brood 2)	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574		Daphnia longispina (Crustacean)	daily growth rate	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						1.80 mg/L (1,8 mg/L)	3.20 mg/L		Marques et al. 2004b
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574		Daphnia longispina (Crustacean)	population growth rate	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						84.5 mg/L (84,5 mg/L)	186.0 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	age at each reproduction (brood 4)	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.56 mg/L (0,56 mg/L)	1.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	neonates per brood (brood 3)	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.56 mg/L (0,56 mg/L)	1.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	average size of juveniles from first brood	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						84.5 mg/L (84,5 mg/L)	186.0 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	average size of juveniles from first brood	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.56 mg/L (0,56 mg/L)	1.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	number of viable offspring	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						84.50 mg/L (84,5 mg/L)	186.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	number of viable offspring	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.32 mg/L (0,32 mg/L)	0.56 mg/L		Marques et al. 2004b
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia longispina (Crustacean)	immobilization	48 h		180.00-1800.00 mg/L		<24h	Four replicates of five individuals for each treatment			>1800.00 mg/L					Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia longispina (Crustacean)	immobilization	48 h		180.00-910.00 mg/L		<24h	Four replicates of five individuals for each treatment			342.41 mg/L (342,41 mg/L)					Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia longispina (Crustacean)	immobilization	48 h		347.00-900.00 mg/L		<24h	Five animals in each vessel, four replicates per treatment			647.31 mg/L (647,31 mg/L)					Marques et al. 2004a
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	neonates per brood (brood 5)	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						1.80 mg/L (1,8 mg/L)	3.20 mg/L		Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	neonates per brood (brood 2)	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.80 mg/L (1,8 mg/L)	3.20 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	size of neonates-first brood	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						>10.00 mg/L	>10.00 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia longispina (Crustacean)	number of viable offspring	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	European Guideline; EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	24 h and 48 h				Younger than 24h	four replicates, 5 daphnids each			88.1 mg/L (88,1 mg/L)		75 mg/L (75 mg/L)			Cleuvers 2004
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								2.97 umol/L					Calleja et al. 1994 (b)
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia magna (Crustacean)	immobilization	48 h		180.00-910.00 mg/L		<24h	Four replicates of five individuals for each treatment			402.55 mg/L (402,55 mg/L)					Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574		Daphnia magna (Crustacean)	daily growth rate	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.56 mg/L (0,56 mg/L)	1.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD Guidelines No. 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								932 umol/L (167,9066968 mg/L)					Calleja et al. 1994 (a)
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574		Daphnia magna (Crustacean)	population growth rate	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						1.80 mg/L (1,8 mg/L)	3.20 mg/L		Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia magna (Crustacean)	immobilization	48 h		900.0-2350.00 mg/L		<24h	Five animals in each vessel, four replicates per treatment			1293.05 mg/L (1293,05 mg/L)					Marques et al. 2004a
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	neonates per brood (brood 1,2,3,4 and 5)	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						409.0 mg/L (409 mg/L)	900.0 mg/L		Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						8.15 mM					Lilius et al. 1995
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	number of viable offspring	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			8.15 mM (1468,28281 mg/L)					Lilius et al. 1994
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	average size of juveniles from first brood	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						409.0 mg/L (409 mg/L)	900.0 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	average size of juveniles from first brood	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						>3.20 mg/L	>3.20 mg/L		Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	daily growth rate	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	size of neonates-first brood	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004a
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	number of viable offspring	21 days		38.4, 84.5, 186.0, 409.0, 900.0 mg/L		<24h						186.00 mg/L (186 mg/L)	409.00 mg/L		Marques et al. 2004b
Acetylsalicylic acid	gentisic acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	number of viable offspring	21 days		0.32, 0.56, 1.00, 1.80, 3.20 mg/L		<24h						0.32 mg/L (0,32 mg/L)	0.56 mg/L		Marques et al. 2004b
Acetylsalicylic acid	o-hydroxyhippuric acid, acetylsalicylic acid metabolite	N02BA01	Analgesic	180.1574	OECD no. 202 (2000)	Daphnia magna (Crustacean)	immobilization	48 h		180.00-1800.00 mg/L		<24h	Four replicates of five individuals for each treatment			>1800.00 mg/L					Marques et al. 2004b
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD no. 202 (1996)	Daphnia magna (Crustacean)	neonates per brood (brood 3)	21 days		1.00, 1.80, 3.20, 5.60, 10.00 mg/L		<24h						1.00 mg/L (1 mg/L)	1.80 mg/L		Marques et al. 2004a
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	OECD 202 (1993)	Daphnia pulex (Crustacean)	immobilization	24 h		5 concentrations						2 mM					Lilius et al. 1995
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	European Guideline; EEC Directive 92/69/EEC (1993)	Desmodesmus subspicatus (Green algae)	growth inhibition									106.7 mg/L (106,7 mg/L)		32 mg/L (32 mg/L)			Cleuvers 2004
Acetylsalicylic acid		N02BA01	Analgesic	180.1574		Hydra vulgaris (Cnidarian)	partially contracted polyp, slow reactions	7 days		10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						1 mg/L		Pascoe et al. 2003
Acetylsalicylic acid		N02BA01	Analgesic	180.1574		Hydra vulgaris (Cnidarian)	mean number of Artemia ingested	7 days	10 day feeding/budding study followed 7 d exposure	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Acetylsalicylic acid		N02BA01	Analgesic	180.1574		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			27.6 mM (4972,34424 mg/L)					Lilius et al. 1994
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Microtox test	Photobacterium phosphoreum (Bacteria)	Luminescence inhibition	5 min								2.16 umol/L					Calleja et al. 1994 (b)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								145 umol/L (26,122823 mg/L)					Calleja et al. 1994 (a)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							177 mg/L	177 mg/L (177 mg/L)					Nalecz-Jawecki and Sawicki 2003
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							988 umol/L (177.9955112 mg/L)						Calleja et al. 1994 (a)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							2.98 umol/L						Calleja et al. 1994 (b)
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Protoxkit FTM	Tetrahymena termophila (Ciliate)	growth inhibition	24 h								720 mg/L (720 mg/L)					Nalecz-Jawecki and Sawicki 2003
Acetylsalicylic acid		N02BA01	Analgesic	180.1574	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			86.2 mg/L						Nalecz-Jawecki and Persoone 2006
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							133 umol/L (36.8946389 mg/L)						Calleja et al. 1994 (a)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033		Artemia salina (Crustacea)	Immobilization	24 h								36,6 mg/L					Callejaa et al. 1993
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							2.12 umol/L						Calleja et al. 1994 (b)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033		Brachionus calyciflorus (Rotifera)	Immobilization	24 h								0,8 mg/L					Callejaa et al. 1993
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							0.46 umol/L						Calleja et al. 1994 (b)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							2.9 umol/L (0.80446957 mg/L)						Calleja et al. 1994 (a)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						4150 mM					Lilius et al. 1995
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								1.25 umol/L					Calleja et al. 1994 (b)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								20 umol/L (5,548066 mg/L)					Calleja et al. 1994 (a)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.00415 mM (1151,223695 mg/L)					Lilius et al. 1994
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	OECD 202 (1993)	Daphnia pulex (Crustacean)	immobilization	24 h		5 concentrations						3730 mM					Lilius et al. 1995
Amitriptyline	Amitryptyline HCl	N06AA09	Psychoanaleptics	277.4033	ISO/WD 20079 (2001)	Lemna minor (Duckweed)	growth inhibition	7 days				Initially three or four fronds	Six-well plates, one plant in each well, three replicates			1.69 mg/L (1,69 mg/L)					Kaza et al. 2007
Amitriptyline		N06AA09	Psychoanaleptics	277.4033		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			0.475 mM (131,7665675 mg/L)					Lilius et al. 1994
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Microtox test	Photobacterium phosphoreum (Bacteria)	Luminescence inhibition	5 min								1.89 umol/L					Calleja et al. 1994 (b)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								77.8 umol/L (21,58197674 mg/L)					Calleja et al. 1994 (a)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Spirotox	Spirostomum ambiguum (Ciliate)	pherical deformation and autolysis	24 h							1.13 mg/L	0.58 mg/L (0,58 mg/L)					Nalecz-Jawecki 2008
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							0,7 mg/L (0.7 mg/L)	0.44 mg/L (0,44 mg/L)					Nalecz-Jawecki and Sawicki 2003
Amitriptyline		N06AA09	Psychoanaleptics	277.4033		Streptocephalus proboscideus (Crustacea)	Immobilization	24 h								0,76 mg/L					Callejaa et al. 1993
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							2.8 umol/L (0.77672924 mg/L)						Calleja et al. 1994 (a)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							0.44 umol/L						Calleja et al. 1994 (b)
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Protoxkit FTM	Tetrahymena termophila (Ciliate)	growth inhibition	24 h								40 mg/L (40 mg/L)					Nalecz-Jawecki and Sawicki 2003
Amitriptyline	Amitriptyline HCl	N06AA09	Psychoanaleptics	277.4033	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			0.63 mg/L						Nalecz-Jawecki and Persoone 2006
Amitriptyline		N06AA09	Psychoanaleptics	277.4033	Thamnotoxkit F	Thamnocephalus platyurus (Crustacean)	mortality	24 h							1.12 mg/L						Nalecz-Jawecki 2008
Amitriptyline	Amitriptyline HCl	N06AA09	Psychoanaleptics	277.4033	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			3.0 mg/L (3 mg/L)					Nalecz-Jawecki and Persoone 2006
Amlodipine		C08CA01	Calcium antagonists	408.8759		Hydra vulgaris (Cnidarian)	clubbed tentacles, body slightly contracted	7 days		10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						100 ug/L (0.1 mg/L)		Pascoe et al. 2003
Amlodipine		C08CA01	Calcium antagonists	408.8759		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 48h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Amlodipine		C08CA01	Calcium antagonists	408.8759		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 72h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Amlodipine		C08CA01	Calcium antagonists	408.8759		Hydra vulgaris (Cnidarian)	mean number of Artemia ingested	7 days	10 day feeding/budding study followed 7 d exposure	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						1 mg/L		Pascoe et al. 2003
Amlodipine		C08CA01	Calcium antagonists	408.8759		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 24h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Amoxicillin		J01CA04	Antibacterial agents	365.4042	Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Amoxicillin		J01CA04	Antibacterial agents	365.4042	OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Amoxicillin		J01CA04	Antibacterial agents	365.4042	Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											20		Hartmann et al. 1998
Amoxicillin		J01CA04	Antibacterial agents	365.4042		Hydra vulgaris (Cnidarian)	partially contracted polyp, slow reactions	7 days		10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						100 ug/L (0.1 mg/L)		Pascoe et al. 2003
Amoxicillin		J01CA04	Antibacterial agents	365.4042	ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			> 1000 ug/L					Brain et al. 2004 (a)
Amoxicillin		J01CA04	Antibacterial agents	365.4042	ISO 8692 (1989), modified version	Microcystis aeruginosa (Freshwater cyanobacteria)	growth inhibition	7 days		0.0009 to 0.0038 mg/L			Initial density; 2*10^4 cells/ml			0.0037 mg/L (0,0037 mg/L)					Holten Lutzhoft et al. 1999
Amoxicillin		J01CA04	Antibacterial agents	365.4042	ISO 8692 (1989), modified version	Rhodomonas salina (Marine cryptophycean)	growth inhibition			5 to 500 mg/L			Initial density; 1*10^4 cells/mL			3108 mg/L (out of measured range)					Holten Lutzhoft et al. 1999
Amoxicillin		J01CA04	Antibacterial agents	365.4042	ISO 8692 (1989), modified version	Selenastrum capricornutum (Freshwater green algae)	growth inhibition			2.5 to 250 mg/L			Initial density; 1*10^4 cells/mL					250 mg/L (250 mg/L)			Holten Lutzhoft et al. 1999
Amoxicillin		J01CA04	Antibacterial agents	365.4042		Synechococcus leopolensis (Blue-green algae, strain UTEX 625)	growth inhibition	96 h		50 ng/L to 50 mg/L			10 000 or 100 000 cells/mL (inocula)			2.22 ug/L (0,00222 mg/L)		0.78 ug/L (0,00078 mg/L)	1.56 ug/L (0.00156 mg/L)		Andreozzi et al. 2004
Amoxicillin		J01CA04	Antibacterial agents	365.4042	Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	15 min									3597.0 mg/L				Park and Choi 2008
Amoxicillin		J01CA04	Antibacterial agents	365.4042	Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	5 min									1320.0 mg/L				Park and Choi 2008
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							3.61umol/L						Calleja et al. 1994 (b)
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							0.98 umol/L						Calleja et al. 1994 (b)
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								2.86 umol/L					Calleja et al. 1994 (b)
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.164 mM (22,1741776 mg/L)					Lilius et al. 1994
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						0.164 mM					Lilius et al. 1995
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			53.05 mM (7172,80562 mg/L)					Lilius et al. 1994
Amphetamine sulfate		N06BA01	Psychoanaleptics	135.2084	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							2.16 umol/L						Calleja et al. 1994 (b)
Ampicillin		J01CA01	Antibacterial agents	349.4048		Anabaena cylindrica NIES-19	Growth inhibition	144 h								0,14		0,013			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Anabaena flos-aquae ATCC 29413	Growth inhibition	144 h								3,3		0,16			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Anabaena variabilis NIES-23	Growth inhibition	144 h								2,2		0,16			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048	OECD (1993) no 201	Chlorella vulgaris (Green algae)	growth inhibition			5 concentrations, triplicates						>1000 mg/L		>1000 mg/L			Eguchi et al. 2004
Ampicillin		J01CA01	Antibacterial agents	349.4048		Microcystis aeruginosa NIES-44	Growth inhibition	144 h								0,0002		0,000031			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Microcystis wesenbergii NIES-107	Growth inhibition	144 h								0,013		0,002			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Nostoc sp. PCC 7120	Growth inhibition	144 h								>200		100			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Pseudokirchneriella subcapitata ATCC 22662	Growth inhibition	144 h								>1000		>1000			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048	OECD (1993) no 201	Selenastrum capricornutum (Freshwater green algae)	growth inhibition			5 concentrations, triplicates						>1000 mg/L		>1000 mg/L			Eguchi et al. 2004
Ampicillin		J01CA01	Antibacterial agents	349.4048		Synechococcus leopoldensis IAM M-6	Growth inhibition	144 h								0,083		0,025			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048		Synechococcus sp. PCC 7002	Growth inhibition	144 h								0,0069		0,00031			Ando and Nagase, 2007
Ampicillin		J01CA01	Antibacterial agents	349.4048	Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	5 min									1056.0 mg/L				Park and Choi 2008
Ampicillin		J01CA01	Antibacterial agents	349.4048	Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	15 min									2627.0 mg/L				Park and Choi 2008
Ampicillin		J01CA01	Antibacterial agents	349.4048	Chronic bioluminescence assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h								163 mg/L (163 mg/L)					Backhaus and Grimme 1999
Atenolol		C07AB03	Beta-receptor blockers	266.3361	Acute toxicity to Daphnia: EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	48 h				<24h	Twenty daphnids for the controls and each treatment, subdivided in 4 replicates			313 mg/L (313 mg/L)					Cleuvers 2005
Atenolol		C07AB03	Beta-receptor blockers	266.3361	Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	48 h				<24h				200 mg/L (200 mg/L)					Hernando et al. 2004
Atenolol		C07AB03	Beta-receptor blockers	266.3361	Algal inhibition test: EEC Directive 92/69/EEC (1993)	Desmodesmus subspicatus (Green algae)	growth	48 h					Initial density: 10^4 cells/mL			620 mg/L (620 mg/L)					Cleuvers 2005
Atenolol		C07AB03	Beta-receptor blockers	266.3361		Desmodesmus subspicatus (Green algae)	photosynthesis inhibition	24 h								1335 mg/L (1335 mg/L)					Escher et al. 2006
Atenolol		C07AB03	Beta-receptor blockers	266.3361	OECD Test 210 (1992)	Pimephales promelas (Fathead minnow)	hatchability	ended 28 d post-hatch		0.1, 0.32, 1, 3.2, 10 mg/L		embryos 2-24 h	20 embryos in each cup, approximately 80 embryos per conc.					10 mg/L (10 mg/L)	>10 mg/L		Winter et al. 2008
Atenolol		C07AB03	Beta-receptor blockers	266.3361	OECD Test 210 (1992)	Pimephales promelas (Fathead minnow)	survival (%)	ended 28 d post-hatch		0.1, 0.32, 1, 3.2, 10 mg/L		embryos 2-24 h	20 embryos in each cup, approximately 80 embryos per conc.					10 mg/L (10 mg/L)	>10 mg/L		Winter et al. 2008
Atenolol		C07AB03	Beta-receptor blockers	266.3361	OECD Test 210 (1992)	Pimephales promelas (Fathead minnow)	wet weight	ended 28 d post-hatch		0.1, 0.32, 1, 3.2, 10 mg/L		embryos 2-24 h	20 embryos in each cup, approximately 80 embryos per conc.					3.2 mg/L (3,2 mg/L)	10 mg/L		Winter et al. 2008
Atenolol		C07AB03	Beta-receptor blockers	266.3361	OECD Test 210 (1992)	Pimephales promelas (Fathead minnow)	standard length	ended 28 d post-hatch		0.1, 0.32, 1, 3.2, 10 mg/L		embryos 2-24 h	20 embryos in each cup, approximately 80 embryos per conc.					3.2 mg/L (3,2 mg/L)	10 mg/L		Winter et al. 2008
Atenolol		C07AB03	Beta-receptor blockers	266.3361		Pimephales promelas (Fathead minnow)	reproduction (condition index)	21 days		0.1, 0.32, 1, 3.2, 10 mg/L		adult	8 pairs per concentation					1 mg/L (1 mg/L)	3.2 mg/L		Winter et al. 2008
Atenolol		C07AB03	Beta-receptor blockers	266.3361	ISO Guideline 11348-3 (1998)	Vibrio fischeri (Bacteria)	bioluminescence inhibition	30 min								1304 mg/L (1304 mg/L)					Escher et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	EPA/600/R-99/064 (2000)	Chironomus tentans, now Chironomus dilutus (Insecta, diptera)	growth	10 days				12 days	8-9 conc. 4-5 replicates and 9-10 animals in each beaker			10.2 mg/L (10,2 mg/L)					Dussault et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	EPA/600/R-99/064 (2000)	Chironomus tentans, now Chironomus dilutus (Insecta, diptera)	survival	10 days				12 days	8-9 conc. 4-5 replicates and 9-10 animals in each beaker		14.3 mg/L						Dussault et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Daucus carota (Wild carrot)	Growth (root length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						259.4 ug/L (0,2594 mg/L)			300 ug/L (0.3 mg/L)		Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Daucus carota (Wild carrot)	Growth (root length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						208.6 ug/L (0,2086 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Daucus carota (Wild carrot)	Growth (root length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						172.9 ug/L (0,1729 mg/L)			300 ug/L (0.3 mg/L)		Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						65.4 ug/L (0,0654 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Spore production	28 days		0, 10, 30, 100, 300, 1000 ug/L						41.8 ug/L (0,0418 mg/L)					Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Spore production	21 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						154.3 ug/L (0,1543 mg/L)					Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						153.6 ug/L (0,1536 mg/L)					Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398		Glomus intraradices (Mycorrhizal fungus)	Spore production	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	EPA/600/R-99/064 (2000)	Hyalella azteca (Freshwater amphipod)	survival	10 days				7-14 days	8-9 conc. 4-5 replicates and 8-15 animals in each beaker		1.5 mg/L						Dussault et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	EPA/600/R-99/064 (2000)	Hyalella azteca (Freshwater amphipod)	growth	10 days				7-14 days	8-9 conc. 4-5 replicates and 8-15 animals in each beaker			2.4 mg/L (2,4 mg/L)					Dussault et al. 2008
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			214 ug/L (0,214 mg/L)			300 ug/L (0.3 mg/L)		Brain et al. 2004 (b)
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	increase in total plastoquinone (PQ)	7 days					Two plants in each of the 18 culture dishes			85.1 ug/L (0,0851 mg/L)			217 ug/L (0.217 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	increase in reduced plastoquinone (PQ)	7 days					Two plants in each of the 18 culture dishes			37.7 ug/L (0,0377 mg/L)			217 ug/L (0.217 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	increase in oxidized plastoquinone (PQ)	7 days					Two plants in each of the 18 culture dishes			3055 ug/L (3,055 mg/L)					Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	increase in total ubiquinone (UQ)	7 days					Two plants in each of the 18 culture dishes			967 ug/L (0,967 mg/L)			67 ug/L (0.067 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	decrease in fresh weight (sterols)	7 days					Two plants in each of the 18 culture dishes			157 ug/L (0,157 mg/L)			200 ug/L (0.2 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	decrease in beta-Sitosterol	7 days					Two plants in each of the 18 culture dishes			64.4 ug/L (0,0644 mg/L)			67 ug/L (0.067 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	decrease in stigmasterol	7 days					Two plants in each of the 18 culture dishes			71.6 ug/L (0,0716 mg/L)			67 ug/L (0.067 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	Modified ASTM E 1415-91 Guideline (1999)	Lemna gibba (Duckweed)	decrease in fresh weight (quinones)	7 days					Two plants in each of the 18 culture dishes			135 ug/L (0,135 mg/L)			19 ug/L (0.019 mg/L)		Brain et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	MTT assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.0818 mM (45,69673564 mg/L)					Caminada et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	NR assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.0781 mM (43,62976838 mg/L)					Caminada et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	MTT assay	RTG-2 cell line (Rainbow trout gonad)	cell viability	24 h					3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.302 mM (168,7092196 mg/L)					Caminada et al. 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	ASTM: Standard guide for conducting FETAX E1439-98 (2002)	Xenopus laevis (African clawed frog)	malformations	96 h				eggs, stage 9	Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.			23.1 mg/L (23,1 mg/L)		10.0 mg/L (10 mg/L)			Richards and Cole 2006
Atorvastatin		C10AA05	Blood lipid lowering agents	558.6398	ASTM: Standard guide for conducting FETAX E1439-98 (2002)	Xenopus laevis (African clawed frog)	mortality	96 h				eggs, stage 9	Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs.		38.6 mg/L						Richards and Cole 2006
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							22700 umol/L (6568.68538 mg/L)						Calleja et al. 1994 (a)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Artemia salina (Crustacea)	Immobilization	24 h								15556 mg/L					Callejaa et al. 1993
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							4.35 umol/L						Calleja et al. 1994 (b)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							2.67 umol/L						Calleja et al. 1994 (b)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Brachionus calyciflorus (Rotifera)	Immobilization	24 h								325 mg/L					Callejaa et al. 1993
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							481 umol/L (139.1866814 mg/L)						Calleja et al. 1994 (a)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Daphnia magna (Crustacean)	Immobilization	24 h								356 mg/L					Callejaa et al. 1993
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								2.71 umol/L					Calleja et al. 1994 (b)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								513 umol/L (148,4465022 mg/L)					Calleja et al. 1994 (a)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.372 mM (107,6454168 mg/L)					Lilius et al. 1994
Atropine	sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						0.372 mM					Lilius et al. 1995
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			16.83 mM (4870,087002 mg/L)					Lilius et al. 1994
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Microtox test	Photobacterium phosphoreum (Bacteria)	Luminescence inhibition	5 min								3.9 umol/L					Calleja et al. 1994 (b)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								8010 umol/L (2317,848894 mg/L)					Calleja et al. 1994 (a)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							2.98 umol/L						Calleja et al. 1994 (b)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Streptocephalus proboscideus (Crustacea)	Immobilization	24 h								664 mg/L					Callejaa et al. 1993
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							951 umol/L (275.1902994 mg/L)						Calleja et al. 1994 (a)
Atropine	Atropine sulfate	A03BA01	Drugs for functional gastrointestinal disorders	289.3694		Vibrio fischeri (Bacteria)	Bioluminescence inhibition	15 min								5519 mg/L					Callejaa et al. 1993
Azithromycin		J01FA10	Antibacterial agents		Algal Growth Inhibition test	Pseudokirchneriella subcapitata	Growth inhibition rate	96 h		maximum 10mg/L						0,019 mg/L		5.2 ug/L (0,0052 mg/L)			Harada et al. 2008
Benzylpenicillin	sodium	J01CE01	Antibacterial agents		OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Benzylpenicillin	sodium	J01CE01	Antibacterial agents		Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Benzylpenicillin		J01CE01	Antibacterial agents		ISO 8692 (1989), modified version	Microcystis aeruginosa (Freshwater cyanobacteria)	growth inhibition	7 days		0.002-0.01 mg/L			Initial density; 2*10^4 cells/mL			0.006 mg/L (0,006 mg/L)					Halling-Sorensen 2000
Benzylpenicillin		J01CE01	Antibacterial agents		ISO 8692 (1989), modified version	Selenastrum capricornutum (Freshwater green algae)	growth inhibition	3 days		3-100 mg/L			Initial density; 1*10^4 cells/mL					100 mg/L (100 mg/L)			Halling-Sorensen 2000
Betaxolol		S01ED02	Ophthalmologicals	307.4278	Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	48 h				<24h				>300 mg/L					Hernando et al. 2004
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	ISO/CD 20666 (2001)	Brachionus calyciflorus (Rotifera)	population growth inhibition	48 h					24-well plates, one rotifer in each well (initially), four replicates per concentration			0.44 mg/L (0,44 mg/L)		0.156 mg/L (0,156 mg/L)	0.3125 mg/L		Isidori et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	ASTM E1440-91 (1991)	Brachionus calyciflorus (Rotifera)	mortality	24 h				neonates	36-well plates, five animals per well, six replicates for each of the five concentrations		60.91 mg/L						Isidori et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	ISO/CD 20665 (2001)	Ceriodaphnia dubia (Crustacean cladocera)	population growth inhibition	7 days				< 24 h	Single organisms in beakers, seven concentrations, ten replicates			0.13 mg/L (0,13 mg/L)		0.023 mg/L (0,023 mg/L)	0.047 mg/L		Isidori et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	EPA 600/4-90/027F (1993)	Ceriodaphnia dubia (Crustacean cladocera)	immobilization	48 h				< 24 h	24-well plates, ten organisms per well, three replicates per concentration, five concentrations			75.79 mg/L					Isidori et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	ISO 6341 (1996)	Daphnia magna (Crustacean)	immobilization	24 h				< 24 h	Five daphnids per vessel, four replicates for each of five concentrations			100.08 mg/L					Isidori et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	48 h				<24h				>200 mg/L					Hernando et al. 2004
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	EPA/600/4-90/027F (1993)	Daphnia magna (Crustacean)	mortality	48 h				<24h (neonates)	Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.		30.3 mg/L						Han et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Elliptio complanata (Freshwater mussel)	immunotoxic effect: induction of phagocytosis	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						2 uM (0.7236388 mg/L)		Gagné et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Elliptio complanata (Freshwater mussel)	immunotoxic effect: increased cell viability	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						2 uM (0.7236388 mg/L)		Gagné et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Elliptio complanata (Freshwater mussel)	immunotoxic effect: decreased cell adherence	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						2 uM (0.7236388 mg/L)		Gagné et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Hydra attenuata (Cnidarian)	regeneration	96 h		0, 0.1, 1, 5, 10, 25, 50, 100 mg/L			10 per concentration				22.5 mg/L				Quinn et al. 2008b
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Hydra attenuata (Cnidarian)	morphological changes	96 h		0.1-50/100mg/L			3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate		70.71 mg/L	25.85 mg/L (25,85 mg/L)		0.1mg/L (0,1 mg/L)	1 mg/L		Quinn et al. 2008a
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Hydra attenuata (Cnidarian)	feeding behaviour and hydranth no.	96 h		0.1-50/100mg/L			3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate			8.59 mg/L (8,59 mg/L)					Quinn et al. 2008a
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Mytilus galloprovincialis (Blue mussel)	immune parameters in the hemocytes	24 h						Injection						0.01 nmol (3.61 ng/g dry weight)	Canesi et al. 2007
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	MTT assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			2.60 mM (940,73044 mg/L)					Caminada et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	NR assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			1.74 mM (629,565756 mg/L)					Caminada et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	MTT assay	RTG-2 cell line (Rainbow trout gonad)	cell viability	24 h					3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates			1.23 mM (445,037862 mg/L)					Caminada et al. 2006
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	Alamar Blue assay	RTL-W1 (Rainbow trout liver cell line)	change in energy metabolism (cytotoxicity)	24 h		five-six different concentrations						275.7 uM					Schnell et al. 2009
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194	CFDA-AM assay	RTL-W1 (Rainbow trout liver cell line)	decrease in membrane integrity (cytotoxicity)	24 h		five-six different concentrations						266 uM					Schnell et al. 2009
Bezafibrate		C10AB02	Blood lipid lowering agents	361.8194		Thamnocephalus platyurus (Crustacean)	mortality	24 h				second- and third instar larvae	24-well plates, ten animals per well, three replicates for each of the five concentrations		39.69 mg/L						Isidori et al. 2007
Bleomycin		L01DC01	Antineoplastic agents		Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											0,05		Hartmann et al. 1998
Captopril		C09AA01	Agents acting on the renin-angiotensin system		European Guideline; EEC Directive 92/69/EEC	Daphnia magna (Crustacean)	immobilization	48 h		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L		< 24 h	Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.			>100 mg/L					Cleuvers 2003
Captopril		C09AA01	Agents acting on the renin-angiotensin system		European Guideline; EEC Directive 92/69/EEC	Desmodesmus subspicatus (Green algae)	inhibition of average growth rate	3 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Initial density; 10^4 cells/mL			168 mg/L (168 mg/L)					Cleuvers 2003
Captopril		C09AA01	Agents acting on the renin-angiotensin system		ISO/WD 20079 (2001), using the Steinberg-medium	Lemna minor (Duckweed)	inhibition of average growth rate	7 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Three treatment replicates and six control replicates.			25 mg/L (25 mg/L)					Cleuvers 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Allium cepa (Terrestrial plant)	root growth	72 h					Five bulbs and three roots per bulb were used for each treatment			447 uM (105,6120642 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Allium cepa (Terrestrial plant)	mitotic index	48 h					Five bulbs and three roots per bulb were used for each treatment			498 uM (117,6617628 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Rotoxkit according to the standard AFNOR T90-377 (2000)	Brachionus calyciflorus (Rotifera)	reproduction	48 h													Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	AFNOR T90-377 (2000)	Brachionus calyciflorus (Rotifera)	reproduction inhibition	48 h				newly hatched	48 rotifers; five concentrations and one control, eight replicates					0.377 mg/L (0,377 mg/L)	0.754 mg/L		Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Chronic toxicity test according to the standard AFNOR T90-376 (2000)	Ceriodaphnia dubia (Crustacean cladocera)	reproduction	7 days										25 ug/L (0,025 mg/L)			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA 600/4_90/027 (1991)	Ceriodaphnia dubia (Crustacean cladocera)	mortality	48 h								77.70 mg/L (77,7 mg/L)		377 ug/L (0,377 mg/L)			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA 600/4_90/027 (1991)	Ceriodaphnia dubia (Crustacean cladocera)	mobility inhibition	48 h				< 24 h	28 cups, five daphnids in each, six concentrations and one control, four replicates			77.7 mg/L (77,7 mg/L)					Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	AFNOR T90-376 (2000)	Ceriodaphnia dubia (Crustacean cladocera)	reproduction inhibition	7 days				< 24 h						0.025 mg/L (0,025 mg/L)	0.1 mg/L		Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Chironomus riparius (Insecta, diptera)	Mortality	24 h		0.5, 10, 200, 4000 ug/L								>4 mg/L			Nentwig et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	Sediment assay	Chironomus riparius (Insecta, diptera)	Life-cycle	28 days		0.16-100 mg/kg dw								0.625 mg/kg dw	1.25 mg/kg dw		Nentwig et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/R-99/064 (2000)	Chironomus tentans, now Chironomus dilutus (Insecta, diptera)	growth	10 days				12 days	8-9 conc. 4-5 replicates and 9-10 animals in each beaker			9.5 mg/L (9,5 mg/L)					Dussault et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/R-99/064 (2000)	Chironomus tentans, now Chironomus dilutus (Insecta, diptera)	survival	10 days				12 days	8-9 conc. 4-5 replicates and 9-10 animals in each beaker		47.3 mg/L						Dussault et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Chlorella vulgaris var viridis (Green algae)	growth inhibition	24 h					1 000 000 cells/mL algae culture			469.5 uM (110,9281077 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Chlorella vulgaris var viridis (Green algae)	growth inhibition	48 h					1 000 000 cells/mL algae culture			155 uM (36,621633 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	algal growth inhibition test	Cyclotella meneghiniana (Diatom)	growth	96 h								31.60 mg/L (31,6 mg/L)		10.00 mg/L (10 mg/L)			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686		Cyprinus carpio (Common carp)	liver, ultrastructural effects	28 days		1, 5, 20, 50, 100 ug/L	F+M	1,5 year-old	24 per conc. 6-8 were used						>100 ug/L		Triebskorn et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686		Cyprinus carpio (Common carp)	kidney, ultrastructural effects	28 days		1, 5, 20, 50, 100 ug/L	F+M	1,5 year-old	24 per conc. 6-8 were used						1 ug/L (0.001 mg/L)		Triebskorn et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	10-d early life stage test according to ISO 12890 (1999)	Danio rerio (Zebrafish)	mortality	10 days				fish embryo						25 mg/L (25 mg/L)			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	ISO 12890 (1999)	Danio rerio (Zebrafish)	embryos and larvae mortality	10 days				embryos, larvae	50 embryos					25 mg/L (25 mg/L)	50 mg/L		Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	OECD protocol "Fish Embryo Toxicity"	Danio rerio (Zebrafish)	Developmental effects	72 h				Embryo (2 hours old)			>245 mg/L	86.5 mg/L (86,5 mg/L)		30.6 mg/L (30,6 mg/L)			van den Brandhof and Montforts, 2010
Carbamazepine		N03AF01	Antiepileptics	236.2686	Acute toxicity test according to the standard AFNOR T90-301 (1996)	Daphnia magna (Crustacean)	mortality	48 h								>13.80 mg/L					Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/4-90/027F (1993)	Daphnia magna (Crustacean)	mortality	48 h				<24h (neonates)	Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.		111 mg/L						Han et al. 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686	AFNOR T90-301 (1996)	Daphnia magna (Crustacean)	mobility inhibition	48 h				< 24 h	28 cups, five daphnids in each, six concentrations and one control, four replicates			>13.8 mg/L					Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	European Guideline; EEC Directive 92/69/EEC	Daphnia magna (Crustacean)	immobilization	48 h		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L		< 24 h	Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.			>100 mg/L					Cleuvers 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	48 h								>100 mg/L					Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	OECD Guideline 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h				neonates	replicate groups of ten neonates			475 uM (112,227585 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	OECD Guideline 202 (1993)	Daphnia magna (Crustacean)	immobilization	48 h				neonates	replicate groups of ten neonates			414 uM (97,8152004 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	96 h								76.3 mg/L (76,3 mg/L)					Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686		Daucus carota (Wild carrot)	Growth (root length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Daucus carota (Wild carrot)	Growth (root length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Daucus carota (Wild carrot)	Growth (root length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686	European Guideline; EEC Directive 92/69/EEC	Desmodesmus subspicatus (Green algae)	inhibition of average growth rate	3 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Initial density; 10^4 cells/mL			74 mg/L (74 mg/L)					Cleuvers 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996)	Dunaliella tertiolecta (Phytoplankton)	cell density	96 h		25, 50, 100, 200, 400 mg/L			Initial density; approximately 50 000 cells/mL			>80.00 mg/L					DeLorenzo and Fleming 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Elliptio complanata (Freshwater mussel)	immunotoxic effect: decreased cell adherence	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						61 uM (14.4123846 mg/L)		Gagné et al. 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686		Elliptio complanata (Freshwater mussel)	immunotoxic effect: induction of phagocytosis	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						61 uM (14.4123846 mg/L)		Gagné et al. 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686		Elliptio complanata (Freshwater mussel)	immunotoxic effect: increased cell viability	24 h		0, 2.5, 25, 50, 100 uM			Hemolymphs from 10 mussels were collected and analysed						3 uM (0.7088058 mg/L)		Gagné et al. 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686		Gammarus pulex (Crustacea, amphipoda)	activity	1.5 h	nine measurements per concentration	0, 1 ng/L to 1 mg/L			24 chambers, one G. pulex in each						0.010 ug/L (0.00001 mg/L)		De Lange et al. 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Spore production	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						388.2 ug/L (0,3882 mg/L)					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Spore production	21 days		0, 10, 30, 100, 300, 1000 ug/L						43.6 ug/L (0,0436 mg/L)					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Spore production	28 days		0, 10, 30, 100, 300, 1000 ug/L						113.4 ug/L (0,1134 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/R-99/064 (2000)	Hyalella azteca (Freshwater amphipod)	survival	10 days				7-14 days	8-9 conc. 4-5 replicates and 8-15 animals in each beaker		9.9 mg/L						Dussault et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686	EPA/600/R-99/064 (2000)	Hyalella azteca (Freshwater amphipod)	growth	10 days				7-14 days	8-9 conc. 4-5 replicates and 8-15 animals in each beaker			15.0 mg/L (15 mg/L)					Dussault et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Hydra attenuata (Cnidarian)	feeding behaviour and hydranth no.	96 h		0.1-50/100mg/L			3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate			3.76 mg/L (3,76 mg/L)					Quinn et al. 2008a
Carbamazepine		N03AF01	Antiepileptics	236.2686		Hydra attenuata (Cnidarian)	morphological changes	96 h		0.1-50/100mg/L			3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate		29.4 mg/L	15.52 mg/L (15,52 mg/L)		1 mg/L (1 mg/L)	5 mg/L		Quinn et al. 2008a
Carbamazepine		N03AF01	Antiepileptics	236.2686	ISO/WD 20079 (2001), using the Steinberg-medium	Lemna minor (Duckweed)	inhibition of average growth rate	7 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Three treatment replicates and six control replicates.			25.5 mg/L (25,5 mg/L)					Cleuvers 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Lumbriculus variegatus (Oligochaeta)	Mortality	96 h		0.5, 10, 200, 4000 ug/L								>4 mg/L			Nentwig et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	Sediment assay	Lumbriculus variegatus (Oligochaeta)	Reproduction	28 days										10 mg/kg dw			Nentwig et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	cell viability: MTT metabolization	24 h					Initial density: 14 000 cells/mL into 24-well culture plates			>100 uM (23,62686 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	total protein content	48 h					Initial density: 14 000 cells/mL into 24-well culture plates			62.9 uM (14,86129494 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	cell viability: MTT metabolization	72 h					Initial density: 14 000 cells/mL into 24-well culture plates			24.6 uM (5,81220756 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	total protein content	24 h					Initial density: 14 000 cells/mL into 24-well culture plates			76.2 uM (18,00366732 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	total protein content	72 h					Initial density: 14 000 cells/mL into 24-well culture plates			33.6 uM (7,93862496 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	neutral red uptake	24 h					Initial density: 14 000 cells/mL into 24-well culture plates			>100 uM					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	neutral red uptake	48 h					Initial density: 14 000 cells/mL into 24-well culture plates			81.4 uM (19,23226404 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	cell viability: MTT metabolization	48 h					Initial density: 14 000 cells/mL into 24-well culture plates			94.2 uM (22,25650212 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	LDH activity	24 h					Initial density: 14 000 cells/mL into 24-well culture plates			72 uM (17,0113392 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	LDH activity	48 h					Initial density: 14 000 cells/mL into 24-well culture plates			67 uM (15,8299962 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	LDH activity	72 h					Initial density: 14 000 cells/mL into 24-well culture plates			38.5 uM (9,0963411 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Monkey kidney (Vero cell line)	neutral red uptake	72 h					Initial density: 14 000 cells/mL into 24-well culture plates			19 uM (4,4891034 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Oncorhynchus mykiss (Rainbow trout)	Condition factor (CF)	42 days		0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L	M+F	10-12 months old	30						2.0 mg/L		Li et al. 2009
Carbamazepine		N03AF01	Antiepileptics	236.2686		Oncorhynchus mykiss (Rainbow trout)	Changes in muscle RNA-DNA ratio	42 days		0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L	M+F	10-12 months old	30						2.0 mg/L		Li et al. 2009
Carbamazepine		N03AF01	Antiepileptics	236.2686	EROD activity test	Oncorhynchus mykiss (Rainbow trout)	inhibition	24 h				immature				318 uM (75,1334148 mg/L)					Laville et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	test on hepatocytes, cytotoxicity test, MTT assay	Oncorhynchus mykiss (Rainbow trout)	cytotoxicity	24 h		31.3-500 uM		immature				318 uM (75,1334148 mg/L)					Laville et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686		Oncorhynchus mykiss (Rainbow trout)	Antioxidant responces in muscle	42 days		0, 1.0 ug/L, 0.2 mg/L, 2.0 mg/L	M+F	10-12 months old	30						1.0 ug/L - 0.2 mg/L		Li et al. 2009
Carbamazepine		N03AF01	Antiepileptics	236.2686	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	96 h							35.4 mg/L						Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	48 h							35.4 mg/L						Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	test on hepatocytes, cytotoxicity test, MTT assay	Poeciliopsis lucida (Topminnow)	cytotoxicity	24 h		3.9-500 uM						651 uM (153,8108586 mg/L)					Laville et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686		Potamopyrgus antipodarum (Freshwater mudsnail)	No of embryos	28 days		0.4, 2, 10, 50, 250 ug/L			80					250 ug/L			Nentwig et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	Algal Growth Inhibition test	Pseudokirchneriella subcapitata	Growth inhibition rate	96 h		maximum 10mg/L						48,9 mg/L		520.6 ug/L (0,5206 mg/L)			Harada et al. 2008
Carbamazepine		N03AF01	Antiepileptics	236.2686		Pseudokirchneriella subcapitata (Green algae)	growth inhibition	96 h										>100 mg/L	>100 mg/L		Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	algal growth inhibition test	Pseudokirchneriella subcapitata (Green algae)	growth	96 h								>100,00 mg/L		>100 mg/L			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	increase in LGC354c and HGC69a probe positive cells	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	increase in beta proteobacteria and decrease in gamma proteobacteria	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	increase in fungal populations	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	increased bacterial counts (R2A media)	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	carbohydrate utility spectra	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	decrease in bacterial biomass	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686	Riverine biofilm community structure and activity	Riverine biofilm community	decrease in cyanobacterial biomass	8 weeks		10 ug/L									10 ug/L (0.01 mg/L)		Lawrence et al. 2005
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	G6PDH activity	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			853 uM (201,5371158 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	MTS metabolization	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			698 uM (164,9154828 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	LDH activity	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			>1200 uM					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	total protein content	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			832 uM (196,5754752 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	total protein content	48 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			713 uM (168,4595118 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	total protein content	72 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			933 uM (220,4386038 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	neutral red uptake	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			496 uM (117,1892256 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	LDH leakage	24 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			>1200 uM					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	neutral red uptake	72 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			495 uM (116,952957 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	MTS metabolization	48 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			608.6 uM (143,79306996 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	MTS metabolization	72 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			601.4 uM (142,09193604 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	G6PDH activity	72 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			687 uM (162,3165282 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	G6PDH activity	48 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			716.7 uM (169,33370562 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		RTG-2 cell line (Rainbow trout gonad)	neutral red uptake	48 h					Initial density: 8000 cells/well in 96-well tissue-culture plates			472.6 uM (111,66054036 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							70,7 mg/L (70.7 mg/L)	70,7 mg/L (70,7 mg/L)					Nalecz-Jawecki and Sawicki 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	algal growth inhibition test	Synechococcus leopolensis (Blue-green algae)	growth	96 h								33.60 mg/L (33,6 mg/L)		17.50 mg/L (17,5 mg/L)			Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686	Protoxkit FTM	Tetrahymena termophila (Ciliate)	growth inhibition	24 h								40,5 mg/L (40,5 mg/L)					Nalecz-Jawecki and Sawicki 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			43.0 mg/L (43 mg/L)					Nalecz-Jawecki and Persoone 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			140 mg/L						Nalecz-Jawecki and Persoone 2006
Carbamazepine		N03AF01	Antiepileptics	236.2686		Vibrio fischeri (Bacteria)	bioluminescence	15 min								332 uM (78,4411752 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686		Vibrio fischeri (Bacteria)	bioluminescence	5 min								370 uM (87,419382 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	15 min								52.5 mg/L (52,5 mg/L)					Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	AFNOR T90-320-3 (1999)	Vibrio fischeri (Bacteria)	luminescence	30 min								>81 mg/L					Ferrari et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	5 min								52.5 mg/L (52,5 mg/L)					Kim et al. 2007
Carbamazepine		N03AF01	Antiepileptics	236.2686	Microtox test according to the standard AFNOR T90-320-3 (1999)	Vibrio fischeri (Bacteria)	luminescence	30 min								>81.00 mg/L					Ferrari et al. 2004
Carbamazepine		N03AF01	Antiepileptics	236.2686		Vibrio fischeri (Bacteria)	bioluminescence	60 min								272 uM (64,2650592 mg/L)					Jos et al. 2003
Carbamazepine		N03AF01	Antiepileptics	236.2686	Microtox	Vibro fischeri	bioluminescence inhibition	15 min		maximum 10mg/L						28,3 mg/L					Harada et al. 2008
Cefazolin	Cefazolin Na	J01DB04	Antibacterial agents		OECD (1993) no 201	Selenastrum capricornutum (Freshwater green algae)	growth inhibition			5 concentrations, triplicates						>1000 mg/L		>1000 mg/L			Eguchi et al. 2004
Ceftriaxon	disodium	J01DD04	Antibacterial agents	554.5799	Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Ceftriaxon	disodium	J01DD04	Antibacterial agents	554.5799	OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Cefuroxime	sodium	J01DA06	Antibacterial agents	424.3853	Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Cefuroxime	sodium	J01DA06	Antibacterial agents	424.3853	OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Celecoxib		M01AH01	Anti-inflammatory and anti-reumatic agents		EPA 1000.2	Ceriodaphnia dubia	Survival	7 days		0.0021 - 1.6 mg/L	F				>1.6 mg/L			1.6 mg/L (1,6 mg/L)			Constantine and Huggett, 2010
Celecoxib		M01AH01	Anti-inflammatory and anti-reumatic agents		EPA 1000.2	Ceriodaphnia dubia	Reproduction	7 days		0.0021 - 1.6 mg/L	F							0.17 mg/L (0,17 mg/L)	0.48 mg/L		Constantine and Huggett, 2010
Celecoxib		M01AH01	Anti-inflammatory and anti-reumatic agents		OECD 211	Daphnia magna (Crustacean)	Survival	21 days		0.026 - 1 mg/L	F				>0.89 mg/L			0.062 mg/L (0,062 mg/L)			Constantine and Huggett, 2010
Celecoxib		M01AH01	Anti-inflammatory and anti-reumatic agents		OECD 211	Daphnia magna (Crustacean)	Reproduction	21 days		0.026 - 1 mg/L	F							0.062 mg/L (0,062 mg/L)	0.14 mg/L		Constantine and Huggett, 2010
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							6320 umol/L (2042.177808 mg/L)						Calleja et al. 1994 (a)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Artemia salina (Crustacea)	Immobilization	24 h								2039 mg/L					Callejaa et al. 1993
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							3.8 umol/L						Calleja et al. 1994 (b)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Bacterial community	Inhibation of bacterial protein biosynthesis									3.388 umol/L		0.212 umol/L			Brosche and Backhaus, 2010
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Bacterial community	Inhibation of bacterial protein biosynthesis									5.698 umol/L		0.074 umol/L			Brosche and Backhaus, 2010
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Brachionus calyciflorus (Rotifera)	Immobilization	24 h								2086 mg/L					Callejaa et al. 1993
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							3.81 umol/L						Calleja et al. 1994 (b)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							6420 umol/L (2074.490748 mg/L)						Calleja et al. 1994 (a)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						1.68 mM					Lilius et al. 1995
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								3.53 umol/L					Calleja et al. 1994 (b)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								3360 umol/L (1085,714784 mg/L)					Calleja et al. 1994 (a)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	EPA 821/R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	48 h				<24h				372.4 mg/L (372,4 mg/L)					Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	EPA 821/R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	96 h				<24h				81.2 mg/L (81,2 mg/L)					Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			1.68 mM (542,857392 mg/L)					Lilius et al. 1994
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	EPA 821/R-02-012 (2002)	Moina macrocopa (Crustacean)	immobilization	48 h				<24h				511.5 mg/L (511,5 mg/L)					Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	EPA 821/R-02-012 (2002)	Moina macrocopa (Crustacean)	immobilization	96 h				<24h				273.3 mg/L (273,3 mg/L)					Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			0.011 mM (3,5544234 mg/L)					Lilius et al. 1994
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD (1992) no 203	Oryzias latipes (Japanese medaka)	mortality	96 h				12 +/- 2d posthatch			>1000 mg/L						Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	OECD (1992) no 203	Oryzias latipes (Japanese medaka)	mortality	48 h				12 +/- 2d posthatch			>1000 mg/L						Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								5310 umol/L (1715,817114 mg/L)					Calleja et al. 1994 (a)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Microtox test	Photobacterium phosphoreum (Bacteria)	Luminescence inhibition	5 min								3.72 umol/L					Calleja et al. 1994 (b)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							707 mg/L	707 mg/L (707 mg/L)					Nalecz-Jawecki and Sawicki 2003
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							2.97 umol/L						Calleja et al. 1994 (b)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Streptocephalus proboscideus (Crustacea)	Immobilization	24 h								302 mg/L					Callejaa et al. 1993
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							943 umol/L (304.7110242 mg/L)						Calleja et al. 1994 (a)
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Protoxkit FTM	Tetrahymena termophila (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h								53,3 mg/L (53,3 mg/L)					Nalecz-Jawecki and Sawicki 2003
Chloramphenicol		J01BA01	Antibacterial agents	323.1294		Vibrio fischeri	Bioluminescence inhibition	24 h								0.16 mg/L					Thomulka et al. 1993
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	ISO/CD 11348 (1994) with minor modifications	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h		16 test concentrations						0.06 mg/L (0,06 mg/L)					Backhaus et al. 1997
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Standard test, bacterial toxicity	Vibrio fischeri (Bacteria)	inhibition	15 min									537.5 mg/L				Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Standard test, bacterial toxicity	Vibrio fischeri (Bacteria)	inhibition	5 min									598.0 mg/L				Choi et al. 2008
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	Chronic bioluminescence assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h								0.0643 mg/L (0,0643 mg/L)					Backhaus and Grimme 1999
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	ISO/CD 11348 (1994)	Vibrio fischeri (Bacteria)	bioluminescence inhibition	30 min		16 test concentrations						80.1 mg/L (80,1 mg/L)					Backhaus et al. 1997
Chloramphenicol		J01BA01	Antibacterial agents	323.1294	ISO/CD 11348 (1994)	Vibrio fischeri (Bacteria)	bioluminescence inhibition	30 min		16 test concentrations						19.9 mg/L (19,9 mg/L)					Backhaus et al. 1997
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							3.6umol/L						Calleja et al. 1994 (b)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							3960 umol/L (1266.693516 mg/L)						Calleja et al. 1994 (a)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							8.5 umol/L (2.71891285 mg/L)						Calleja et al. 1994 (a)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	Mortality	24 h							0.8 umol/L						Calleja et al. 1994 (b)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.096 mM (30,7077216 mg/L)					Lilius et al. 1994
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								84.3 umol/L (26,96521803 mg/L)					Calleja et al. 1994 (a)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								1.92 umol/L					Calleja et al. 1994 (b)
Chloroquine	P01BA01	P01BA01	Antiprotozoals	319.8721		Glycine max (Soybean)	inhibited growth	13 days		0, 2, 4, 8 and 16 mg/g soil			15 (3 per concentration)	Through soil				2 mg/g	4 mg/g		Jjemba 2002
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			40.66 mM (13005,999586 mg/L)					Lilius et al. 1994
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Microtox test	Photobacterium phosphoreum (Bacteria)	Luminescence inhibition	5 min								3.22 umol/L					Calleja et al. 1994 (b)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								1680 umol/L (537,385128 mg/L)					Calleja et al. 1994 (a)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							22.6 umol/L (7.22910946 mg/L)						Calleja et al. 1994 (a)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							1.34 umol/L						Calleja et al. 1994 (b)
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			6.40 mg/L (6,4 mg/L)					Nalecz-Jawecki and Persoone 2006
Chloroquine	Chloroquine phosphate	P01BA01	Antiprotozoals	319.8721	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			4.70 mg/L						Nalecz-Jawecki and Persoone 2006
Chlorpromazine	Chlorpromazine HCl	N05AA01	Psycholeptics	318.8642	ISO/WD 20079 (2001)	Lemna minor (Duckweed)	growth inhibition	7 days				Initially three or four fronds	Six-well plates, one plant in each well, three replicates			0.92 mg/L (0,92 mg/L)					Kaza et al. 2007
Chlorpromazine	Chlorpromazine HCl	N05AA01	Psycholeptics	318.8642	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			0.38 mg/L						Nalecz-Jawecki and Persoone 2006
Chlorpromazine	Chlorpromazine HCl	N05AA01	Psycholeptics	318.8642	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			1.60 mg/L (1,6 mg/L)					Nalecz-Jawecki and Persoone 2006
Chlortetracycline	hydrochloride	J01AA03	Antibacterial agents		Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Chlortetracycline	hydrochloride	J01AA03	Antibacterial agents		OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							10-100 mg/L				Kümmerer K. et al. 2004
Chlortetracycline		J01AA03	Antibacterial agents			Bacterial community	Inhibation of bacterial protein biosynthesis									0.496 umol/L		0.01 umol/L			Brosche and Backhaus, 2010
Chlortetracycline		J01AA03	Antibacterial agents			Bacterial community	Inhibation of bacterial protein biosynthesis									0.138 umol/L		<0.01 umol/L			Brosche and Backhaus, 2010
Chlortetracycline		J01AA03	Antibacterial agents		US EPA-821-R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	24 h				<24h	four replicates of five organisms			380 mg/L (380 mg/L)					Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		US EPA-821-R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	48 h				<24h	four replicates of five organisms			225 mg/L (225 mg/L)					Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						950.6 ug/L (0,9506 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						575 ug/L (0,575 mg/L)					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						552.8 ug/L (0,5528 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						147 ug/L (0,147 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	21 days		0, 10, 30, 100, 300, 1000 ug/L						358.6 ug/L (0,3586 mg/L)					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						885.7 ug/L (0,8857 mg/L)					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	28 days		0, 10, 30, 100, 300, 1000 ug/L						734.5 ug/L (0,7345 mg/L)					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						397.5 ug/L (0,3975 mg/L)					Hillis et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents		ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			219 ug/L (0,219 mg/L)			100 ug/L (0.1 mg/L)		Brain et al. 2004 (a)
Chlortetracycline		J01AA03	Antibacterial agents		ISO 8692 (1989), modified version	Microcystis aeruginosa (Freshwater cyanobacteria)	growth inhibition	7 days		0.002-10 mg/L			Initial density; 2*10^4 cells/mL			0.05 mg/L (0,05 mg/L)					Halling-Sorensen 2000
Chlortetracycline		J01AA03	Antibacterial agents		US EPA-821-R-02-012 (2002)	Moina macrocopa (Crustacean)	immobilization	48 h				<24h	four replicates of five organisms			272 mg/L (272 mg/L)					Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		US EPA-821-R-02-012 (2002)	Moina macrocopa (Crustacean)	immobilization	24 h				<24h	four replicates of five organisms			515 mg/L (515 mg/L)					Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		OECD guideline 203 (1993)	Oryzias latipes (Japanese medaka)	mortality	96 h				10-14 days post hatch	four replicates of five fish each		78.9 mg/L						Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		OECD guideline 203 (1993)	Oryzias latipes (Japanese medaka)	mortality	48 h				10-14 days post hatch	four replicates of five fish each		88.4 mg/L						Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		OECD 201(2006) with minor modifications	Pseudokirchnerella subcapitata	Growth inhibition	72 h		250-8000 ug/L							1800 ug/L (1.8 mg/L)	500 ug/L (0,5 mg/L)	1000 ug/L (1 mg/L)		Yang et al. 2008
Chlortetracycline		J01AA03	Antibacterial agents		ISO 8692 (1989), modified version	Selenastrum capricornutum (Freshwater green algae)	growth inhibition	3 days		0.005-10 mg/L			Initial density; 1*10^4 cells/mL			3.1 mg/L (3,1 mg/L)					Halling-Sorensen 2000
Chlortetracycline		J01AA03	Antibacterial agents		Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	15 min									13 mg/L				Park and Choi 2008
Chlortetracycline		J01AA03	Antibacterial agents		Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	5 min									>20 mg/L				Park and Choi 2008
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	48 h								379.7 mg/L (379,7 mg/L)					Kim et al. 2007
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	96 h								271.3 mg/L (271,3 mg/L)					Kim et al. 2007
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	96 h							>100 mg/L						Kim et al. 2007
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	48 h							>100 mg/L						Kim et al. 2007
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	15 min								375.9 mg/L (375,9 mg/L)					Kim et al. 2007
Cimetidine		A02BA01	Drugs for acid related disorders	252.3392	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	5 min								458.9 mg/L (458,9 mg/L)					Kim et al. 2007
Cinoxacin		J01MB06	Antibacterial agents		Long-term bioluminescence inhibition assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h		At least 16 different concentrations						116.95 ug/L (0,11695 mg/L)		26.22 ug/L (0,02622 mg/L)			Backhaus et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											0,005		Hartmann et al. 1998
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	Genotoxicity assay (umuC test)	Bacteria	Genetoxicity	30 min											5.9 ug/L (0.0059 mg/L)		Hartmann et al. 1999
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	OECD 203 (1992)	Brachydanio rerio (zebrafish)				30 and 100 mg/L								100 mg/L (100 mg/L)			Halling-Sorensen et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	OECD 202 (1984)	Daphnia magna (Crustacean)				30 and 60 mg/L								60 mg/L (60 mg/L)			Halling-Sorensen et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			697 ug/L (0,697 mg/L)			300 ug/L (0.3 mg/L)		Brain et al. 2004 (a)
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415		Lemna minor (Duckweed)	reproduction	7 days		four different concentrations			10-15 fronds, triplicate experiments with four concentrations and a control			203 ug/L (0,203 mg/L)					Robinson et al. 2005
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415		Microcystis aeruginosa (Freshwater cyanobacteria)	growth and reproduction	5 days		five different concentrations						17 ug/L (0,017 mg/L)					Robinson et al. 2005
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415		Microcystis aeruginosa (Freshwater cyanobacteria)										0.005 mg/L (0,005 mg/L)					Halling-Sorensen et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	OECD 201(2006) with minor modifications	Pseudokirchnerella subcapitata	Growth inhibition	72 h		5000-20000 ug/L							6700 ug/L (6.7 mg/L)	<500 ug/L	5000 ug/L (5 mg/L)		Yang et al. 2008
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415		Pseudokirchneriella subcapitata (Green algae)	growth and reproduction	3 days		five different concentrations						18 700 ug/L (18,7 mg/L)					Robinson et al. 2005
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	ISO 17 012 (1995), modified	Pseudomonas putida (Bacteria)	growth inhibition									80 ug/L (0,08 mg/L)					Kümmerer et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	OECD.201 (1984)	Selenastrum capricornutum (Freshwater green algae)										2.97 mg/L (2,97 mg/L)					Halling-Sorensen et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415	ISO 15522 (1998)	Sludge bacteria										0.61 mg/L (0,61 mg/L)					Halling-Sorensen et al. 2000
Ciprofloxacin		J01MA02	Antibacterial agents	331.3415		Stream microbial communities	microbial respiration	12 days		1.0, 10, 100.0 ug/L (nominal conc.)			Two leaf disks in each experimental chamber						100 ug/L (0.1 mg/L)		Maul et al. 2006
Cisplatin		L01XA01	Antineoplastic agents		Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											1,25		Hartmann et al. 1998
Cisplatin		L01XA01	Antineoplastic agents		ISO 6341:1996 (with modifications)	Daphnia magna (Crustacean)	Immobilization	48 h				less than 24 h old	20 per concentration			0,64 mg/L		0,2 mg/L	0.5 mg/L		Zounkova et al. 2007
Cisplatin		L01XA01	Antineoplastic agents		SOS-Chromotest	Escherichia coli (Bacteria)	Genotoxicity	4 h											0.09 mg/L		Zounkova et al. 2007
Cisplatin		L01XA01	Antineoplastic agents		ISO 8692:1989, DIN 38412	Pseudokirchneriella subcapitata (Freshwater green alga)	Growth inhibition	72 h								2,3 mg/L		0,1 mg/L	1 mg/L		Zounkova et al. 2007
Cisplatin		L01XA01	Antineoplastic agents		ISO 10712:1995	Pseudomonas putida (Bacteria)	Growth inhibition									1,2 mg/L		0,03 mg/L	0.1 mg/L		Zounkova et al. 2007
Cisplatin		L01XA01	Antineoplastic agents		GreenScreen assay	Saccharomyces cerevisiae (Yeast cells)	Genotoxicity	16 h											0.44 mg/L		Zounkova et al. 2007
Citalopram		N06AB04	Psychoanaleptics	324.3919	EPA/600/4-90/027F (1993)	Ceriodaphnia dubia (Crustacean cladocera)	mortality	48 h		0.59-7.84 mg/L		< 24 h	Five treatment concentrations, 20 neonates (4 cups) were exposed to each treatment concentration and the control.		3.90 mg/L						Henry et al. 2004
Citalopram		N06AB04	Psychoanaleptics	324.3919	EPA/600/4-91/002 (1994)	Ceriodaphnia dubia (Crustacean cladocera)	reproduction inhibition	7-8 days				< 24 h	Five treatment concentrations, each treatment and the control had ten replicates, each replicate consisted of one neonate.					0.80 mg/L (0,8 mg/L)	4.00 mg/L		Henry et al. 2004
Citalopram		N06AB04	Psychoanaleptics	324.3919	ISO 6341 (1989), except for the test media; OECD guideline 211, Daphnia magna reproduction test. (2006)	Daphnia magna (Crustacean)	immobilization	48 h				< 24 h	Five animals were used for each of four replicates per concentration and 20-40 animals in the control group			20 mg/L (20 mg/L)					Christensen et al. 2007
Citalopram		N06AB04	Psychoanaleptics	324.3919		Oncorhynchus mykiss (Rainbow trout)	decrease in aggressive behavior and stress responsiveness	7 days		0, 100 ug/kg		2 years old	16	Through food						100 ug/kg	Lepage et a.l 2005
Citalopram		N06AB04	Psychoanaleptics	324.3919	A miniscale algal toxicity test. P. Arensberg et al. (1995). Chem. 30, 2103-2115	Pseudokirchneriella subcapitata (Green algae)	algal growth inhibition	48 h					Initial density; 10^4 cells/mL			1.6 mg/L (1,6 mg/L)					Christensen et al. 2007
Clarithromycin		J01FA09	Antibacterial agents	747.9534	OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	24 h		(0,001-750 mg/L)							10-100 mg/L				Kümmerer K. et al. 2004
Clarithromycin		J01FA09	Antibacterial agents	747.9534	Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Clarithromycin		J01FA09	Antibacterial agents	747.9534	ISO/CD 20666 (2001)	Brachionus calyciflorus (Rotifera)	population growth inhibition	48 h					24-well microplates, one rotifer placed into each well, four replicates per concentration			12.21 mg/L (12,21 mg/L)					Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534	ASTM E1440-91 (1991)	Brachionus calyciflorus (Rotifera)	mortality	24 h				juveniles (0-2 h)	Five test dilutions with six replicates of five animals		35.46 mg/L						Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534	USEPA, EPA-600-4-90-027F (1993)	Ceriodaphnia dubia (Crustacean cladocera)	immobilization	48 h				<24h	24-well plates, ten animals per well, three replicates per concentration			18.66 mg/L (18,66 mg/L)					Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534	ISO/CD 20665 (2001)	Ceriodaphnia dubia (Crustacean cladocera)	population growth inhibition	7 days		seven different concentrations		<24h		Exposed individually		8.16 mg/L (8,16 mg/L)					Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534	ISO/6341 (1996)	Daphnia magna Straus (Crustacean)	immobilization	24 h				<24h	Five daphnids per vessel, four replicates for each of five concentrations			25.72 mg/L (25,72 mg/L)					Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534	OECD 201(2006) with minor modifications	Pseudokirchnerella subcapitata	Growth inhibition	72 h		5-160 ug/L							46 ug/L (0.046 mg/L)	<40 ug/L	40 ug/L (0.04 mg/L)		Yang et al. 2008
Clarithromycin		J01FA09	Antibacterial agents	747.9534	Algal Growth Inhibition test	Pseudokirchneriella subcapitata	Growth inhibition rate	96 h		maximum 10mg/L						0,012 mg/L		5.2 ug/L (0,0052 mg/L)			Harada et al. 2008
Clarithromycin		J01FA09	Antibacterial agents	747.9534	ISO/DIS 8692 (1989)	Pseudokirchneriella subcapitata (Green algae)	growth inhibition	72 h		five different concentrations			Initial density was in the order of 10^4 cells/mL			0.0020 mg/L (0,002 mg/L)					Isidori et al. 2005b
Clarithromycin		J01FA09	Antibacterial agents	747.9534		Thamnocephalus platyurus (Crustacean)	mortality	24 h				second- and third-instar fairy shrimp larvae	24-well plates, ten animals per well, three replicates per concentration		33.64 mg/L						Isidori et al. 2005b
Clindamycin		G01AA10	Gynecological antiinfectives and antiseptics		Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Clindamycin		G01AA10	Gynecological antiinfectives and antiseptics		OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Clofibrate		C10AB01	Blood lipid lowering agents			Oncorhynchus mykiss (Rainbow trout)	kidney, ultrastructural effects	28 days		1, 5, 20, 50, 100 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						>100 ug/L		Triebskorn et al. 2007
Clofibrate		C10AB01	Blood lipid lowering agents			Oncorhynchus mykiss (Rainbow trout)	liver, ultrastructural effects	28 days		1, 5, 20, 50, 100 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						>100 ug/L		Triebskorn et al. 2007
Clofibrate		C10AB01	Blood lipid lowering agents			Oncorhynchus mykiss (Rainbow trout)	gills, ultrastructural effects	28 days		1, 5, 20, 50, 100 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						5 ug/L (0.005 mg/L)		Triebskorn et al. 2007
Clofibrate		C10AB01	Blood lipid lowering agents		Alamar Blue assay	RTL-W1 (Rainbow trout liver cell line)	change in energy metabolism (cytotoxicity)	24 h		five-six different concentrations						21.8 uM					Schnell et al. 2009
Clofibrate		C10AB01	Blood lipid lowering agents		CFDA-AM assay	RTL-W1 (Rainbow trout liver cell line)	decrease in membrane integrity (cytotoxicity)	24 h		five-six different concentrations						24.4 uM					Schnell et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Microalgal communities (Periphyton)	Inhibition of sterol biosynthesis												50 pmol/L		Porsbring et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Microalgal communities (Periphyton)	Pigment composition											10 nmol/L			Porsbring et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Microalgal communities (Periphyton)	Xanthophyll cycle pigment ratio											5 pmol/L			Porsbring et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Microalgal communities (Periphyton)	Chlorophyll a content											10 nmol/L	500 pmol/L		Porsbring et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Xenopus tropicalis (Frog)	aromatase activity in brain			6, 41, 375 nM		Tadpoles							375 nM		Gyllenhammar et al. 2009
Clotrimazole		D01AC01	Antifungals for dermatological use			Xenopus tropicalis (Frog)	aromatase activity in gonad/kidney			6, 41, 375 nM	F+M	Tadpoles							41 nM		Gyllenhammar et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents			Aterias rubens (sea star)	increase in righting time	7 days		18, 32, 56 mg/L			4 per concentration						32 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents		Mn assay	Aterias rubens (sea star)	increase in micronuclei induction (cytogenetic damage) (per 1000 cells)	7 days		18, 32, 56 mg/L									18 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents		Comet assay	Aterias rubens (sea star)	increase in DNA strand breaks (% tail DNA)	7 days		18, 32, 56 mg/L									18 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents			Aterias rubens (sea star)	mortality	7 days		18, 32, 56 mg/L									56 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents		ISO 6341:1996 (with modifications)	Daphnia magna (Crustacean)	Immobilization	48 h				less than 24 h old	20 per concentration			>1000 mg/L		>1000 mg/L	>1000 mg/L		Zounkova et al. 2007
Cyclophosphamide		L01AA01	Antineoplastic agents		Mn assay	Mytilus edulis (blue mussel)	increase in micronuclei induction (cytogenetic damage) (per 1000 cells)	7 days		18, 32, 56, 100, 180 mg/L									18 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents		Comet assay	Mytilus edulis (blue mussel)	increase in DNA strand breaks (% tail DNA)	7 days		18, 32, 56, 100, 180 mg/L									18 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents			Mytilus edulis (blue mussel)	mortality	7 days		18, 32, 56, 100, 180 mg/L									>180 mg/L		Canty et al. 2009
Cyclophosphamide		L01AA01	Antineoplastic agents		ISO 8692:1989, DIN 38412	Pseudokirchneriella subcapitata (Freshwater green alga)	Growth inhibition	72 h								930 mg/L		250 mg/L	500 mg/L		Zounkova et al. 2007
Cyclophosphamide		L01AA01	Antineoplastic agents		ISO 10712:1995	Pseudomonas putida (Bacteria)	Growth inhibition									>1000 mg/L		1000 mg/L	>1000 mg/L		Zounkova et al. 2007
Cyclophosphamide		L01AA01	Antineoplastic agents		GreenScreen assay	Saccharomyces cerevisiae (Yeast cells)	Genotoxicity	16 h											470 mg/L		Zounkova et al. 2007
Cycloserine		J04AB01	Antimycobacterials		Chronic bioluminescence assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h								65.5 mg/L (65,5 mg/L)					Backhaus and Grimme 1999
Cytarabine		L01BC01	Antineoplastic agents		ISO 6341:1996 (with modifications)	Daphnia magna (Crustacean)	Immobilization	48 h				less than 24 h old	20 per concentration			200 mg/L			100 mg/L		Zounkova et al. 2010
Cytarabine		L01BC01	Antineoplastic agents		OECD 211: 1998 (with modifications)	Daphnia magna (Crustacean)	Reproduction	21 days								10 mg/L			3.7 mg/L		Zounkova et al. 2010
Cytarabine		L01BC01	Antineoplastic agents		ISO 8692:1989, DIN 38412	Desmodesmus subspicatus (Green algae)	Growth inhibition	72 h					100 000 cells /mL in 24 wells			53 mg/L			40 mg/L		Zounkova et al. 2010
Cytarabine		L01BC01	Antineoplastic agents		ISO 10712:1995	Pseudomonas putida (Bacteria)	Growth inhibition									17 mg/L			10 mg/L		Zounkova et al. 2010
Cytarabine		L01BC01	Antineoplastic agents		ISO/FDIS 13829, DIN 38415-3	Salmonella choleraesius subsp. chol.	Genotoxicity	4 h											167 mg/L		Zounkova et al. 2010
Dacarbazine		L01AX04	Antineoplastic agents		Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											>1		Hartmann et al. 1998
Dexamethasone		H02AB02	Corticosteroids for systemic use	392.4611	ASTM, E1440-91 (1991)	Brachionus calyciflorus (Rotifera)	mortality	24 h				0-2 h (juveniles)	36-well plates with five rotifers per well, six replicates for each of the five conc.		48.22 mg/L						DellaGreca et al. 2004
Dexamethasone		H02AB02	Corticosteroids for systemic use	392.4611	ISO/CD 20665 (2001)	Ceriodaphnia dubia (Crustacean cladocera)	population growth inhibition	7 days				<24h (juveniles)	Exposed individually to seven concentrations, ten replicates per conc.			0.05 ppm					DellaGreca et al. 2004
Dexamethasone		H02AB02	Corticosteroids for systemic use	392.4611	ISO 6341 (1996)	Daphnia magna (Crustacean)	immobilization	24 h				<24h (juveniles)	Five daphnids per vessel, four replicates for each of the five conc.			48.30 mg/L (48,3 mg/L)					DellaGreca et al. 2004
Dexamethasone		H02AB02	Corticosteroids for systemic use	392.4611		Thamnocephalus platyurus (Crustacean)	mortality	24 h				second- and third-instar fairy larvae	24-well plates, ten organisms per well, three replicates for each of the five conc.		60.11 mg/L						DellaGreca et al. 2004
Dextropropoxyphene	HCI	N02AC54	Analgesic		OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						0.05576 mM					Lilius et al. 1995
Dextropropoxyphene	HCI	N02AC54	Analgesic		OECD 202 (1993)	Daphnia pulex (Crustacean)	immobilization	24 h		5 concentrations						0.05644 mM					Lilius et al. 1995
Diazepam		N05BA01	Psycholeptics	284.7402		Artemia parthenogenetica (Hypersaline crustacean)	oxidative stress biomarker: increase in glutathione peroxidase activity	48 h		4.07, 4.89, 5.86, 7.04, 8.44 mg/L		<24h	100 animals per replicate and treatment						6.13 mg/L		Nunes et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402		Artemia parthenogenetica (Hypersaline crustacean)	oxidative stress biomarker: decrease in TBARS content	48 h		4.07, 4.89, 5.86, 7.04, 8.44 mg/L		<24h	100 animals per replicate and treatment						7.04 mg/L		Nunes et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402		Artemia parthenogenetica (Hypersaline crustacean)	oxidative stress biomarker: inhibition of ChE	48 h		4.07, 4.89, 5.86, 7.04, 8.44 mg/L		<24h	100 animals per replicate and treatment						7.04 mg/L		Nunes et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402	Modified OECD test 202	Artemia parthenogenetica (Hypersaline crustacean)	mortality	48 h		6.25, 12.5, 25, 50, 100 mg/L		<24h	10 specimens per replicate, three replicates per concentration		12.2 mg/L						Nunes et al. 2005
Diazepam		N05BA01	Psycholeptics	284.7402		Artemia salina (Crustacea)	Immobilization	24 h								63,7 mg/L					Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	Mortality	24 h							2.35 umol/L						Calleja et al. 1994 (b)
Diazepam		N05BA01	Psycholeptics	284.7402	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							230 umol/L (65.490246 mg/L)						Calleja et al. 1994 (a)
Diazepam		N05BA01	Psycholeptics	284.7402	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							>35100 umol/L (9994.38102 mg/L)						Calleja et al. 1994 (a)
Diazepam		N05BA01	Psycholeptics	284.7402		Danio rerio (Zebrafish)	Increased activity	3 days		0, 273 ng/l, 273 ug/L		Embryo	15. Six replicates.						273 ug/L (0.273 mg/L)		Oggier et al. 2010
Diazepam		N05BA01	Psycholeptics	284.7402		Danio rerio (Zebrafish)	Changes in gene expression of circadian rhythm	14 days		0, 273 ng/l, 273 ug/L	M	Adult	20. Four replicates.						273 ng/L (0.000237 mg/L)		Oggier et al. 2010
Diazepam		N05BA01	Psycholeptics	284.7402	OECD 202, 1984	Daphnia magna (Crustacean)	Immobility	24 h								1.69 umol/L					Calleja et al. 1994 (b)
Diazepam		N05BA01	Psycholeptics	284.7402	OECD 202 (1993)	Daphnia magna (Crustacean)	immobilization	24 h		5 concentrations						0.015 mM					Lilius et al. 1995
Diazepam	Formulation	N05BA01	Psycholeptics	284.7402		Daphnia magna (Crustacean)	Mortality								14.1 mg/L						Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402		Daphnia magna (Crustacean)	Immobilization	24 h								13,9 mg/L					Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402		Daphnia magna (Crustacean)	Mortality								4.2 mg/L						Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								49.5 umol/L (14,0946399 mg/L)					Calleja et al. 1994 (a)
Diazepam		N05BA01	Psycholeptics	284.7402	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.015 mM (4,271103 mg/L)					Lilius et al. 1994
Diazepam		N05BA01	Psycholeptics	284.7402		Daphnia magna (Crustacean)	Immobilization									4,3 mg/L					Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402	OECD 202 (1993)	Daphnia pulex (Crustacean)	immobilization	24 h		5 concentrations						0.042 mM					Lilius et al. 1995
Diazepam		N05BA01	Psycholeptics	284.7402	Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984)	Gambusia holbrooki (Euryhaline fish)	alteration of pigmentation and surface swimming	96 h		4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.)	M	2-2.5 cm long	Ten individually exposed fish per treatment, three replicates						4.26 mg/L		Nunes et al. 2008
Diazepam		N05BA01	Psycholeptics	284.7402	Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984)	Gambusia holbrooki (Euryhaline fish)	major behavioural changes and increase of the swim bladder size	96 h		4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.)	M	2-2.5 cm long	Ten individually exposed fish per treatment, three replicates						7.36 mg/L		Nunes et al. 2008
Diazepam		N05BA01	Psycholeptics	284.7402	Modified OECD 203 (1984)	Gambusia holbrooki (Euryhaline fish)	mortality	96 h		5.21, 7.29, 10.2, 14.28, 20 mg/L	F+M	2-2.5 cm long		Exposed individually	12.7 mg/L						Nunes et al. 2005
Diazepam		N05BA01	Psycholeptics	284.7402		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 72h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Diazepam		N05BA01	Psycholeptics	284.7402		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 48h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Diazepam		N05BA01	Psycholeptics	284.7402		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 24h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Diazepam		N05BA01	Psycholeptics	284.7402		Hydra vulgaris (Cnidarian)	clubbed tentacles, body slightly contracted	7 days		10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Diazepam		N05BA01	Psycholeptics	284.7402		Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			2.314 mM (658,8888228 mg/L)					Lilius et al. 1994
Diazepam		N05BA01	Psycholeptics	284.7402	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								>35000 umol/L (9965,907 mg/L)					Calleja et al. 1994 (a)
Diazepam		N05BA01	Psycholeptics	284.7402	MTT assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.363 mM (103,3606926 mg/L)					Caminada et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402	NR assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.440 mM (125,285688 mg/L)					Caminada et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402	MTT assay	RTG-2 cell line (Rainbow trout gonad)	cell viability	24 h					3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.604 mM (171,9830808 mg/L)					Caminada et al. 2006
Diazepam		N05BA01	Psycholeptics	284.7402	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							362 umol/L (103.0759524 mg/L)						Calleja et al. 1994 (a)
Diazepam		N05BA01	Psycholeptics	284.7402	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	Mortality	24 h							2.55 umol/L						Calleja et al. 1994 (b)
Diazepam		N05BA01	Psycholeptics	284.7402		Streptocephalus proboscideus (Crustacea)	Immobilization	24 h								101 mg/L					Callejaa et al. 1993
Diazepam		N05BA01	Psycholeptics	284.7402	Modified OECD 201 (1984)	Tetraselmis chuii (Marine algae)	growth inhibition	96 h		7.9, 11.85, 17.78, 26.67, 40 mg/L							16.5 mg/L				Nunes et al. 2005
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Rotoxkit according to the standard AFNOR T90-377 (2000)	Brachionus calyciflorus (Rotifera)	reproduction	48 h										12.5 mg/L (12,5 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	AFNOR T90-377 (2000)	Brachionus calyciflorus (Rotifera)	reproduction inhibition	48 h				newly hatched	48 rotifers; five concentrations and one control, eight replicates					12.5 mg/L (12,5 mg/L)	25 mg/L		Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Chronic toxicity test according to the standard AFNOR T90-376 (2000)	Ceriodaphnia dubia (Crustacean cladocera)	reproduction	7 days										1,0 mg/L (1 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	EPA 600/4_90/027 (1991)	Ceriodaphnia dubia (Crustacean cladocera)	mortality	48 h								22.704 mg/L (22,704 mg/L)					Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	AFNOR T90-376 (2000)	Ceriodaphnia dubia (Crustacean cladocera)	reproduction inhibition	7 days				< 24 h						1 mg/L (1 mg/L)	2 mg/L		Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	EPA 600/4_90/027 (1991)	Ceriodaphnia dubia (Crustacean cladocera)	mobility inhibition	48 h				< 24 h	28 cups, five daphnids in each, six concentrations and one control, four replicates			22.7 mg/L (22,7 mg/L)					Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	algal growth inhibition test	Cyclotella meneghiniana (Diatom)	growth	96 h								19.24 mg/L (19,24 mg/L)		10.0 mg/L (10 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	ISO 12890 (1999)	Danio rerio (Zebrafish)	embryos and larvae mortality	10 days				embryos, larvae	50 embryos					4 mg/L (4 mg/L)	8 mg/L		Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	10-d early life stage test according to ISO 12890 (1999)	Danio rerio (Zebrafish)	mortality	10 days				fish embryo						4,0 mg/L (4 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	OECD protocol "Fish Embryo Toxicity"	Danio rerio (Zebrafish)	Developmental effects	72 h				Embryo (2 hours old)			7.8 mg/L	5.3 mg/L (5,3 mg/L)		1.5 mg/L (1,5 mg/L)			van den Brandhof and Montforts, 2010
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	OECD guideline 202 (2004)	Daphnia magna (Crustacean)	immobilization	48 h		0, 10, 20, 30, 40, 50, 60, 75, 100, 125, 150 mg/L		<24 h	20 per concentration			39.9 mg/L (39,9 mg/L)					Haap et al. 2008
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Daphnia magna (Crustacean)	hsp70-level	48 h		0, 5, 10, 20, 30, 40, 50 mg/L		12-19 days						30 mg/L (30 mg/L)	40 mg/L		Haap et al. 2008
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Acute toxicity test according to the standard AFNOR T90-301 (1996)	Daphnia magna (Crustacean)	mortality	48 h								22.430 mg/L (22,43 mg/L)					Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	EPA/600/4-91/002 (1994)	Daphnia magna (Crustacean)	reproduction inhibition	21 days		0.1-80 mg/L		<24h (neonates)	Five replicates, containing one organism per test chamber, were exposed to nine conc and a control.					10 mg/L (10 mg/L)			Han et al. 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	EPA/600/4-90/027F (1993)	Daphnia magna (Crustacean)	mortality	48 h				<24h (neonates)	Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control.		80.1 mg/L						Han et al. 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	European Guideline; EEC Directive 92/69/EEC (1992)	Daphnia magna (Crustacean)	immobilization	24 h and 48 h				Younger than 24h	four replicates, 5 daphnids each			68.0 mg/L (68 mg/L)		45 mg/L (45 mg/L)			Cleuvers 2004
Diclofenac	Diclofenac-Na	M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	European Guideline; EEC Directive 92/69/EEC	Daphnia magna (Crustacean)	immobilization	48 h		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L		< 24 h	Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids.			68 mg/L (68 mg/L)					Cleuvers 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	AFNOR T90-301 (1996)	Daphnia magna (Crustacean)	mobility inhibition	48 h				< 24 h	28 cups, five daphnids in each, six concentrations and one control, four replicates			224.3 mg/L (224,3 mg/L)					Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	European Guideline; EEC Directive 92/69/EEC (1993)	Desmodesmus subspicatus (Green algae)	growth inhibition									71.9 mg/L (71,9 mg/L)		50 mg/L (50 mg/L)			Cleuvers 2004
Diclofenac	Diclofenac-Na	M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	European Guideline; EEC Directive 92/69/EEC	Desmodesmus subspicatus (Green algae)	inhibition of average growth rate	3 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Initial density; 10^4 cells/mL			72 mg/L (72 mg/L)					Cleuvers 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Trypan blue exclusion method	Dreissena polymorpha (freshwater bivalve zebra mussel)	haemocyte viability						4 or 5 mussels, 2 replicates			178 ug/L (0,178 mg/L)					Parolini et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	NRR assay	Dreissena polymorpha (freshwater bivalve zebra mussel)	decrease in neutral red retention time (cytotoxicity)			60, 156, 250 ug/L									250 ug/L (0.25 mg/L)		Parolini et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	DNA diffusion assay	Dreissena polymorpha (freshwater bivalve zebra mussel)	increase in frequency of apoptotic cells (genotoxicity)			60, 156, 250 ug/L									156 ug/L (0.156 mg/L)		Parolini et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	SCGE assay	Dreissena polymorpha (freshwater bivalve zebra mussel)	increase in DNA damage represented by LDR (genotoxicity)			60, 156, 250 ug/L									60 ug/L (0.06 mg/L)		Parolini et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996)	Dunaliella tertiolecta (Phytoplankton)	cell density	96 h		25, 50, 100, 200, 400 mg/L			Initial density; approximately 50 000 cells/mL			185.69 mg/L (185,69 mg/L)					DeLorenzo and Fleming 2008
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Gyps bengalensis (Oriental white-backed vulture)	renal disease	varying		0,007 mg/kg to 0,940 mg/kg		adult, subadult, juvenile	20 (+ 6 controls)	Direct orally+through diclofenac-treated livestock						0.007 mg/kg	Oaks et al. 2004
Diclofenac	Diclofenac-Na	M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	ISO/WD 20079 (2001), using the Steinberg-medium	Lemna minor (Duckweed)	inhibition of average growth rate	7 days		(0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L			Three treatment replicates and six control replicates.			7.5 mg/L (7,5 mg/L)					Cleuvers 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	ISO/WD 20079 (2001)	Lemna minor (Duckweed)	growth inhibition	7 days				Initially three or four fronds	Six-well plates, one plant in each well, three replicates			148 mg/L (148 mg/L)					Kaza et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oncorhynchus mykiss (Rainbow trout)	gills, ultrastructural effects	28 days		1, 5, 20, 100, 500 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						1 ug/L (0.001 mg/L)		Triebskorn et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oncorhynchus mykiss (Rainbow trout)	kidney, ultrastructural effects	28 days		1, 5, 20, 100, 500 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						1 ug/L (0.001 mg/L)		Triebskorn et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oncorhynchus mykiss (Rainbow trout)	liver, ultrastructural effects	28 days		1, 5, 20, 100, 500 ug/L	F+M	1,5-1,8 year-old	24 per conc. 6-8 were used						1 ug/L (0.001 mg/L)		Triebskorn et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oncorhynchus mykiss (rainbow trout)	renal lesions and alterations of the gill	28 days		0, 1, 5, 20, 100, 500 ug/L		1.8 years	10 per concentration.					1 ug/L (0,001 mg/L)	5 ug/L (0.005 mg/L)		Schwaiger et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oncorhynchus mykiss (rainbow trout)	cytological alterations in liver, kidney and gills	28 days		0, 1, 5, 20, 100, 500 ug/L		about 2 years old	6 per concentration						1 ug/L (0.001 mg/L)		Triebskorn et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	test on hepatocytes, cytotoxicity test, MTT assay	Oncorhynchus mykiss (Rainbow trout)	cytotoxicity	24 h		31.3-500 uM		immature				420 uM					Laville et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	EROD activity test	Oncorhynchus mykiss (Rainbow trout)	inhibition	24 h				immature				63 uM					Laville et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oryzias latipes (Japanese medaka)	induction of CYP1A, p53 gene and VTG	4 days		1 ug/L and 8 mg/L		5-6 months old	Three fish per concentration and solvent at each time point (0h, 12h, 1 day, 2 days, 4 days)						1 ug/L (0.001 mg/L)		Hong et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Oryzias latipes (Japanese medaka)	mortality	96 h		1, 12.5, 19, 25, 50, 100, 120 mg/L		35-50 days old (juveniles)	Seven fish per each concentration (7) and each test was conducted three times		8 mg/L (LC10)				1 mg/L		Hong et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	MTT assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.243 mM (71,963964 mg/L)					Caminada et al. 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	NR assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.269 mM (79,663812 mg/L)					Caminada et al. 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	test on hepatocytes, cytotoxicity test, MTT assay	Poeciliopsis lucida (Topminnow)	cytotoxicity	24 h		31.3-500 uM						19 uM					Laville et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Pseudokirchneriella subcapitata (Green algae)	growth inhibition	96 h										10 mg/L (10 mg/L)	20 mg/L		Ferrari et al. 2003
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	algal growth inhibition test	Pseudokirchneriella subcapitata (Green algae)	growth	96 h								16.3 mg/L (16,3 mg/L)		10.0 mg/L (10 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	MTT assay	RTG-2 cell line (Rainbow trout gonad)	cell viability	24 h					3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates			1.78 mM (527,14344 mg/L)					Caminada et al. 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Alamar Blue assay	RTL-W1 (Rainbow trout liver cell line)	change in energy metabolism (cytotoxicity)	24 h		five-six different concentrations						257.4 uM					Schnell et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	CFDA-AM assay	RTL-W1 (Rainbow trout liver cell line)	decrease in membrane integrity (cytotoxicity)	24 h		five-six different concentrations						266.8 uM					Schnell et al. 2009
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148		Salmo trutta f. fario (Fish)	monocyte infiltration/accumulation in liver	21 days		0.5, 5, 50ug/L		18 months	36 fish per exposure concentration					0.5 ug/L (0,0005 mg/L)			Hoeger et al. 2005
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	A cell-reproduction test	Scenedesmus vacuolatus (Green algae)	inhibition of algal reproduction	144 h		50 mg/L			Initial density: 7.5*10^4 cells/mL			0.023 mg/L (0,023 mg/L)					Schmitt-Jansen et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	A cell-reproduction test	Scenedesmus vacuolatus (Green algae)	inhibition of algal reproduction	53 h		50 mg/L			Initial density: 7.5*10^4 cells/mL			0.48 mg/L (0,48 mg/L)					Schmitt-Jansen et al. 2007
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	algal growth inhibition test	Synechococcus leopolensis (Blue-green algae)	growth	96 h								14.5 mg/L (14,5 mg/L)		10.0 mg/L (10 mg/L)			Ferrari et al. 2004
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			46 mg/L (46 mg/L)					Nalecz-Jawecki and Persoone 2006
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			41 mg/L						Nalecz-Jawecki and Persoone 2006
Diclofenac	Diclofenac-Na	M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	ToxAlert 100	Vibrio fischeri (Bacteria)	bioluminescence inhibition	15 min								13.5 mg/L (13,5 mg/L)					Farré et al. 2001
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Microtox test according to the standard AFNOR T90-320-3 (1999)	Vibrio fischeri (Bacteria)	luminescence	30 min								11.454 mg/L (11,454 mg/L)					Ferrari et al. 2004
Diclofenac	Diclofenac-Na	M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	Microtox	Vibrio fischeri (Bacteria)	bioluminescence inhibition	15 min								13.7 mg/L (13,7 mg/L)					Farré et al. 2001
Diclofenac		M01AB05	Anti-inflammatory and anti-reumatic agents	296.148	AFNOR T90-320-3 (1999)	Vibrio fischeri (Bacteria)	luminescence	30 min								11.45 mg/L (11,45 mg/L)					Ferrari et al. 2003
Digoxin		C01AA05	Cardiac therapy	780.9385	Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							>12800 umol/L (9996.0128 mg/L)						Calleja et al. 1994 (a)
Digoxin		C01AA05	Cardiac therapy	780.9385	Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							>12800 umol/L (9996.0128 mg/L)						Calleja et al. 1994 (a)
Digoxin		C01AA05	Cardiac therapy	780.9385	OECD standard protocol (1980), with a few modifications	Daphnia magna (Crustacean)	immobilization	24 h				<24h (neonates)	Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times			0.031 mM (24,2090935 mg/L)					Lilius et al. 1994
Digoxin		C01AA05	Cardiac therapy	780.9385	OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								>12800 umol/L (9996,0128 mg/L)					Calleja et al. 1994 (a)
Digoxin		C01AA05	Cardiac therapy	780.9385		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 72h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Digoxin		C01AA05	Cardiac therapy	780.9385		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 48h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Digoxin		C01AA05	Cardiac therapy	780.9385		Hydra vulgaris (Cnidarian)	regeneration of digestive region	17 days	regeneration of digestive region observed for 24h	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						10 ug/L (0.01 mg/L)		Pascoe et al. 2003
Digoxin		C01AA05	Cardiac therapy	780.9385		Hydra vulgaris (Cnidarian)	mean number of Artemia ingested	7 days	10 day feeding/budding study followed 7 d exposure	10, 100 ug/L, 1.0, 10 mg/L			Five replicate animals used for each concentration and controls						100 ug/L (0.1 mg/L)		Pascoe et al. 2003
Digoxin		C01AA05	Cardiac therapy	780.9385	Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								>12800 umol/L (9996,0128 mg/L)					Calleja et al. 1994 (a)
Digoxin		C01AA05	Cardiac therapy	780.9385	Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							35.4 mg/L	8.84 mg/L (8,84 mg/L)					Nalecz-Jawecki and Sawicki 2003
Digoxin		C01AA05	Cardiac therapy	780.9385	Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							>12800 umol/L (9996.0128 mg/L)						Calleja et al. 1994 (a)
Digoxin		C01AA05	Cardiac therapy	780.9385	Protoxkit FTM	Tetrahymena termophila (Ciliate)	growth inhibition	24 h								26,3 mg/L (26,3 mg/L)					Nalecz-Jawecki and Sawicki 2003
Dihydrostreptomycin	Veterinary use	QA07AA90	Antidiarrheals, intestinal antiinflammatory /antiinfective agents		OECD (1993) no 201	Selenastrum capricornutum (Freshwater green algae)	growth inhibition			5 concentrations, triplicates						0.107 mg/L (0,107 mg/L)		<0.039 mg/L			Eguchi et al. 2004
Diltiazem		C08DB01	Calcium antagonists	414.5179	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	96 h								8.2 mg/L (8,2 mg/L)					Kim et al. 2007
Diltiazem		C08DB01	Calcium antagonists	414.5179	EPA/600/4-90/027F (2002)	Daphnia magna (Crustacean)	immobilization	48 h								28 mg/L (28 mg/L)					Kim et al. 2007
Diltiazem		C08DB01	Calcium antagonists	414.5179	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	48 h							25.6 mg/L						Kim et al. 2007
Diltiazem		C08DB01	Calcium antagonists	414.5179	OECD, 1992, TG 203	Oryzias latipes (Japanese medaka)	mortality	96 h							15.0 mg/L						Kim et al. 2007
Diltiazem	Diltiazem HCl	C08DB01	Calcium antagonists	414.5179	Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			10.2 mg/L (10,2 mg/L)					Nalecz-Jawecki and Persoone 2006
Diltiazem	Diltiazem HCl	C08DB01	Calcium antagonists	414.5179	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			73 mg/L						Nalecz-Jawecki and Persoone 2006
Diltiazem		C08DB01	Calcium antagonists	414.5179	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	15 min								263.7 mg/L (263,7 mg/L)					Kim et al. 2007
Diltiazem		C08DB01	Calcium antagonists	414.5179	Microtox Toxicity Analyzer	Vibrio fischeri (Bacteria)	alteration in light output	5 min								407.4 mg/L (407,4 mg/L)					Kim et al. 2007
Diltiazem		C08DB01	Calcium antagonists	414.5179	Chronic bioluminescence assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h								152 mg/L (152 mg/L)					Backhaus and Grimme 1999
Diphenylhydantoin		N03AB02	Antiepileptics		Artoxkit M (with slight modifications)	Artemia salina (Crustacea)	mortality	24 h							>39600 umol/L						Calleja et al. 1994 (a)
Diphenylhydantoin		N03AB02	Antiepileptics		Rotoxkit F (with slight modifications)	Brachionus calyciflorus (Rotifera)	mortality	24 h							>39600 umol/L						Calleja et al. 1994 (a)
Diphenylhydantoin		N03AB02	Antiepileptics		OECD guideline 202 (1984)	Daphnia magna (Crustacean)	immobilization	24 h								>39600 umol/L					Calleja et al. 1994 (a)
Diphenylhydantoin		N03AB02	Antiepileptics			Oncorhynchus mykiss (Rainbow trout hepatocytes)	extracellular radioactivity	3h					Cell density: 2*10^6 cells/mL			5.63 mM					Lilius et al. 1994
Diphenylhydantoin		N03AB02	Antiepileptics		Microtox test	Photobacterium phosphoreum (Bacteria)	bioluminescence inhibition	5 or 15 min								>39600 umol/L					Calleja et al. 1994 (a)
Diphenylhydantoin		N03AB02	Antiepileptics		Spirotox	Spirostomum ambiguum (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h							>100 mg/L	>100 mg/L					Nalecz-Jawecki and Sawicki 2003
Diphenylhydantoin		N03AB02	Antiepileptics		Streptoxkit F (with slight modifications)	Streptocephalus proboscideus (Crustacea)	mortality	24 h							248 umol/L						Calleja et al. 1994 (a)
Diphenylhydantoin		N03AB02	Antiepileptics		Protoxkit FTM	Tetrahymena termophila (Ciliate)	morphological changes/ spherical deformation and autolysis	24 h								47,6 mg/L (47,6 mg/L)					Nalecz-Jawecki and Sawicki 2003
Diphenylhydantoin	5,5-Diphenylhydantion	N03AB02	Antiepileptics		Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			44 mg/L						Nalecz-Jawecki and Persoone 2006
Diphenylhydantoin	5,5-Diphenylhydantion	N03AB02	Antiepileptics		Rapidtoxkit (2004)	Thamnocephalus platyurus (Crustacean)	food ingestion	1h				larvae hatched from dormant eggs	12 cup multiwells, 15-25 organisms in each			33.7 mg/L (33,7 mg/L)					Nalecz-Jawecki and Persoone 2006
Doxorubicin	Adriamycin hydrochloride = Doxorubicinklorid	L01DB01	Antineoplastic agents	543.5193	Genotoxicity assay (umuC test)	Bacteria	Genotoxicity	30 min											2,5		Hartmann et al. 1998
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	ISO 6341:1996 (with modifications)	Daphnia magna (Crustacean)	Immobilization	48 h				less than 24 h old	20 per concentration			2 mg/L		0,01 mg/L	0.1 mg/L		Zounkova et al. 2007
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	SOS-Chromotest	Escherichia coli (Bacteria)	Genotoxicity	4 h											0.074 mg/L		Zounkova et al. 2007
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	MTT assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.00260 mM (1,41315018 mg/L)					Caminada et al. 2006
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	NR assay	PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes)	cell viability	24 h					6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.00217 mM (1,179436881 mg/L)					Caminada et al. 2006
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	ISO 8692:1989, DIN 38412	Pseudokirchneriella subcapitata (Freshwater green alga)	Growth inhibition	72 h								13 mg/L		1 mg/L	10 mg/L		Zounkova et al. 2007
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	ISO 10712:1995	Pseudomonas putida (Bacteria)	Growth inhibition									>1000 mg/L		1 mg/L	10 mg/L		Zounkova et al. 2007
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	MTT assay	RTG-2 cell line (Rainbow trout gonad)	cell viability	24 h					3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates			0.00470 mM (2,55454071 mg/L)					Caminada et al. 2006
Doxorubicin		L01DB01	Antineoplastic agents	543.5193	GreenScreen assay	Saccharomyces cerevisiae (Yeast cells)	Genotoxicity	16 h											2.8 mg/L		Zounkova et al. 2007
Doxycycline		J01AA02	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Daucus carota (Wild carrot)	Growth (root length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	21 days		0, 10, 30, 100, 300, 1000 ug/L						87.1 ug/L (0,0871 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	28 days		0, 10, 30, 100, 300, 1000 ug/L						45 ug/L (0,045 mg/L)			100 ug/L (0.1 mg/L)		Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	14 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	21 days		0, 10, 30, 100, 300, 1000 ug/L						>1000 ug/L					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Spore production	28 days		0, 10, 30, 100, 300, 1000 ug/L						36.9 ug/L (0,0369 mg/L)			1000 ug/L (1 mg/L)		Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents			Glomus intraradices (Mycorrhizal fungus)	Growth (hyphal length)	14 days		0, 10, 30, 100, 300, 1000 ug/L						274.9 ug/L (0,2749 mg/L)					Hillis et al. 2008
Doxycycline		J01AA02	Antibacterial agents		ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			316 ug/L (0,316 mg/L)					Brain et al. 2004 (a)
Drosperinone		G03FA17	Sex hormones		OECD 21 days fish reproduction (draft)	Pimephales promelas (Fathead minnows)	Inhibition of reproduction (no of laid eggs)	21 days		0, 0.66, 6.5, 70 ug/L	F+M	Adult	4 pairs					0.66 ug/L (0,00066 mg/L)	6.5 ug/L (0.0065 mg/L)		Zeilinger et al. 2009
Enalapril	Enalapril maleate	C09AA02	Agents acting on the renin-angiotensin system	376.4467	Thamnotoxkit F (1995)	Thamnocephalus platyurus (Crustacean)	mortality	24 h				larvae hatched from dormant eggs			184 mg/L						Nalecz-Jawecki and Persoone 2006
Enoxacin		J01MA04	Antibacterial agents		Long-term bioluminescence inhibition assay	Vibrio fischeri (Bacteria)	bioluminescence inhibition	24 h		At least 16 different concentrations						49.33ug/L (0,04933 mg/L)		2.88 ug/L (0,00288 mg/L)			Backhaus et al. 2000
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		US EPA-821-R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	24 h				<24h	four replicates of five organisms			131,7 mg/L (131,7 mg/L)					Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		US EPA-821-R-02-012 (2002)	Daphnia magna (Crustacean)	immobilization	48 h				<24h	four replicates of five organisms			56,7 mg/L (56,7 mg/L)					Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		OECD guideline 202 (1993)	Daphnia magna (Crustacean)	reproduction	21 days		five different concentrations: 0.03-0.5 mg/L		<24h	organisms maintained individually					5 mg/L (5 mg/L)	15 mg/L		Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		OECD guideline 202 (1993)	Daphnia magna (Crustacean)	adult survival	21 days		five different concentrations: 0.03-0.5 mg/L		<24h	organisms maintained individually			11.47 mg/L (11,47 mg/L)		5 mg/L (5 mg/L)	15 mg/L		Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents			Lemna minor (Duckweed)	reproduction	7 days		four different concentrations			10-15 fronds, triplicate experiments with four concentrations and a control			114 ug/L (0,114 mg/L)					Robinson et al. 2005
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents			Microcystis aeruginosa (Freshwater cyanobacteria)	growth and reproduction	5 days		five different concentrations						49 ug/L (0,049 mg/L)					Robinson et al. 2005
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		US EPA-821-R-02-012 (2002)	Moina macrocopa (Crustacean)	immobilization	24 h				<24h	four replicates of five organisms			285,7 mg/L (285,7 mg/L)					Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents			Pseudokirchneriella subcapitata (Green algae)	growth and reproduction	3 days		five different concentrations						3100 ug/L (3,1 mg/L)					Robinson et al. 2005
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	15 min									326.8 mg/L				Park and Choi 2008
Enrofloxacin	Veterinary use	QJ01MA90	Antibacterial agents		Microtox Model 500 analyser	Vibrio fischeri (Bacteria)	luminescence	5 min									425 mg/L				Park and Choi 2008
Erythromycin		J01FA01	Antibacterial agents	733.9268	Respiration inhibition test OECD 209	aerobic bacteria	inhibition of respiration	30 min		(0,001-750 mg/L)							>100 mg/L				Kümmerer K. et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268	OECD 209, prolonged test	aerobic bacteria	inhibition of respiration	20 h		(0,001-750 mg/L)							10-100 mg/L				Kümmerer K. et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268		Anabaena cylindrica NIES-19	Growth inhibition	144 h								0,035		0,0031			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Anabaena flos-aquae ATCC 29413	Growth inhibition	144 h								0,27		0,047			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Anabaena variabilis NIES-23	Growth inhibition	144 h								0,43		0,047			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268	ISO/CD 20666 (2001)	Brachionus calyciflorus (Rotifera)	population growth inhibition	48 h					24-well microplates, one rotifer placed into each well, four replicates per concentration			0.94 mg/L (0,94 mg/L)					Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268	ASTM E1440-91 (1991)	Brachionus calyciflorus (Rotifera)	mortality	24 h				juveniles (0-2 h)	Five test dilutions with six replicates of five animals		27.53 mg/L						Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268	ISO/CD 20665 (2001)	Ceriodaphnia dubia (Crustacean cladocera)	population growth inhibition	7 days		seven different concentrations		<24h		Exposed individually		0.22 mg/L (0,22 mg/L)					Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268	USEPA, EPA-600-4-90-027F (1993)	Ceriodaphnia dubia (Crustacean cladocera)	immobilization	48 h		five different concentrations		<24h	24-well plates, ten animals per well, three replicates per concentration			10.23 mg/L (10,23 mg/L)					Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268	OECD (1993) no 201	Chlorella vulgaris (Green algae)	growth inhibition			5 concentrations, triplicates						33.8 mg/L (33,8 mg/L)		12.5 mg/L (12,5 mg/L)			Eguchi et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268	EEC 84/449 1984	Daphnia magna (Crustacean)		48 h		0, 100-800 mg/L		<24 days old	5 per bottle, 4 per replicates			210,57 mg/L					di Delupis et al. 1992
Erythromycin		J01FA01	Antibacterial agents	733.9268	EEC 84/449 1984	Daphnia magna (Crustacean)		24 h		0, 100-800 mg/L		<24 days old	5 per bottle, 4 per replicates			387,7 mg/L					di Delupis et al. 1992
Erythromycin		J01FA01	Antibacterial agents	733.9268	ISO/6341 (1996)	Daphnia magna Straus (Crustacean)	immobilization	24 h		five different concentrations		<24h	Five daphnids per vessel, four replicates for each of five concentrations			22.45 mg/L (22,45 mg/L)					Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268	ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998)	Lemna gibba (Duckweed)	growth inhibition	7 days					Two L. gibba plants, each with four fronds, in each dish, eighteen dishes			> 1000 ug/L					Brain et al. 2004 (a)
Erythromycin		J01FA01	Antibacterial agents	733.9268	USEPA(1996)	Lemna minor FBR006 (Duckweed)	growth inhibition	7 days		0, 1, 10, 100, 1000 ug/L			A total of 12 fronds per test chamber, three replicates			5.62 mg/L (5,62 mg/L)					Pomati et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268		Microcystis aeruginosa NIES-44	Growth inhibition	144 h								0,023		0,01			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Microcystis wesenbergii NIES-107	Growth inhibition	144 h								0,023		0,0047			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Nostoc sp. PCC 7120	Growth inhibition	144 h								0,2		0,1			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268	ISO/DIS 8692 (1989)	Pseudokirchneriella subcapitata (Green algae)	growth inhibition	72 h		five different concentrations			Initial density was in the order of 10^4 cells/mL			0.020 mg/L (0,02 mg/L)					Isidori et al. 2005b
Erythromycin		J01FA01	Antibacterial agents	733.9268		Pseudokirchneriella subcapitata ATCC 22662	Growth inhibition	144 h								0,366		0,0103			Ando and Nagase, 2007
Erythromycin	Erythromycin phosphate	J01FA01	Antibacterial agents	733.9268	According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975)	Salvelinus namaycush (Lake trout)	mortality	24 h		200-800 mg/L		7.0-8.2 g	20 fish (two replicates of 10 fish each)	Water bath exposure	818.0 mg/L						Marking et al. 1988
Erythromycin	Erythromycin phosphate	J01FA01	Antibacterial agents	733.9268	According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975)	Salvelinus namaycush (Lake trout)	mortality	96 h		200-800 mg/L		7.0-8.2 g	20 fish (two replicates of 10 fish each)	Water bath exposure	410.0 mg/L						Marking et al. 1988
Erythromycin		J01FA01	Antibacterial agents	733.9268	OECD (1993) no 201	Selenastrum capricornutum (Freshwater green algae)	growth inhibition			5 concentrations, triplicates						0.0366 mg/L (0,0366 mg/L)		0.0103 mg/L (0,0103 mg/L)			Eguchi et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268		Synechococcus leopoldensis IAM M-6	Growth inhibition	144 h								0,16		0,0020			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Synechococcus sp. PCC 7002	Growth inhibition	144 h								0,23		0,0078			Ando and Nagase, 2007
Erythromycin		J01FA01	Antibacterial agents	733.9268		Synechocystis sp. PCC6803 (Cyanobacteria)	growth inhibition	0-5 days		0, 1, 10, 100, 1000 ug/L		Culture in late-logarithmic growth-phase	Initial cell density set to approx. 0.1 OD750						1 ug/L (0.001 mg/L)		Pomati et al. 2004
Erythromycin		J01FA01	Antibacterial agents	733.9268		Thamnocephalus platyurus (Crustacean)	mortality	24 h		five different concentrations		second- and third-instar fairy shrimp larvae	24-well plates, ten animals per well, three replicates per concentration		17.68 mg/L						Isidori et al. 2005b
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Carassius auratus (crucian carp)	induction of vitellogenin (reproductive endocrine disruption)	14 days		5, 15, 30, 100, 150, 500 ng/L	M		groups of 3			98.14 ng/L (0,00009814 mg/L)		30 ng/L (0,00003 mg/L)	100 ng/L (0.0001 mg/L)		Zhang et al. 2008
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	In vitro competitive radioreceptor assay	Cyprinus carpio (Common carp hepatic ER)	displacement of specific ER binding									32 nM (0,00871744 mg/L)					Segner et al. 2003a
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	In vitro VTG induction assay	Cyprinus carpio (Common carp hepatocytes)	VTG induction	3 days	4 days		sexually immature or F		Initial density: 1.5-2.0*10^6 cells/mL			90 nM (0,0245178 mg/L)					Segner et al. 2003a
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Danio rerio (Zebrafish)	vitellogenin induction	8 days		0, 10, 20, 40, 70, 100, 200, 200 or 500 ng/L	M	adult	20-25 fish exposed to each concentration			41.2 ng/L (0,0000412 mg/L)			21 ng/L (0.000021 mg/L)		Rose et al. 2002
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	ISO Guideline 6341 (1996)	Daphnia magna (Crustacean)	moulting frequency	24 h				<24 h	5 daphnids in each beaker, 3 beakers for each test concentration			1.55 mg/L (1,55 mg/L)					Brennan et al. 2006
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	ISO Guideline 6341 (1996)	Daphnia magna (Crustacean)	immobilization	24 h				<24 h	5 daphnids in each beaker, 3 beakers for each test concentration			3.67 mg/L (3,67 mg/L)					Brennan et al. 2006
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	ISO Guideline 6341 (1996)	Daphnia magna (Crustacean)	moulting frequency	48 h				<24 h	5 daphnids in each beaker, 3 beakers for each test concentration			2.04 mg/L (2,04 mg/L)					Brennan et al. 2006
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	ISO Guideline 6341 (1996)	Daphnia magna (Crustacean)	immobilization	48 h				<24 h	5 daphnids in each beaker, 3 beakers for each test concentration			2.87 mg/L (2,87 mg/L)					Brennan et al. 2006
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Gasterosteus aculeatus (three-spined stickleback) kidney cell primary culture	inhibition of DHT-induced spiggin production	48 h		10^-14 - 10^-6 M	F								272 ug/L (272 mg/L)		Jolly et al. 2009
Estradiol		G03CA03	Sex hormones	272.42	In vitro study	Ictalurus punctatus (Channel catfish)	binding inhibition				F	2 years					2.20 nM (0.000599324 mg/L)				Nimrod and Benson 1997
Estradiol		G03CA03	Sex hormones	272.42	In vivo study	Ictalurus punctatus (Channel catfish)	increase in Kd		10 days	0.6 mg/kg on days 1, 4 and 7	F	2 years	3-5 fish	Intraperitoneally injected (i.p.)						0.6 mg/kg	Nimrod and Benson 1997
Estradiol		G03CA03	Sex hormones	272.42	In vivo study	Ictalurus punctatus (Channel catfish)	increase in Kd		10 days	0.6 mg/kg on days 1, 4 and 7	M	2 years	5-7 fish	Intraperitoneally injected (i.p.)						0.6 mg/kg	Nimrod and Benson 1997
Estradiol		G03CA03	Sex hormones	272.42	In vivo study	Ictalurus punctatus (Channel catfish)	increased number of hepatic binding sites		10 days	0.6 mg/kg on days 1, 4 and 7	M	2 years	5-7 fish	Intraperitoneally injected (i.p.)						0.6 mg/kg	Nimrod and Benson 1997
Estradiol		G03CA03	Sex hormones	272.42	In vivo study	Ictalurus punctatus (Channel catfish)	hepatic somatic index		10 days	0.6 mg/kg on days 1, 4 and 7	M	2 years	5-7 fish	Intraperitoneally injected (i.p.)						0.6 mg/kg	Nimrod and Benson 1997
Estradiol	17B-estradiol-glucuronide	G03CA03	Sex hormones	272.42		Ictalurus punctatus (Channel catfish)	elevated serum E2 concentration	7 days		1 mg/kg	M	12-18 months (200-500 g)	Five fish	Intraperitoneally injected (i.p.)						1 mg/kg	Tilton et al. 2001
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Ictalurus punctatus (Channel catfish)	elevated serum E2 concentration	7 days		1 mg/kg	M	12-18 months (200-500 g)	Five fish	Intraperitoneally injected (i.p.)						1 mg/kg	Tilton et al. 2001
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Ictalurus punctatus (Channel catfish)	induction of vitellogenin	7 days		1 mg/kg	M	12-18 months (200-500 g)	Five fish	Intraperitoneally injected (i.p.)						1 mg/kg	Tilton et al. 2001
Estradiol		G03CA03	Sex hormones	272.42	In vivo study	Ictalurus punctatus (Channel catfish)	increase in serum Vg levels		10 days	0.6 mg/kg on days 1, 4 and 7	M	2 years	5-7 fish	Intraperitoneally injected (i.p.)						0.6 mg/kg	Nimrod and Benson 1997
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	MCF-7 breast tumor cell proliferation (E-Screen) assay	MCF-7 cells	growth									8.7*10^-3 ug/L (0,0087 mg/L)					Folmar et al. 2002
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	Swedish standard SS 02 81 06, SIS (1991)	Nitocra spinipes (Harpacticoid copepod)	mortality	96 h				<24h	10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group		1.6 mg/L						Breitholtz and Bengtsson 2001
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42		Nitocra spinipes (Harpacticoid copepod)	sex ratio	18 days				<24h	10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group						0.05 mg/L		Breitholtz and Bengtsson 2001
Estradiol	17B-estradiol	G03CA03	Sex hormones	272.42	In vitro VTG induction assay	Oncorhynchus mykiss (Rainbow trout hepatocytes)	VTG induction	3 days	4 days		sexually immature or F		Initial density: 1.5-2.0*10^6 cells/mL			26 nM (0,00708292 mg/L)					Segner et al. 2003a
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Hepatic Vtg concentrations	25 days		0, 31.3, 62.5, 125, 250, 500 ug/L	M	Adults	46					29.3 ng/L	55.7 ng/L		Kang et al. 2002
Estradiol		G03CA03	Sex hormones	272.42	OECD 203	Oryzias latipes (Japanese medaka)	Survival								2 mg/L						Kang et al. 2002
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Fecundity			0, 0.01, 0.12, 1.33 ug/L	F								1.33 ug/L		Nimrod and Benson, 1998
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Sex ratio			0, 0.01, 0.12, 1.33 ug/L	M+F								0.01 ug/L		Nimrod and Benson, 1998
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Survival			0, 0.01, 0.12, 1.33 ug/L	M+F	5-8 days old							1.33 ug/L		Nimrod and Benson, 1998
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Gonadosomatic index (GSI)	25 days		0, 31.3, 62.5, 125, 250, 500 ug/L	M	Adults	46					227 ng/L	463 ng/L		Kang et al. 2002
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Developed testis-ova (intersex)	25 days		0, 31.3, 62.5, 125, 250, 500 ug/L	M	Adults	46						29.3 ng/L		Kang et al. 2002
Estradiol		G03CA03	Sex hormones	272.42		Oryzias latipes (Japanese medaka)	Fertility of eggs	21 days för F, 25 days for M