HOME | Effect data
| Substance | Substance comment | ATC | Pharmaceutical group | Molar mass | Type of test | Species | Critical effect | Exposure time | Study period | Concentrations/Doses | Sex | Age | Number of organisms | Route of exposure | LC50 | EC50 | IC50 | NOEC | LOEC | NOEL | LOEL | Reference short |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 2120 umol/L (381.933688 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 785 umol/L (141.423559 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | neonates per brood (brood 3) | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.56 mg/L | 1.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | Daphnia longispina (Crustacean) | daily growth rate | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 1.80 mg/L | 3.20 mg/L | Marques et al. 2004b | ||||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | Daphnia longispina (Crustacean) | population growth rate | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 84.5 mg/L | 186.0 mg/L | Marques et al. 2004b | ||||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | age at each reproduction (brood 4) | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.56 mg/L | 1.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | neonates per brood (brood 5) | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 1.80 mg/L | 3.20 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | neonates per brood (brood 2) | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | average size of juveniles from first brood | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 84.5 mg/L | 186.0 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | average size of juveniles from first brood | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.56 mg/L | 1.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | number of viable offspring | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 84.50 mg/L | 186.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | number of viable offspring | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.32 mg/L | 0.56 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia longispina (Crustacean) | immobilization | 48 h | 180.00-1800.00 mg/L | <24h | Four replicates of five individuals for each treatment | >1800.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia longispina (Crustacean) | immobilization | 48 h | 180.00-910.00 mg/L | <24h | Four replicates of five individuals for each treatment | 342.41 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | neonates per brood (brood 2) | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.80 mg/L | 3.20 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | size of neonates-first brood | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | >10.00 mg/L | >10.00 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia longispina (Crustacean) | number of viable offspring | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia longispina (Crustacean) | immobilization | 48 h | 347.00-900.00 mg/L | <24h | Five animals in each vessel, four replicates per treatment | 647.31 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | average size of juveniles from first brood | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | >3.20 mg/L | >3.20 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | Daphnia magna (Crustacean) | daily growth rate | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.56 mg/L | 1.00 mg/L | Marques et al. 2004b | ||||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | Daphnia magna (Crustacean) | population growth rate | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 1.80 mg/L | 3.20 mg/L | Marques et al. 2004b | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 8.15 mM (1468.28281 mg/L) |
Lilius et al. 1994 | |||||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | neonates per brood (brood 1,2,3,4 and 5) | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 409.0 mg/L | 900.0 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD Guidelines No. 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 932 umol/L (167.9066968 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia magna (Crustacean) | immobilization | 48 h | 900.0-2350.00 mg/L | <24h | Five animals in each vessel, four replicates per treatment | 1293.05 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | neonates per brood (brood 3) | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | number of viable offspring | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | European Guideline; EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 24 h and 48 h | Younger than 24h | four replicates, 5 daphnids each | 88.1 mg/L | 75 mg/L | Cleuvers 2004 | ||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | daily growth rate | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | number of viable offspring | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 186.00 mg/L | 409.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | size of neonates-first brood | 21 days | 1.00, 1.80, 3.20, 5.60, 10.00 mg/L | <24h | 1.00 mg/L | 1.80 mg/L | Marques et al. 2004a | ||||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | number of viable offspring | 21 days | 0.32, 0.56, 1.00, 1.80, 3.20 mg/L | <24h | 0.32 mg/L | 0.56 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia magna (Crustacean) | immobilization | 48 h | 180.00-1800.00 mg/L | <24h | Four replicates of five individuals for each treatment | >1800.00 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | gentisic acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (2000) | Daphnia magna (Crustacean) | immobilization | 48 h | 180.00-910.00 mg/L | <24h | Four replicates of five individuals for each treatment | 402.55 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | o-hydroxyhippuric acid, acetylsalicylic acid metabolite | N02BA01 | Analgesic | 180.1574 | OECD no. 202 (1996) | Daphnia magna (Crustacean) | average size of juveniles from first brood | 21 days | 38.4, 84.5, 186.0, 409.0, 900.0 mg/L | <24h | 409.0 mg/L | 900.0 mg/L | Marques et al. 2004b | |||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | European Guideline; EEC Directive 92/69/EEC (1993) | Desmodesmus subspicatus (Green algae) | growth inhibition | 106.7 mg/L | 32 mg/L | Cleuvers 2004 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Hydra vulgaris (Cnidarian) | partially contracted polyp, slow reactions | 7 days | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 1 mg/L | Pascoe et al. 2003 | ||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Hydra vulgaris (Cnidarian) | mean number of Artemia ingested | 7 days | 10 day feeding/budding study followed 7 d exposure | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 27.6 mM (4972.34424 mg/L) |
Lilius et al. 1994 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | 145 umol/L (26.122823 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 177 mg/L | 177 mg/L | Nalecz-Jawecki and Sawicki 2003 | ||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 988 umol/L (177.9955112 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Protoxkit FTM | Tetrahymena termophila (Ciliate) | growth inhibition | 24 h | 720 mg/L | Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Acetylsalicylic acid | N02BA01 | Analgesic | 180.1574 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 86.2 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 133 umol/L (36.8946389 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 2.9 umol/L (0.80446957 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 20 umol/L (5.548066 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.00415 mM (1151.223695 mg/L) |
Lilius et al. 1994 | |||||||||||
| Amitriptyline | Amitryptyline HCl | N06AA09 | Psychoanaleptics | 277.4033 | ISO/WD 20079 (2001) | Lemna minor (Duckweed) | growth inhibition | 7 days | Initially three or four fronds | Six-well plates, one plant in each well, three replicates | 1.69 mg/L | Kaza et al. 2007 | ||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 0.475 mM (131.7665675 mg/L) |
Lilius et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | 77.8 umol/L (21.58197674 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 0,7 mg/L (0.7 mg/L) |
0.44 mg/L | Nalecz-Jawecki and Sawicki 2003 | ||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Spirotox | Spirostomum ambiguum (Ciliate) | pherical deformation and autolysis | 24 h | 1.13 mg/L | 0.58 mg/L | Nalecz-Jawecki 2008 | ||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 2.8 umol/L (0.77672924 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Protoxkit FTM | Tetrahymena termophila (Ciliate) | growth inhibition | 24 h | 40 mg/L | Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Amitriptyline | Amitriptyline HCl | N06AA09 | Psychoanaleptics | 277.4033 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 3.0 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||
| Amitriptyline | Amitriptyline HCl | N06AA09 | Psychoanaleptics | 277.4033 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 0.63 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Amitriptyline | N06AA09 | Psychoanaleptics | 277.4033 | Thamnotoxkit F | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | 1.12 mg/L | Nalecz-Jawecki 2008 | |||||||||||||
| Amlodipine | C08CA01 | Calcium antagonists | 408.8759 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 72h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Amlodipine | C08CA01 | Calcium antagonists | 408.8759 | Hydra vulgaris (Cnidarian) | mean number of Artemia ingested | 7 days | 10 day feeding/budding study followed 7 d exposure | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 1 mg/L | Pascoe et al. 2003 | |||||||||||
| Amlodipine | C08CA01 | Calcium antagonists | 408.8759 | Hydra vulgaris (Cnidarian) | clubbed tentacles, body slightly contracted | 7 days | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 100 ug/L (0.1 mg/L) |
Pascoe et al. 2003 | ||||||||||||
| Amlodipine | C08CA01 | Calcium antagonists | 408.8759 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 48h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Amlodipine | C08CA01 | Calcium antagonists | 408.8759 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 24h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | Hydra vulgaris (Cnidarian) | partially contracted polyp, slow reactions | 7 days | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 100 ug/L (0.1 mg/L) |
Pascoe et al. 2003 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) | Lemna gibba (Duckweed) | growth inhibition | 7 days | Two L. gibba plants, each with four fronds, in each dish, eighteen dishes | > 1000 ug/L | Brain et al. 2004 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | ISO 8692 (1989), modified version | Microcystis aeruginosa (Freshwater cyanobacteria) | growth inhibition | 7 days | 0.0009 to 0.0038 mg/L | Initial density; 2*10^4 cells/ml | 0.0037 mg/L | Holten Lutzhoft et al. 1999 | |||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | ISO 8692 (1989), modified version | Rhodomonas salina (Marine cryptophycean) | growth inhibition | 5 to 500 mg/L | Initial density; 1*10^4 cells/mL | 3108 mg/L (out of measured range) | Holten Lutzhoft et al. 1999 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | ISO 8692 (1989), modified version | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 2.5 to 250 mg/L | Initial density; 1*10^4 cells/mL | 250 mg/L | Holten Lutzhoft et al. 1999 | ||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | Synechococcus leopolensis (Blue-green algae, strain UTEX 625) | growth inhibition | 96 h | 50 ng/L to 50 mg/L | 10 000 or 100 000 cells/mL (inocula) | 2.22 ug/L (0.00222 mg/L) |
0.78 ug/L (0.00078 mg/L) |
1.56 ug/L (0.00156 mg/L) |
Andreozzi et al. 2004 | ||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 5 min | 1320.0 mg/L | Park and Choi 2008 | |||||||||||||
| Amoxicillin | J01CA04 | Antibacterial agents | 365.4042 | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 15 min | 3597.0 mg/L | Park and Choi 2008 | |||||||||||||
| Amphetamine sulfate | N06BA01 | Psychoanaleptics | 135.2084 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.164 mM (22.1741776 mg/L) |
Lilius et al. 1994 | |||||||||||
| Amphetamine sulfate | N06BA01 | Psychoanaleptics | 135.2084 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 53.05 mM (7172.80562 mg/L) |
Lilius et al. 1994 | |||||||||||||
| Ampicillin | J01CA01 | Antibacterial agents | 349.4048 | OECD (1993) no 201 | Chlorella vulgaris (Green algae) | growth inhibition | 5 concentrations, triplicates | >1000 mg/L | >1000 mg/L | Eguchi et al. 2004 | ||||||||||||
| Ampicillin | J01CA01 | Antibacterial agents | 349.4048 | OECD (1993) no 201 | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 5 concentrations, triplicates | >1000 mg/L | >1000 mg/L | Eguchi et al. 2004 | ||||||||||||
| Ampicillin | J01CA01 | Antibacterial agents | 349.4048 | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 5 min | 1056.0 mg/L | Park and Choi 2008 | |||||||||||||
| Ampicillin | J01CA01 | Antibacterial agents | 349.4048 | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 15 min | 2627.0 mg/L | Park and Choi 2008 | |||||||||||||
| Ampicillin | J01CA01 | Antibacterial agents | 349.4048 | Chronic bioluminescence assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 163 mg/L | Backhaus and Grimme 1999 | |||||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | Acute toxicity to Daphnia: EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | Twenty daphnids for the controls and each treatment, subdivided in 4 replicates | 313 mg/L | Cleuvers 2005 | |||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | 200 mg/L | Hernando et al. 2004 | ||||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | Algal inhibition test: EEC Directive 92/69/EEC (1993) | Desmodesmus subspicatus (Green algae) | growth | 48 h | Initial density: 10^4 cells/mL | 620 mg/L | Cleuvers 2005 | ||||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | Desmodesmus subspicatus (Green algae) | photosynthesis inhibition | 24 h | 1335 mg/L | Escher et al. 2006 | ||||||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | Pimephales promelas (Fathead minnow) | reproduction (condition index) | 21 days | 0.1, 0.32, 1, 3.2, 10 mg/L | adult | 8 pairs per concentation | 1 mg/L | 3.2 mg/L | Winter et al. 2008 | ||||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | OECD Test 210 (1992) | Pimephales promelas (Fathead minnow) | hatchability | ended 28 d post-hatch | 0.1, 0.32, 1, 3.2, 10 mg/L | embryos 2-24 h | 20 embryos in each cup, approximately 80 embryos per conc. | 10 mg/L | >10 mg/L | Winter et al. 2008 | |||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | OECD Test 210 (1992) | Pimephales promelas (Fathead minnow) | survival (%) | ended 28 d post-hatch | 0.1, 0.32, 1, 3.2, 10 mg/L | embryos 2-24 h | 20 embryos in each cup, approximately 80 embryos per conc. | 10 mg/L | >10 mg/L | Winter et al. 2008 | |||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | OECD Test 210 (1992) | Pimephales promelas (Fathead minnow) | wet weight | ended 28 d post-hatch | 0.1, 0.32, 1, 3.2, 10 mg/L | embryos 2-24 h | 20 embryos in each cup, approximately 80 embryos per conc. | 3.2 mg/L | 10 mg/L | Winter et al. 2008 | |||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | OECD Test 210 (1992) | Pimephales promelas (Fathead minnow) | standard length | ended 28 d post-hatch | 0.1, 0.32, 1, 3.2, 10 mg/L | embryos 2-24 h | 20 embryos in each cup, approximately 80 embryos per conc. | 3.2 mg/L | 10 mg/L | Winter et al. 2008 | |||||||||
| Atenolol | C07AB03 | Beta-receptor blockers | 266.3361 | ISO Guideline 11348-3 (1998) | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 30 min | 1304 mg/L | Escher et al. 2006 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | survival | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 14.3 mg/L | Dussault et al. 2008 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | growth | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 10.2 mg/L | Dussault et al. 2008 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Daucus carota (Wild carrot) | Growth (root length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 208.6 ug/L (0.2086 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Daucus carota (Wild carrot) | Growth (root length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 259.4 ug/L (0.2594 mg/L) |
300 ug/L (0.3 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Daucus carota (Wild carrot) | Growth (root length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 172.9 ug/L (0.1729 mg/L) |
300 ug/L (0.3 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 41.8 ug/L (0.0418 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 153.6 ug/L (0.1536 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 65.4 ug/L (0.0654 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 154.3 ug/L (0.1543 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | growth | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 2.4 mg/L | Dussault et al. 2008 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | survival | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 1.5 mg/L | Dussault et al. 2008 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | decrease in fresh weight (sterols) | 7 days | Two plants in each of the 18 culture dishes | 157 ug/L (0.157 mg/L) |
200 ug/L (0.2 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | decrease in stigmasterol | 7 days | Two plants in each of the 18 culture dishes | 71.6 ug/L (0.0716 mg/L) |
67 ug/L (0.067 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | increase in total ubiquinone (UQ) | 7 days | Two plants in each of the 18 culture dishes | 967 ug/L (0.967 mg/L) |
67 ug/L (0.067 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | increase in oxidized plastoquinone (PQ) | 7 days | Two plants in each of the 18 culture dishes | 3055 ug/L (3.055 mg/L) |
Brain et al. 2006 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | increase in reduced plastoquinone (PQ) | 7 days | Two plants in each of the 18 culture dishes | 37.7 ug/L (0.0377 mg/L) |
217 ug/L (0.217 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | increase in total plastoquinone (PQ) | 7 days | Two plants in each of the 18 culture dishes | 85.1 ug/L (0.0851 mg/L) |
217 ug/L (0.217 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | decrease in fresh weight (quinones) | 7 days | Two plants in each of the 18 culture dishes | 135 ug/L (0.135 mg/L) |
19 ug/L (0.019 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | Modified ASTM E 1415-91 Guideline (1999) | Lemna gibba (Duckweed) | decrease in beta-Sitosterol | 7 days | Two plants in each of the 18 culture dishes | 64.4 ug/L (0.0644 mg/L) |
67 ug/L (0.067 mg/L) |
Brain et al. 2006 | |||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | MTT assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.0818 mM (45.69673564 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | NR assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.0781 mM (43.62976838 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | MTT assay | RTG-2 cell line (Rainbow trout gonad) | cell viability | 24 h | 3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.302 mM (168.7092196 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | ASTM: Standard guide for conducting FETAX E1439-98 (2002) | Xenopus laevis (African clawed frog) | malformations | 96 h | eggs, stage 9 | Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs. | 23.1 mg/L | 10.0 mg/L | Richards and Cole 2006 | ||||||||||
| Atorvastatin | C10AA05 | Blood lipid lowering agents | 558.6398 | ASTM: Standard guide for conducting FETAX E1439-98 (2002) | Xenopus laevis (African clawed frog) | mortality | 96 h | eggs, stage 9 | Three tests with each concentration, using 50 eggs (25 per dish) from three different couples for a total of 150 eggs. | 38.6 mg/L | Richards and Cole 2006 | |||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 22700 umol/L (6568.68538 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 481 umol/L (139.1866814 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.372 mM (107.6454168 mg/L) |
Lilius et al. 1994 | ||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 513 umol/L (148.4465022 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 16.83 mM (4870.087002 mg/L) |
Lilius et al. 1994 | ||||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | 8010 umol/L (2317.848894 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Atropine | Atropine sulfate | A03BA01 | Drugs for functional gastrointestinal disorders | 289.3694 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 951 umol/L (275.1902994 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Azithromycin | J01FA10 | Antibacterial agents | Algal Growth Inhibition test | Pseudokirchneriella subcapitata | Growth inhibition rate | 96 h | maximum 10mg/L | 0.019 mg/L | 5.2 ug/L (0.0052 mg/L) |
Harada et al. 2008 | ||||||||||||
| Benzylpenicillin | sodium | J01CE01 | Antibacterial agents | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Benzylpenicillin | sodium | J01CE01 | Antibacterial agents | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Benzylpenicillin | J01CE01 | Antibacterial agents | ISO 8692 (1989), modified version | Microcystis aeruginosa (Freshwater cyanobacteria) | growth inhibition | 7 days | 0.002-0.01 mg/L | Initial density; 2*10^4 cells/mL | 0.006 mg/L | Halling-Sorensen 2000 | ||||||||||||
| Benzylpenicillin | J01CE01 | Antibacterial agents | ISO 8692 (1989), modified version | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 3 days | 3-100 mg/L | Initial density; 1*10^4 cells/mL | 100 mg/L | Halling-Sorensen 2000 | ||||||||||||
| Betaxolol | S01ED02 | Ophthalmologicals | 307.4278 | Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | >300 mg/L | Hernando et al. 2004 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | ISO/CD 20666 (2001) | Brachionus calyciflorus (Rotifera) | population growth inhibition | 48 h | 24-well plates, one rotifer in each well (initially), four replicates per concentration | 0.44 mg/L | 0.156 mg/L | 0.3125 mg/L | Isidori et al. 2007 | ||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | ASTM E1440-91 (1991) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | neonates | 36-well plates, five animals per well, six replicates for each of the five concentrations | 60.91 mg/L | Isidori et al. 2007 | |||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | EPA 600/4-90/027F (1993) | Ceriodaphnia dubia (Crustacean cladocera) | immobilization | 48 h | < 24 h | 24-well plates, ten organisms per well, three replicates per concentration, five concentrations | 75.79 mg/L | Isidori et al. 2007 | |||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | ISO/CD 20665 (2001) | Ceriodaphnia dubia (Crustacean cladocera) | population growth inhibition | 7 days | < 24 h | Single organisms in beakers, seven concentrations, ten replicates | 0.13 mg/L | 0.023 mg/L | 0.047 mg/L | Isidori et al. 2007 | |||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | ISO 6341 (1996) | Daphnia magna (Crustacean) | immobilization | 24 h | < 24 h | Five daphnids per vessel, four replicates for each of five concentrations | 100.08 mg/L | Isidori et al. 2007 | |||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | EPA/600/4-90/027F (1993) | Daphnia magna (Crustacean) | mortality | 48 h | <24h (neonates) | Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control. | 30.3 mg/L | Han et al. 2006 | |||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Acute toxicity to Daphnia, L. 383A. EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | >200 mg/L | Hernando et al. 2004 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: decreased cell adherence | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 2 uM (0.7236388 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: induction of phagocytosis | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 2 uM (0.7236388 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: increased cell viability | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 2 uM (0.7236388 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Hydra attenuata (Cnidarian) | morphological changes | 96 h | 0.1-50/100mg/L | 3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate | 70.71 mg/L | 25.85 mg/L | 0.1mg/L | 1 mg/L | Quinn et al. 2008a | |||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Hydra attenuata (Cnidarian) | feeding behaviour and hydranth no. | 96 h | 0.1-50/100mg/L | 3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate | 8.59 mg/L | Quinn et al. 2008a | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Hydra attenuata (Cnidarian) | regeneration | 96 h | 0, 0.1, 1, 5, 10, 25, 50, 100 mg/L | 10 per concentration | 22.5 mg/L | Quinn et al. 2008b | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Mytilus galloprovincialis (Blue mussel) | immune parameters in the hemocytes | 24 h | Injection | 0.01 nmol (3.61 ng/g dry weight) | Canesi et al. 2007 | |||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | MTT assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 2.60 mM (940.73044 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | NR assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 1.74 mM (629.565756 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | MTT assay | RTG-2 cell line (Rainbow trout gonad) | cell viability | 24 h | 3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates | 1.23 mM (445.037862 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Alamar Blue assay | RTL-W1 (Rainbow trout liver cell line) | change in energy metabolism (cytotoxicity) | 24 h | five-six different concentrations | 275.7 uM | Schnell et al. 2009 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | CFDA-AM assay | RTL-W1 (Rainbow trout liver cell line) | decrease in membrane integrity (cytotoxicity) | 24 h | five-six different concentrations | 266 uM | Schnell et al. 2009 | ||||||||||||
| Bezafibrate | C10AB02 | Blood lipid lowering agents | 361.8194 | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | second- and third instar larvae | 24-well plates, ten animals per well, three replicates for each of the five concentrations | 39.69 mg/L | Isidori et al. 2007 | ||||||||||||
| Captopril | C09AA01 | Agents acting on the renin-angiotensin system | European Guideline; EEC Directive 92/69/EEC | Daphnia magna (Crustacean) | immobilization | 48 h | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | < 24 h | Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids. | >100 mg/L | Cleuvers 2003 | |||||||||||
| Captopril | C09AA01 | Agents acting on the renin-angiotensin system | European Guideline; EEC Directive 92/69/EEC | Desmodesmus subspicatus (Green algae) | inhibition of average growth rate | 3 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Initial density; 10^4 cells/mL | 168 mg/L | Cleuvers 2003 | ||||||||||||
| Captopril | C09AA01 | Agents acting on the renin-angiotensin system | ISO/WD 20079 (2001), using the Steinberg-medium | Lemna minor (Duckweed) | inhibition of average growth rate | 7 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Three treatment replicates and six control replicates. | 25 mg/L | Cleuvers 2003 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Allium cepa (Terrestrial plant) | root growth | 72 h | Five bulbs and three roots per bulb were used for each treatment | 447 uM (105.6120642 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Allium cepa (Terrestrial plant) | mitotic index | 48 h | Five bulbs and three roots per bulb were used for each treatment | 498 uM (117.6617628 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | AFNOR T90-377 (2000) | Brachionus calyciflorus (Rotifera) | reproduction inhibition | 48 h | newly hatched | 48 rotifers; five concentrations and one control, eight replicates | 0.377 mg/L | 0.754 mg/L | Ferrari et al. 2003 | ||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Rotoxkit according to the standard AFNOR T90-377 (2000) | Brachionus calyciflorus (Rotifera) | reproduction | 48 h | Ferrari et al. 2004 | ||||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA 600/4_90/027 (1991) | Ceriodaphnia dubia (Crustacean cladocera) | mobility inhibition | 48 h | < 24 h | 28 cups, five daphnids in each, six concentrations and one control, four replicates | 77.7 mg/L | Ferrari et al. 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Chronic toxicity test according to the standard AFNOR T90-376 (2000) | Ceriodaphnia dubia (Crustacean cladocera) | reproduction | 7 days | 25 ug/L (0.025 mg/L) |
Ferrari et al. 2004 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA 600/4_90/027 (1991) | Ceriodaphnia dubia (Crustacean cladocera) | mortality | 48 h | 77.70 mg/L | 377 ug/L (0.377 mg/L) |
Ferrari et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | AFNOR T90-376 (2000) | Ceriodaphnia dubia (Crustacean cladocera) | reproduction inhibition | 7 days | < 24 h | 0.025 mg/L | 0.1 mg/L | Ferrari et al. 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | growth | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 9.5 mg/L | Dussault et al. 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | survival | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 47.3 mg/L | Dussault et al. 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Chlorella vulgaris var viridis (Green algae) | growth inhibition | 24 h | 1 000 000 cells/mL algae culture | 469.5 uM (110.9281077 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Chlorella vulgaris var viridis (Green algae) | growth inhibition | 48 h | 1 000 000 cells/mL algae culture | 155 uM (36.621633 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | algal growth inhibition test | Cyclotella meneghiniana (Diatom) | growth | 96 h | 31.60 mg/L | 10.00 mg/L | Ferrari et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Cyprinus carpio (Common carp) | kidney, ultrastructural effects | 28 days | 1, 5, 20, 50, 100 ug/L | F+M | 1,5 year-old | 24 per conc. 6-8 were used | 1 ug/L (0.001 mg/L) |
Triebskorn et al. 2007 | ||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Cyprinus carpio (Common carp) | liver, ultrastructural effects | 28 days | 1, 5, 20, 50, 100 ug/L | F+M | 1,5 year-old | 24 per conc. 6-8 were used | >100 ug/L | Triebskorn et al. 2007 | ||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | 10-d early life stage test according to ISO 12890 (1999) | Danio rerio (Zebrafish) | mortality | 10 days | fish embryo | 25 mg/L | Ferrari et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | ISO 12890 (1999) | Danio rerio (Zebrafish) | embryos and larvae mortality | 10 days | embryos, larvae | 50 embryos | 25 mg/L | 50 mg/L | Ferrari et al. 2003 | ||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | OECD Guideline 202 (1993) | Daphnia magna (cladoceran) | immobilization | 48 h | neonates | replicate groups of ten neonates | 414 uM (97.8152004 mg/L) |
Jos et al. 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | OECD Guideline 202 (1993) | Daphnia magna (cladoceran) | immobilization | 24 h | neonates | replicate groups of ten neonates | 475 uM (112.227585 mg/L) |
Jos et al. 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | >100 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | AFNOR T90-301 (1996) | Daphnia magna (Crustacean) | mobility inhibition | 48 h | < 24 h | 28 cups, five daphnids in each, six concentrations and one control, four replicates | >13.8 mg/L | Ferrari et al. 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | European Guideline; EEC Directive 92/69/EEC | Daphnia magna (Crustacean) | immobilization | 48 h | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | < 24 h | Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids. | >100 mg/L | Cleuvers 2003 | ||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 96 h | 76.3 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Acute toxicity test according to the standard AFNOR T90-301 (1996) | Daphnia magna (Crustacean) | mortality | 48 h | >13.80 mg/L | Ferrari et al. 2004 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/4-90/027F (1993) | Daphnia magna (Crustacean) | mortality | 48 h | <24h (neonates) | Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control. | 111 mg/L | Han et al. 2006 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Daucus carota (Wild carrot) | Growth (root length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Daucus carota (Wild carrot) | Growth (root length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Daucus carota (Wild carrot) | Growth (root length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | European Guideline; EEC Directive 92/69/EEC | Desmodesmus subspicatus (Green algae) | inhibition of average growth rate | 3 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Initial density; 10^4 cells/mL | 74 mg/L | Cleuvers 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996) | Dunaliella tertiolecta (Phytoplankton) | cell density | 96 h | 25, 50, 100, 200, 400 mg/L | Initial density; approximately 50 000 cells/mL | >80.00 mg/L | DeLorenzo and Fleming 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: increased cell viability | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 3 uM (0.7088058 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: induction of phagocytosis | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 61 uM (14.4123846 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Elliptio complanata (Freshwater mussel) | immunotoxic effect: decreased cell adherence | 24 h | 0, 2.5, 25, 50, 100 uM | Hemolymphs from 10 mussels were collected and analysed | 61 uM (14.4123846 mg/L) |
Gagné et al. 2006 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Gammarus pulex (Crustacea, amphipoda) | activity | 1.5 h | nine measurements per concentration | 0, 1 ng/L to 1 mg/L | 24 chambers, one G. pulex in each | 0.010 ug/L (0.00001 mg/L) |
De Lange et al. 2006 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 43.6 ug/L (0.0436 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 113.4 ug/L (0.1134 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 388.2 ug/L (0.3882 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | growth | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 15.0 mg/L | Dussault et al. 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | survival | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 9.9 mg/L | Dussault et al. 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Hydra attenuata (Cnidarian) | morphological changes | 96 h | 0.1-50/100mg/L | 3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate | 29.4 mg/L | 15.52 mg/L | 1 mg/L | 5 mg/L | Quinn et al. 2008a | |||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Hydra attenuata (Cnidarian) | feeding behaviour and hydranth no. | 96 h | 0.1-50/100mg/L | 3 Hydra in each of the 3 wells per exposure concentration on a 12 well multi-well plate | 3.76 mg/L | Quinn et al. 2008a | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | ISO/WD 20079 (2001), using the Steinberg-medium | Lemna minor (Duckweed) | inhibition of average growth rate | 7 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Three treatment replicates and six control replicates. | 25.5 mg/L | Cleuvers 2003 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | neutral red uptake | 48 h | Initial density: 14 000 cells/mL into 24-well culture plates | 81.4 uM (19.23226404 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | LDH activity | 48 h | Initial density: 14 000 cells/mL into 24-well culture plates | 67 uM (15.8299962 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | LDH activity | 72 h | Initial density: 14 000 cells/mL into 24-well culture plates | 38.5 uM (9.0963411 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | LDH activity | 24 h | Initial density: 14 000 cells/mL into 24-well culture plates | 72 uM (17.0113392 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | cell viability: MTT metabolization | 72 h | Initial density: 14 000 cells/mL into 24-well culture plates | 24.6 uM (5.81220756 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | cell viability: MTT metabolization | 48 h | Initial density: 14 000 cells/mL into 24-well culture plates | 94.2 uM (22.25650212 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | neutral red uptake | 72 h | Initial density: 14 000 cells/mL into 24-well culture plates | 19 uM (4.4891034 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | neutral red uptake | 24 h | Initial density: 14 000 cells/mL into 24-well culture plates | >100 uM | Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | total protein content | 72 h | Initial density: 14 000 cells/mL into 24-well culture plates | 33.6 uM (7.93862496 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | total protein content | 48 h | Initial density: 14 000 cells/mL into 24-well culture plates | 62.9 uM (14.86129494 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | total protein content | 24 h | Initial density: 14 000 cells/mL into 24-well culture plates | 76.2 uM (18.00366732 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Monkey kidney (Vero cell line) | cell viability: MTT metabolization | 24 h | Initial density: 14 000 cells/mL into 24-well culture plates | >100 uM (23.62686 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | test on hepatocytes, cytotoxicity test, MTT assay | Oncorhynchus mykiss (Rainbow trout) | cytotoxicity | 24 h | 31.3-500 uM | immature | 318 uM (75.1334148 mg/L) |
Laville et al. 2004 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | EROD activity test | Oncorhynchus mykiss (Rainbow trout) | inhibition | 24 h | immature | 318 uM (75.1334148 mg/L) |
Laville et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 48 h | 35.4 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 96 h | 35.4 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | test on hepatocytes, cytotoxicity test, MTT assay | Poeciliopsis lucida (Topminnow) | cytotoxicity | 24 h | 3.9-500 uM | 651 uM (153.8108586 mg/L) |
Laville et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Algal Growth Inhibition test | Pseudokirchneriella subcapitata | Growth inhibition rate | 96 h | maximum 10mg/L | 48.9 mg/L | 520.6 ug/L (0.5206 mg/L) |
Harada et al. 2008 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | algal growth inhibition test | Pseudokirchneriella subcapitata (Green algae) | growth | 96 h | >100,00 mg/L | >100 mg/L | Ferrari et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Pseudokirchneriella subcapitata (Green algae) | growth inhibition | 96 h | >100 mg/L | >100 mg/L | Ferrari et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | increase in beta proteobacteria and decrease in gamma proteobacteria | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | increase in LGC354c and HGC69a probe positive cells | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | increase in fungal populations | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | increased bacterial counts (R2A media) | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | decrease in cyanobacterial biomass | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | decrease in bacterial biomass | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Riverine biofilm community structure and activity | Riverine biofilm community | carbohydrate utility spectra | 8 weeks | 10 ug/L | 10 ug/L (0.01 mg/L) |
Lawrence et al. 2005 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | total protein content | 48 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 713 uM (168.4595118 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | MTS metabolization | 48 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 608.6 uM (143.79306996 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | MTS metabolization | 72 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 601.4 uM (142.09193604 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | G6PDH activity | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 853 uM (201.5371158 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | G6PDH activity | 48 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 716.7 uM (169.33370562 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | G6PDH activity | 72 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 687 uM (162.3165282 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | LDH leakage | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | >1200 uM | Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | neutral red uptake | 48 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 472.6 uM (111.66054036 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | total protein content | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 832 uM (196.5754752 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | total protein content | 72 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 933 uM (220.4386038 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | neutral red uptake | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 496 uM (117.1892256 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | neutral red uptake | 72 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 495 uM (116.952957 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | MTS metabolization | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | 698 uM (164.9154828 mg/L) |
Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | RTG-2 cell line (Rainbow trout gonad) | LDH activity | 24 h | Initial density: 8000 cells/well in 96-well tissue-culture plates | >1200 uM | Jos et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 70,7 mg/L (70.7 mg/L) |
70,7 mg/L (70.7 mg/L) |
Nalecz-Jawecki and Sawicki 2003 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | algal growth inhibition test | Synechococcus leopolensis (Blue-green algae) | growth | 96 h | 33.60 mg/L | 17.50 mg/L | Ferrari et al. 2004 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Protoxkit FTM | Tetrahymena termophila (Ciliate) | growth inhibition | 24 h | 40,5 mg/L (40.5 mg/L) |
Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 43.0 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 140 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Microtox test according to the standard AFNOR T90-320-3 (1999) | Vibrio fischeri (Bacteria) | luminescence | 30 min | >81.00 mg/L | Ferrari et al. 2004 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Vibrio fischeri (Bacteria) | bioluminescence | 60 min | 272 uM (64.2650592 mg/L) |
Jos et al. 2003 | ||||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Vibrio fischeri (Bacteria) | bioluminescence | 15 min | 332 uM (78.4411752 mg/L) |
Jos et al. 2003 | ||||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Vibrio fischeri (Bacteria) | bioluminescence | 5 min | 370 uM (87.419382 mg/L) |
Jos et al. 2003 | ||||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 15 min | 52.5 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 5 min | 52.5 mg/L | Kim et al. 2007 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | AFNOR T90-320-3 (1999) | Vibrio fischeri (Bacteria) | luminescence | 30 min | >81 mg/L | Ferrari et al. 2003 | |||||||||||||
| Carbamazepine | N03AF01 | Antiepileptics | 236.2686 | Microtox | Vibro fischeri | bioluminescence inhibition | 15 min | maximum 10mg/L | 28.3 mg/L | Harada et al. 2008 | ||||||||||||
| Cefazolin | Cefazolin Na | J01DB04 | Antibacterial agents | OECD (1993) no 201 | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 5 concentrations, triplicates | >1000 mg/L | >1000 mg/L | Eguchi et al. 2004 | ||||||||||||
| Ceftriaxon | disodium | J01DD04 | Antibacterial agents | 554.5799 | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||
| Ceftriaxon | disodium | J01DD04 | Antibacterial agents | 554.5799 | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||
| Cefuroxime | sodium | J01DA06 | Antibacterial agents | 424.3853 | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||
| Cefuroxime | sodium | J01DA06 | Antibacterial agents | 424.3853 | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 6320 umol/L (2042.177808 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 6420 umol/L (2074.490748 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | EPA 821/R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | 372.4 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | EPA 821/R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 96 h | <24h | 81.2 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 1.68 mM (542.857392 mg/L) |
Lilius et al. 1994 | |||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 3360 umol/L (1085.714784 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | EPA 821/R-02-012 (2002) | Moina macrocopa (Crustacean) | immobilization | 48 h | <24h | 511.5 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | EPA 821/R-02-012 (2002) | Moina macrocopa (Crustacean) | immobilization | 96 h | <24h | 273.3 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 0.011 mM (3.5544234 mg/L) |
Lilius et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | OECD (1992) no 203 | Oryzias latipes (Japanese medaka) | mortality | 48 h | 12 +/- 2d posthatch | >1000 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | OECD (1992) no 203 | Oryzias latipes (Japanese medaka) | mortality | 96 h | 12 +/- 2d posthatch | >1000 mg/L | Choi et al. 2008 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | 5310 umol/L (1715.817114 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 707 mg/L | 707 mg/L | Nalecz-Jawecki and Sawicki 2003 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 943 umol/L (304.7110242 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Protoxkit FTM | Tetrahymena termophila (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 53,3 mg/L (53.3 mg/L) |
Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Chronic bioluminescence assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 0.0643 mg/L | Backhaus and Grimme 1999 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Standard test, bacterial toxicity | Vibrio fischeri (Bacteria) | inhibition | 5 min | 598.0 mg/L | Choi et al. 2008 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | ISO/CD 11348 (1994) | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 30 min | 16 test concentrations | 80.1 mg/L | Backhaus et al. 1997 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | ISO/CD 11348 (1994) | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 30 min | 16 test concentrations | 19.9 mg/L | Backhaus et al. 1997 | ||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | Standard test, bacterial toxicity | Vibrio fischeri (Bacteria) | inhibition | 15 min | 537.5 mg/L | Choi et al. 2008 | |||||||||||||
| Chloramphenicol | J01BA01 | Antibacterial agents | 323.1294 | ISO/CD 11348 (1994) with minor modifications | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 16 test concentrations | 0.06 mg/L | Backhaus et al. 1997 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 3960 umol/L (1266.693516 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 8.5 umol/L (2.71891285 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.096 mM (30.7077216 mg/L) |
Lilius et al. 1994 | ||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 84.3 umol/L (26.96521803 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Chloroquine | P01BA01 | P01BA01 | Antiprotozoals | 319.8721 | Glycine max (Soybean) | inhibited growth | 13 days | 0, 2, 4, 8 and 16 mg/g soil | 15 (3 per concentration) | Through soil | 2 mg/g | 4 mg/g | Jjemba 2002 | |||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 40.66 mM (13005.999586 mg/L) |
Lilius et al. 1994 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | 1680 umol/L (537.385128 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 22.6 umol/L (7.22910946 mg/L) |
Calleja et al. 1994 | ||||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 6.40 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||
| Chloroquine | Chloroquine phosphate | P01BA01 | Antiprotozoals | 319.8721 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 4.70 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Chlorpromazine | Chlorpromazine HCl | N05AA01 | Psycholeptics | 318.8642 | ISO/WD 20079 (2001) | Lemna minor (Duckweed) | growth inhibition | 7 days | Initially three or four fronds | Six-well plates, one plant in each well, three replicates | 0.92 mg/L | Kaza et al. 2007 | ||||||||||
| Chlorpromazine | Chlorpromazine HCl | N05AA01 | Psycholeptics | 318.8642 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 0.38 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Chlorpromazine | Chlorpromazine HCl | N05AA01 | Psycholeptics | 318.8642 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 1.60 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||
| Chlortetracycline | hydrochloride | J01AA03 | Antibacterial agents | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Chlortetracycline | hydrochloride | J01AA03 | Antibacterial agents | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | 10-100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 24 h | <24h | four replicates of five organisms | 380 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | four replicates of five organisms | 225 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 552.8 ug/L (0.5528 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 575 ug/L (0.575 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 950.6 ug/L (0.9506 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 885.7 ug/L (0.8857 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 734.5 ug/L (0.7345 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 397.5 ug/L (0.3975 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 147 ug/L (0.147 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 358.6 ug/L (0.3586 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) | Lemna gibba (Duckweed) | growth inhibition | 7 days | Two L. gibba plants, each with four fronds, in each dish, eighteen dishes | 219 ug/L (0.219 mg/L) |
100 ug/L (0.1 mg/L) |
Brain et al. 2004 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | ISO 8692 (1989), modified version | Microcystis aeruginosa (Freshwater cyanobacteria) | growth inhibition | 7 days | 0.002-10 mg/L | Initial density; 2*10^4 cells/mL | 0.05 mg/L | Halling-Sorensen 2000 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Moina macrocopa (Crustacean) | immobilization | 48 h | <24h | four replicates of five organisms | 272 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Moina macrocopa (Crustacean) | immobilization | 24 h | <24h | four replicates of five organisms | 515 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | OECD guideline 203 (1993) | Oryzias latipes (Japanese medaka) | mortality | 48 h | 10-14 days post hatch | four replicates of five fish each | 88.4 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | OECD guideline 203 (1993) | Oryzias latipes (Japanese medaka) | mortality | 96 h | 10-14 days post hatch | four replicates of five fish each | 78.9 mg/L | Park and Choi 2008 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | OECD 201(2006) with minor modifications | Pseudokirchnerella subcapitata | Growth inhibition | 72 h | 250-8000 ug/L | 1800 ug/L (1.8 mg/L) |
500 ug/L (0.5 mg/L) |
1000 ug/L (1 mg/L) |
Yang et al. 2008 | |||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | ISO 8692 (1989), modified version | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 3 days | 0.005-10 mg/L | Initial density; 1*10^4 cells/mL | 3.1 mg/L | Halling-Sorensen 2000 | ||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 15 min | 13 mg/L | Park and Choi 2008 | ||||||||||||||
| Chlortetracycline | J01AA03 | Antibacterial agents | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 5 min | >20 mg/L | Park and Choi 2008 | ||||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | 379.7 mg/L | Kim et al. 2007 | |||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 96 h | 271.3 mg/L | Kim et al. 2007 | |||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 96 h | >100 mg/L | Kim et al. 2007 | |||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 48 h | >100 mg/L | Kim et al. 2007 | |||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 5 min | 458.9 mg/L | Kim et al. 2007 | |||||||||||||
| Cimetidine | A02BA01 | Drugs for acid related disorders | 252.3392 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 15 min | 375.9 mg/L | Kim et al. 2007 | |||||||||||||
| Cinoxacin | J01MB06 | Antibacterial agents | Long-term bioluminescence inhibition assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | At least 16 different concentrations | 116.95 ug/L (0.11695 mg/L) |
26.22 ug/L (0.02622 mg/L) |
Backhaus et al. 2000 | ||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | OECD 203 (1992) | Brachydanio rerio (zebrafish) | 30 and 100 mg/L | 100 mg/L | Halling-Sorensen et al. 2000 | ||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | OECD 202 (1984) | Daphnia magna (Crustacean) | 30 and 60 mg/L | 60 mg/L | Halling-Sorensen et al. 2000 | ||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) | Lemna gibba (Duckweed) | growth inhibition | 7 days | Two L. gibba plants, each with four fronds, in each dish, eighteen dishes | 697 ug/L (0.697 mg/L) |
300 ug/L (0.3 mg/L) |
Brain et al. 2004 | |||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | Lemna minor (Duckweed) | reproduction | 7 days | four different concentrations | 10-15 fronds, triplicate experiments with four concentrations and a control | 203 ug/L (0.203 mg/L) |
Robinson et al. 2005 | ||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | Microcystis aeruginosa (Freshwater cyanobacteria) | growth and reproduction | 5 days | five different concentrations | 17 ug/L (0.017 mg/L) |
Robinson et al. 2005 | |||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | Microcystis aeruginosa (Freshwater cyanobacteria) | 0.005 mg/L | Halling-Sorensen et al. 2000 | ||||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | OECD 201(2006) with minor modifications | Pseudokirchnerella subcapitata | Growth inhibition | 72 h | 5000-20000 ug/L | 6700 ug/L (6.7 mg/L) |
<500 ug/L | 5000 ug/L (5 mg/L) |
Yang et al. 2008 | ||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | Pseudokirchneriella subcapitata (Green algae) | growth and reproduction | 3 days | five different concentrations | 18 700 ug/L (18.7 mg/L) |
Robinson et al. 2005 | |||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | ISO 17 012 (1995), modified | Pseudomonas putida (Bacteria) | growth inhibition | 80 ug/L (0.08 mg/L) |
Kümmerer et al. 2000 | ||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | OECD.201 (1984) | Selenastrum capricornutum (Freshwater green algae) | 2.97 mg/L | Halling-Sorensen et al. 2000 | |||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | ISO 15522 (1998) | Sludge bacteria | 0.61 mg/L | Halling-Sorensen et al. 2000 | |||||||||||||||
| Ciprofloxacin | J01MA02 | Antibacterial agents | 331.3415 | Stream microbial communities | microbial respiration | 12 days | 1.0, 10, 100.0 ug/L (nominal conc.) | Two leaf disks in each experimental chamber | 100 ug/L (0.1 mg/L) |
Maul et al. 2006 | ||||||||||||
| Citalopram | N06AB04 | Psychoanaleptics | 324.3919 | EPA/600/4-90/027F (1993) | Ceriodaphnia dubia (Crustacean cladocera) | mortality | 48 h | 0.59-7.84 mg/L | < 24 h | Five treatment concentrations, 20 neonates (4 cups) were exposed to each treatment concentration and the control. | 3.90 mg/L | Henry et al. 2004 | ||||||||||
| Citalopram | N06AB04 | Psychoanaleptics | 324.3919 | EPA/600/4-91/002 (1994) | Ceriodaphnia dubia (Crustacean cladocera) | reproduction inhibition | 7-8 days | < 24 h | Five treatment concentrations, each treatment and the control had ten replicates, each replicate consisted of one neonate. | 0.80 mg/L | 4.00 mg/L | Henry et al. 2004 | ||||||||||
| Citalopram | N06AB04 | Psychoanaleptics | 324.3919 | ISO 6341 (1989), except for the test media; OECD guideline 211, Daphnia magna reproduction test. (2006) | Daphnia magna (Crustacean) | immobilization | 48 h | < 24 h | Five animals were used for each of four replicates per concentration and 20-40 animals in the control group | 20 mg/L | Christensen et al. 2007 | |||||||||||
| Citalopram | N06AB04 | Psychoanaleptics | 324.3919 | Oncorhynchus mykiss (Rainbow trout) | decrease in aggressive behavior and stress responsiveness | 7 days | 0, 100 ug/kg | 2 years old | 16 | Through food | 100 ug/kg | Lepage et a.l 2005 | ||||||||||
| Citalopram | N06AB04 | Psychoanaleptics | 324.3919 | A miniscale algal toxicity test. P. Arensberg et al. (1995). Chem. 30, 2103-2115 | Pseudokirchneriella subcapitata (Green algae) | algal growth inhibition | 48 h | Initial density; 10^4 cells/mL | 1.6 mg/L | Christensen et al. 2007 | ||||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 24 h | (0,001-750 mg/L) | 10-100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | ASTM E1440-91 (1991) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | juveniles (0-2 h) | Five test dilutions with six replicates of five animals | 35.46 mg/L | Isidori et al. 2005b | |||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | ISO/CD 20666 (2001) | Brachionus calyciflorus (Rotifera) | population growth inhibition | 48 h | 24-well microplates, one rotifer placed into each well, four replicates per concentration | 12.21 mg/L | Isidori et al. 2005b | ||||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | USEPA, EPA-600-4-90-027F (1993) | Ceriodaphnia dubia (Crustacean cladocera) | immobilization | 48 h | <24h | 24-well plates, ten animals per well, three replicates per concentration | 18.66 mg/L | Isidori et al. 2005b | |||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | ISO/CD 20665 (2001) | Ceriodaphnia dubia (Crustacean cladocera) | population growth inhibition | 7 days | seven different concentrations | <24h | Exposed individually | 8.16 mg/L | Isidori et al. 2005b | ||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | ISO/6341 (1996) | Daphnia magna Straus (Crustacean) | immobilization | 24 h | <24h | Five daphnids per vessel, four replicates for each of five concentrations | 25.72 mg/L | Isidori et al. 2005b | |||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | OECD 201(2006) with minor modifications | Pseudokirchnerella subcapitata | Growth inhibition | 72 h | 5-160 ug/L | 46 ug/L (0.046 mg/L) |
<40 ug/L | 40 ug/L (0.04 mg/L) |
Yang et al. 2008 | ||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | Algal Growth Inhibition test | Pseudokirchneriella subcapitata | Growth inhibition rate | 96 h | maximum 10mg/L | 0.012 mg/L | 5.2 ug/L (0.0052 mg/L) |
Harada et al. 2008 | |||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | ISO/DIS 8692 (1989) | Pseudokirchneriella subcapitata (Green algae) | growth inhibition | 72 h | five different concentrations | Initial density was in the order of 10^4 cells/mL | 0.0020 mg/L | Isidori et al. 2005b | |||||||||||
| Clarithromycin | J01FA09 | Antibacterial agents | 747.9534 | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | second- and third-instar fairy shrimp larvae | 24-well plates, ten animals per well, three replicates per concentration | 33.64 mg/L | Isidori et al. 2005b | ||||||||||||
| Clindamycin | G01AA10 | Gynecological antiinfectives and antiseptics | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||||
| Clindamycin | G01AA10 | Gynecological antiinfectives and antiseptics | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | |||||||||||||
| Clofibrate | C10AB01 | Blood lipid lowering agents | Oncorhynchus mykiss (Rainbow trout) | kidney, ultrastructural effects | 28 days | 1, 5, 20, 50, 100 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | >100 ug/L | Triebskorn et al. 2007 | |||||||||||
| Clofibrate | C10AB01 | Blood lipid lowering agents | Oncorhynchus mykiss (Rainbow trout) | liver, ultrastructural effects | 28 days | 1, 5, 20, 50, 100 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | >100 ug/L | Triebskorn et al. 2007 | |||||||||||
| Clofibrate | C10AB01 | Blood lipid lowering agents | Oncorhynchus mykiss (Rainbow trout) | gills, ultrastructural effects | 28 days | 1, 5, 20, 50, 100 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | 5 ug/L (0.005 mg/L) |
Triebskorn et al. 2007 | |||||||||||
| Clofibrate | C10AB01 | Blood lipid lowering agents | Alamar Blue assay | RTL-W1 (Rainbow trout liver cell line) | change in energy metabolism (cytotoxicity) | 24 h | five-six different concentrations | 21.8 uM | Schnell et al. 2009 | |||||||||||||
| Clofibrate | C10AB01 | Blood lipid lowering agents | CFDA-AM assay | RTL-W1 (Rainbow trout liver cell line) | decrease in membrane integrity (cytotoxicity) | 24 h | five-six different concentrations | 24.4 uM | Schnell et al. 2009 | |||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Microalgal communities (Periphyton) | Inhibition of sterol biosynthesis | 50 pmol/L | Porsbring et al. 2009 | ||||||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Microalgal communities (Periphyton) | Xanthophyll cycle pigment ratio | 5 pmol/L | Porsbring et al. 2009 | ||||||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Microalgal communities (Periphyton) | Pigment composition | 10 nmol/L | Porsbring et al. 2009 | ||||||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Microalgal communities (Periphyton) | Chlorophyll a content | 10 nmol/L | 500 pmol/L | Porsbring et al. 2009 | |||||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Xenopus tropicalis (Frog) | aromatase activity in brain | 6, 41, 375 nM | Tadpoles | 375 nM | Gyllenhammar et al. 2009 | ||||||||||||||
| Clotrimazole | D01AC01 | Antifungals for dermatological use | Xenopus tropicalis (Frog) | aromatase activity in gonad/kidney | 6, 41, 375 nM | F+M | Tadpoles | 41 nM | Gyllenhammar et al. 2009 | |||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Aterias rubens (sea star) | increase in righting time | 7 days | 18, 32, 56 mg/L | 4 per concentration | 32 mg/L | Canty et al. 2009 | |||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Mn assay | Aterias rubens (sea star) | increase in micronuclei induction (cytogenetic damage) (per 1000 cells) | 7 days | 18, 32, 56 mg/L | 18 mg/L | Canty et al. 2009 | |||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Comet assay | Aterias rubens (sea star) | increase in DNA strand breaks (% tail DNA) | 7 days | 18, 32, 56 mg/L | 18 mg/L | Canty et al. 2009 | |||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Aterias rubens (sea star) | mortality | 7 days | 18, 32, 56 mg/L | 56 mg/L | Canty et al. 2009 | ||||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Mytilus edulis (blue mussel) | mortality | 7 days | 18, 32, 56, 100, 180 mg/L | >180 mg/L | Canty et al. 2009 | ||||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Comet assay | Mytilus edulis (blue mussel) | increase in DNA strand breaks (% tail DNA) | 7 days | 18, 32, 56, 100, 180 mg/L | 18 mg/L | Canty et al. 2009 | |||||||||||||
| Cyclophosphamide | L01AA01 | Antineoplastic agents | Mn assay | Mytilus edulis (blue mussel) | increase in micronuclei induction (cytogenetic damage) (per 1000 cells) | 7 days | 18, 32, 56, 100, 180 mg/L | 18 mg/L | Canty et al. 2009 | |||||||||||||
| Cycloserine | J04AB01 | Antimycobacterials | Chronic bioluminescence assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 65.5 mg/L | Backhaus and Grimme 1999 | ||||||||||||||
| Dexamethasone | H02AB02 | Corticosteroids for systemic use | 392.4611 | ASTM, E1440-91 (1991) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | 0-2 h (juveniles) | 36-well plates with five rotifers per well, six replicates for each of the five conc. | 48.22 mg/L | DellaGreca et al. 2004 | |||||||||||
| Dexamethasone | H02AB02 | Corticosteroids for systemic use | 392.4611 | ISO/CD 20665 (2001) | Ceriodaphnia dubia (Crustacean cladocera) | population growth inhibition | 7 days | <24h (juveniles) | Exposed individually to seven concentrations, ten replicates per conc. | 0.05 ppm | DellaGreca et al. 2004 | |||||||||||
| Dexamethasone | H02AB02 | Corticosteroids for systemic use | 392.4611 | ISO 6341 (1996) | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (juveniles) | Five daphnids per vessel, four replicates for each of the five conc. | 48.30 mg/L | DellaGreca et al. 2004 | |||||||||||
| Dexamethasone | H02AB02 | Corticosteroids for systemic use | 392.4611 | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | second- and third-instar fairy larvae | 24-well plates, ten organisms per well, three replicates for each of the five conc. | 60.11 mg/L | DellaGreca et al. 2004 | ||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Artemia parthenogenetica (Hypersaline crustacean) | oxidative stress biomarker: inhibition of ChE | 48 h | 4.07, 4.89, 5.86, 7.04, 8.44 mg/L | <24h | 100 animals per replicate and treatment | 7.04 mg/L | Nunes et al. 2006 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Artemia parthenogenetica (Hypersaline crustacean) | oxidative stress biomarker: decrease in TBARS content | 48 h | 4.07, 4.89, 5.86, 7.04, 8.44 mg/L | <24h | 100 animals per replicate and treatment | 7.04 mg/L | Nunes et al. 2006 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Modified OECD test 202 | Artemia parthenogenetica (Hypersaline crustacean) | mortality | 48 h | 6.25, 12.5, 25, 50, 100 mg/L | <24h | 10 specimens per replicate, three replicates per concentration | 12.2 mg/L | Nunes et al. 2005 | ||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Artemia parthenogenetica (Hypersaline crustacean) | oxidative stress biomarker: increase in glutathione peroxidase activity | 48 h | 4.07, 4.89, 5.86, 7.04, 8.44 mg/L | <24h | 100 animals per replicate and treatment | 6.13 mg/L | Nunes et al. 2006 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | 230 umol/L (65.490246 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | >35100 umol/L (9994.38102 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.015 mM (4.271103 mg/L) |
Lilius et al. 1994 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | 49.5 umol/L (14.0946399 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Modified OECD 203 (1984) | Gambusia holbrooki (Euryhaline fish) | mortality | 96 h | 5.21, 7.29, 10.2, 14.28, 20 mg/L | F+M | 2-2.5 cm long | Exposed individually | 12.7 mg/L | Nunes et al. 2005 | |||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984) | Gambusia holbrooki (Euryhaline fish) | major behavioural changes and increase of the swim bladder size | 96 h | 4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.) | M | 2-2.5 cm long | Ten individually exposed fish per treatment, three replicates | 7.36 mg/L | Nunes et al. 2008 | |||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Modified version of OECD test guideline 203: Fish, Acute Toxicity Test (1984) | Gambusia holbrooki (Euryhaline fish) | alteration of pigmentation and surface swimming | 96 h | 4.26, 5.11, 6.13, 7.36, 8.83 mg/L (nominal conc.) | M | 2-2.5 cm long | Ten individually exposed fish per treatment, three replicates | 4.26 mg/L | Nunes et al. 2008 | |||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Hydra vulgaris (Cnidarian) | clubbed tentacles, body slightly contracted | 7 days | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | ||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 24h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 48h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 72h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 2.314 mM (658.8888228 mg/L) |
Lilius et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | >35000 umol/L (9965.907 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | NR assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.440 mM (125.285688 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | MTT assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.363 mM (103.3606926 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | MTT assay | RTG-2 cell line (Rainbow trout gonad) | cell viability | 24 h | 3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.604 mM (171.9830808 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 362 umol/L (103.0759524 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Diazepam | N05BA01 | Psycholeptics | 284.7402 | Modified OECD 201 (1984) | Tetraselmis chuii (Marine algae) | growth inhibition | 96 h | 7.9, 11.85, 17.78, 26.67, 40 mg/L | 16.5 mg/L | Nunes et al. 2005 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | AFNOR T90-377 (2000) | Brachionus calyciflorus (Rotifera) | reproduction inhibition | 48 h | newly hatched | 48 rotifers; five concentrations and one control, eight replicates | 12.5 mg/L | 25 mg/L | Ferrari et al. 2003 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Rotoxkit according to the standard AFNOR T90-377 (2000) | Brachionus calyciflorus (Rotifera) | reproduction | 48 h | 12.5 mg/L | Ferrari et al. 2004 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | EPA 600/4_90/027 (1991) | Ceriodaphnia dubia (Crustacean cladocera) | mobility inhibition | 48 h | < 24 h | 28 cups, five daphnids in each, six concentrations and one control, four replicates | 22.7 mg/L | Ferrari et al. 2003 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | EPA 600/4_90/027 (1991) | Ceriodaphnia dubia (Crustacean cladocera) | mortality | 48 h | 22.704 mg/L | Ferrari et al. 2004 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | AFNOR T90-376 (2000) | Ceriodaphnia dubia (Crustacean cladocera) | reproduction inhibition | 7 days | < 24 h | 1 mg/L | 2 mg/L | Ferrari et al. 2003 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Chronic toxicity test according to the standard AFNOR T90-376 (2000) | Ceriodaphnia dubia (Crustacean cladocera) | reproduction | 7 days | 1,0 mg/L (1 mg/L) |
Ferrari et al. 2004 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | algal growth inhibition test | Cyclotella meneghiniana (Diatom) | growth | 96 h | 19.24 mg/L | 10.0 mg/L | Ferrari et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | 10-d early life stage test according to ISO 12890 (1999) | Danio rerio (Zebrafish) | mortality | 10 days | fish embryo | 4,0 mg/L (4 mg/L) |
Ferrari et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | ISO 12890 (1999) | Danio rerio (Zebrafish) | embryos and larvae mortality | 10 days | embryos, larvae | 50 embryos | 4 mg/L | 8 mg/L | Ferrari et al. 2003 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | OECD guideline 202 (2004) | Daphnia magna | immobilization | 48 h | 0, 10, 20, 30, 40, 50, 60, 75, 100, 125, 150 mg/L | <24 h | 20 per concentration | 39.9 mg/L | Haap et al. 2008 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Daphnia magna | hsp70-level | 48 h | 0, 5, 10, 20, 30, 40, 50 mg/L | 12-19 days | 30 mg/L | 40 mg/L | Haap et al. 2008 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | European Guideline; EEC Directive 92/69/EEC (1992) | Daphnia magna (Crustacean) | immobilization | 24 h and 48 h | Younger than 24h | four replicates, 5 daphnids each | 68.0 mg/L | 45 mg/L | Cleuvers 2004 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Acute toxicity test according to the standard AFNOR T90-301 (1996) | Daphnia magna (Crustacean) | mortality | 48 h | 22.430 mg/L | Ferrari et al. 2004 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | EPA/600/4-91/002 (1994) | Daphnia magna (Crustacean) | reproduction inhibition | 21 days | 0.1-80 mg/L | <24h (neonates) | Five replicates, containing one organism per test chamber, were exposed to nine conc and a control. | 10 mg/L | Han et al. 2006 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | EPA/600/4-90/027F (1993) | Daphnia magna (Crustacean) | mortality | 48 h | <24h (neonates) | Four replicates, containing five organisms per test chamber, were exposed to eight different conc and a control. | 80.1 mg/L | Han et al. 2006 | |||||||||||
| Diclofenac | Diclofenac-Na | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | European Guideline; EEC Directive 92/69/EEC | Daphnia magna (Crustacean) | immobilization | 48 h | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | < 24 h | Twenty daphnids for the controls and each treatment subdivided in four replicates each containing five daphnids. | 68 mg/L | Cleuvers 2003 | |||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | AFNOR T90-301 (1996) | Daphnia magna (Crustacean) | mobility inhibition | 48 h | < 24 h | 28 cups, five daphnids in each, six concentrations and one control, four replicates | 224.3 mg/L | Ferrari et al. 2003 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | European Guideline; EEC Directive 92/69/EEC (1993) | Desmodesmus subspicatus (Green algae) | growth inhibition | 71.9 mg/L | 50 mg/L | Cleuvers 2004 | |||||||||||||
| Diclofenac | Diclofenac-Na | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | European Guideline; EEC Directive 92/69/EEC | Desmodesmus subspicatus (Green algae) | inhibition of average growth rate | 3 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Initial density; 10^4 cells/mL | 72 mg/L | Cleuvers 2003 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | SCGE assay | Dreissena polymorpha (freshwater bivalve zebra mussel) | increase in DNA damage represented by LDR (genotoxicity) | 60, 156, 250 ug/L | 60 ug/L (0.06 mg/L) |
Parolini et al. 2009 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Trypan blue exclusion method | Dreissena polymorpha (freshwater bivalve zebra mussel) | haemocyte viability | 4 or 5 mussels, 2 replicates | 178 ug/L (0.178 mg/L) |
Parolini et al. 2009 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | NRR assay | Dreissena polymorpha (freshwater bivalve zebra mussel) | decrease in neutral red retention time (cytotoxicity) | 60, 156, 250 ug/L | 250 ug/L (0.25 mg/L) |
Parolini et al. 2009 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | DNA diffusion assay | Dreissena polymorpha (freshwater bivalve zebra mussel) | increase in frequency of apoptotic cells (genotoxicity) | 60, 156, 250 ug/L | 156 ug/L (0.156 mg/L) |
Parolini et al. 2009 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | ASTM, standard 96-hour static algal bioassays, Vol. 11.05 (1996) | Dunaliella tertiolecta (Phytoplankton) | cell density | 96 h | 25, 50, 100, 200, 400 mg/L | Initial density; approximately 50 000 cells/mL | 185.69 mg/L | DeLorenzo and Fleming 2008 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Gyps bengalensis (Oriental white-backed vulture) | renal disease | varying | 0,007 mg/kg to 0,940 mg/kg | adult, subadult, juvenile | 20 (+ 6 controls) | Direct orally+through diclofenac-treated livestock | 0.007 mg/kg | Oaks et al. 2004 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | ISO/WD 20079 (2001) | Lemna minor (Duckweed) | growth inhibition | 7 days | Initially three or four fronds | Six-well plates, one plant in each well, three replicates | 148 mg/L | Kaza et al. 2007 | |||||||||||
| Diclofenac | Diclofenac-Na | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | ISO/WD 20079 (2001), using the Steinberg-medium | Lemna minor (Duckweed) | inhibition of average growth rate | 7 days | (0.1, 0.32), 1, 3.2, 10, 32, 100, (320) mg/L | Three treatment replicates and six control replicates. | 7.5 mg/L | Cleuvers 2003 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | test on hepatocytes, cytotoxicity test, MTT assay | Oncorhynchus mykiss (Rainbow trout) | cytotoxicity | 24 h | 31.3-500 uM | immature | 420 uM | Laville et al. 2004 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oncorhynchus mykiss (Rainbow trout) | kidney, ultrastructural effects | 28 days | 1, 5, 20, 100, 500 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | 1 ug/L (0.001 mg/L) |
Triebskorn et al. 2007 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oncorhynchus mykiss (Rainbow trout) | liver, ultrastructural effects | 28 days | 1, 5, 20, 100, 500 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | 1 ug/L (0.001 mg/L) |
Triebskorn et al. 2007 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oncorhynchus mykiss (rainbow trout) | renal lesions and alterations of the gill | 28 days | 0, 1, 5, 20, 100, 500 ug/L | 1.8 years | 10 per concentration. | 1 ug/L (0.001 mg/L) |
5 ug/L (0.005 mg/L) |
Schwaiger et al. 2004 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oncorhynchus mykiss (Rainbow trout) | gills, ultrastructural effects | 28 days | 1, 5, 20, 100, 500 ug/L | F+M | 1,5-1,8 year-old | 24 per conc. 6-8 were used | 1 ug/L (0.001 mg/L) |
Triebskorn et al. 2007 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oncorhynchus mykiss (rainbow trout) | cytological alterations in liver, kidney and gills | 28 days | 0, 1, 5, 20, 100, 500 ug/L | about 2 years old | 6 per concentration | 1 ug/L (0.001 mg/L) |
Triebskorn et al. 2004 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | EROD activity test | Oncorhynchus mykiss (Rainbow trout) | inhibition | 24 h | immature | 63 uM | Laville et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oryzias latipes (Japanese medaka) | mortality | 96 h | 1, 12.5, 19, 25, 50, 100, 120 mg/L | 35-50 days old (juveniles) | Seven fish per each concentration (7) and each test was conducted three times | 8 mg/L (LC10) | 1 mg/L | Hong et al. 2007 | ||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Oryzias latipes (Japanese medaka) | induction of CYP1A, p53 gene and VTG | 4 days | 1 ug/L and 8 mg/L | 5-6 months old | Three fish per concentration and solvent at each time point (0h, 12h, 1 day, 2 days, 4 days) | 1 ug/L (0.001 mg/L) |
Hong et al. 2007 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | NR assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.269 mM (79.663812 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | MTT assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.243 mM (71.963964 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | test on hepatocytes, cytotoxicity test, MTT assay | Poeciliopsis lucida (Topminnow) | cytotoxicity | 24 h | 31.3-500 uM | 19 uM | Laville et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Pseudokirchneriella subcapitata (Green algae) | growth inhibition | 96 h | 10 mg/L | 20 mg/L | Ferrari et al. 2003 | |||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | algal growth inhibition test | Pseudokirchneriella subcapitata (Green algae) | growth | 96 h | 16.3 mg/L | 10.0 mg/L | Ferrari et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | MTT assay | RTG-2 cell line (Rainbow trout gonad) | cell viability | 24 h | 3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates | 1.78 mM (527.14344 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Alamar Blue assay | RTL-W1 (Rainbow trout liver cell line) | change in energy metabolism (cytotoxicity) | 24 h | five-six different concentrations | 257.4 uM | Schnell et al. 2009 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | CFDA-AM assay | RTL-W1 (Rainbow trout liver cell line) | decrease in membrane integrity (cytotoxicity) | 24 h | five-six different concentrations | 266.8 uM | Schnell et al. 2009 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Salmo trutta f. fario (Fish) | monocyte infiltration/accumulation in liver | 21 days | 0.5, 5, 50ug/L | 18 months | 36 fish per exposure concentration | 0.5 ug/L (0.0005 mg/L) |
Hoeger et al. 2005 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | A cell-reproduction test | Scenedesmus vacuolatus (Green algae) | inhibition of algal reproduction | 144 h | 50 mg/L | Initial density: 7.5*10^4 cells/mL | 0.023 mg/L | Schmitt-Jansen et al. 2007 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | A cell-reproduction test | Scenedesmus vacuolatus (Green algae) | inhibition of algal reproduction | 53 h | 50 mg/L | Initial density: 7.5*10^4 cells/mL | 0.48 mg/L | Schmitt-Jansen et al. 2007 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | algal growth inhibition test | Synechococcus leopolensis (Blue-green algae) | growth | 96 h | 14.5 mg/L | 10.0 mg/L | Ferrari et al. 2004 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 46 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 41 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Microtox test according to the standard AFNOR T90-320-3 (1999) | Vibrio fischeri (Bacteria) | luminescence | 30 min | 11.454 mg/L | Ferrari et al. 2004 | |||||||||||||
| Diclofenac | Diclofenac-Na | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | ToxAlert 100 | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 15 min | 13.5 mg/L | Farré et al. 2001 | ||||||||||||
| Diclofenac | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | AFNOR T90-320-3 (1999) | Vibrio fischeri (Bacteria) | luminescence | 30 min | 11.45 mg/L | Ferrari et al. 2003 | |||||||||||||
| Diclofenac | Diclofenac-Na | M01AB05 | Anti-inflammatory and anti-reumatic agents | 296.148 | Microtox | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 15 min | 13.7 mg/L | Farré et al. 2001 | ||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | >12800 umol/L (9996.0128 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | >12800 umol/L (9996.0128 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | OECD standard protocol (1980), with a few modifications | Daphnia magna (Crustacean) | immobilization | 24 h | <24h (neonates) | Twenty neonates were introduced into vessels containing different concentrations, repeated at least three times | 0.031 mM (24.2090935 mg/L) |
Lilius et al. 1994 | |||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | >12800 umol/L (9996.0128 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Hydra vulgaris (Cnidarian) | mean number of Artemia ingested | 7 days | 10 day feeding/budding study followed 7 d exposure | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 100 ug/L (0.1 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 24h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 48h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Hydra vulgaris (Cnidarian) | regeneration of digestive region | 17 days | regeneration of digestive region observed for 72h | 10, 100 ug/L, 1.0, 10 mg/L | Five replicate animals used for each concentration and controls | 10 ug/L (0.01 mg/L) |
Pascoe et al. 2003 | |||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | >12800 umol/L (9996.0128 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 35.4 mg/L | 8.84 mg/L | Nalecz-Jawecki and Sawicki 2003 | ||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | >12800 umol/L (9996.0128 mg/L) |
Calleja et al. 1994 | |||||||||||||
| Digoxin | C01AA05 | Cardiac therapy | 780.9385 | Protoxkit FTM | Tetrahymena termophila (Ciliate) | growth inhibition | 24 h | 26,3 mg/L (26.3 mg/L) |
Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Dihydrostreptomycin | Veterinary use | QA07AA90 | Antidiarrheals, intestinal antiinflammatory /antiinfective agents | OECD (1993) no 201 | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 5 concentrations, triplicates | 0.107 mg/L | <0.039 mg/L | Eguchi et al. 2004 | ||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | 28 mg/L | Kim et al. 2007 | |||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | EPA/600/4-90/027F (2002) | Daphnia magna (Crustacean) | immobilization | 96 h | 8.2 mg/L | Kim et al. 2007 | |||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 96 h | 15.0 mg/L | Kim et al. 2007 | |||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | OECD, 1992, TG 203 | Oryzias latipes (Japanese medaka) | mortality | 48 h | 25.6 mg/L | Kim et al. 2007 | |||||||||||||
| Diltiazem | Diltiazem HCl | C08DB01 | Calcium antagonists | 414.5179 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 73 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Diltiazem | Diltiazem HCl | C08DB01 | Calcium antagonists | 414.5179 | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 10.2 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 15 min | 263.7 mg/L | Kim et al. 2007 | |||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | Chronic bioluminescence assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 152 mg/L | Backhaus and Grimme 1999 | |||||||||||||
| Diltiazem | C08DB01 | Calcium antagonists | 414.5179 | Microtox Toxicity Analyzer | Vibrio fischeri (Bacteria) | alteration in light output | 5 min | 407.4 mg/L | Kim et al. 2007 | |||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Artoxkit M (with slight modifications) | Artemia salina (Crustacea) | mortality | 24 h | >39600 umol/L | Calleja et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Rotoxkit F (with slight modifications) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | >39600 umol/L | Calleja et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | OECD guideline 202 (1984) | Daphnia magna (Crustacean) | immobilization | 24 h | >39600 umol/L | Calleja et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Oncorhynchus mykiss (Rainbow trout hepatocytes) | extracellular radioactivity | 3h | Cell density: 2*10^6 cells/mL | 5.63 mM | Lilius et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Microtox test | Photobacterium phosphoreum (Bacteria) | bioluminescence inhibition | 5 or 15 min | >39600 umol/L | Calleja et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Spirotox | Spirostomum ambiguum (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | >100 mg/L | >100 mg/L | Nalecz-Jawecki and Sawicki 2003 | |||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Streptoxkit F (with slight modifications) | Streptocephalus proboscideus (Crustacea) | mortality | 24 h | 248 umol/L | Calleja et al. 1994 | ||||||||||||||
| Diphenylhydantoin | N03AB02 | Antiepileptics | Protoxkit FTM | Tetrahymena termophila (Ciliate) | morphological changes/ spherical deformation and autolysis | 24 h | 47,6 mg/L (47.6 mg/L) |
Nalecz-Jawecki and Sawicki 2003 | ||||||||||||||
| Diphenylhydantoin | 5,5-Diphenylhydantion | N03AB02 | Antiepileptics | Rapidtoxkit (2004) | Thamnocephalus platyurus (Crustacean) | food ingestion | 1h | larvae hatched from dormant eggs | 12 cup multiwells, 15-25 organisms in each | 33.7 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Diphenylhydantoin | 5,5-Diphenylhydantion | N03AB02 | Antiepileptics | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 44 mg/L | Nalecz-Jawecki and Persoone 2006 | ||||||||||||
| Doxorubicin | L01DB01 | Antineoplastic agents | 543.5193 | MTT assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.00260 mM (1.41315018 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Doxorubicin | L01DB01 | Antineoplastic agents | 543.5193 | NR assay | PLHC-1 fish cell line (Poeciliopsis lucida hepatocytes) | cell viability | 24 h | 6.0*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.00217 mM (1.179436881 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Doxorubicin | L01DB01 | Antineoplastic agents | 543.5193 | MTT assay | RTG-2 cell line (Rainbow trout gonad) | cell viability | 24 h | 3.5*10^5 cells/mL in 96-well tissue-culture microtiter plates | 0.00470 mM (2.55454071 mg/L) |
Caminada et al. 2006 | ||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Daucus carota (Wild carrot) | Growth (root length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 274.9 ug/L (0.2749 mg/L) |
Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 87.1 ug/L (0.0871 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 45 ug/L (0.045 mg/L) |
100 ug/L (0.1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | ||||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | Glomus intraradices (Mycorrhizal fungus) | Spore production | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 36.9 ug/L (0.0369 mg/L) |
1000 ug/L (1 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Doxycycline | J01AA02 | Antibacterial agents | ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) | Lemna gibba (Duckweed) | growth inhibition | 7 days | Two L. gibba plants, each with four fronds, in each dish, eighteen dishes | 316 ug/L (0.316 mg/L) |
Brain et al. 2004 | |||||||||||||
| Enalapril | Enalapril maleate | C09AA02 | Agents acting on the renin-angiotensin system | 376.4467 | Thamnotoxkit F (1995) | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | larvae hatched from dormant eggs | 184 mg/L | Nalecz-Jawecki and Persoone 2006 | |||||||||||
| Enoxacin | J01MA04 | Antibacterial agents | Long-term bioluminescence inhibition assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | At least 16 different concentrations | 49.33ug/L (0.04933 mg/L) |
2.88 ug/L (0.00288 mg/L) |
Backhaus et al. 2000 | ||||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 24 h | <24h | four replicates of five organisms | 131,7 mg/L (131.7 mg/L) |
Park and Choi 2008 | |||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Daphnia magna (Crustacean) | immobilization | 48 h | <24h | four replicates of five organisms | 56,7 mg/L (56.7 mg/L) |
Park and Choi 2008 | |||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | OECD guideline 202 (1993) | Daphnia magna (Crustacean) | reproduction | 21 days | five different concentrations: 0.03-0.5 mg/L | <24h | organisms maintained individually | 5 mg/L | 15 mg/L | Park and Choi 2008 | |||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | OECD guideline 202 (1993) | Daphnia magna (Crustacean) | adult survival | 21 days | five different concentrations: 0.03-0.5 mg/L | <24h | organisms maintained individually | 11.47 mg/L | 5 mg/L | 15 mg/L | Park and Choi 2008 | ||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | Lemna minor (Duckweed) | reproduction | 7 days | four different concentrations | 10-15 fronds, triplicate experiments with four concentrations and a control | 114 ug/L (0.114 mg/L) |
Robinson et al. 2005 | ||||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | Microcystis aeruginosa (Freshwater cyanobacteria) | growth and reproduction | 5 days | five different concentrations | 49 ug/L (0.049 mg/L) |
Robinson et al. 2005 | |||||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | US EPA-821-R-02-012 (2002) | Moina macrocopa (Crustacean) | immobilization | 24 h | <24h | four replicates of five organisms | 285,7 mg/L (285.7 mg/L) |
Park and Choi 2008 | |||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | Pseudokirchneriella subcapitata (Green algae) | growth and reproduction | 3 days | five different concentrations | 3100 ug/L (3.1 mg/L) |
Robinson et al. 2005 | |||||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 15 min | 326.8 mg/L | Park and Choi 2008 | |||||||||||||
| Enrofloxacin | Veterinary use | QJ01MA90 | Antibacterial agents | Microtox Model 500 analyser | Vibrio fischeri (Bacteria) | luminescence | 5 min | 425 mg/L | Park and Choi 2008 | |||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | Respiration inhibition test OECD 209 | aerobic bacteria | inhibition of respiration | 30 min | (0,001-750 mg/L) | >100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | OECD 209, prolonged test | aerobic bacteria | inhibition of respiration | 20 h | (0,001-750 mg/L) | 10-100 mg/L | Kümmerer K. et al. 2004 | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ASTM E1440-91 (1991) | Brachionus calyciflorus (Rotifera) | mortality | 24 h | juveniles (0-2 h) | Five test dilutions with six replicates of five animals | 27.53 mg/L | Isidori et al. 2005b | |||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ISO/CD 20666 (2001) | Brachionus calyciflorus (Rotifera) | population growth inhibition | 48 h | 24-well microplates, one rotifer placed into each well, four replicates per concentration | 0.94 mg/L | Isidori et al. 2005b | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ISO/CD 20665 (2001) | Ceriodaphnia dubia (Crustacean cladocera) | population growth inhibition | 7 days | seven different concentrations | <24h | Exposed individually | 0.22 mg/L | Isidori et al. 2005b | ||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | USEPA, EPA-600-4-90-027F (1993) | Ceriodaphnia dubia (Crustacean cladocera) | immobilization | 48 h | five different concentrations | <24h | 24-well plates, ten animals per well, three replicates per concentration | 10.23 mg/L | Isidori et al. 2005b | ||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | OECD (1993) no 201 | Chlorella vulgaris (Green algae) | growth inhibition | 5 concentrations, triplicates | 33.8 mg/L | 12.5 mg/L | Eguchi et al. 2004 | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ISO/6341 (1996) | Daphnia magna Straus (Crustacean) | immobilization | 24 h | five different concentrations | <24h | Five daphnids per vessel, four replicates for each of five concentrations | 22.45 mg/L | Isidori et al. 2005b | ||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ASTM, static toxicity test with Lemna gibba G-3, E 1415-91 (1998) | Lemna gibba (Duckweed) | growth inhibition | 7 days | Two L. gibba plants, each with four fronds, in each dish, eighteen dishes | > 1000 ug/L | Brain et al. 2004 | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | USEPA(1996) | Lemna minor FBR006 (Duckweed) | growth inhibition | 7 days | 0, 1, 10, 100, 1000 ug/L | A total of 12 fronds per test chamber, three replicates | 5.62 mg/L | Pomati et al. 2004 | |||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | ISO/DIS 8692 (1989) | Pseudokirchneriella subcapitata (Green algae) | growth inhibition | 72 h | five different concentrations | Initial density was in the order of 10^4 cells/mL | 0.020 mg/L | Isidori et al. 2005b | |||||||||||
| Erythromycin | Erythromycin phosphate | J01FA01 | Antibacterial agents | 733.9268 | According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975) | Salvelinus namaycush (Lake trout) | mortality | 24 h | 200-800 mg/L | 7.0-8.2 g | 20 fish (two replicates of 10 fish each) | Water bath exposure | 818.0 mg/L | Marking et al. 1988 | ||||||||
| Erythromycin | Erythromycin phosphate | J01FA01 | Antibacterial agents | 733.9268 | According to ASTM E729-80 (1980) and USEPA EPA-660/3-75-009 (1975) | Salvelinus namaycush (Lake trout) | mortality | 96 h | 200-800 mg/L | 7.0-8.2 g | 20 fish (two replicates of 10 fish each) | Water bath exposure | 410.0 mg/L | Marking et al. 1988 | ||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | OECD (1993) no 201 | Selenastrum capricornutum (Freshwater green algae) | growth inhibition | 5 concentrations, triplicates | 0.0366 mg/L | 0.0103 mg/L | Eguchi et al. 2004 | ||||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | Synechocystis sp. PCC6803 (Cyanobacteria) | growth inhibition | 0-5 days | 0, 1, 10, 100, 1000 ug/L | Culture in late-logarithmic growth-phase | Initial cell density set to approx. 0.1 OD750 | 1 ug/L (0.001 mg/L) |
Pomati et al. 2004 | |||||||||||
| Erythromycin | J01FA01 | Antibacterial agents | 733.9268 | Thamnocephalus platyurus (Crustacean) | mortality | 24 h | five different concentrations | second- and third-instar fairy shrimp larvae | 24-well plates, ten animals per well, three replicates per concentration | 17.68 mg/L | Isidori et al. 2005b | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Carassius auratus (crucian carp) | induction of vitellogenin (reproductive endocrine disruption) | 14 days | 5, 15, 30, 100, 150, 500 ng/L | M | groups of 3 | 98.14 ng/L (0.00009814 mg/L) |
30 ng/L (0.00003 mg/L) |
100 ng/L (1 mg/L) |
Zhang et al. 2008 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | In vitro competitive radioreceptor assay | Cyprinus carpio (Common carp hepatic ER) | displacement of specific ER binding | 32 nM (0.00871744 mg/L) |
Segner et al. 2003a | |||||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | In vitro VTG induction assay | Cyprinus carpio (Common carp hepatocytes) | VTG induction | 3 days | 4 days | sexually immature or F | Initial density: 1.5-2.0*10^6 cells/mL | 90 nM (0.0245178 mg/L) |
Segner et al. 2003a | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Danio rerio (Zebrafish) | vitellogenin induction | 8 days | 0, 10, 20, 40, 70, 100, 200, 200 or 500 ng/L | M | adult | 20-25 fish exposed to each concentration | 41.2 ng/L (0.0000412 mg/L) |
21 ng/L (0.000021 mg/L) |
Rose et al. 2002 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | ISO Guideline 6341 (1996) | Daphnia magna (Crustacean) | moulting frequency | 48 h | <24 h | 5 daphnids in each beaker, 3 beakers for each test concentration | 2.04 mg/L | Brennan et al. 2006 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | ISO Guideline 6341 (1996) | Daphnia magna (Crustacean) | immobilization | 24 h | <24 h | 5 daphnids in each beaker, 3 beakers for each test concentration | 3.67 mg/L | Brennan et al. 2006 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | ISO Guideline 6341 (1996) | Daphnia magna (Crustacean) | immobilization | 48 h | <24 h | 5 daphnids in each beaker, 3 beakers for each test concentration | 2.87 mg/L | Brennan et al. 2006 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | ISO Guideline 6341 (1996) | Daphnia magna (Crustacean) | moulting frequency | 24 h | <24 h | 5 daphnids in each beaker, 3 beakers for each test concentration | 1.55 mg/L | Brennan et al. 2006 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Gasterosteus aculeatus (three-spined stickleback) kidney cell primary culture | inhibition of DHT-induced spiggin production | 48 h | 10^-14 - 10^-6 M | F | 272 ug/L (272 mg/L) |
Jolly et al. 2009 | |||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vivo study | Ictalurus punctatus (Channel catfish) | increase in serum Vg levels | 10 days | 0.6 mg/kg on days 1, 4 and 7 | M | 2 years | 5-7 fish | Intraperitoneally injected (i.p.) | 0.6 mg/kg | Nimrod and Benson 1997 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vivo study | Ictalurus punctatus (Channel catfish) | hepatic somatic index | 10 days | 0.6 mg/kg on days 1, 4 and 7 | M | 2 years | 5-7 fish | Intraperitoneally injected (i.p.) | 0.6 mg/kg | Nimrod and Benson 1997 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vitro study | Ictalurus punctatus (Channel catfish) | binding inhibition | F | 2 years | 2.20 nM (0.000599324 mg/L) |
Nimrod and Benson 1997 | ||||||||||||
| Estradiol | 17B-estradiol-glucuronide | G03CA03 | Sex hormones | 272.42 | Ictalurus punctatus (Channel catfish) | elevated serum E2 concentration | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Ictalurus punctatus (Channel catfish) | elevated serum E2 concentration | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Ictalurus punctatus (Channel catfish) | induction of vitellogenin | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vivo study | Ictalurus punctatus (Channel catfish) | increase in Kd | 10 days | 0.6 mg/kg on days 1, 4 and 7 | F | 2 years | 3-5 fish | Intraperitoneally injected (i.p.) | 0.6 mg/kg | Nimrod and Benson 1997 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vivo study | Ictalurus punctatus (Channel catfish) | increased number of hepatic binding sites | 10 days | 0.6 mg/kg on days 1, 4 and 7 | M | 2 years | 5-7 fish | Intraperitoneally injected (i.p.) | 0.6 mg/kg | Nimrod and Benson 1997 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | In vivo study | Ictalurus punctatus (Channel catfish) | increase in Kd | 10 days | 0.6 mg/kg on days 1, 4 and 7 | M | 2 years | 5-7 fish | Intraperitoneally injected (i.p.) | 0.6 mg/kg | Nimrod and Benson 1997 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | MCF-7 breast tumor cell proliferation (E-Screen) assay | MCF-7 cells | growth | 8.7*10^-3 ug/L (0.0087 mg/L) |
Folmar et al. 2002 | |||||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Nitocra spinipes (Harpacticoid copepod) | sex ratio | 18 days | <24h | 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group | 0.05 mg/L | Breitholtz and Bengtsson 2001 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Swedish standard SS 02 81 06, SIS (1991) | Nitocra spinipes (Harpacticoid copepod) | mortality | 96 h | <24h | 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group | 1.6 mg/L | Breitholtz and Bengtsson 2001 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | In vitro VTG induction assay | Oncorhynchus mykiss (Rainbow trout hepatocytes) | VTG induction | 3 days | 4 days | sexually immature or F | Initial density: 1.5-2.0*10^6 cells/mL | 26 nM (0.00708292 mg/L) |
Segner et al. 2003a | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Oryzias latipes (Japanese ricefish) | induced intersex (testis-ova) | approximately 90 days | 1 day | Four test concentrations, one control, 60 fish in each | 0.0004 ug/L (0.0000004 mg/L) |
0.004 ug/L (0.000004 mg/L) |
Metcalfe et al. 2001 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | increase in total length (growth) | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 2,86 ng/L (0.00000286 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | increase in body weight | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 2,86 ng/L (0.00000286 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | sex ratio (M:F) skewed towards female | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | change in number of fish with testis (gonadal histology) | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | change in number of fish with testis-ova | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | decrease in fecundity (total number of eggs per pair) | 71-100 days | 0.939, 2.86, 8.66, 27.9 ng/L | F+M | 71-100 days posthatch | 6 mating pairs treatment group | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | decrease in fertility | 71-100 days | 0.939, 2.86, 8.66, 27.9 ng/L | F+M | 71-100 days posthatch | 6 mating pairs treatment group | 8,66 ng/L (0.00000866 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | reduction in gonadosomal index (GSI) | 101 days | 0.939, 2.86, 8.66, 27.9 ng/L | M | 101 days posthatch | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | increase in vitellogenin (VTG) concentration | 101 days | 0.939, 2.86, 8.66, 27.9 ng/L | M | 101 days posthatch | 8,66 ng/L (0.00000866 mg/L) |
Seki et al. 2004 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | mortality | 59 days | 0.939, 2.86, 8.66 ng/L | F+M | 59 days posthatch, F1 generation | 0,939 ng/L (0.000000939 mg/L) |
Seki et al. 2004 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | increase in total length (growth) | 59 days | 0.939, 2.86, 8.66 ng/L | F+M | 59 days posthatch, F1 generation | 8,66 ng/L (0.00000866 mg/L) |
Seki et al. 2004 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | decrease in vitellogenindecrease in vitellogenin (VTG) concentration | 59 days | 0.939, 2.86, 8.66 ng/L | F | 59 days posthatch, F1 generation | 2,86 ng/L (0.00000286 mg/L) |
Seki et al. 2004 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Twogeneration study | Oryzias latipes (medaka) | change in number of fish with ovary (gonadal histology) | 60 days | 0.939, 2.86, 8.66, 27.9 92.4 ng/L | F+M | 60 days posthatch | 15 per concentration, four replicates | 27,9 ng/L (0.0000279 mg/L) |
Seki et al. 2004 | ||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | lower gonadosomatic index | 14 days | 0, 32, 100, 320 ng/L | F | 6 months old (mature) | 7 females per concentraion | 320 ng/L (0.00032 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | P450aromB mRNA expression in the brain | 14 days | 0, 32, 100, 320 ng/L | M | 6 months old (mature) | 7 males per concentraion | 100 ng/L (0.0001 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | VTG induction | 2 weeks | 25 ng/L (0.000025 mg/L) |
Brian et al. 2005 | |||||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | P450aromB mRNA expression in the gonads | 14 days | 0, 32, 100, 320 ng/L | M | 6 months old (mature) | 7 males per concentraion | 320 ng/L (0.00032 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | P450aromB mRNA expression in the gonads | 14 days | 0, 32, 100, 320 ng/L | F | 6 months old (mature) | 7 females per concentraion | 100 ng/L (0.0001 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | lower gonadosomatic index | 14 days | 0, 32, 100, 320 ng/L | M | 6 months old (mature) | 7 males per concentraion | 100 ng/L (0.0001 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | increased VTG concentration in plasma | 14 days | 0, 32, 100, 320 ng/L | F | 6 months old (mature) | 7 females per concentraion | 100 ng/L (0.0001 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | increased VTG concentration in plasma | 14 days | 0, 32, 100, 320 ng/L | M | 6 months old (mature) | 7 males per concentraion | 32 ng/L (0.000032 mg/L) |
Halm et al. 2002 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | reduction in gonadosomatic index (GSI) | 21 days | 10, 32, 100, 320, 1000 ng/L + control | M | approaching sexual maturity | At the start of the test 7 fish were randomly allocated to each treatment | 320 ng/L (0.00032 mg/L) |
Panter et al. 1998 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Pimephales promelas (Fathead minnow) | induction of plasma vitellogenin | 21 days | 10, 32, 100, 320, 1000 ng/L + control | M | approaching sexual maturity | At the start of the test 7 fish were randomly allocated to each treatment | 100 ng/L (0.0001 mg/L) |
Panter et al. 1998 | |||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Rana temporaria (Brown frog hepatocytes) | vitellogenesis | 5 days | M | Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups. | 19 nM (0.00517598 mg/L) |
0-10 nM | Rankouhi et al. 2005 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Rana temporaria (Brown frog hepatocytes) | vitellogenesis | 5 days | M | Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups. | 43 nM (0.01171406 mg/L) |
10-100 nM | Rankouhi et al. 2005 | ||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Tisbe battagliai (Crustacean) | reproduction | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Tisbe battagliai (Crustacean) | survival | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Tisbe battagliai (Crustacean) | survival | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Tisbe battagliai (Crustacean) | survival | 10 days | <24h | 24 well microplate, one organism in each well | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Tisbe battagliai (Crustacean) | survival | 10 days | <24h | 24 well microplate, one organism in each well | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | In vitro recombinant yeast ER assay | Yeast (Saccharomyces cerevisiae strain) | induction of B-galactosidase activity | 0.78 nM (0.0002124876 mg/L) |
Segner et al. 2003a | |||||||||||||
| Estradiol | 17B-estradiol | G03CA03 | Sex hormones | 272.42 | Yeast estrogen screen (YES) assay | Yeast strain hER-ERE | growth | 5.7*10^-2 ug/L (0.0057 mg/L) |
Folmar et al. 2002 | |||||||||||||
| Estriol | G03CA04 | Sex hormones | 288.3813 | Oryzias latipes (Japanese ricefish) | induced intersex (testis-ova) | approximately 90 days | 1 day | Four test concentrations, one control, 60 fish in each | 0.075 ug/L (0.000075 mg/L) |
0.75 ug/L (0.00075 mg/L) |
Metcalfe et al. 2001 | |||||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Ictalurus punctatus (Channel catfish) | elevated serum E2 concentration | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | |||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Oryzias latipes (Japanese ricefish) | induced intersex (testis-ova) | approximately 90 days | 1 day | Four test concentrations, one control, 60 fish in each | <0.0008 ug/L | 0.008 ug/L (0.000008 mg/L) |
Metcalfe et al. 2001 | |||||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Pimephales promelas (Fathead minnow) | induction of plasma vitellogenin | 21 days | 9.9, 31.8, 99.3, 318, 993 ng/L + control | M | approaching sexual maturity | At the start of the test 7 fish were randomly allocated to each treatment | 31.8 ng/L (0.0000318 mg/L) |
Panter et al. 1998 | ||||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Pimephales promelas (Fathead minnow) | reduction in gonadosomatic index (GSI) | 21 days | 9.9, 31.8, 99.3, 318, 993 ng/L + control | M | approaching sexual maturity | At the start of the test 7 fish were randomly allocated to each treatment | 317.7 ng/L (0.0003177 mg/L) |
Panter et al. 1998 | ||||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Rana temporaria (Brown frog hepatocytes) | vitellogenesis | 5 days | M | Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups. | 218 nM (0.05893981 mg/L) |
10-100 nM | Rankouhi et al. 2005 | |||||||||||
| Estrone | G03CA07 | Sex hormones | 270.3661 | Rana temporaria (Brown frog hepatocytes) | vitellogenesis | 5 days | M | Approx. 600,000 hepatocytes/ml in 96-well plates, each conc tested in six different wells. Two experimental set-ups. | 241 nM (0.06515823 mg/L) |
10-100 nM | Rankouhi et al. 2005 | |||||||||||
| Estrone | main metabolite of estradiol | G03CA07 | Sex hormones | 270.3661 | Tisbe battagliai (Crustacean) | reproduction | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estrone | main metabolite of estradiol | G03CA07 | Sex hormones | 270.3661 | Tisbe battagliai (Crustacean) | survival | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estrone | main metabolite of estradiol | G03CA07 | Sex hormones | 270.3661 | Tisbe battagliai (Crustacean) | survival | 21 days | <24h | 24 well microplate, one organism in each well (first 10 days), then females were randomly selected and transferred individually to 12 well microplates until day 21 | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estrone | main metabolite of estradiol | G03CA07 | Sex hormones | 270.3661 | Tisbe battagliai (Crustacean) | survival | 10 days | <24h | 24 well microplate, one organism in each well | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Estrone | main metabolite of estradiol | G03CA07 | Sex hormones | 270.3661 | Tisbe battagliai (Crustacean) | survival | 10 days | <24h | 24 well microplate, one organism in each well | >/= 100 ug/L (0.1 mg/L) |
Hutchinson et al. 1999 | |||||||||||
| Etacrynic acid | C03CC01 | Diuretic agents | Chronic bioluminescence assay | Vibrio fischeri (Bacteria) | bioluminescence inhibition | 24 h | 0.561 mg/L | Backhaus and Grimme 1999 | ||||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Algae | 0.84 mg/L | Kopf 1995 in Halling-Sorensen et al. (1998) | |||||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Brachionus calyciflorus (Rotifera) | intrinsic rate of population increase | 72 h | newly hatched | Eight chambers (7 conc and one control), with eight replicates | 4.15 uM/L (1.23007411 mg/L) |
Radix et al. 2002 | |||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Brachionus calyciflorus (Rotifera) | ovigerous/non-ovigerous females | 72 h | newly hatched | Eight chambers (7 conc and one control), with eight replicates | 4.18 uM/L (1.238966212 mg/L) |
Radix et al. 2002 | |||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Carassius auratus (crucian carp) | induction of vitellogenin (reproductive endocrine disruption) | 14 days | 0.1, 0.4, 1, 4, 10, 40 ng/L | M | groups of 3 | 7.26 ng/L (0.00000726 mg/L) |
1 ng/L (0.000001 mg/L) |
4 ng/L (4 mg/L) |
Zhang et al. 2008 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Ceriodaphnia reticulata (Cladoceran) | swim inhibition | 24 h | 410, 656, 984, 1640, 2050, 2460, 3280, 4100 ug/L | juveniles | 10 cladocerans per concentration, two replicates with eight concentrations | 1814 ug/L (1.814 mg/L) |
Jaser et al. 2003 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A three generation test | Ceriodaphnia reticulata (Cladoceran) | survivorship of newly hatched juveniles | 4 weeks | 10, 50, 80, 100, 200, 300 ug/L | juveniles | One neonate per test vessel, two replicates with eight different concentrations and one control | 200 ug/L (0.2 mg/L) |
Jaser et al. 2003 | |||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Chironomus riparius (Diptera) | Deformities in the mouthparts | 10, 100 ng/L, 1, 100 ug/L, 1 mg/L | 10 per concentration | 10 ng/L (0.00001 mg/L) |
Watts et al. 2003 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Chironomus riparius (Diptera) | Reduced wet weight | 10, 100 ng/L, 1, 100 ug/L, 1 mg/L | 10 per concentration | 1 mg/L | Watts et al. 2003 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Chironomus riparius (Diptera) | Delayed moulting | 10, 100 ng/L, 1, 100 ug/L, 1 mg/L | 10 per concentration | 1 mg/L | Watts et al. 2003 | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Chironomus riparius (Insecta, diptera) | mortality | 10 days | 8.83 mg/L | Segner et al. 2003b | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | survival | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 4.1 mg/L | Dussault et al. 2008 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | EPA/600/R-99/064 (2000) | Chironomus tentans, now Chironomus dilutus (Insecta, diptera) | growth | 10 days | 12 days | 8-9 conc. 4-5 replicates and 9-10 animals in each beaker | 6.6 mg/L | Dussault et al. 2008 | ||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Coturnix japonica (Japanese quail) | Induced oviductal malformations | 0, 300 ng/egg (1 nmol/egg | F | Injection | 300 ng/egg (1 nmol/egg) | Mattsson et al. 2008 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Coturnix japonica (Japanese quail) | Weight asymmetry in left and right testes and reduction in the cloacal gland area | 0, 300 ng/egg (1 nmol/egg | M | Injection | 300 ng/egg (1 nmol/egg) | Mattsson et al. 2008 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Coturnix japonica (Japanese quail) | Retention of oviducts | 0, 300 ng/egg (1 nmol/egg | M | Injection | 300 ng/egg (1 nmol/egg) | Mattsson et al. 2008 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Coturnix japonica (Japanese quail) | Reduction of copulatory behavior | 0, 300 ng/egg (1 nmol/egg | M | Injection | 300 ng/egg (1 nmol/egg) | Mattsson et al. 2008 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Coturnix japonica (Japanese quail) | anatomical and histological changes in the oviduct | 0, 2, 20 ng/g egg | F | Immature and adult | Injection | 2 ng/g egg | Berg et al. 2001 | |||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | In vitro competitive radioreceptor assay | Cyprinus carpio (Common carp hepatic ER) | displacement of specific ER binding | 30 nM (0.008892102 mg/L) |
Segner et al. 2003a | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | In vitro VTG induction assay | Cyprinus carpio (Common carp hepatocytes) | VTG induction | 3 days | 4 days | sexually immature or F | Initial density: 1.5-2.0*10^6 cells/mL | 110 nM (0.032604374 mg/L) |
Segner et al. 2003a | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | severe morphological alterations in kidney, liver and spleen | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | reduction of total number of leukocytes | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | decrease in the mean corpuscular haemoglobin concentration | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | decrease in the haemooglobin content | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | increase in reticulocytes | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Cyprinus carpio (Common carp) | decrease in total number of erythrocytes | 70 days | 500 ug/kg three times (1st, 5th, 9th week) | Five months (juveniles) | 22 fish | Intramuscular injection | 500 ug/kg bw | Schwaiger et al. 2000 | |||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio | Increase in vitellogenin production | 18 days | 1, 2, 5, 10, 25 ng/L | 20 dph | Three replicates per concentration.,10 fish per replicate. | 2 ng/L (0.002 mg/L) |
Örn et al. 2003 | |||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio | Changes in sex ratios | 40 days | 1, 2, 5, 10, 25 ng/L | F | 20 dph | Three replicates per concentration., 30 fish per replicate. | 1 ng/L (0.001 mg/L) |
Örn et al. 2003 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | VTG induction | from fertilization to reproductive age | F+M | 1.67 ng/L (0.00000167 mg/L) |
Segner et al. 2003b | ||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | vitellogenin induction | 8 days | 0, 1, 2, 4, 8, 12, 16, 20, 30, 100 ng/L | M | adult | 20 fish exposed to each concentration | 2.51 ng/L (0.00000251 mg/L) |
3.0 ng/L (0.000003 mg/L) |
Rose et al. 2002 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | fertilization success | from fertilization to reproductive age | F+M | 1.67 ng/L (0.00000167 mg/L) |
Segner et al. 2003b | ||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | increase in average total RNA | 17 days | 50 ng/L | M | adult (2.5-4 cm) | 8 individuals exposed per concentration | 50 ng/L (0.00005 mg/L) |
Islinger et al. 2003 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | expression of estrogen regulated genes (ERa) | 4 days | 0.25-85 ng/L | M | adult (2.5-4 cm) | 8 individuals exposed per concentration | 2.5 ng/L (0.0000025 mg/L) |
Islinger et al. 2003 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | expression of estrogen regulated genes (zfvg 3) | 21 days | 0.25-85 ng/L | M | adult (2.5-4 cm) | 8 individuals exposed per concentration | 2.5 ng/L (0.0000025 mg/L) |
Islinger et al. 2003 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | expression of estrogen regulated genes (zfvg 3) | 4 days | 0.25-85 ng/L | M | adult (2.5-4 cm) | 8 individuals exposed per concentration | 8.5 ng/L (0.0000085 mg/L) |
Islinger et al. 2003 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | In vivo full life cycle test | Danio rerio (Zebrafish) | fertilization success | From fertilized eggs until sexual maturation | 0.05, 0.28, 1.7, 10 ng/L (nominal conc.) | Initially 100 fertilized eggs per test vessel were exposed | 0.0037 nM (0.00000109669258 mg/L) |
Segner et al. 2003a | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | egg production | 210 days | 0.5, 5 ng/L | F+M | F1 generation, life-long exposure | 0.5 ng/L (0.0000005 mg/L) |
5 ng/L (0.000005 mg/L) |
Nash et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Danio rerio (Zebrafish) | egg production | 10 days | 0.5, 5, 50 ng/L | F+M | adults | 12 fish per replicare, 12 replicates per koncentration | 5 ng/L (0.000005 mg/L) |
50 ng/L (0.00005 mg/L) |
Nash et al. 2004 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | OECD 210 (extended until 42 days postfertilization) | Danio rerio (Zebrafish) | induction of plasma vitellogenin | 42 days | 3 ng/L | F | hatch to juvenile (early life exposure) | 3 ng/L (0.000003 mg/L) |
Fenske et al. 2005 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | OECD 210 (extended until 42 days postfertilization) | Danio rerio (Zebrafish) | gonadal feminization (inhibited reproduction) | 118 days | 3 ng/L | hatch to adult (full life-cycle exposure) | 3 ng/L (0.000003 mg/L) |
Fenske et al. 2005 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Daphnia (Crustacean) | reproduction | 0.105 mg/L | 0.01 mg/L | Kopf 1995 in Halling-Sorensen et al. (1998) | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Daphnia (Crustacean) | 5.7 mg/L | Kopf 1995 in Halling-Sorensen et al. (1998) | |||||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Daucus carota (Wild carrot) | Growth (root length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Daucus carota (Wild carrot) | Growth (root length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Daucus carota (Wild carrot) | Growth (root length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Domestic hen | eggshell thinning and altered shell gland carbonic anhydrase expression | 0, 2, 7, 20 ng/g egg | 32 weeks | 37-40 per dose | Injection | 20ng/g egg | Berg et al. 2004 | |||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Gammarus pulex (Crustacea, amphipoda) | mortality | 10 days | 0.84 mg/L | Segner et al. 2003b | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 354.2 ug/L (0.3542 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | 115.9 ug/L (0.1159 mg/L) |
300 ug/L (0.3 mg/L) |
Hillis et al. 2008 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 36.9 ug/L (0.0369 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Spore production | 14 days | 0, 10, 30, 100, 300, 1000 ug/L | 168.6 ug/L (0.1686 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 28 days | 0, 10, 30, 100, 300, 1000 ug/L | >1000 ug/L | Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Glomus intraradices (Mycorrhizal fungus) | Growth (hyphal length) | 21 days | 0, 10, 30, 100, 300, 1000 ug/L | 312.6 ug/L (0.3126 mg/L) |
Hillis et al. 2008 | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | growth | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 1.3 mg/L | Dussault et al. 2008 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Multigeneration toxicity test | Hyalella azteca (Freshwater amphipod) | sexual development | 35 weeks | 0.1, 0.32, 1, 3.2, 10 ug/L | At the start of the experiment, 150 precopulatory pairs were added to each treatment. | 0.0001 mg/L | Vandenbergh et al. 2003 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | EPA/600/R-99/064 (2000) | Hyalella azteca (Freshwater amphipod) | survival | 10 days | 7-14 days | 8-9 conc. 4-5 replicates and 8-15 animals in each beaker | 1.1 mg/L | Dussault et al. 2008 | ||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Hydra vulgaris (Cnidaria) | Impaired sexual reproduction | 6 weeks | 10 ng/L-5 mg/L | 500 ug/L (0.0005 mg/L) |
Pascoe et al. 2002 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Hydra vulgaris (Cnidaria) | mortality | 96 h | 1.6, 2.5, 4, 4.6, 5.6, 6.2, 6.8, 7.5, 8.2, 8.6, 9.2, 10 mg/L | 3,8 | Pascoe et al. 2002 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Hydra vulgaris (Cnidaria) | Effects on the structure and physiology of the polyps | 72 h | 10 ng/L-5 mg/L | 58 ug/L (0.000058 mg/L) |
Pascoe et al. 2002 | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Hydra vulgaris (Cnidaria) | Inhibition of generation | 72 h | 10 ng/L-5 mg/L | 150 ug/L (0.00015 mg/L) |
Pascoe et al. 2002 | |||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Hydra vulgaris (Coelenterate) | mortality | 96 h | 3.78 mg/L | Segner et al. 2003b | |||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | In vitro study | Ictalurus punctatus (Channel catfish) | binding inhibition | F | 2 years | 0.43 nM (0.000127453462 mg/L) |
Nimrod and Benson 1997 | ||||||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Ictalurus punctatus (Channel catfish) | induction of vitellogenin | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | |||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Ictalurus punctatus (Channel catfish) | elevated serum E2 concentration | 7 days | 1 mg/kg | M | 12-18 months (200-500 g) | Five fish | Intraperitoneally injected (i.p.) | 1 mg/kg | Tilton et al. 2001 | |||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | MCF-7 breast tumor cell proliferation (E-Screen) assay | MCF-7 cells | growth | 5.0*10^-3 ug/L (0.005 mg/L) |
Folmar et al. 2002 | ||||||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Swedish standard SS 02 81 06, SIS (1991) | Nitocra spinipes (Harpacticoid copepod) | mortality | 96 h | <24h | 10-15 nauplii in each vial, randomly allocated into different groups, six replicates per group | 0.51 mg/L | Breitholtz and Bengtsson 2001 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | In vitro VTG induction assay | Oncorhynchus mykiss (Rainbow trout hepatocytes) | VTG induction | 3 days | 4 days | sexually immature or F | Initial density: 1.5-2.0*10^6 cells/mL | 65 nM (0.019266221 mg/L) |
Segner et al. 2003a | |||||||||
| Ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Oryzias latipes (Japanese medaka) | Phenotypic sex-reversal of genetic males | 0, 0.005, 0.05, 0.5, 2.5, 5 ng/egg | M | embryo | Injection | 0.5 ng/egg | Papoulias et al. 1999 | |||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Oryzias latipes (Japanese medaka) | decrease in egg production | 2 months | recovery period of 6 weeks | 0, 1, 10 and 100 ng/L | juvenile | 50 per konc, 25 for control | 10 ng/L (0.01 mg/L) |
Scholz and Gutzeit 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Oryzias latipes (Japanese medaka) | sexual differentiation | 2 months | recovery period of 6 weeks | 0, 1, 10 and 100 ng/L | juvenile | 50 per konc, 25 for control | 100 ng/L (0.1 mg/L) |
Scholz and Gutzeit 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Oryzias latipes (Japanese medaka) | aromatase gene expression | 2 months | recovery period of 6 weeks | 0, 1, 10 and 100 ng/L | juvenile | 50 per konc, 25 for control | 10 ng/L (0.01 mg/L) |
Scholz and Gutzeit 2000 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Oryzias latipes (Japanese ricefish) | induced intersex (testis-ova) | approximately 90 days | 1 day | Five test concentrations, one control, 60 fish in each | <0.00003 ug/L | 0.00003 ug/L (0.00000003 mg/L) |
Metcalfe et al. 2001 | ||||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | plasma vitellogenin | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | F+M | 6-12 months | 1 ng/L (0.000001 mg/L) |
Pawlowski et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Life-cycle assay | Pimephales promelas (Fathead minnow) | mean condition factor | sampled at 8, 15, 30, 60 and 150 days posthatch | 150 days | 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) | F+M | exposure began 48-60 h after fertilization | 30 eggs in each of two cups, placed in each aquarium | 9.6 ng/L (60 dph) (0.0000096 mg/L) |
Parrott and B. R. Blunt 2005 | |||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Life-cycle assay | Pimephales promelas (Fathead minnow) | growth | sampled at 8, 15, 30, 60 and 150 days posthatch | 150 days | 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) | F+M | exposure began 48-60 h after fertilization | 30 eggs in each of two cups, placed in each aquarium | 23 ng/L (60 dph) (0.000023 mg/L) |
Parrott and B. R. Blunt 2005 | |||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | OECD test guideline 204 (1992) | Pimephales promelas (Fathead minnow) | vitellogenin induction | 4, 7, 14 and 21 days | 0.002, 0.005, 0.02 ug/L (measured conc.) | 45-100 days posthatch | 64 fish with two replicates for each concentration and control(s) | 0.002 ug/L (4 days of exposure) (0.000002 mg/L) |
Panter et al. 2002 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | fertilization rate | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | M | 6-12 months | 10 ng/L (0.00001 mg/L) |
Pawlowski et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | number of tubercles | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | M | 6-12 months | </= 12 individuals | 1 ng/L (0.000001 mg/L) |
Pawlowski et al. 2004 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | liver (ultrastructure) | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | F | 6-12 months | 3 ng/L (0.000003 mg/L) |
Pawlowski et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | liver (ultrastructure) | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | M | 6-12 months | 1 ng/L (0.000001 mg/L) |
Pawlowski et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | liver (histology) | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | F+M | 6-12 months | three fish per concentration | 3 ng/L (0.000003 mg/L) |
Pawlowski et al. 2004 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | Life-cycle assay | Pimephales promelas (Fathead minnow) | ovipositor development | sampled at 8, 15, 30, 60 and 150 days posthatch | 150 days | 0, 0.32, 0.96, 3.2, 9.6, 32 ng/L (nominal conc.) | F+M | exposure began 48-60 h after fertilization | 30 eggs in each of two cups, placed in each aquarium | 3.5 ng/L (60 dph) (0.0000035 mg/L) |
Parrott and B. R. Blunt 2005 | |||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | testes (histology) | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | M | 6-12 months | five fish per concentration and for the control | 10 ng/L (0.00001 mg/L) |
Pawlowski et al. 2004 | ||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | mean no of spawned eggs/pair | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng/L (nominal conc.) | F | 6-12 months | 0.1 ng/L (0.0000001 mg/L) |
Pawlowski et al. 2004 | |||||||||
| Ethinylestradiol | 17a-ethinylestradiol | G03CA01 | Sex hormones | 296.4034 | A gonadal recrudescence assay | Pimephales promelas (Fathead minnow) | gonadosomatic index | 3 weeks | 0, 0.1, 1, 3, 10, 100 ng |